iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055431

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

JSUE03016056

Gene Name

USP43

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000014039.3	ENSMMUT00000019707.3	ENSMMUP00000018450.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-91	308.5	101	710

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +GlkN+gNtC+mN+v+QcLsn+  l+e+l     ++ +        +e++++l+ l+++lw+++ +     e+++a++k+ ++f+g++q
   Q: 101  QGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG------RAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQ 183
           6****************************9955555555......479***************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +Da Efl +lld+++e+l+ +++ p+ e+   + +++s++  +++ +   ++s+++  Fq q++s+++c++c ++s++++pfl +slp+
   Q: 184  HDALEFLLWLLDRVHEDLEGSSRGPVLEKLPPEANKTSENclSPSAQLPLGESFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPI 272
           ******************99999999999888888887777789999999*************************************** PP
   S: 177  pgkeetkke................................................................................ 185
           p ++++ ++                                                                                
   Q: 273  PLRQTRFLSvtlvfpsksqrflrvglavpilstvavlrrmvaeeggvpadevilvelypsgfqrsffdeedlntiaegdnvyafqvpps 361
           ****98888******************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 362  psqgtlsahplalsvsprlaaregqrfslslhseskvlilfcnlvgsgqqasrfgppfliredravswaqlqqsilskvrhlmkseapv 450
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 451  qnlgslfsirvvglsvacsylspkdsrplchwavdralhlrrpggpphvklavewdssvkerlfgnlqeeraqdadsvwqqqqahqqhs 539
           ***************************************************************************************** PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekq 272
            +l++c++ +tkee+l ++++++c++c+ +q+   kl+l++lP++Li+hLkRf   + +++r+k+++ v+fpl+ L+++p++++++++ 
   Q: 540  cTLDECFQFYTKEEQLAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRF--CQVGERRNKLSTLVKFPLSgLNMAPHVAQRSTSP 626
           *****************************************************..88899************************88777 PP
   S: 273  ke....................kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +                     +  Y+L+av++H+G+l++GHY+ay++n  +g+W+ +dDs+V++++e+ev++   + aY+lfY++r
   Q: 627  EAglgpwpswkppgclptscplDFLYDLYAVCNHHGNLQGGHYTAYCRNsLDGQWYSYDDSTVEPLREDEVNT---RGAYILFYQKR 710
           6699999999999999999999***************************55788*******************...********985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MDPGPGDAAG GGPPAPRPRR RRSLRRLFSR FLLALGSRSR PGDSPPRPQP GYCDGDGEGG 60
FACAPGPAPA APGSPGEERP PGPQPQLQLP AGDGARPPGA QGLKNHGNTC FMNAVVQCLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACGACTCCC AGTCAGCGCC GCGGGGGCGG CACCAGGCAG GGGTAGGGGT GGCCCTGCGC 60
TGCCCTGCAG GGGGCTGGTC GTGCGGCCGG ATTCCCGCGC GGGGCGGGGC TGCCCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:100428727

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001922	Ailuropoda melanoleuca	77.46	0.00e+00	1436.00
IUUC-Aca-004436	Anolis carolinensis	53.92	0.00e+00	798.00
IUUC-Ame-011153	Astyanax mexicanus	50.72	0.00e+00	882.00
IUUC-Bta-013560	Bos taurus	79.65	0.00e+00	1574.00
IUUC-Cja-018737	Callithrix jacchus	92.69	0.00e+00	1870.00
IUUC-Cfa-020347	Canis familiaris	77.00	0.00e+00	1465.00
IUUC-Csa-023656	Chlorocebus sabaeus	98.93	0.00e+00	1967.00
IUUC-Cho-024864	Choloepus hoffmanni	72.01	0.00e+00	916.00
IUUC-Dre-028066	Danio rerio	50.18	0.00e+00	914.00
IUUC-Dno-028855	Dasypus novemcinctus	72.35	0.00e+00	1359.00
IUUC-Dor-030475	Dipodomys ordii	87.79	0.00e+00	716.00
IUUC-Dme-032088	Drosophila melanogaster	36.58	5.00e-110	392.00
IUUC-Eca-034147	Equus caballus	84.95	0.00e+00	1454.00
IUUC-Eeu-034703	Erinaceus europaeus	61.89	0.00e+00	748.00
IUUC-Fca-036550	Felis catus	74.59	0.00e+00	1258.00
IUUC-Gac-042087	Gasterosteus aculeatus	51.88	0.00e+00	893.00
IUUC-Ggo-045171	Gorilla gorilla	97.57	0.00e+00	1939.00
IUUC-Hsa-045961	Homo sapiens	97.67	0.00e+00	1951.00
IUUC-Itr-048673	Ictidomys tridecemlineatus	74.33	0.00e+00	673.00
IUUC-Loc-052852	Lepisosteus oculatus	60.09	0.00e+00	929.00
IUUC-Laf-054033	Loxodonta africana	76.46	0.00e+00	1518.00
IUUC-Mmr-061035	Microcebus murinus	86.50	0.00e+00	1673.00
IUUC-Mdo-062172	Monodelphis domestica	66.45	0.00e+00	969.00
IUUC-Mmu-063966	Mus musculus	79.83	0.00e+00	1565.00
IUUC-Mpu-066307	Mustela putorius furo	78.15	0.00e+00	1411.00
IUUC-Nle-070172	Nomascus leucogenys	96.92	0.00e+00	1945.00
IUUC-Opr-070499	Ochotona princeps	74.42	0.00e+00	1395.00
IUUC-Ont-071920	Oreochromis niloticus	52.66	0.00e+00	944.00
IUUC-Ocu-074014	Oryctolagus cuniculus	82.89	0.00e+00	1206.00
IUUC-Ola-086360	Oryzias latipes	52.52	0.00e+00	931.00
IUUC-Oga-088202	Otolemur garnettii	81.13	0.00e+00	1666.00
IUUC-Oar-089819	Ovis aries	77.39	0.00e+00	1473.00
IUUC-Ptr-091076	Pan troglodytes	97.29	0.00e+00	1941.00
IUUC-Pan-092248	Papio anubis	99.51	0.00e+00	1979.00
IUUC-Pfo-096332	Poecilia formosa	58.81	0.00e+00	840.00
IUUC-Pab-098453	Pongo abelii	94.97	0.00e+00	1874.00
IUUC-Pca-100290	Procavia capensis	63.53	0.00e+00	723.00
IUUC-Pva-102317	Pteropus vampyrus	73.64	0.00e+00	1392.00
IUUC-Rno-104948	Rattus norvegicus	77.82	0.00e+00	1399.00
IUUC-Sha-106558	Sarcophilus harrisii	57.21	0.00e+00	1134.00
IUUC-Sar-113105	Sorex araneus	63.99	0.00e+00	1059.00
IUUC-Ssc-115312	Sus scrofa	80.08	0.00e+00	1561.00
IUUC-Tru-117995	Takifugu rubripes	52.83	0.00e+00	914.00
IUUC-Tsy-119325	Tarsius syrichta	77.58	0.00e+00	768.00
IUUC-Tni-120517	Tetraodon nigroviridis	57.85	0.00e+00	857.00
IUUC-Tbe-127439	Tupaia belangeri	71.24	3.00e-142	499.00
IUUC-Ttr-128829	Tursiops truncatus	72.58	0.00e+00	1387.00
IUUC-Vpa-130306	Vicugna pacos	81.11	0.00e+00	630.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence