iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afl-008502

Ensembl Protein ID

EED53743

UniProt Accession

B8N9H4; LIS1_ASPFN

Genbank Protein ID

EED53743.1

Protein Name

Nuclear distribution protein nudF; Lissencephaly-1 homolog

Genbank Nucleotide ID

EQ963475

Gene Name

nudF; lis1; AFLA_111200

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AFLA_111200	EED53743	EED53743

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.90e-48	157.5	98	133
UBD/Beta-Prp	2.90e-63	213.3	96	386

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H d+v+c+af ++   ++sGsdD+tik+WD+  g l
   Q: 98   HRDKVNCVAFhPTfSSIASGSDDCTIKIWDWELGEL 133
           9**********88889**************876665 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvw.dlstgkcvhtlkghedsvlslsfsp 104
           ++h + ++cv+f+p  s +a+gs+d tik+wd++ g l r+l+gh+ +v++v++   ++  +l+++s+D  ik+w + +++k ++tl+gh++ v +++f p
   Q: 96   ESHRDKVNCVAFHPTFSSIASGSDDCTIKIWDWELGELERTLKGHTRAVRDVDYGGPRDnvLLASCSSDLSIKLWkPTDNYKNIRTLQGHDHIVSAVRFIP 196
           456778889*********************************************8776678**************8899********************** PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkllrtltgghtdsvyslsfdsng.......... 192
           s++ lvs+s+d+  r+wd+ tg+c++ t +gh+++v+ v+++ dg+ l+s + D t rlWd+   ++ +  rt+ g h++ +++ +f +            
   Q: 197  SRNLLVSASRDNDMRIWDVTTGYCVK-TINGHTDWVRDVSISFDGRFLFSTGQDMTARLWDIstvSNIEHKRTMLG-HENFIECCAFAPPTsyqflaplag 295
           **************************.***********************************44444445567798.*********877667888888888 PP
   S: 193  ...........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvav 272
                       ++++gs+d+t+k+wd  +g+c++tl gh+++v+ + f+p +++l+s+s+D+++r+Wdl ++g+++ktl  h+s v+s   
   Q: 296  lgkrpsstngaDFMATGSRDNTIKIWDS-RGTCLMTLVGHDSWVQALVFHPGGKYLLSVSDDKTLRCWDLnQQGKCVKTLDAHESFVTSLRW 386
           8888888888999**************8.899************************************984689**********99988765 PP

Organism

Aspergillus flavus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MIAYLVASDL PDTAAALRRE VNLSEDVFDP TTAKRYEGML EKKWTSIARL QKKIMDLESR 60
NATLQSELDN STPASRLKRN QDPASWLPST VRYSLESHRD KVNCVAFHPT FSSIASGSDD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATAGCGT ACCTCGTGGC GAGCGACCTA CCGGACACCG CAGCGGCACT CAGGAGAGAA 60
GTGAACCTCA GCGAAGATGT GTTCGATCCA ACTACAGCGA AAAGGTACGA AGGGATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

afv:AFLA_111200

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	45.69	5.00e-95	339.00
IUUC-Apl-004024	Anas platyrhynchos	46.21	4.00e-95	339.00
IUUC-Aca-004564	Anolis carolinensis	45.69	1.00e-92	331.00
IUUC-Ago-007862	Ashbya gossypii	28.64	4.00e-30	123.00
IUUC-Acl-008360	Aspergillus clavatus	61.89	7.00e-154	535.00
IUUC-Afu-008848	Aspergillus fumigatus	61.66	3.00e-160	555.00
IUUC-Ani-009173	Aspergillus nidulans	56.08	8.00e-144	501.00
IUUC-Ang-009873	Aspergillus niger	54.11	5.00e-142	495.00
IUUC-Aor-009973	Aspergillus oryzae	95.22	0.00e+00	830.00
IUUC-Ate-010523	Aspergillus terreus	53.41	1.00e-140	491.00
IUUC-Ame-011154	Astyanax mexicanus	45.69	1.00e-95	340.00
IUUC-Bgr-011972	Blumeria graminis	61.16	1.00e-160	557.00
IUUC-Bta-013106	Bos taurus	45.69	3.00e-95	339.00
IUUC-Bci-013615	Botrytis cinerea	63.11	6.00e-169	585.00
IUUC-Cel-018459	Caenorhabditis elegans	42.86	3.00e-84	303.00
IUUC-Cja-018755	Callithrix jacchus	45.69	4.00e-95	339.00
IUUC-Cfa-020749	Canis familiaris	45.69	3.00e-95	339.00
IUUC-Cpo-022371	Cavia porcellus	45.69	3.00e-95	339.00
IUUC-Csa-023524	Chlorocebus sabaeus	46.99	1.00e-83	301.00
IUUC-Cho-024764	Choloepus hoffmanni	42.05	3.00e-78	283.00
IUUC-Cin-025753	Ciona intestinalis	45.31	6.00e-89	319.00
IUUC-Csv-025817	Ciona savignyi	44.27	2.00e-90	323.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	62.89	7.00e-160	554.00
IUUC-Cne-027087	Cryptococcus neoformans	47.75	7.00e-101	358.00
IUUC-Dre-028314	Danio rerio	45.69	5.00e-94	335.00
IUUC-Dno-029050	Dasypus novemcinctus	45.69	3.00e-95	340.00
IUUC-Dor-030222	Dipodomys ordii	40.84	3.00e-82	296.00
IUUC-Dse-031164	Dothistroma septosporum	56.12	3.00e-151	526.00
IUUC-Dme-031745	Drosophila melanogaster	44.91	6.00e-87	312.00
IUUC-Ete-032508	Echinops telfairi	49.04	5.00e-69	253.00
IUUC-Eca-034288	Equus caballus	45.17	7.00e-94	335.00
IUUC-Eeu-034984	Erinaceus europaeus	40.84	6.00e-82	295.00
IUUC-Fca-036498	Felis catus	45.69	3.00e-95	339.00
IUUC-Fal-036920	Ficedula albicollis	46.21	4.00e-95	339.00
IUUC-Fox-037996	Fusarium oxysporum	62.72	9.00e-168	581.00
IUUC-Fso-038160	Fusarium solani	61.61	4.00e-163	565.00
IUUC-Gmo-038983	Gadus morhua	45.17	1.00e-93	334.00
IUUC-Ggr-040051	Gaeumannomyces graminis	67.91	2.00e-174	603.00
IUUC-Gga-040623	Gallus gallus	46.21	4.00e-95	339.00
IUUC-Gac-041613	Gasterosteus aculeatus	45.17	1.00e-93	334.00
IUUC-Ggo-045410	Gorilla gorilla	44.54	8.00e-82	295.00
IUUC-Hsa-046358	Homo sapiens	46.21	4.00e-95	339.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	45.69	3.00e-95	339.00
IUUC-Kpa-049351	Komagataella pastoris	30.83	8.00e-41	159.00
IUUC-Lch-049936	Latimeria chalumnae	44.91	4.00e-94	336.00
IUUC-Loc-052476	Lepisosteus oculatus	45.95	1.00e-95	341.00
IUUC-Lma-053170	Leptosphaeria maculans	62.95	1.00e-156	543.00
IUUC-Laf-053713	Loxodonta africana	45.69	2.00e-95	340.00
IUUC-Mcc-054628	Macaca mulatta	45.69	6.00e-95	338.00
IUUC-Meu-055927	Macropus eugenii	41.76	2.00e-52	197.00
IUUC-Mor-056962	Magnaporthe oryzae	65.40	3.00e-173	599.00
IUUC-Mpo-057583	Magnaporthe poae	67.44	4.00e-166	575.00
IUUC-Mla-058819	Melampsora laricipopulina	44.07	4.00e-99	353.00
IUUC-Mga-059945	Meleagris gallopavo	46.21	5.00e-95	339.00
IUUC-Mvi-060403	Microbotryum violaceum	48.65	2.00e-112	397.00
IUUC-Mmr-061289	Microcebus murinus	45.69	5.00e-95	339.00
IUUC-Mdo-061912	Monodelphis domestica	45.43	3.00e-94	336.00
IUUC-Mmu-063253	Mus musculus	45.69	3.00e-95	339.00
IUUC-Mpu-066638	Mustela putorius furo	45.69	3.00e-95	339.00
IUUC-Mlu-067267	Myotis lucifugus	45.69	5.00e-95	339.00
IUUC-Nfi-068571	Neosartorya fischeri	57.93	6.00e-144	501.00
IUUC-Ncr-068895	Neurospora crassa	66.27	2.00e-167	580.00
IUUC-Nle-069087	Nomascus leucogenys	42.90	3.00e-74	270.00
IUUC-Opr-070579	Ochotona princeps	45.69	3.00e-95	340.00
IUUC-Ont-072432	Oreochromis niloticus	45.17	4.00e-94	336.00
IUUC-Oan-073072	Ornithorhynchus anatinus	45.69	3.00e-95	339.00
IUUC-Ocu-074180	Oryctolagus cuniculus	45.69	3.00e-95	340.00
IUUC-Ola-086815	Oryzias latipes	45.71	6.00e-95	338.00
IUUC-Oga-088219	Otolemur garnettii	45.69	3.00e-95	339.00
IUUC-Oar-090394	Ovis aries	45.69	3.00e-95	339.00
IUUC-Ptr-091517	Pan troglodytes	45.69	3.00e-95	339.00
IUUC-Pan-092421	Papio anubis	45.69	6.00e-95	338.00
IUUC-Psi-093370	Pelodiscus sinensis	45.69	8.00e-95	338.00
IUUC-Pma-094319	Petromyzon marinus	44.78	9.00e-80	288.00
IUUC-Pno-094815	Phaeosphaeria nodorum	62.36	5.00e-161	558.00
IUUC-Pfo-097089	Poecilia formosa	45.29	1.00e-94	338.00
IUUC-Pab-098421	Pongo abelii	45.69	3.00e-95	339.00
IUUC-Pca-100120	Procavia capensis	35.76	4.00e-53	199.00
IUUC-Pva-102960	Pteropus vampyrus	45.43	4.00e-94	336.00
IUUC-Pgr-103538	Puccinia graminis	46.10	4.00e-108	383.00
IUUC-Ptt-103990	Puccinia triticina	39.08	3.00e-37	148.00
IUUC-Pte-104261	Pyrenophora teres	62.50	2.00e-161	560.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	62.72	9.00e-162	561.00
IUUC-Rno-105123	Rattus norvegicus	45.69	3.00e-95	339.00
IUUC-Sce-106208	Saccharomyces cerevisiae	30.60	2.00e-40	157.00
IUUC-Sha-107010	Sarcophilus harrisii	45.69	2.00e-94	337.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	37.74	8.00e-64	235.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	64.54	3.00e-162	563.00
IUUC-Sar-113309	Sorex araneus	44.91	3.00e-92	330.00
IUUC-Sre-115003	Sporisorium reilianum	46.83	3.00e-109	386.00
IUUC-Ssc-116148	Sus scrofa	45.69	3.00e-95	339.00
IUUC-Tgu-117299	Taeniopygia guttata	45.69	4.00e-95	339.00
IUUC-Tru-118179	Takifugu rubripes	45.69	3.00e-95	340.00
IUUC-Tsy-119493	Tarsius syrichta	45.43	9.00e-94	335.00
IUUC-Tni-120288	Tetraodon nigroviridis	45.04	5.00e-93	332.00
IUUC-Tre-121977	Trichoderma reesei	60.74	2.00e-156	543.00
IUUC-Tvi-122661	Trichoderma virens	61.20	1.00e-154	537.00
IUUC-Tme-127031	Tuber melanosporum	60.63	7.00e-153	531.00
IUUC-Tbe-127492	Tupaia belangeri	41.76	7.00e-47	179.00
IUUC-Ttr-128929	Tursiops truncatus	45.69	4.00e-95	339.00
IUUC-Uma-129347	Ustilago maydis	47.42	8.00e-111	391.00
IUUC-Vda-129837	Verticillium dahliae	60.80	3.00e-153	533.00
IUUC-Vpa-130532	Vicugna pacos	38.22	6.00e-72	262.00
IUUC-Xtr-131985	Xenopus tropicalis	45.17	1.00e-94	338.00
IUUC-Xma-133314	Xiphophorus maculatus	45.43	2.00e-94	337.00
IUUC-Yli-134403	Yarrowia lipolytica	43.68	9.00e-94	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence