iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052648

Ensembl Protein ID

ENSLOCP00000006266.1

UniProt Accession

W5MD07; W5MD07_LEPOC

Genbank Protein ID

ENSLOCP00000006266

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01028901

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000005202.1	ENSLOCT00000006274.1	ENSLOCP00000006266.1
ENSLOCG00000005202.1	ENSLOCT00000006296.1	ENSLOCP00000006288.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-121	404.9	1222	1554

Active Site

Position(s)	Description	Evidence
1522	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1222 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1307
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipV ++Nk+eY+++
   Q: 1308 AFFTRPFYKGLLRIPCDLSDLEYLDEEFHQSLQWMKDN---DINDM-LDLTFTVNEEVFGQITERELKPGGANIPVSEKNKKEYIER 1390
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1391 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1477
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ek+l+A+eet+ F+l+
   Q: 1478 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKMLTAVEETSTFGLE 1554
           **************************************************************************985 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MAASAREHLL FVRRRSPQMR YTLSPENLQS LAEQSSGPPE PMGLQRANSD TNLVTSDSRS 60
SLTASTYEFT LGLAQNLIIS WDIKEEVDAT DWIGLYHIDE TCPANVWDSK NRGVNGTQKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCCCATTG AAGTCCGGAA ACTCAGCCCT GCTCCTAATT CTCCATACAA CAGGGCTTGT 60
AAGATACCCA TTTATAAAAC TCAGGTTTCC TGGATATAAC CCTCCCATCC TCACTCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	71.78	0.00e+00	2177.00
IUUC-Apl-003935	Anas platyrhynchos	79.14	0.00e+00	1523.00
IUUC-Aca-004558	Anolis carolinensis	79.17	0.00e+00	1516.00
IUUC-Ame-010893	Astyanax mexicanus	93.65	0.00e+00	1372.00
IUUC-Bta-013093	Bos taurus	89.07	0.00e+00	1470.00
IUUC-Cja-019651	Callithrix jacchus	70.24	0.00e+00	2064.00
IUUC-Cfa-021232	Canis familiaris	91.68	0.00e+00	1511.00
IUUC-Cpo-021770	Cavia porcellus	70.79	0.00e+00	2172.00
IUUC-Csa-023970	Chlorocebus sabaeus	76.53	0.00e+00	1529.00
IUUC-Cho-024512	Choloepus hoffmanni	81.85	0.00e+00	1296.00
IUUC-Csv-026127	Ciona savignyi	71.71	2.00e-154	538.00
IUUC-Dre-028275	Danio rerio	91.04	0.00e+00	1577.00
IUUC-Dno-029963	Dasypus novemcinctus	70.39	0.00e+00	2040.00
IUUC-Dme-032217	Drosophila melanogaster	70.92	0.00e+00	657.00
IUUC-Ete-033132	Echinops telfairi	77.38	0.00e+00	1170.00
IUUC-Eca-033978	Equus caballus	71.40	0.00e+00	2149.00
IUUC-Fca-036157	Felis catus	71.59	0.00e+00	2149.00
IUUC-Fal-037110	Ficedula albicollis	88.90	0.00e+00	1513.00
IUUC-Gmo-039291	Gadus morhua	69.92	0.00e+00	1199.00
IUUC-Gga-040821	Gallus gallus	72.18	0.00e+00	2181.00
IUUC-Gac-042181	Gasterosteus aculeatus	81.84	0.00e+00	1457.00
IUUC-Ggo-044862	Gorilla gorilla	71.14	0.00e+00	2059.00
IUUC-Hsa-046219	Homo sapiens	77.64	0.00e+00	1565.00
IUUC-Lch-050526	Latimeria chalumnae	82.42	0.00e+00	1497.00
IUUC-Laf-054005	Loxodonta africana	79.24	0.00e+00	1550.00
IUUC-Mcc-055314	Macaca mulatta	70.80	0.00e+00	2157.00
IUUC-Meu-056356	Macropus eugenii	78.46	0.00e+00	773.00
IUUC-Mga-060074	Meleagris gallopavo	78.71	0.00e+00	1446.00
IUUC-Mmr-061526	Microcebus murinus	91.42	0.00e+00	1513.00
IUUC-Mdo-063017	Monodelphis domestica	71.88	0.00e+00	2160.00
IUUC-Mmu-064165	Mus musculus	71.06	0.00e+00	2149.00
IUUC-Mpu-065835	Mustela putorius furo	88.26	0.00e+00	1446.00
IUUC-Mlu-067709	Myotis lucifugus	69.23	0.00e+00	2115.00
IUUC-Nle-069308	Nomascus leucogenys	71.98	0.00e+00	2166.00
IUUC-Opr-070330	Ochotona princeps	59.73	0.00e+00	1709.00
IUUC-Ont-071345	Oreochromis niloticus	89.67	0.00e+00	1471.00
IUUC-Ocu-074775	Oryctolagus cuniculus	69.53	0.00e+00	1944.00
IUUC-Ola-087225	Oryzias latipes	85.19	0.00e+00	1402.00
IUUC-Oga-088177	Otolemur garnettii	78.98	0.00e+00	1519.00
IUUC-Oar-089452	Ovis aries	71.09	0.00e+00	2154.00
IUUC-Ptr-090806	Pan troglodytes	71.98	0.00e+00	2176.00
IUUC-Pan-091838	Papio anubis	70.45	0.00e+00	2048.00
IUUC-Psi-094090	Pelodiscus sinensis	77.24	0.00e+00	1484.00
IUUC-Pfo-096520	Poecilia formosa	84.95	0.00e+00	1474.00
IUUC-Pab-098405	Pongo abelii	71.80	0.00e+00	2165.00
IUUC-Pva-102324	Pteropus vampyrus	90.94	0.00e+00	1499.00
IUUC-Rno-105943	Rattus norvegicus	71.06	0.00e+00	2185.00
IUUC-Sha-106985	Sarcophilus harrisii	76.89	0.00e+00	1461.00
IUUC-Sar-113505	Sorex araneus	88.40	0.00e+00	1429.00
IUUC-Ssc-115534	Sus scrofa	98.07	0.00e+00	747.00
IUUC-Tgu-117078	Taeniopygia guttata	88.58	0.00e+00	1511.00
IUUC-Tru-118671	Takifugu rubripes	85.60	0.00e+00	1499.00
IUUC-Tni-120619	Tetraodon nigroviridis	89.81	0.00e+00	1464.00
IUUC-Ttr-128469	Tursiops truncatus	70.85	0.00e+00	1314.00
IUUC-Vpa-130498	Vicugna pacos	64.74	0.00e+00	1118.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence