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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-104945
Ensembl Protein ID ENSRNOP00000013779.3
UniProt Accession Q6P6U0; Q63206; FGR_RAT
Genbank Protein ID CAA40337.1; EDL80655.1; EDL80656.1; EDL80657.1; AAH62025.1
Protein Name Tyrosine-protein kinase Fgr; Proto-oncogene c-Fgr; p55-Fgr
Genbank Nucleotide ID X57018; CH473968; CH473968; CH473968; BC062025
Gene Name Fgr
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000009912.5 ENSRNOT00000013778.5 ENSRNOP00000013779.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-14 54.3 70 125
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea + d+Lt++kG++ +++  ++++ +W+++ +  +g+ G +P+n+v+ ++
   Q: 70   FVALYDYEARTGDDLTFTKGEKFHIL--NNTEYDWWEARSLSSGRTGYVPSNYVAPVD 125
           789***********************..889999********************9987 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
 Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Protein Sequence
(Fasta)
MGCVFCKKLE PAPKEDVGLE GDFRSQGAEE RYYPDPTQGR SSSISPQPIS PAFLNVGNIR 60
SVSGTGVTIF VALYDYEART GDDLTFTKGE KFHILNNTEY DWWEARSLSS GRTGYVPSNY 120
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Protein Fasta Sequence


>IUUC-Rno-104945|UBD,SH3|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GGACAGGGGC GGGTAGCACT TCACTTTCCC CTCACATCGT TCCTGAAAAT TAGGGTTGGC 60
TCGCCCCAGA TCGGGTCACC AGCAGCTGGC TCCCTTGAGA CCAGGTAGGC GGCCAAACCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-104945|UBD,SH3|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0391--Immunity
KW-0399--Innate immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0496--Mitochondrion
KW-0999--Mitochondrion inner membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005758--C:mitochondrial intermembrane space
GO:0005886--C:plasma membrane
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0034987--F:immunoglobulin receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001784--F:phosphotyrosine binding
GO:0019901--F:protein kinase binding
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0050830--P:defense response to Gram-positive bacterium
GO:0045087--P:innate immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0030335--P:positive regulation of cell migration
GO:0050715--P:positive regulation of cytokine secretion
GO:0043306--P:positive regulation of mast cell degranulation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0045088--P:regulation of innate immune response
GO:0050764--P:regulation of phagocytosis
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG rno:79113
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001938 Ailuropoda melanoleuca 85.93 0.00e+00 941.00
IUUC-Bta-012607 Bos taurus 85.20 0.00e+00 928.00
IUUC-Cja-018914 Callithrix jacchus 82.37 0.00e+00 906.00
IUUC-Cfa-020165 Canis familiaris 84.44 0.00e+00 925.00
IUUC-Cpo-021476 Cavia porcellus 84.82 0.00e+00 906.00
IUUC-Csa-023692 Chlorocebus sabaeus 84.69 0.00e+00 920.00
IUUC-Dno-028920 Dasypus novemcinctus 82.54 0.00e+00 902.00
IUUC-Eca-033581 Equus caballus 85.39 0.00e+00 940.00
IUUC-Fca-036499 Felis catus 84.25 0.00e+00 925.00
IUUC-Ggo-044640 Gorilla gorilla 85.26 0.00e+00 927.00
IUUC-Hsa-046751 Homo sapiens 85.07 0.00e+00 924.00
IUUC-Itr-048218 Ictidomys tridecemlineatus 88.59 0.00e+00 957.00
IUUC-Laf-054128 Loxodonta africana 83.49 0.00e+00 917.00
IUUC-Mcc-054715 Macaca mulatta 84.88 0.00e+00 925.00
IUUC-Meu-056155 Macropus eugenii 80.57 0.00e+00 767.00
IUUC-Mmr-060615 Microcebus murinus 85.31 0.00e+00 924.00
IUUC-Mmu-063286 Mus musculus 94.58 0.00e+00 1013.00
IUUC-Mpu-066641 Mustela putorius furo 85.74 0.00e+00 936.00
IUUC-Oan-073486 Ornithorhynchus anatinus 73.97 0.00e+00 810.00
IUUC-Ocu-074552 Oryctolagus cuniculus 84.60 0.00e+00 915.00
IUUC-Oga-088731 Otolemur garnettii 84.82 0.00e+00 935.00
IUUC-Oar-090207 Ovis aries 86.78 0.00e+00 941.00
IUUC-Ptr-090979 Pan troglodytes 85.44 0.00e+00 929.00
IUUC-Pan-092188 Papio anubis 85.26 0.00e+00 928.00
IUUC-Pab-098617 Pongo abelii 85.07 0.00e+00 926.00
IUUC-Pca-100834 Procavia capensis 72.85 0.00e+00 778.00
Created Date 25-Jun-2017

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