iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059388

UUCD1 version

UUC-MeG-00468

Ensembl Protein ID

ENSMGAP00000010563.1

UniProt Accession

G1NCR4; G1NCR4_MELGA

Protein Name

Uncharacterized protein

Gene Name

BTRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000010164.1	ENSMGAT00000011423.1	ENSMGAP00000010563.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.90e-59	192.7	505	540
UBD/Beta-Prp	1.40e-68	231.0	419	584

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 505  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLVAALDP 540
           8**********.44****************9876665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 419  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 502
           445579*************9..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlq 210
           l+gh+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+ 
   Q: 503  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLvaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDFL 584
           **************9..*************************877889****98.************..99**************85 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

RKGLTLVLEK RSKVSFLCSM PRSLWLGCSS LADSMPSLRC LYNPGTGALP AFQNSSERED 60
CNNDEPPRKI IPEKNSLRQT YNSCARLCLN QETVCLGSTA MKTENCVAKT KLANGTSSMI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAAAGGTC TCACGTTAGT GTTAGAGAAA CGATCAAAAG TTTCTTTCCT GGTCCGTAGT 60
ACCTTTTTTT CTTGCTATTC TGCCGTTGTA AAGCTTCTCT GAAGGAAGAG TCTCGCCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0071407--P:cellular response to organic cyclic compound
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001961	Ailuropoda melanoleuca	97.00	0.00e+00	1214.00
IUUC-Apl-003437	Anas platyrhynchos	99.40	0.00e+00	1030.00
IUUC-Aca-004410	Anolis carolinensis	96.77	0.00e+00	1195.00
IUUC-Acl-008355	Aspergillus clavatus	29.69	4.00e-51	195.00
IUUC-Afl-008580	Aspergillus flavus	27.46	2.00e-44	173.00
IUUC-Afu-008790	Aspergillus fumigatus	29.81	1.00e-48	187.00
IUUC-Ani-009324	Aspergillus nidulans	29.40	2.00e-48	186.00
IUUC-Ang-009766	Aspergillus niger	31.80	7.00e-53	201.00
IUUC-Aor-009916	Aspergillus oryzae	28.42	1.00e-47	184.00
IUUC-Ate-010492	Aspergillus terreus	30.18	3.00e-50	192.00
IUUC-Bgr-012194	Blumeria graminis	32.08	4.00e-54	205.00
IUUC-Bta-013453	Bos taurus	98.20	0.00e+00	1138.00
IUUC-Bci-013685	Botrytis cinerea	32.17	7.00e-55	208.00
IUUC-Cel-018392	Caenorhabditis elegans	63.88	0.00e+00	634.00
IUUC-Cja-019121	Callithrix jacchus	93.00	0.00e+00	1151.00
IUUC-Cfa-020553	Canis familiaris	97.17	0.00e+00	1216.00
IUUC-Cpo-022126	Cavia porcellus	96.29	0.00e+00	1155.00
IUUC-Csa-023688	Chlorocebus sabaeus	97.33	0.00e+00	1217.00
IUUC-Cin-025188	Ciona intestinalis	80.71	0.00e+00	828.00
IUUC-Csv-026020	Ciona savignyi	76.54	0.00e+00	791.00
IUUC-Cgl-026429	Colletotrichum gloeosporioides	33.55	4.00e-61	229.00
IUUC-Dno-029484	Dasypus novemcinctus	93.22	0.00e+00	1163.00
IUUC-Dor-031010	Dipodomys ordii	90.70	0.00e+00	1067.00
IUUC-Dse-031287	Dothistroma septosporum	29.12	1.00e-52	201.00
IUUC-Dme-031885	Drosophila melanogaster	80.21	0.00e+00	818.00
IUUC-Ete-032978	Echinops telfairi	84.46	0.00e+00	1016.00
IUUC-Eca-033374	Equus caballus	97.47	0.00e+00	1205.00
IUUC-Eeu-034760	Erinaceus europaeus	75.83	0.00e+00	904.00
IUUC-Fca-035427	Felis catus	93.00	0.00e+00	1150.00
IUUC-Fal-037530	Ficedula albicollis	100.00	0.00e+00	1229.00
IUUC-Fox-037978	Fusarium oxysporum	34.51	2.00e-63	236.00
IUUC-Fso-038077	Fusarium solani	32.97	4.00e-58	219.00
IUUC-Ggr-039974	Gaeumannomyces graminis	32.08	1.00e-56	214.00
IUUC-Gga-041087	Gallus gallus	100.00	0.00e+00	1230.00
IUUC-Ggo-045369	Gorilla gorilla	98.20	0.00e+00	1137.00
IUUC-Hsa-045962	Homo sapiens	97.33	0.00e+00	1217.00
IUUC-Itr-047872	Ictidomys tridecemlineatus	98.90	0.00e+00	935.00
IUUC-Lch-050285	Latimeria chalumnae	90.18	0.00e+00	943.00
IUUC-Loc-052686	Lepisosteus oculatus	91.67	0.00e+00	1155.00
IUUC-Lma-053289	Leptosphaeria maculans	38.08	2.00e-47	183.00
IUUC-Laf-054022	Loxodonta africana	97.81	0.00e+00	1209.00
IUUC-Mcc-055782	Macaca mulatta	98.64	0.00e+00	1207.00
IUUC-Meu-056078	Macropus eugenii	84.41	0.00e+00	901.00
IUUC-Mor-057283	Magnaporthe oryzae	33.26	5.00e-59	222.00
IUUC-Mpo-057540	Magnaporthe poae	32.30	4.00e-57	216.00
IUUC-Mla-058989	Melampsora laricipopulina	40.57	1.00e-60	226.00
IUUC-Mvi-060284	Microbotryum violaceum	43.43	2.00e-68	253.00
IUUC-Mmr-060969	Microcebus murinus	97.17	0.00e+00	1216.00
IUUC-Mdo-063041	Monodelphis domestica	97.17	0.00e+00	1195.00
IUUC-Mmu-064096	Mus musculus	96.50	0.00e+00	1209.00
IUUC-Mpu-066875	Mustela putorius furo	97.08	0.00e+00	1111.00
IUUC-Mlu-067621	Myotis lucifugus	98.01	0.00e+00	1023.00
IUUC-Nfi-068263	Neosartorya fischeri	29.28	5.00e-50	192.00
IUUC-Ncr-068639	Neurospora crassa	34.54	9.00e-45	175.00
IUUC-Nle-069548	Nomascus leucogenys	97.17	0.00e+00	1216.00
IUUC-Opr-071194	Ochotona princeps	91.33	0.00e+00	1123.00
IUUC-Oan-072867	Ornithorhynchus anatinus	94.50	0.00e+00	1208.00
IUUC-Ocu-074246	Oryctolagus cuniculus	97.17	0.00e+00	1216.00
IUUC-Oga-088244	Otolemur garnettii	98.59	0.00e+00	1025.00
IUUC-Oar-089199	Ovis aries	98.03	0.00e+00	1035.00
IUUC-Pan-092826	Papio anubis	97.33	0.00e+00	1217.00
IUUC-Psi-093485	Pelodiscus sinensis	95.28	0.00e+00	1173.00
IUUC-Pma-094315	Petromyzon marinus	80.97	0.00e+00	897.00
IUUC-Pab-097680	Pongo abelii	96.83	0.00e+00	1212.00
IUUC-Pca-100843	Procavia capensis	90.17	0.00e+00	1092.00
IUUC-Pva-102793	Pteropus vampyrus	87.00	0.00e+00	1053.00
IUUC-Pgr-103331	Puccinia graminis	37.69	2.00e-52	199.00
IUUC-Ptt-103853	Puccinia triticina	32.52	8.00e-62	230.00
IUUC-Pte-104392	Pyrenophora teres	37.01	3.00e-47	183.00
IUUC-Pyt-104678	Pyrenophora triticirepentis	37.37	2.00e-47	184.00
IUUC-Rno-105304	Rattus norvegicus	97.61	0.00e+00	1197.00
IUUC-Sha-107454	Sarcophilus harrisii	92.69	0.00e+00	1179.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.61	8.00e-74	270.00
IUUC-Spo-108200	Schizosaccharomyces pombe	31.50	2.00e-66	246.00
IUUC-Sar-113471	Sorex araneus	76.00	0.00e+00	886.00
IUUC-Sre-114916	Sporisorium reilianum	34.08	6.00e-46	179.00
IUUC-Ssc-115490	Sus scrofa	98.62	0.00e+00	1042.00
IUUC-Tgu-117445	Taeniopygia guttata	98.50	0.00e+00	1234.00
IUUC-Tsy-118983	Tarsius syrichta	94.06	0.00e+00	1147.00
IUUC-Tre-122207	Trichoderma reesei	33.85	7.00e-56	211.00
IUUC-Tvi-122344	Trichoderma virens	33.92	3.00e-56	212.00
IUUC-Tme-127141	Tuber melanosporum	34.71	1.00e-63	236.00
IUUC-Tbe-128146	Tupaia belangeri	87.33	0.00e+00	1029.00
IUUC-Ttr-128946	Tursiops truncatus	97.00	0.00e+00	1215.00
IUUC-Uma-129491	Ustilago maydis	33.97	5.00e-47	182.00
IUUC-Vda-129941	Verticillium dahliae	32.23	1.00e-57	217.00
IUUC-Vpa-130709	Vicugna pacos	95.33	0.00e+00	1186.00
IUUC-Xtr-132861	Xenopus tropicalis	93.42	0.00e+00	1167.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence