iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000012206.2	ENSLACT00000026703.1	ENSLACP00000022424.1
ENSLACG00000012206.2	ENSLACT00000013961.1	ENSLACP00000013864.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.90e-12	44.9	647	722
E3 adaptor/Cullin RING/DCX/DWD	1.20e-29	101.3	444	476
UBD/Beta-Prp	1.10e-54	185.9	340	475

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenp..........kepkgellkslqklfeelwkskk 65
           +GlkN+gNtC++N+v+QcLsn+  ++e+l   ++k++ln+ +            +  ge++++l++l+++lw+ + 
   Q: 647  QGLKNHGNTCFLNAVVQCLSNTDLFAEYLGLeQYKSDLNQGKLngivrsnsgeLQGRGEVTEQLASLVRALWTLEY 722
           6***************************966467777776555677777776666677**************5443 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           H++sv+c++   +d   v++s Dgt+ +WD+ +
   Q: 444  HKASVSCIRVksNDQECVTASTDGTCIIWDIVR 476
           99*********66699**************765 PP

UBD/Beta-Prp

   S: 76   ikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlW 164
           i+vw  ++ k +  ++  + +   ++f+++g++++sG +d  ir +  e+g  ++ +++ h+  v+ ++  ++++ +vsG+  ++vr+W
   Q: 340  IRVWHTQSKKELLRITIPNMTCHGIDFMKDGKSIISGWNDGKIRAFTPESGRLMYVINNAHSIGVTAIAAIGSCKRIVSGGGEGMVRVW 428
           78998888888888887777777899999999999999999999999999999888999999999999999999999999999999999 PP
   S: 165  dl..ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq 210
            +   +++l++ +++ h+ sv ++ ++sn +e+v++s+dgt ++wd+ 
   Q: 429  EIgqGFNTLIESMKE-HKASVSCIRVKSNDQECVTASTDGTCIIWDIV 475
           997777889999988.99999999999999999999999999999986 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

FPFPLLTGQV PAGLIAHPDR ENILYPLGCT VIIQSLKNKK QSFLHGHTNN VCCLGVSRDG 60
TYLASGQVTY MGFKADVIIW NYAQRELYAR LSLHKAKVQS VAFSPNGLYL ATLGGQDDGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCTGCCCTG CCCTGCCCTG GAGACCTCTT CAACATGGAT GCCATTAGGA TCTGGAATAA 60
AAAAAAAAAA AAGTTTTACA AATTCAAATA CTTTTGAAAC GGAAAAGGTT TTAGCAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR033015--CFAP52
IPR001394--Peptidase_C19_UCH
IPR011047--Quinoprotein_ADH-like_supfam
IPR018200--USP_CS
IPR028889--USP_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00972--USP_1
PS50235--USP_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00443--UCH
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002048	Ailuropoda melanoleuca	65.74	0.00e+00	808.00
IUUC-Apl-004011	Anas platyrhynchos	65.71	0.00e+00	818.00
IUUC-Aca-004805	Anolis carolinensis	67.78	0.00e+00	822.00
IUUC-Ame-010655	Astyanax mexicanus	66.31	0.00e+00	777.00
IUUC-Bta-013493	Bos taurus	65.51	0.00e+00	790.00
IUUC-Cja-019923	Callithrix jacchus	65.85	0.00e+00	792.00
IUUC-Cfa-020609	Canis familiaris	67.08	0.00e+00	800.00
IUUC-Cpo-022158	Cavia porcellus	66.03	0.00e+00	793.00
IUUC-Cre-022705	Chlamydomonas reinhardtii	46.35	8.00e-155	540.00
IUUC-Csa-023338	Chlorocebus sabaeus	66.20	0.00e+00	796.00
IUUC-Cho-024884	Choloepus hoffmanni	63.13	1.00e-139	490.00
IUUC-Cin-025634	Ciona intestinalis	62.48	0.00e+00	740.00
IUUC-Csv-026211	Ciona savignyi	62.56	1.00e-79	289.00
IUUC-Dre-028268	Danio rerio	67.42	0.00e+00	823.00
IUUC-Dno-029202	Dasypus novemcinctus	61.30	0.00e+00	716.00
IUUC-Dor-030197	Dipodomys ordii	59.74	2.00e-160	558.00
IUUC-Dme-032037	Drosophila melanogaster	37.42	8.00e-111	394.00
IUUC-Ete-033049	Echinops telfairi	59.82	0.00e+00	684.00
IUUC-Eca-033884	Equus caballus	66.90	0.00e+00	799.00
IUUC-Eeu-034477	Erinaceus europaeus	59.40	2.00e-130	459.00
IUUC-Fca-035453	Felis catus	66.90	0.00e+00	797.00
IUUC-Gmo-039448	Gadus morhua	69.29	4.00e-105	375.00
IUUC-Gga-040295	Gallus gallus	66.55	0.00e+00	815.00
IUUC-Gac-042074	Gasterosteus aculeatus	57.17	0.00e+00	657.00
IUUC-Ggo-044438	Gorilla gorilla	68.21	1.00e-180	626.00
IUUC-Hsa-046794	Homo sapiens	66.90	0.00e+00	797.00
IUUC-Itr-048315	Ictidomys tridecemlineatus	70.00	2.00e-138	485.00
IUUC-Loc-052080	Lepisosteus oculatus	71.08	0.00e+00	862.00
IUUC-Laf-054288	Loxodonta africana	65.74	0.00e+00	791.00
IUUC-Mcc-055746	Macaca mulatta	58.89	0.00e+00	678.00
IUUC-Meu-056507	Macropus eugenii	61.08	5.00e-112	398.00
IUUC-Mga-059858	Meleagris gallopavo	65.49	0.00e+00	770.00
IUUC-Mmr-061757	Microcebus murinus	66.53	0.00e+00	694.00
IUUC-Mdo-062670	Monodelphis domestica	67.48	0.00e+00	815.00
IUUC-Mmu-064084	Mus musculus	66.55	0.00e+00	795.00
IUUC-Mpu-066253	Mustela putorius furo	65.57	0.00e+00	793.00
IUUC-Mlu-067944	Myotis lucifugus	57.39	0.00e+00	630.00
IUUC-Nle-069098	Nomascus leucogenys	66.38	0.00e+00	794.00
IUUC-Opr-070525	Ochotona princeps	60.78	0.00e+00	662.00
IUUC-Ont-071609	Oreochromis niloticus	62.23	0.00e+00	741.00
IUUC-Oan-073543	Ornithorhynchus anatinus	65.50	0.00e+00	777.00
IUUC-Ocu-074209	Oryctolagus cuniculus	66.09	0.00e+00	793.00
IUUC-Ola-086464	Oryzias latipes	57.50	0.00e+00	674.00
IUUC-Olu-087600	Ostreococcus lucimarinus	32.90	3.00e-82	299.00
IUUC-Oga-088977	Otolemur garnettii	65.74	0.00e+00	797.00
IUUC-Oar-089192	Ovis aries	65.67	0.00e+00	790.00
IUUC-Ptr-090882	Pan troglodytes	64.24	0.00e+00	768.00
IUUC-Pan-092865	Papio anubis	63.49	0.00e+00	751.00
IUUC-Psi-093270	Pelodiscus sinensis	68.76	0.00e+00	736.00
IUUC-Pma-094291	Petromyzon marinus	69.18	0.00e+00	847.00
IUUC-Ppa-095984	Physcomitrella patens	40.50	3.00e-128	452.00
IUUC-Pfo-097344	Poecilia formosa	51.50	4.00e-178	617.00
IUUC-Pab-098278	Pongo abelii	66.90	0.00e+00	795.00
IUUC-Pca-101037	Procavia capensis	66.90	0.00e+00	792.00
IUUC-Pva-102351	Pteropus vampyrus	67.47	0.00e+00	672.00
IUUC-Rno-105262	Rattus norvegicus	67.07	0.00e+00	797.00
IUUC-Smo-109009	Selaginella moellendorffii	43.43	3.00e-148	518.00
IUUC-Sar-113156	Sorex araneus	53.94	2.00e-91	329.00
IUUC-Ssc-116319	Sus scrofa	68.37	2.00e-36	144.00
IUUC-Tru-117963	Takifugu rubripes	57.72	0.00e+00	697.00
IUUC-Tsy-119115	Tarsius syrichta	53.53	9.00e-155	540.00
IUUC-Tni-120388	Tetraodon nigroviridis	57.63	0.00e+00	672.00
IUUC-Tbe-127930	Tupaia belangeri	58.06	4.00e-127	448.00
IUUC-Ttr-128981	Tursiops truncatus	66.02	0.00e+00	767.00
IUUC-Vpa-130492	Vicugna pacos	60.42	0.00e+00	721.00
IUUC-Xtr-132142	Xenopus tropicalis	70.07	0.00e+00	862.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence