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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106251
UUCD1 version UUC-SaC-00141
Ensembl Protein ID YMR146C
UniProt Accession P40217; D6VZW8; EIF3I_YEAST
Genbank Protein ID AAC49616.1; CAA87361.1; AAS56742.1; DAA10042.1
Protein Name Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 39 kDa subunit
Genbank Nucleotide ID U56937; Z47071; AY558416; BK006946
Gene Name TIF34; YMR146C; YM9375.16C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YMR146C YMR146C YMR146C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.70e-16 57.5 50 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gHt+ +++++    +++ v+Gs D +ik+WD++ g ++
   Q: 50   GHTGTIWSIDVdcFTKYCVTGSADYSIKLWDVSNGQCV 87
           8*******98855349*****************99997 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Protein Sequence
(Fasta)
MKAIKLTGHE RPLTQVKYNK EGDLLFSCSK DSSASVWYSL NGERLGTLDG HTGTIWSIDV 60
DCFTKYCVTG SADYSIKLWD VSNGQCVATW KSPVPVKRVE FSPCGNYFLA ILDNVMKNPG 120
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Protein Fasta Sequence


>IUUC-Sce-106251|E3,WD_repeat|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGAAGGCTA TCAAATTAAC AGGTCATGAA CGTCCATTAA CTCAAGTGAA GTACAACAAA 60
GAAGGTGATT TACTATTTTC ATGTTCGAAA GATAGCTCGG CCAGTGTTTG GTATTCGTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106251|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0010494--C:cytoplasmic stress granule
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0043614--C:multi-eIF complex
GO:0003743--F:translation initiation factor activity
GO:0002183--P:cytoplasmic translational initiation
GO:0002188--P:translation reinitiation
GO:0006413--P:translational initiation
KEGG sce:YMR146C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000115 Aegilops tauschii 47.79 2.00e-28 117.00
IUUC-Aml-001321 Ailuropoda melanoleuca 45.18 3.00e-83 299.00
IUUC-Atr-002468 Amborella trichopoda 45.40 9.00e-43 164.00
IUUC-Apl-003841 Anas platyrhynchos 45.78 2.00e-85 306.00
IUUC-Aca-005123 Anolis carolinensis 46.55 5.00e-86 308.00
IUUC-Aly-005473 Arabidopsis lyrata 39.46 2.00e-70 256.00
IUUC-Ath-007094 Arabidopsis thaliana 39.52 2.00e-71 260.00
IUUC-Ago-008000 Ashbya gossypii 61.10 3.00e-129 452.00
IUUC-Acl-008098 Aspergillus clavatus 54.44 1.00e-106 377.00
IUUC-Afl-008494 Aspergillus flavus 54.60 3.00e-108 382.00
IUUC-Afu-009080 Aspergillus fumigatus 53.85 4.00e-106 375.00
IUUC-Ani-009230 Aspergillus nidulans 54.60 8.00e-109 384.00
IUUC-Aor-010114 Aspergillus oryzae 54.60 3.00e-108 382.00
IUUC-Ate-010285 Aspergillus terreus 54.01 5.00e-108 382.00
IUUC-Ame-011534 Astyanax mexicanus 45.95 3.00e-85 306.00
IUUC-Bgr-012121 Blumeria graminis 51.32 2.00e-98 350.00
IUUC-Bta-013143 Bos taurus 45.05 1.00e-83 301.00
IUUC-Bci-013950 Botrytis cinerea 52.34 1.00e-103 367.00
IUUC-Bdi-015019 Brachypodium distachyon 41.44 1.00e-72 264.00
IUUC-Bol-015709 Brassica oleracea 39.88 3.00e-70 257.00
IUUC-Bra-017760 Brassica rapa 40.18 9.00e-71 259.00
IUUC-Cel-018226 Caenorhabditis elegans 40.24 3.00e-74 269.00
IUUC-Cja-019741 Callithrix jacchus 45.05 1.00e-83 301.00
IUUC-Cfa-021204 Canis familiaris 44.58 2.00e-82 296.00
IUUC-Cpo-021661 Cavia porcellus 44.88 6.00e-83 298.00
IUUC-Cre-022952 Chlamydomonas reinhardtii 40.79 2.00e-77 280.00
IUUC-Csa-024038 Chlorocebus sabaeus 45.05 1.00e-83 301.00
IUUC-Cin-025597 Ciona intestinalis 45.48 2.00e-92 329.00
IUUC-Csv-026287 Ciona savignyi 26.99 6.00e-27 112.00
IUUC-Cgl-026583 Colletotrichum gloeosporioides 50.88 2.00e-99 353.00
IUUC-Cne-026838 Cryptococcus neoformans 50.30 7.00e-96 341.00
IUUC-Cme-027304 Cyanidioschyzon merolae 40.12 5.00e-66 242.00
IUUC-Dre-028567 Danio rerio 45.65 6.00e-84 301.00
IUUC-Dno-029171 Dasypus novemcinctus 45.18 1.00e-82 298.00
IUUC-Dor-030257 Dipodomys ordii 35.56 1.00e-25 108.00
IUUC-Dse-031191 Dothistroma septosporum 51.18 7.00e-97 345.00
IUUC-Dme-031879 Drosophila melanogaster 45.12 1.00e-83 300.00
IUUC-Ete-032336 Echinops telfairi 39.27 7.00e-40 154.00
IUUC-Eca-033259 Equus caballus 44.88 7.00e-83 298.00
IUUC-Eeu-035153 Erinaceus europaeus 36.05 2.00e-25 107.00
IUUC-Fca-036489 Felis catus 44.88 7.00e-83 298.00
IUUC-Fal-037485 Ficedula albicollis 45.48 4.00e-85 305.00
IUUC-Fox-037860 Fusarium oxysporum 52.23 6.00e-103 365.00
IUUC-Fso-038188 Fusarium solani 51.73 1.00e-100 357.00
IUUC-Gmo-039311 Gadus morhua 43.92 2.00e-82 297.00
IUUC-Ggr-040045 Gaeumannomyces graminis 52.74 4.00e-106 375.00
IUUC-Gga-040645 Gallus gallus 44.87 4.00e-84 302.00
IUUC-Gac-042086 Gasterosteus aculeatus 43.88 4.00e-80 289.00
IUUC-Gma-043246 Glycine max 41.02 4.00e-73 266.00
IUUC-Ggo-045578 Gorilla gorilla 45.05 1.00e-83 301.00
IUUC-Hsa-046734 Homo sapiens 45.05 1.00e-83 301.00
IUUC-Hvu-047553 Hordeum vulgare 41.27 1.00e-72 264.00
IUUC-Itr-048467 Ictidomys tridecemlineatus 44.58 2.00e-82 296.00
IUUC-Kpa-049325 Komagataella pastoris 55.30 2.00e-114 402.00
IUUC-Lch-049620 Latimeria chalumnae 45.25 4.00e-75 272.00
IUUC-Lpe-051338 Leersia perrieri 41.10 6.00e-70 255.00
IUUC-Loc-052094 Lepisosteus oculatus 39.88 4.00e-70 256.00
IUUC-Lma-053047 Leptosphaeria maculans 52.23 2.00e-102 363.00
IUUC-Laf-053801 Loxodonta africana 44.58 5.00e-82 295.00
IUUC-Mcc-055498 Macaca mulatta 38.14 3.00e-63 233.00
IUUC-Meu-056729 Macropus eugenii 42.22 6.00e-75 271.00
IUUC-Mor-057025 Magnaporthe oryzae 52.72 3.00e-105 372.00
IUUC-Mpo-057511 Magnaporthe poae 54.01 4.00e-105 372.00
IUUC-Mtr-058051 Medicago truncatula 41.02 4.00e-71 259.00
IUUC-Mla-059061 Melampsora laricipopulina 46.22 2.00e-88 316.00
IUUC-Mga-059229 Meleagris gallopavo 45.21 6.00e-83 298.00
IUUC-Mvi-060399 Microbotryum violaceum 45.88 9.00e-87 311.00
IUUC-Mmr-060764 Microcebus murinus 45.35 3.00e-84 303.00
IUUC-Mdo-062088 Monodelphis domestica 45.65 1.00e-83 300.00
IUUC-Mmu-064304 Mus musculus 45.05 7.00e-84 301.00
IUUC-Mac-065520 Musa acuminata 41.46 1.00e-73 267.00
IUUC-Mpu-066340 Mustela putorius furo 44.88 7.00e-83 298.00
IUUC-Mlu-067111 Myotis lucifugus 45.18 2.00e-83 300.00
IUUC-Nfi-068478 Neosartorya fischeri 54.14 7.00e-107 378.00
IUUC-Ncr-068820 Neurospora crassa 53.80 8.00e-105 371.00
IUUC-Nle-069903 Nomascus leucogenys 44.88 4.00e-83 299.00
IUUC-Opr-070221 Ochotona princeps 44.14 4.00e-81 292.00
IUUC-Ont-071765 Oreochromis niloticus 44.18 6.00e-83 298.00
IUUC-Oan-073660 Ornithorhynchus anatinus 43.14 2.00e-70 256.00
IUUC-Ocu-074039 Oryctolagus cuniculus 44.88 6.00e-83 298.00
IUUC-Oba-075395 Oryza barthii 36.45 5.00e-59 219.00
IUUC-Obr-076334 Oryza brachyantha 39.76 9.00e-70 254.00
IUUC-Ogl-077060 Oryza glaberrima 40.96 1.00e-72 264.00
IUUC-Ogu-078207 Oryza glumaepatula 41.27 6.00e-74 268.00
IUUC-Oin-079878 Oryza indica 41.27 9.00e-74 268.00
IUUC-Olo-080677 Oryza longistaminata 36.01 2.00e-66 243.00
IUUC-Ome-081228 Oryza meridionalis 32.50 1.00e-30 124.00
IUUC-Oni-082411 Oryza nivara 35.84 1.00e-57 214.00
IUUC-Opu-083136 Oryza punctata 40.96 2.00e-74 270.00
IUUC-Oru-084916 Oryza rufipogon 39.88 2.00e-72 263.00
IUUC-Osa-085776 Oryza sativa 41.27 8.00e-75 271.00
IUUC-Ola-087053 Oryzias latipes 45.65 3.00e-85 306.00
IUUC-Olu-087602 Ostreococcus lucimarinus 41.57 3.00e-76 276.00
IUUC-Oga-088154 Otolemur garnettii 44.88 5.00e-83 298.00
IUUC-Oar-089915 Ovis aries 44.88 5.00e-83 298.00
IUUC-Ptr-091124 Pan troglodytes 40.43 1.00e-60 224.00
IUUC-Pan-092035 Papio anubis 45.05 1.00e-83 301.00
IUUC-Psi-094096 Pelodiscus sinensis 45.88 8.00e-50 187.00
IUUC-Pma-094255 Petromyzon marinus 28.04 2.00e-21 94.40
IUUC-Pno-094988 Phaeosphaeria nodorum 48.83 1.00e-90 324.00
IUUC-Ppa-095536 Physcomitrella patens 43.07 1.00e-75 274.00
IUUC-Pfo-096101 Poecilia formosa 45.65 6.00e-84 301.00
IUUC-Pab-097726 Pongo abelii 45.05 1.00e-83 301.00
IUUC-Pop-099617 Populus trichocarpa 41.57 2.00e-71 260.00
IUUC-Pca-101014 Procavia capensis 45.35 5.00e-84 302.00
IUUC-Ppe-101320 Prunus persica 40.60 2.00e-71 260.00
IUUC-Pva-102789 Pteropus vampyrus 40.84 6.00e-73 265.00
IUUC-Pgr-103479 Puccinia graminis 45.62 7.00e-89 318.00
IUUC-Ptt-103981 Puccinia triticina 45.92 1.00e-88 317.00
IUUC-Pte-104278 Pyrenophora teres 51.04 1.00e-98 350.00
IUUC-Pyt-104492 Pyrenophora triticirepentis 51.04 1.00e-98 350.00
IUUC-Rno-105867 Rattus norvegicus 40.06 2.00e-70 256.00
IUUC-Sha-107039 Sarcophilus harrisii 45.54 3.00e-84 302.00
IUUC-Sja-107758 Schizosaccharomyces japonicus 52.24 2.00e-106 377.00
IUUC-Spo-108314 Schizosaccharomyces pombe 52.08 8.00e-105 371.00
IUUC-Ssl-108478 Sclerotinia sclerotiorum 52.63 2.00e-103 366.00
IUUC-Smo-108728 Selaginella moellendorffii 41.27 1.00e-74 271.00
IUUC-Sit-110801 Setaria italica 41.87 1.00e-74 271.00
IUUC-Sly-111326 Solanum lycopersicum 41.44 2.00e-72 263.00
IUUC-Stu-112458 Solanum tuberosum 41.44 4.00e-72 262.00
IUUC-Sbi-114063 Sorghum bicolor 40.36 1.00e-72 264.00
IUUC-Sre-115096 Sporisorium reilianum 48.14 4.00e-87 312.00
IUUC-Ssc-116080 Sus scrofa 45.35 6.00e-84 301.00
IUUC-Tgu-116988 Taeniopygia guttata 45.48 4.00e-85 305.00
IUUC-Tru-118766 Takifugu rubripes 44.67 2.00e-84 303.00
IUUC-Tsy-119522 Tarsius syrichta 26.93 2.00e-17 80.90
IUUC-Tni-120197 Tetraodon nigroviridis 44.18 9.00e-84 301.00
IUUC-Tca-121316 Theobroma cacao 41.62 5.00e-73 265.00
IUUC-Tre-122097 Trichoderma reesei 53.41 9.00e-105 370.00
IUUC-Tvi-122442 Trichoderma virens 53.12 7.00e-105 371.00
IUUC-Tae-125800 Triticum aestivum 41.27 2.00e-72 264.00
IUUC-Tur-126334 Triticum urartu 35.54 2.00e-54 203.00
IUUC-Tme-127038 Tuber melanosporum 54.30 3.00e-108 382.00
IUUC-Ttr-128659 Tursiops truncatus 42.04 8.00e-65 238.00
IUUC-Uma-129464 Ustilago maydis 48.42 1.00e-86 310.00
IUUC-Vda-129841 Verticillium dahliae 52.52 5.00e-103 365.00
IUUC-Vpa-130382 Vicugna pacos 27.47 1.00e-20 91.70
IUUC-Vvi-131076 Vitis vinifera 40.42 4.00e-72 262.00
IUUC-Xtr-132395 Xenopus tropicalis 46.08 7.00e-85 305.00
IUUC-Xma-133383 Xiphophorus maculatus 45.65 8.00e-84 301.00
IUUC-Yli-134586 Yarrowia lipolytica 54.65 8.00e-99 351.00
IUUC-Zma-135904 Zea mays 41.27 4.00e-74 269.00
Created Date 25-Jun-2017

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