iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063024

UUCD1 version

UUC-MoD-00800

Ensembl Protein ID

ENSMODP00000039790.1

UniProt Accession

K7E1Y9; K7E1Y9_MONDO

Protein Name

Uncharacterized protein

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000008132.3	ENSMODT00000042895.1	ENSMODP00000039790.1
ENSMODG00000008132.3	ENSMODT00000010305.2	ENSMODP00000010110.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-116	388.4	607	908

Active Site

Position(s)	Description	Evidence
908	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 607  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 694
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNkeeY+ l++e
   Q: 695  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKEEYIGLMAE 780
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r +++qFv
   Q: 781  WRFSRGVQDQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLMQFV 868
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTC 304
           Tg++rlPlgGfael+    p++f+i+k +++++lP+s+TC
   Q: 869  TGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTC 908
           **************************************** PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MATASPRSDT SNNQNRRSQL QVTVSSAKLK RKKNWFGTAI YAELSVDGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LREALELHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGCAGCG TGCTATAGTG GAAAAGCAGC ACTGGATTTG GAGTCAGGAG AGACCTGGTT 60
TTGAATTCTA CCTCCAGTTC TTACTCTGTG ACCATGGGTA AGTCACTTGA CCTTACTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	83.21	0.00e+00	1498.00
IUUC-Apl-003310	Anas platyrhynchos	82.69	0.00e+00	1479.00
IUUC-Aca-005388	Anolis carolinensis	80.09	0.00e+00	1409.00
IUUC-Bta-012857	Bos taurus	82.33	0.00e+00	1447.00
IUUC-Cja-019448	Callithrix jacchus	82.99	0.00e+00	1497.00
IUUC-Cfa-020728	Canis familiaris	83.21	0.00e+00	1475.00
IUUC-Cpo-021635	Cavia porcellus	78.75	0.00e+00	1439.00
IUUC-Csa-023805	Chlorocebus sabaeus	84.80	0.00e+00	1120.00
IUUC-Cho-024943	Choloepus hoffmanni	72.75	0.00e+00	968.00
IUUC-Dre-028245	Danio rerio	91.32	0.00e+00	1098.00
IUUC-Dno-029618	Dasypus novemcinctus	83.32	0.00e+00	1490.00
IUUC-Dor-030665	Dipodomys ordii	68.18	0.00e+00	1007.00
IUUC-Ete-032779	Echinops telfairi	91.42	0.00e+00	1016.00
IUUC-Eca-033313	Equus caballus	82.11	0.00e+00	1455.00
IUUC-Eeu-035259	Erinaceus europaeus	75.85	0.00e+00	1312.00
IUUC-Fca-035420	Felis catus	82.00	0.00e+00	1469.00
IUUC-Fal-037335	Ficedula albicollis	80.96	0.00e+00	1453.00
IUUC-Gmo-039172	Gadus morhua	86.36	0.00e+00	992.00
IUUC-Gga-040246	Gallus gallus	81.36	0.00e+00	1460.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.86	0.00e+00	1110.00
IUUC-Ggo-045001	Gorilla gorilla	82.00	0.00e+00	1308.00
IUUC-Hsa-046544	Homo sapiens	82.44	0.00e+00	1490.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	82.23	0.00e+00	1443.00
IUUC-Loc-052116	Lepisosteus oculatus	93.67	0.00e+00	1120.00
IUUC-Laf-053551	Loxodonta africana	81.91	0.00e+00	1460.00
IUUC-Meu-056455	Macropus eugenii	73.93	0.00e+00	837.00
IUUC-Mga-059986	Meleagris gallopavo	81.29	0.00e+00	1462.00
IUUC-Mmr-060945	Microcebus murinus	80.90	0.00e+00	1437.00
IUUC-Mmu-063202	Mus musculus	80.86	0.00e+00	1412.00
IUUC-Mpu-065773	Mustela putorius furo	82.48	0.00e+00	1461.00
IUUC-Nle-069188	Nomascus leucogenys	82.77	0.00e+00	1493.00
IUUC-Opr-070965	Ochotona princeps	79.54	0.00e+00	1402.00
IUUC-Ont-072226	Oreochromis niloticus	90.32	0.00e+00	1117.00
IUUC-Oan-073497	Ornithorhynchus anatinus	87.38	0.00e+00	1521.00
IUUC-Ocu-073891	Oryctolagus cuniculus	80.00	0.00e+00	1389.00
IUUC-Ola-087438	Oryzias latipes	92.99	0.00e+00	1103.00
IUUC-Oga-087922	Otolemur garnettii	82.48	0.00e+00	1466.00
IUUC-Oar-089317	Ovis aries	82.04	0.00e+00	1438.00
IUUC-Ptr-090484	Pan troglodytes	82.44	0.00e+00	1489.00
IUUC-Pan-092117	Papio anubis	82.77	0.00e+00	1494.00
IUUC-Psi-093338	Pelodiscus sinensis	82.86	0.00e+00	1500.00
IUUC-Pfo-096171	Poecilia formosa	92.74	0.00e+00	1111.00
IUUC-Pab-098654	Pongo abelii	82.14	0.00e+00	1082.00
IUUC-Pva-102811	Pteropus vampyrus	73.55	0.00e+00	1261.00
IUUC-Rno-106125	Rattus norvegicus	80.75	0.00e+00	1427.00
IUUC-Sha-107243	Sarcophilus harrisii	91.90	0.00e+00	1629.00
IUUC-Ssc-115368	Sus scrofa	82.06	0.00e+00	1440.00
IUUC-Tgu-117079	Taeniopygia guttata	81.20	0.00e+00	1442.00
IUUC-Tru-118062	Takifugu rubripes	70.54	0.00e+00	1296.00
IUUC-Tsy-119507	Tarsius syrichta	77.39	0.00e+00	1365.00
IUUC-Tni-120151	Tetraodon nigroviridis	90.64	0.00e+00	1105.00
IUUC-Ttr-129260	Tursiops truncatus	73.41	0.00e+00	1241.00
IUUC-Vpa-130390	Vicugna pacos	70.33	0.00e+00	765.00
IUUC-Xtr-132877	Xenopus tropicalis	66.85	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence