iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108276

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit; Ubiquitin-activating enzyme E1-like 1; Ubiquitin-like activation protein 1

Genbank Nucleotide ID

CU329670

Gene Name

uba5; ula1; SPAC323.06c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC323.06c	SPAC323.06c.1	SPAC323.06c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.80e-73	244.8	10	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea 92
           YDRQ+rlw +e+q+++++++v+l+ a ++GcE lKnL+l G+gs+ vvD+  v++s  +++F+++ ++ gks+A ++a  l++lnp+v++e 
   Q: 10   YDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDGMNFFIQYDQEGKSRARCTASLLQQLNPNVEMEY 101
           ******************************************************************************************** PP
   S: 93   heesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd..dppqktiPfctlketpn 181
            e s+++l +++  +f+kf+vV++ + +++   ++ + ++++++pl+   + G+ G +r++ ++ t  +s+++  +++++++P+++l++++ 
   Q: 102  LEMSPEALIDKNIeYFSKFSVVLSSNLKEKPLFRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPElpQDLRLKNPWPELINYVK 193
           ********999999****************************************************************************88 PP
   S: 182  .........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecd 263
                       + i+++vl+ ++l + + ++  +++ ++ +  ++++  ++   + d+en eea +++ kaf+++  +s + ++l++ +c 
   Q: 194  smdldnmdsSSLSEIPYIVLIIHVLLKVSPAHAQNSQ-EADDCAMFRKIMEEYKGKCDSENIEEASSNSWKAFKEYKLPSnVYEVLHDTRCV 284
           7888887778888899996666666555554444443.4556777777777777779*********************************** PP
   S: 264  ivtkskspfwv................................................................................. 274
           ++++++ +fw+                                                                                 
   Q: 285  KIQEDSESFWImahclkmfydeteflplsgllpdmncstqqyvklqviykeksendilkfkkyvqqtlkrlnrsveeitdleikhfsrncln 376
           **********************************************************9999999999999999999999999999888888 PP
   S: 275  ....sfcsnaealq.vpekvekdeevvkasap.lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep..kldddli 358
                f++ +e  q +  +v+++  +++ s   +yl++r+ ++  +k+g++  +  f +  +  ++++++++    +++g+e+  ++ +++i
   Q: 377  ikvmDFKTMKEEYQpTSNSVLESSSIDSNSLLpWYLAFRIYDTILEKHGKNY-KEAFSDTTK-TISVAQSFL----SQIGLEKffDVVYTAI 462
           877655555555444223344444444333336*****************86.778887777.899999999....8999999999****** PP
   S: 359  keiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +e+ +   ++++++++++gG++aqE iK++ +++ pl+n+f+fd+ 
   Q: 463  QELERADGHELHSISSFIGGIVAQETIKLLAQQYLPLNNTFVFDGV 508
           *******************************************985 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Regulatory subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).

Protein Sequence
(Fasta)

MGTSAKMQKY DRQVRLWKAE GQNAIEKSHV CLLYANTVGC EALKNLILPG IGSFAVVDDT 60
SVDFSMDGMN FFIQYDQEGK SRARCTASLL QQLNPNVEME YLEMSPEALI DKNIEYFSKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCGGTTCCCT TTAATTACCA TTTTTATTGT TACAAGCCAA ATTTATTTTT ATTTCATTTG 60
ATATATTTTC GTAGAGATTT TGTTCAAGCT GTCTTATTAA CATCCTTCTT CCTTCCTACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

spo:SPAC323.06c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	34.54	3.00e-85	306.00
IUUC-Aml-002333	Ailuropoda melanoleuca	34.77	5.00e-88	316.00
IUUC-Atr-002644	Amborella trichopoda	31.26	1.00e-77	282.00
IUUC-Apl-003446	Anas platyrhynchos	34.48	1.00e-78	285.00
IUUC-Aca-004450	Anolis carolinensis	34.65	8.00e-88	315.00
IUUC-Aly-006187	Arabidopsis lyrata	31.61	6.00e-85	305.00
IUUC-Ath-007600	Arabidopsis thaliana	31.54	6.00e-84	302.00
IUUC-Ago-007900	Ashbya gossypii	24.67	8.00e-36	142.00
IUUC-Acl-008333	Aspergillus clavatus	32.79	4.00e-76	276.00
IUUC-Afl-008529	Aspergillus flavus	34.36	3.00e-77	280.00
IUUC-Afu-009071	Aspergillus fumigatus	33.45	7.00e-75	272.00
IUUC-Ani-009443	Aspergillus nidulans	32.84	6.00e-71	259.00
IUUC-Ang-009669	Aspergillus niger	35.19	4.00e-81	293.00
IUUC-Aor-009914	Aspergillus oryzae	34.05	8.00e-74	269.00
IUUC-Ate-010450	Aspergillus terreus	32.97	2.00e-76	278.00
IUUC-Ame-011183	Astyanax mexicanus	33.65	3.00e-82	296.00
IUUC-Bgr-012111	Blumeria graminis	31.97	2.00e-67	248.00
IUUC-Bta-012583	Bos taurus	34.90	6.00e-89	319.00
IUUC-Bci-013892	Botrytis cinerea	32.90	4.00e-65	240.00
IUUC-Bdi-014592	Brachypodium distachyon	34.10	7.00e-84	302.00
IUUC-Bol-016401	Brassica oleracea	32.12	2.00e-84	304.00
IUUC-Bra-017506	Brassica rapa	32.25	1.00e-85	308.00
IUUC-Cel-018456	Caenorhabditis elegans	31.72	1.00e-68	251.00
IUUC-Cja-020007	Callithrix jacchus	34.70	1.00e-87	315.00
IUUC-Cfa-020324	Canis familiaris	34.90	2.00e-88	317.00
IUUC-Cpo-022248	Cavia porcellus	32.65	1.00e-45	175.00
IUUC-Csa-023149	Chlorocebus sabaeus	32.53	7.00e-64	236.00
IUUC-Cho-024537	Choloepus hoffmanni	31.13	2.00e-33	134.00
IUUC-Cin-025763	Ciona intestinalis	33.21	2.00e-85	307.00
IUUC-Csv-026113	Ciona savignyi	33.96	6.00e-81	292.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	32.02	8.00e-65	239.00
IUUC-Cne-026884	Cryptococcus neoformans	28.62	2.00e-57	214.00
IUUC-Dre-028140	Danio rerio	34.27	1.00e-85	308.00
IUUC-Dno-030033	Dasypus novemcinctus	34.33	4.00e-76	276.00
IUUC-Dor-030513	Dipodomys ordii	47.62	2.00e-23	101.00
IUUC-Dse-031536	Dothistroma septosporum	31.42	1.00e-75	275.00
IUUC-Dme-031683	Drosophila melanogaster	32.77	4.00e-74	270.00
IUUC-Ete-032420	Echinops telfairi	31.23	7.00e-71	259.00
IUUC-Eca-033992	Equus caballus	31.61	5.00e-61	226.00
IUUC-Eeu-034713	Erinaceus europaeus	50.00	3.00e-25	107.00
IUUC-Fca-036548	Felis catus	34.52	3.00e-87	313.00
IUUC-Fal-037600	Ficedula albicollis	33.52	7.00e-80	289.00
IUUC-Fox-038037	Fusarium oxysporum	32.90	6.00e-69	253.00
IUUC-Fso-038387	Fusarium solani	33.46	1.00e-70	258.00
IUUC-Gmo-038562	Gadus morhua	32.90	3.00e-81	293.00
IUUC-Ggr-040005	Gaeumannomyces graminis	31.74	8.00e-69	252.00
IUUC-Gga-041129	Gallus gallus	35.53	7.00e-84	302.00
IUUC-Gac-042558	Gasterosteus aculeatus	34.08	7.00e-86	309.00
IUUC-Gma-043610	Glycine max	31.68	4.00e-81	293.00
IUUC-Ggo-045611	Gorilla gorilla	34.82	2.00e-87	314.00
IUUC-Hsa-046563	Homo sapiens	34.83	4.00e-88	316.00
IUUC-Hvu-047790	Hordeum vulgare	30.75	4.00e-48	183.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	35.27	3.00e-89	320.00
IUUC-Kpa-049309	Komagataella pastoris	34.30	9.00e-78	282.00
IUUC-Lch-050038	Latimeria chalumnae	34.09	1.00e-82	298.00
IUUC-Lpe-051535	Leersia perrieri	32.93	2.00e-70	257.00
IUUC-Loc-051917	Lepisosteus oculatus	31.48	4.00e-76	276.00
IUUC-Lma-053112	Leptosphaeria maculans	32.09	5.00e-76	276.00
IUUC-Laf-053690	Loxodonta africana	35.65	4.00e-91	326.00
IUUC-Mcc-055117	Macaca mulatta	34.26	1.00e-84	305.00
IUUC-Meu-056761	Macropus eugenii	28.79	2.00e-58	218.00
IUUC-Mor-057230	Magnaporthe oryzae	30.63	3.00e-67	247.00
IUUC-Mpo-057514	Magnaporthe poae	32.11	3.00e-66	244.00
IUUC-Mtr-058551	Medicago truncatula	31.53	4.00e-76	276.00
IUUC-Mla-059183	Melampsora laricipopulina	32.84	3.00e-83	300.00
IUUC-Mga-060144	Meleagris gallopavo	34.61	8.00e-80	288.00
IUUC-Mvi-060221	Microbotryum violaceum	27.30	2.00e-54	204.00
IUUC-Mmr-061325	Microcebus murinus	34.14	1.00e-82	298.00
IUUC-Mdo-062532	Monodelphis domestica	35.21	2.00e-88	317.00
IUUC-Mmu-063956	Mus musculus	34.71	9.00e-89	318.00
IUUC-Mac-064521	Musa acuminata	33.21	3.00e-83	300.00
IUUC-Mpu-066716	Mustela putorius furo	34.61	2.00e-78	284.00
IUUC-Mlu-067459	Myotis lucifugus	36.02	4.00e-91	327.00
IUUC-Nfi-068245	Neosartorya fischeri	34.12	3.00e-76	276.00
IUUC-Ncr-068910	Neurospora crassa	34.22	2.00e-78	284.00
IUUC-Nle-070034	Nomascus leucogenys	33.21	1.00e-80	291.00
IUUC-Opr-070552	Ochotona princeps	32.00	2.00e-61	227.00
IUUC-Ont-071426	Oreochromis niloticus	33.90	4.00e-87	313.00
IUUC-Oan-073389	Ornithorhynchus anatinus	32.06	1.00e-53	201.00
IUUC-Ocu-074911	Oryctolagus cuniculus	35.65	8.00e-91	325.00
IUUC-Oba-075437	Oryza barthii	33.91	3.00e-77	280.00
IUUC-Obr-076684	Oryza brachyantha	33.72	2.00e-69	254.00
IUUC-Ogl-077170	Oryza glaberrima	33.91	3.00e-77	280.00
IUUC-Ogu-078844	Oryza glumaepatula	33.60	1.00e-69	254.00
IUUC-Oin-079105	Oryza indica	33.91	3.00e-77	280.00
IUUC-Olo-080943	Oryza longistaminata	33.00	2.00e-66	244.00
IUUC-Oni-082891	Oryza nivara	32.95	3.00e-73	267.00
IUUC-Opu-083457	Oryza punctata	33.84	1.00e-77	281.00
IUUC-Oru-084960	Oryza rufipogon	33.00	2.00e-66	244.00
IUUC-Osa-085358	Oryza sativa	34.48	6.00e-78	282.00
IUUC-Ola-086420	Oryzias latipes	30.85	7.00e-46	175.00
IUUC-Olu-087625	Ostreococcus lucimarinus	26.61	2.00e-48	184.00
IUUC-Oga-088810	Otolemur garnettii	35.27	2.00e-91	327.00
IUUC-Oar-089196	Ovis aries	34.70	1.00e-87	315.00
IUUC-Ptr-090617	Pan troglodytes	35.02	1.00e-88	318.00
IUUC-Pan-092761	Papio anubis	35.46	2.00e-89	321.00
IUUC-Psi-093191	Pelodiscus sinensis	33.65	3.00e-82	297.00
IUUC-Pma-094380	Petromyzon marinus	30.32	4.00e-65	240.00
IUUC-Pno-095084	Phaeosphaeria nodorum	27.83	2.00e-59	223.00
IUUC-Ppa-095875	Physcomitrella patens	33.14	3.00e-81	293.00
IUUC-Pfo-096467	Poecilia formosa	33.71	1.00e-82	298.00
IUUC-Pab-098255	Pongo abelii	36.38	9.00e-76	275.00
IUUC-Pop-099871	Populus trichocarpa	32.56	1.00e-87	314.00
IUUC-Pca-100807	Procavia capensis	42.63	3.00e-40	157.00
IUUC-Ppe-101280	Prunus persica	32.50	2.00e-85	308.00
IUUC-Pva-102333	Pteropus vampyrus	33.64	3.00e-80	290.00
IUUC-Pgr-103401	Puccinia graminis	29.33	5.00e-60	223.00
IUUC-Ptt-103889	Puccinia triticina	26.04	7.00e-47	179.00
IUUC-Pte-104355	Pyrenophora teres	30.40	9.00e-74	269.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	31.12	3.00e-75	274.00
IUUC-Rno-105810	Rattus norvegicus	33.96	7.00e-87	312.00
IUUC-Sce-106397	Saccharomyces cerevisiae	25.89	1.00e-35	142.00
IUUC-Sha-106770	Sarcophilus harrisii	40.45	1.00e-50	191.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	37.38	3.00e-102	363.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.88	9.00e-67	245.00
IUUC-Smo-109296	Selaginella moellendorffii	31.77	3.00e-79	287.00
IUUC-Sit-110157	Setaria italica	33.91	2.00e-86	310.00
IUUC-Sly-111105	Solanum lycopersicum	32.65	5.00e-86	309.00
IUUC-Stu-112469	Solanum tuberosum	32.08	9.00e-86	308.00
IUUC-Sar-113083	Sorex araneus	40.13	8.00e-33	132.00
IUUC-Sbi-113813	Sorghum bicolor	33.72	4.00e-85	306.00
IUUC-Sre-115058	Sporisorium reilianum	31.01	6.00e-58	216.00
IUUC-Tgu-116772	Taeniopygia guttata	34.34	1.00e-81	295.00
IUUC-Tru-118686	Takifugu rubripes	34.27	1.00e-84	305.00
IUUC-Tsy-119111	Tarsius syrichta	35.32	4.00e-40	157.00
IUUC-Tni-120231	Tetraodon nigroviridis	31.41	6.00e-70	256.00
IUUC-Tca-121491	Theobroma cacao	32.25	4.00e-82	296.00
IUUC-Tre-122103	Trichoderma reesei	34.19	8.00e-75	272.00
IUUC-Tvi-122672	Trichoderma virens	33.58	2.00e-69	254.00
IUUC-Tae-125679	Triticum aestivum	35.26	1.00e-85	308.00
IUUC-Tur-126487	Triticum urartu	33.85	4.00e-81	293.00
IUUC-Tme-127097	Tuber melanosporum	32.60	1.00e-70	258.00
IUUC-Ttr-128465	Tursiops truncatus	33.21	9.00e-83	298.00
IUUC-Uma-129645	Ustilago maydis	28.38	1.00e-60	225.00
IUUC-Vda-129989	Verticillium dahliae	30.09	4.00e-56	210.00
IUUC-Vpa-130529	Vicugna pacos	33.96	2.00e-84	304.00
IUUC-Vvi-131059	Vitis vinifera	32.63	3.00e-82	297.00
IUUC-Xtr-132002	Xenopus tropicalis	36.67	3.00e-91	327.00
IUUC-Xma-133930	Xiphophorus maculatus	33.90	1.00e-83	301.00
IUUC-Yli-134505	Yarrowia lipolytica	35.84	1.00e-81	295.00
IUUC-Zma-135895	Zea mays	33.91	4.00e-86	310.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence