iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aly-006187

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

GL348716

Gene Name

AXL; ARALYDRAFT_902294

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
scaffold_401795.1	scaffold_401795.1	scaffold_401795.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.90e-120	402.9	8	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQ+r+wGe +q +l++a+++l+++g++G+E lKnLvl+G+gsit+vD+++ve+ +l+++F+++a++vg+sK+++++ +l+e+n+ v++ +
   Q: 8    YDRQLRIWGELGQSALENASICLLNCGPTGSEALKNLVLGGIGSITIVDGSKVEIGDLGNNFMVDAKSVGQSKSKTVCGFLQEINDAVKANF 99
           ******************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketp 180
           +ee++++l  +++ Ff++f++V++++  ++++ k++++c++a+v l+ ++++Gl G+vr+++k++t+++s++d   d++++++P+++lk ++
   Q: 100  VEENPDTLISTDPsFFSQFTLVIATQLVEDSMVKLDKICREANVMLVLARSYGLTGFVRICVKEHTAIESKPDhflDDLRLNNPWPELKRYV 191
           *******************************************************************************************8 PP
   S: 181  n.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfec 262
           +         aa+++i+++v++ kl+ee+a+ ++ + ++++eek e+kd+vks++ s+de+n++eai +a+k fa++ i++ i++++++ +c
   Q: 192  EsidlnveepAAHKHIPYVVILVKLAEEWAQTHSSNLPSTREEKNEFKDLVKSKMASMDEDNYKEAIVAAFKVFAPRGISQeIQDIIHD-RC 282
           8888889999*******************************************************************************.** PP
   S: 263  divtkskspfwv...........................................................................sfcsn 279
           ++v +++s+fwv                                                                            fc+n
   Q: 283  AEVGSNSSDFWVmvaalkefisnegggepplegsmpdmisstehyinlqkiyhskaeadflsmeqrvksilvkvgqdpstipkptikIFCKN 374
           ******************************************************************************************** PP
   S: 280  aealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kld 354
           a++l+            ++++++  ++++++++     +y+llra++rf++++++ pg ++   ddd a +l+t a++l  +++g+ + +l+
   Q: 375  ARKLKvcryrtiedefKNPSATELHKYLADEDYssaigFYILLRAVDRFAATYKKFPGLFDGSTDDD-ASQLKTIALSLL-SEMGCDGyVLK 464
           *****7766666555555666666677777766999*******************************.******999998.*********** PP
   S: 355  ddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           ++l +e++++++++i++++a++gG+a+qEviK+++++f+p+  +f+f+++
   Q: 465  EELYSEMCRFGAAEIHVVAAFIGGVASQEVIKLITKQFVPMLGTFIFNGI 514
           ***********************************************986 PP

Organism

Arabidopsis lyrata

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKTKYDR QLRIWGELGQ SALENASICL LNCGPTGSEA LKNLVLGGIG SITIVDGSKV 60
EIGDLGNNFM VDAKSVGQSK SKTVCGFLQE INDAVKANFV EENPDTLIST DPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTCGAGCA AGAACCAACA ATGGCGGAAC CCAAGACCAA GTACGATCGT CAACTCAGGT 60
ATACTCTTTC TCCTCCCAAC TCTCTTTCTC TCTACTTCTC CTCTGTTTCT TTCATGTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005777--C:peroxisome
GO:0019781--F:NEDD8 activating enzyme activity
GO:0009791--P:post-embryonic development
GO:0045116--P:protein neddylation

KEGG

aly:ARALYDRAFT_902294

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002333	Ailuropoda melanoleuca	40.04	2.00e-124	439.00
IUUC-Apl-003446	Anas platyrhynchos	39.92	5.00e-116	410.00
IUUC-Aca-004450	Anolis carolinensis	40.11	1.00e-122	432.00
IUUC-Ath-007600	Arabidopsis thaliana	91.59	0.00e+00	1000.00
IUUC-Ago-007900	Ashbya gossypii	25.97	3.00e-36	145.00
IUUC-Acl-008333	Aspergillus clavatus	33.88	8.00e-72	264.00
IUUC-Afl-008529	Aspergillus flavus	33.51	4.00e-77	281.00
IUUC-Afu-009071	Aspergillus fumigatus	34.00	9.00e-74	270.00
IUUC-Ang-009669	Aspergillus niger	32.12	4.00e-74	271.00
IUUC-Aor-009914	Aspergillus oryzae	33.39	8.00e-76	277.00
IUUC-Ate-010450	Aspergillus terreus	31.39	2.00e-71	262.00
IUUC-Ame-011183	Astyanax mexicanus	40.82	2.00e-125	442.00
IUUC-Bta-012583	Bos taurus	40.19	2.00e-126	445.00
IUUC-Bol-015487	Brassica oleracea	83.81	0.00e+00	913.00
IUUC-Bra-017506	Brassica rapa	83.81	0.00e+00	916.00
IUUC-Cel-018456	Caenorhabditis elegans	29.70	2.00e-72	265.00
IUUC-Cja-020007	Callithrix jacchus	39.96	2.00e-124	438.00
IUUC-Cfa-020324	Canis familiaris	40.19	1.00e-126	446.00
IUUC-Csa-023149	Chlorocebus sabaeus	36.85	2.00e-97	348.00
IUUC-Cho-024537	Choloepus hoffmanni	33.12	7.00e-85	306.00
IUUC-Cin-025763	Ciona intestinalis	39.29	1.00e-110	392.00
IUUC-Csv-026113	Ciona savignyi	39.37	3.00e-108	384.00
IUUC-Cne-026884	Cryptococcus neoformans	31.89	1.00e-70	259.00
IUUC-Cme-027210	Cyanidioschyzon merolae	23.43	4.00e-15	75.90
IUUC-Dre-028140	Danio rerio	42.13	1.00e-129	456.00
IUUC-Dno-030033	Dasypus novemcinctus	39.30	2.00e-106	379.00
IUUC-Dor-030513	Dipodomys ordii	32.67	3.00e-35	142.00
IUUC-Ete-032420	Echinops telfairi	36.56	7.00e-109	386.00
IUUC-Eca-033992	Equus caballus	38.06	1.00e-97	349.00
IUUC-Eeu-034713	Erinaceus europaeus	31.76	3.00e-37	149.00
IUUC-Fca-036548	Felis catus	39.44	5.00e-124	437.00
IUUC-Fal-037600	Ficedula albicollis	40.30	1.00e-116	412.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.44	2.00e-59	223.00
IUUC-Gga-041129	Gallus gallus	39.67	7.00e-119	420.00
IUUC-Ggo-045611	Gorilla gorilla	40.23	2.00e-123	435.00
IUUC-Hsa-046563	Homo sapiens	40.46	1.00e-124	439.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	40.19	3.00e-125	441.00
IUUC-Kpa-049309	Komagataella pastoris	34.10	7.00e-75	273.00
IUUC-Lch-050038	Latimeria chalumnae	40.04	2.00e-121	428.00
IUUC-Loc-051917	Lepisosteus oculatus	37.48	5.00e-109	387.00
IUUC-Laf-053690	Loxodonta africana	40.19	8.00e-126	443.00
IUUC-Mcc-055117	Macaca mulatta	39.52	1.00e-121	429.00
IUUC-Meu-056761	Macropus eugenii	33.02	2.00e-89	322.00
IUUC-Mga-060144	Meleagris gallopavo	39.28	5.00e-114	404.00
IUUC-Mvi-060221	Microbotryum violaceum	33.08	3.00e-71	262.00
IUUC-Mmr-061325	Microcebus murinus	38.66	1.00e-120	426.00
IUUC-Mdo-062532	Monodelphis domestica	40.46	8.00e-125	439.00
IUUC-Mmu-063956	Mus musculus	40.19	2.00e-126	445.00
IUUC-Mpu-066716	Mustela putorius furo	39.17	2.00e-115	409.00
IUUC-Mlu-067459	Myotis lucifugus	40.19	1.00e-124	439.00
IUUC-Nfi-068245	Neosartorya fischeri	34.06	6.00e-75	274.00
IUUC-Nle-070034	Nomascus leucogenys	39.00	6.00e-119	420.00
IUUC-Opr-070552	Ochotona princeps	36.85	4.00e-96	344.00
IUUC-Ont-071426	Oreochromis niloticus	40.64	1.00e-126	445.00
IUUC-Ocu-074911	Oryctolagus cuniculus	40.00	7.00e-126	443.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.44	4.00e-65	241.00
IUUC-Oga-088810	Otolemur garnettii	40.19	5.00e-126	443.00
IUUC-Oar-089196	Ovis aries	40.15	2.00e-125	442.00
IUUC-Ptr-090617	Pan troglodytes	40.46	6.00e-125	440.00
IUUC-Pan-092761	Papio anubis	40.19	5.00e-126	443.00
IUUC-Psi-093191	Pelodiscus sinensis	38.93	2.00e-119	422.00
IUUC-Pma-094380	Petromyzon marinus	40.20	3.00e-110	391.00
IUUC-Pfo-096467	Poecilia formosa	40.23	2.00e-120	425.00
IUUC-Pab-098255	Pongo abelii	39.64	6.00e-104	370.00
IUUC-Pca-100807	Procavia capensis	47.59	2.00e-51	196.00
IUUC-Rno-105810	Rattus norvegicus	40.75	1.00e-124	439.00
IUUC-Sce-106397	Saccharomyces cerevisiae	26.17	5.00e-35	141.00
IUUC-Sha-106770	Sarcophilus harrisii	45.02	5.00e-69	253.00
IUUC-Spo-108276	Schizosaccharomyces pombe	31.61	1.00e-81	296.00
IUUC-Smo-109296	Selaginella moellendorffii	52.99	2.00e-163	568.00
IUUC-Sar-113083	Sorex araneus	31.91	1.00e-85	310.00
IUUC-Tgu-116772	Taeniopygia guttata	41.02	7.00e-117	413.00
IUUC-Tru-118686	Takifugu rubripes	39.51	5.00e-124	437.00
IUUC-Tsy-119111	Tarsius syrichta	42.65	1.00e-61	229.00
IUUC-Tme-127097	Tuber melanosporum	34.62	8.00e-82	297.00
IUUC-Ttr-128465	Tursiops truncatus	38.97	1.00e-113	402.00
IUUC-Vpa-130529	Vicugna pacos	38.48	1.00e-115	409.00
IUUC-Xtr-132002	Xenopus tropicalis	41.41	3.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence