iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108020

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-activating enzyme E1-like; Pmt3-activating enzyme subunit 2

Genbank Nucleotide ID

CU329671

Gene Name

uba2; SPBC16H5.03c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC16H5.03c	SPBC16H5.03c.1	SPBC16H5.03c.1:pep

Annotation

mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	17762864

Classification

Family	E-value	Score	Start	End
E1	6.40e-126	418.9	17	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 10   eeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitel 100
            ea +++ksakvllvGagg+GcEllKnL ++Gv++++++D dt+++snlnrqFLfr+++v+++KA vaa+++  +np+v++ea++ +i+e+
   Q: 17   VEALRNFKSAKVLLVGAGGIGCELLKNLLMSGVKEVHIIDLDTIDLSNLNRQFLFRKKHVKQPKAIVAAKTASSFNPNVKLEAYHANIKED 107
           588999************************************************************************************* PP
   S: 101  eeeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa. 190
             ++ +f++fd+V++aldn++arr+vn+ cl a+vpliesgt+G+lGqv+vii+g+tecy+c++++p kt+P+ct+++tp+++ h+++wa 
   Q: 108  RFNVAWFRQFDLVFNALDNLDARRHVNKQCLLASVPLIESGTTGFLGQVQVIIHGKTECYDCNPKEPPKTYPVCTIRSTPSQPIHCVVWAk 198
           ***99************************************************************************************** PP
   S: 191  .vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv..... 274
            ++f +l++++++++   ++++++e+e+ + ++ +++++e +e         +++   +++n+  k ++k+f++div+ +++p+ +     
   Q: 199  sYFFPQLFSNDQESDGIIDNVSANEMERREIAELARETTELNE---------LRSSIGQSDNGfEKIFTKMFTKDIVRLREVPDAWtyrsp 280
           **********************999999999999888888777.........999999999999*************************** PP
   S: 275  .......sfcsnaealqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddli 358
                  ++ +nae++ +p+ +e++ ++v++s  + +l  +++r++ ++++++++lsf+kdd++ +d+v+aaanlra+ +gi++ l++++i
   Q: 281  pkelsysELLENAEKATSPWLNEQNVWNVAES--FAVLRDSIRRLALRSKSSKDDLSFDKDDKDTLDFVAAAANLRAHVFGIQQ-LSEFDI 368
           ****************************9888..99************************************************.****** PP
   S: 359  keiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflf 401
           k++agniipaiattnav++Gl+ +++iKv++g+ + lkn++l 
   Q: 369  KQMAGNIIPAIATTNAVIAGLCITQAIKVLQGDLNDLKNIYLA 411
           ***************************************9986 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity).

Protein Sequence
(Fasta)

MPTLMQLSND MKPLTFVEAL RNFKSAKVLL VGAGGIGCEL LKNLLMSGVK EVHIIDLDTI 60
DLSNLNRQFL FRKKHVKQPK AIVAAKTASS FNPNVKLEAY HANIKEDRFN VAWFRQFDLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTATCGC GCAGGGACTT CAAAATTAAT AATAGCTGGC GAACTTGCTA TTTATTCTAT 60
TTGTATGGGA TTGTTTTTCT CGCTTCTTTT AAGCCCATAA TTAGAATCGA TTGCTAACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR028077--UAE_UbL_dom
IPR019572--UBA_E1_Cys
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF14732--UAE_UbL
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0005634--C:nucleus
GO:0031510--C:SUMO activating enzyme complex
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

spo:SPBC16H5.03c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	43.59	1.00e-108	384.00
IUUC-Aml-001662	Ailuropoda melanoleuca	43.72	9.00e-97	345.00
IUUC-Atr-002636	Amborella trichopoda	38.09	2.00e-108	384.00
IUUC-Apl-003369	Anas platyrhynchos	45.22	4.00e-90	323.00
IUUC-Aca-004490	Anolis carolinensis	44.99	4.00e-80	290.00
IUUC-Aly-006359	Arabidopsis lyrata	41.52	8.00e-99	352.00
IUUC-Ath-007667	Arabidopsis thaliana	42.22	4.00e-102	363.00
IUUC-Ago-007844	Ashbya gossypii	40.38	9.00e-103	365.00
IUUC-Acl-008270	Aspergillus clavatus	54.17	2.00e-147	514.00
IUUC-Afl-008674	Aspergillus flavus	50.89	3.00e-153	533.00
IUUC-Afu-008883	Aspergillus fumigatus	50.74	9.00e-151	525.00
IUUC-Ani-009500	Aspergillus nidulans	51.81	1.00e-155	540.00
IUUC-Ang-009535	Aspergillus niger	53.58	6.00e-155	538.00
IUUC-Aor-010223	Aspergillus oryzae	52.01	4.00e-153	532.00
IUUC-Ate-010282	Aspergillus terreus	48.26	2.00e-130	457.00
IUUC-Ame-011736	Astyanax mexicanus	44.30	8.00e-103	365.00
IUUC-Bgr-012166	Blumeria graminis	46.85	6.00e-132	462.00
IUUC-Bta-012589	Bos taurus	44.07	2.00e-98	351.00
IUUC-Bci-013802	Botrytis cinerea	48.77	6.00e-142	495.00
IUUC-Bdi-014697	Brachypodium distachyon	37.33	1.00e-103	368.00
IUUC-Bol-016315	Brassica oleracea	38.82	3.00e-102	363.00
IUUC-Bra-018066	Brassica rapa	41.44	7.00e-102	362.00
IUUC-Cel-018708	Caenorhabditis elegans	37.79	3.00e-89	320.00
IUUC-Cja-019120	Callithrix jacchus	43.62	4.00e-96	343.00
IUUC-Cfa-021061	Canis familiaris	44.07	2.00e-98	351.00
IUUC-Cpo-021842	Cavia porcellus	43.62	3.00e-96	343.00
IUUC-Csa-024104	Chlorocebus sabaeus	43.62	4.00e-96	343.00
IUUC-Cho-024332	Choloepus hoffmanni	42.21	3.00e-83	300.00
IUUC-Cin-025363	Ciona intestinalis	40.12	1.00e-95	342.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	50.29	9.00e-128	448.00
IUUC-Cne-026888	Cryptococcus neoformans	43.04	1.00e-90	325.00
IUUC-Cme-027315	Cyanidioschyzon merolae	32.36	3.00e-63	234.00
IUUC-Dre-028420	Danio rerio	43.68	6.00e-99	353.00
IUUC-Dno-030041	Dasypus novemcinctus	43.85	5.00e-97	346.00
IUUC-Dse-031504	Dothistroma septosporum	44.60	6.00e-126	442.00
IUUC-Dme-031771	Drosophila melanogaster	41.61	4.00e-80	290.00
IUUC-Ete-033037	Echinops telfairi	40.49	3.00e-84	303.00
IUUC-Eca-033774	Equus caballus	43.95	2.00e-92	330.00
IUUC-Eeu-035074	Erinaceus europaeus	38.70	1.00e-53	202.00
IUUC-Fca-036508	Felis catus	43.95	4.00e-92	330.00
IUUC-Fal-036813	Ficedula albicollis	44.60	2.00e-92	331.00
IUUC-Fox-038056	Fusarium oxysporum	49.90	1.00e-132	465.00
IUUC-Fso-038223	Fusarium solani	50.78	3.00e-130	456.00
IUUC-Gmo-038526	Gadus morhua	45.56	4.00e-89	320.00
IUUC-Ggr-039767	Gaeumannomyces graminis	51.64	7.00e-127	445.00
IUUC-Gga-040981	Gallus gallus	45.63	9.00e-90	322.00
IUUC-Gac-041437	Gasterosteus aculeatus	44.96	2.00e-102	364.00
IUUC-Gma-044072	Glycine max	41.60	3.00e-107	380.00
IUUC-Ggo-045358	Gorilla gorilla	43.62	4.00e-96	343.00
IUUC-Hsa-046068	Homo sapiens	43.62	4.00e-96	343.00
IUUC-Hvu-047646	Hordeum vulgare	42.83	1.00e-106	378.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	43.85	1.00e-96	345.00
IUUC-Lch-049565	Latimeria chalumnae	44.42	1.00e-102	365.00
IUUC-Lpe-050884	Leersia perrieri	42.86	1.00e-106	379.00
IUUC-Loc-052493	Lepisosteus oculatus	44.40	9.00e-103	365.00
IUUC-Lma-053117	Leptosphaeria maculans	52.32	9.00e-149	518.00
IUUC-Laf-054518	Loxodonta africana	43.37	2.00e-96	344.00
IUUC-Mcc-055334	Macaca mulatta	43.62	5.00e-96	343.00
IUUC-Mor-057137	Magnaporthe oryzae	48.85	5.00e-119	419.00
IUUC-Mpo-057449	Magnaporthe poae	49.49	3.00e-124	437.00
IUUC-Mtr-058045	Medicago truncatula	40.74	1.00e-106	378.00
IUUC-Mla-058864	Melampsora laricipopulina	46.94	1.00e-100	358.00
IUUC-Mga-059422	Meleagris gallopavo	42.89	2.00e-75	275.00
IUUC-Mvi-060536	Microbotryum violaceum	44.66	2.00e-103	367.00
IUUC-Mmr-061161	Microcebus murinus	43.69	1.00e-95	342.00
IUUC-Mdo-061802	Monodelphis domestica	44.04	2.00e-95	341.00
IUUC-Mmu-064357	Mus musculus	44.14	8.00e-103	365.00
IUUC-Mac-065475	Musa acuminata	42.49	1.00e-106	378.00
IUUC-Mpu-066895	Mustela putorius furo	44.07	2.00e-98	351.00
IUUC-Mlu-067862	Myotis lucifugus	44.10	1.00e-98	351.00
IUUC-Nfi-068385	Neosartorya fischeri	54.28	2.00e-155	540.00
IUUC-Ncr-068885	Neurospora crassa	46.12	7.00e-134	468.00
IUUC-Nle-069524	Nomascus leucogenys	43.95	1.00e-95	342.00
IUUC-Opr-071038	Ochotona princeps	43.96	9.00e-103	365.00
IUUC-Ont-071719	Oreochromis niloticus	45.53	9.00e-103	365.00
IUUC-Oan-072877	Ornithorhynchus anatinus	43.46	5.00e-87	313.00
IUUC-Ocu-074080	Oryctolagus cuniculus	43.62	3.00e-96	344.00
IUUC-Oba-075936	Oryza barthii	38.52	2.00e-105	374.00
IUUC-Obr-076841	Oryza brachyantha	39.40	6.00e-107	379.00
IUUC-Ogl-077686	Oryza glaberrima	38.61	1.00e-107	381.00
IUUC-Ogu-078597	Oryza glumaepatula	37.69	1.00e-102	365.00
IUUC-Oin-079791	Oryza indica	38.52	2.00e-105	374.00
IUUC-Olo-081009	Oryza longistaminata	38.52	2.00e-105	374.00
IUUC-Ome-081327	Oryza meridionalis	35.74	1.00e-98	352.00
IUUC-Oni-082334	Oryza nivara	38.06	1.00e-103	368.00
IUUC-Opu-083447	Oryza punctata	41.91	9.00e-105	372.00
IUUC-Oru-084977	Oryza rufipogon	38.52	2.00e-105	374.00
IUUC-Osa-086160	Oryza sativa	45.15	2.00e-96	343.00
IUUC-Ola-087415	Oryzias latipes	39.53	1.00e-100	358.00
IUUC-Olu-087850	Ostreococcus lucimarinus	38.89	3.00e-93	333.00
IUUC-Oga-088434	Otolemur garnettii	43.40	5.00e-96	343.00
IUUC-Oar-089872	Ovis aries	43.95	2.00e-92	331.00
IUUC-Ptr-091212	Pan troglodytes	43.62	4.00e-96	343.00
IUUC-Pan-092708	Papio anubis	59.89	7.00e-60	222.00
IUUC-Psi-093703	Pelodiscus sinensis	44.19	1.00e-92	332.00
IUUC-Pno-094953	Phaeosphaeria nodorum	49.64	1.00e-142	498.00
IUUC-Ppa-095963	Physcomitrella patens	41.72	2.00e-99	354.00
IUUC-Pfo-097515	Poecilia formosa	46.15	5.00e-103	366.00
IUUC-Pab-097951	Pongo abelii	41.76	2.00e-73	267.00
IUUC-Pop-099703	Populus trichocarpa	39.38	3.00e-94	337.00
IUUC-Pca-100426	Procavia capensis	44.39	4.00e-97	347.00
IUUC-Ppe-101152	Prunus persica	41.91	3.00e-110	390.00
IUUC-Pva-102792	Pteropus vampyrus	45.69	6.00e-90	322.00
IUUC-Pgr-103592	Puccinia graminis	42.86	7.00e-110	389.00
IUUC-Ptt-103805	Puccinia triticina	40.04	3.00e-89	320.00
IUUC-Pte-104215	Pyrenophora teres	50.27	1.00e-154	538.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	49.37	1.00e-153	534.00
IUUC-Rno-106117	Rattus norvegicus	43.84	3.00e-103	367.00
IUUC-Sce-106177	Saccharomyces cerevisiae	38.78	3.00e-97	347.00
IUUC-Sha-107006	Sarcophilus harrisii	44.64	1.00e-96	345.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	56.38	0.00e+00	628.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	50.09	1.00e-138	484.00
IUUC-Smo-109264	Selaginella moellendorffii	42.01	4.00e-96	343.00
IUUC-Sit-110581	Setaria italica	41.34	1.00e-103	368.00
IUUC-Sly-111870	Solanum lycopersicum	42.03	3.00e-108	384.00
IUUC-Stu-112283	Solanum tuberosum	41.79	5.00e-108	383.00
IUUC-Sar-113432	Sorex araneus	56.49	5.00e-39	154.00
IUUC-Sbi-114075	Sorghum bicolor	40.51	2.00e-104	370.00
IUUC-Sre-114926	Sporisorium reilianum	46.60	7.00e-119	419.00
IUUC-Ssc-116281	Sus scrofa	59.89	4.00e-59	218.00
IUUC-Tgu-117247	Taeniopygia guttata	44.84	1.00e-92	332.00
IUUC-Tru-118075	Takifugu rubripes	43.70	3.00e-86	310.00
IUUC-Tsy-119398	Tarsius syrichta	59.84	9.00e-39	152.00
IUUC-Tni-120771	Tetraodon nigroviridis	39.28	1.00e-68	252.00
IUUC-Tca-121651	Theobroma cacao	42.66	1.00e-110	391.00
IUUC-Tre-122224	Trichoderma reesei	50.70	8.00e-122	429.00
IUUC-Tvi-122634	Trichoderma virens	49.90	3.00e-118	417.00
IUUC-Tae-123607	Triticum aestivum	42.74	1.00e-106	378.00
IUUC-Tur-126417	Triticum urartu	42.68	4.00e-106	376.00
IUUC-Tme-127016	Tuber melanosporum	53.47	1.00e-136	478.00
IUUC-Tbe-127678	Tupaia belangeri	59.84	2.00e-38	152.00
IUUC-Ttr-128598	Tursiops truncatus	42.73	4.00e-92	330.00
IUUC-Uma-129612	Ustilago maydis	45.76	8.00e-105	372.00
IUUC-Vda-129811	Verticillium dahliae	49.90	6.00e-121	426.00
IUUC-Vpa-130732	Vicugna pacos	35.49	3.00e-64	237.00
IUUC-Vvi-130832	Vitis vinifera	41.99	8.00e-103	365.00
IUUC-Xtr-132823	Xenopus tropicalis	40.92	3.00e-89	320.00
IUUC-Xma-133552	Xiphophorus maculatus	46.15	4.00e-103	366.00
IUUC-Yli-134666	Yarrowia lipolytica	47.92	2.00e-113	400.00
IUUC-Zma-134976	Zea mays	40.83	5.00e-104	370.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence