iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003269

Ensembl Protein ID

ENSAPLP00000000884.1

UniProt Accession

U3I0W4; U3I0W4_ANAPL

Genbank Protein ID

ENSAPLP00000000884

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01087479

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000001201.1	ENSAPLT00000001455.1	ENSAPLP00000000884.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	6.20e-215	715.2	22	609

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 9    ilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkifayldrtyv 95
           i+++ s+++++eely+av+nlc++kv+a lYk+l++v+e+++ +q+ + +e s d+  +Lk++n++W+++++q+ ++r+if++ldrtyv
   Q: 22   IQSSVSIRYNLEELYQAVENLCSYKVSATLYKQLRQVCEDHVkAQILQFREYSLDSLlFLKKINKCWQDHCRQMIMIRSIFLFLDRTYV 110
           5667777***********************************99********************************************* PP
   S: 96   kkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfleatqefyka 182
            +++++ ++++++l+l+r+++++d  +++++++ +l lie+eR+geavdr+ll+++ ++l++L     ++ykesFE++fle+t+ +y+a
   Q: 111  LQNSMLPSIWDMGLELFRNHVISDkqVQNKTIDGILLLIERERSGEAVDRSLLRSLLSMLSDL-----QVYKESFEQRFLEETNCLYAA 194
           ************************9**********************************9998.....9******************** PP
   S: 183  esaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLlsrvlngle 270
           e ++++qe+ev eYl++v++rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++ +dl++ y+L+srv+ g +
   Q: 195  EGQRLMQEREVPEYLHHVNKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDNLLDENRISDLTQTYQLFSRVKGGQQ 283
           ********************************************************9989***************************** PP
   S: 271  ellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.EllAryiDq 358
            ll++++++ik+ g+++++++ek+kd   +V++ll++k+k++++++ +F++++kF++ ++++fetf+nk+     +++p El+A+y+D+
   Q: 284  ILLQHWSEYIKNFGTTIVVNPEKDKD---MVQELLDFKDKVDHIIEVCFQKNEKFINLMKESFETFINKR-----PNKPaELIAKYVDS 364
           **************************...*****************************************.....66666********* PP
   S: 359  lLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedl 447
           +Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+d+++S+d+
   Q: 365  KLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDV 453
           ***************************************************************************************** PP
   S: 448  nrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVs 536
           + qFk+ ++n+++  +++l+v++L++g+Wpt++ +e v+L +e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+gk+e+qVs
   Q: 454  MVQFKQYMQNQSDPGNIDLTVNILTMGYWPTYTPME-VHLNSEMIKLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVS 541
           ********************************9999.**************************************************** PP
   S: 537  tfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
            fQ++vLL+fn+ +++s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++k++e++d+f++N +f
   Q: 542  LFQTLVLLMFNEGDEFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKNPKGKDVEDGDKFIFNGDF 609
           *****************************************************************998 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

ERPKLPDNYT QDTWQKLHDA VIQSSVSIRY NLEELYQAVE NLCSYKVSAT LYKQLRQVCE 60
DHVKAQILQF REYSLDSLLF LKKINKCWQD HCRQMIMIRS IFLFLDRTYV LQNSMLPSIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAGGCCCA AGCTGCCCGA TAACTACACG CAGGACACCT GGCAGAAACT TCACGACGCC 60
GTGGGGGCCA TCCAGAATCC AGAGCAGCGT TTCCATCCGC TACAACCTCG AGGAGCTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	91.84	0.00e+00	1323.00
IUUC-Bta-012355	Bos taurus	90.88	0.00e+00	1320.00
IUUC-Cja-019861	Callithrix jacchus	91.27	0.00e+00	1320.00
IUUC-Cfa-021009	Canis familiaris	93.52	0.00e+00	1349.00
IUUC-Cpo-021867	Cavia porcellus	91.55	0.00e+00	1326.00
IUUC-Csa-024139	Chlorocebus sabaeus	91.69	0.00e+00	1325.00
IUUC-Cho-024899	Choloepus hoffmanni	96.63	0.00e+00	1008.00
IUUC-Dno-028879	Dasypus novemcinctus	88.27	0.00e+00	1263.00
IUUC-Dor-030698	Dipodomys ordii	91.27	0.00e+00	1305.00
IUUC-Ete-033101	Echinops telfairi	88.76	0.00e+00	1252.00
IUUC-Eca-033696	Equus caballus	92.88	0.00e+00	1343.00
IUUC-Fca-036333	Felis catus	92.26	0.00e+00	1333.00
IUUC-Fal-036995	Ficedula albicollis	97.75	0.00e+00	1395.00
IUUC-Gga-040358	Gallus gallus	97.91	0.00e+00	1407.00
IUUC-Hsa-045679	Homo sapiens	91.97	0.00e+00	1327.00
IUUC-Laf-054100	Loxodonta africana	93.15	0.00e+00	1341.00
IUUC-Mcc-055168	Macaca mulatta	92.55	0.00e+00	1235.00
IUUC-Meu-056492	Macropus eugenii	85.67	9.00e-166	576.00
IUUC-Mga-059866	Meleagris gallopavo	98.46	0.00e+00	1403.00
IUUC-Mmr-061551	Microcebus murinus	91.55	0.00e+00	1316.00
IUUC-Mdo-062215	Monodelphis domestica	95.49	0.00e+00	1370.00
IUUC-Mmu-063402	Mus musculus	91.97	0.00e+00	1326.00
IUUC-Mpu-066383	Mustela putorius furo	91.98	0.00e+00	1327.00
IUUC-Nle-069606	Nomascus leucogenys	91.83	0.00e+00	1326.00
IUUC-Opr-070671	Ochotona princeps	82.10	3.00e-113	402.00
IUUC-Oan-073299	Ornithorhynchus anatinus	91.97	0.00e+00	1328.00
IUUC-Ocu-074731	Oryctolagus cuniculus	92.54	0.00e+00	1337.00
IUUC-Oar-089346	Ovis aries	90.58	0.00e+00	1313.00
IUUC-Ptr-091177	Pan troglodytes	91.97	0.00e+00	1327.00
IUUC-Pan-092191	Papio anubis	91.28	0.00e+00	1315.00
IUUC-Pab-097622	Pongo abelii	91.55	0.00e+00	1324.00
IUUC-Pca-100391	Procavia capensis	84.60	0.00e+00	995.00
IUUC-Rno-105829	Rattus norvegicus	91.97	0.00e+00	1328.00
IUUC-Sha-106762	Sarcophilus harrisii	95.79	0.00e+00	1326.00
IUUC-Ssc-116133	Sus scrofa	90.70	0.00e+00	1288.00
IUUC-Tgu-116961	Taeniopygia guttata	97.33	0.00e+00	1392.00
IUUC-Ttr-128326	Tursiops truncatus	85.99	0.00e+00	1142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence