iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cgl-026529

Ensembl Protein ID

ELA32013

UniProt Accession

L2G1X8; L2G1X8_COLGN

Genbank Protein ID

ELA32013.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

KB020726

Gene Name

PAC1; LIS1; CGGC5_7930

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CGGC5_7930	ELA32013	ELA32013

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-48	159.2	108	143
UBD/Beta-Prp	1.20e-65	221.2	106	403

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           H d++tc+af +    l+sGs D tik+WD+  g l
   Q: 108  HRDPITCVAFhPVfSSLASGSEDYTIKIWDWELGEL 143
           9*********955568**************876665 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfsp 104
           ++h ++itcv+f+p  s la+gs+d tik+wd++ g l r+++gh+++v +v+f   +   +l+++s+D tik+wd+s  +k ++tl gh++sv +++f p
   Q: 106  QSHRDPITCVAFHPVFSSLASGSEDYTIKIWDWELGELERTIKGHTKAVLDVDFGGPRGatLLASCSSDLTIKLWDPSdEYKNIRTLPGHDHSVSAVRFIP 206
           45777*************************************************8655557**************887699******************** PP
   S: 105  ........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvyslsfdsng... 192
                   sg+ lvs+s+d+t+r+wd++tg+c++ tl+gh ++v+ v+ +pdg+ l s+++D+t rlWd++ ++   +l   g h++ v++ ++ +     
   Q: 207  sgaagagsSGNLLVSASRDKTLRIWDVSTGYCVK-TLRGHADWVRDVCPSPDGRFLLSAGNDQTGRLWDISAANPEVKLtlVG-HEHVVECCTLAPATayp 305
           9999999888************************.***********************************7766666665266.*********77777777 PP
   S: 193  ..................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisvav 272
                             +++++gs+d+ ++lwd  +g+c++tl+gh+++v+ + f+p +++l+s+s+D+++r+Wdl + g+++k+l   + +++s+  
   Q: 306  hlatlaglkkpppatstvEFMATGSRDKVIRLWDA-RGNCIKTLTGHDNWVRALVFHPGGKYLLSVSDDKTLRCWDLaQEGKCVKVLDDVHGHFVSCLR 403
           788888888888888888****************9.899*************************************85689*******99966655543 PP

Organism

Colletotrichum gloeosporioides

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.

Protein Sequence
(Fasta)

MSQILTSRQA EELHKAIIAY LSSSNLPNAA NALREELQIG EAFDAATSKK YEGLLEKKWT 60
SVIMELESRT ASLQSEIDNA TPTSLSRRNQ DPTSWLPRSP ARHTLQSHRD PITCVAFHPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCAAA TCCTTACCTC TCGGCAAGCC GAGGAGCTGT TCGTCAACCC GCCAAACGTC 60
TTGCGGGGCA CTACTGACCA GCATTGCGCA GGCACAAGGC CATCATCGCC TACCTCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	46.73	1.00e-97	348.00
IUUC-Apl-004024	Anas platyrhynchos	46.81	3.00e-101	360.00
IUUC-Aca-004564	Anolis carolinensis	46.34	7.00e-99	352.00
IUUC-Ago-007862	Ashbya gossypii	27.96	1.00e-30	125.00
IUUC-Acl-008360	Aspergillus clavatus	71.61	0.00e+00	642.00
IUUC-Afl-008502	Aspergillus flavus	62.47	3.00e-163	566.00
IUUC-Afu-008848	Aspergillus fumigatus	72.82	0.00e+00	690.00
IUUC-Ani-009173	Aspergillus nidulans	60.52	1.00e-161	560.00
IUUC-Ang-009873	Aspergillus niger	57.73	9.00e-156	541.00
IUUC-Aor-009973	Aspergillus oryzae	60.91	9.00e-160	554.00
IUUC-Ate-010523	Aspergillus terreus	59.91	2.00e-161	560.00
IUUC-Ame-010969	Astyanax mexicanus	47.93	2.00e-102	363.00
IUUC-Bgr-011972	Blumeria graminis	73.65	0.00e+00	709.00
IUUC-Bta-013106	Bos taurus	46.81	3.00e-101	360.00
IUUC-Bci-013615	Botrytis cinerea	75.54	0.00e+00	706.00
IUUC-Cel-018459	Caenorhabditis elegans	43.73	3.00e-88	317.00
IUUC-Cja-018755	Callithrix jacchus	45.86	4.00e-98	349.00
IUUC-Cfa-020749	Canis familiaris	46.81	3.00e-101	360.00
IUUC-Cpo-022371	Cavia porcellus	46.81	3.00e-101	360.00
IUUC-Csa-023524	Chlorocebus sabaeus	47.61	8.00e-88	315.00
IUUC-Cho-024764	Choloepus hoffmanni	44.05	3.00e-81	293.00
IUUC-Cin-025753	Ciona intestinalis	45.69	3.00e-93	333.00
IUUC-Csv-025817	Ciona savignyi	45.45	2.00e-96	344.00
IUUC-Cne-027087	Cryptococcus neoformans	52.58	6.00e-112	395.00
IUUC-Dre-028314	Danio rerio	47.22	6.00e-101	358.00
IUUC-Dno-029050	Dasypus novemcinctus	46.81	3.00e-101	360.00
IUUC-Dor-030222	Dipodomys ordii	43.65	6.00e-91	325.00
IUUC-Dse-031164	Dothistroma septosporum	69.11	0.00e+00	635.00
IUUC-Dme-031745	Drosophila melanogaster	45.23	4.00e-89	319.00
IUUC-Ete-032508	Echinops telfairi	48.24	7.00e-70	255.00
IUUC-Eca-034288	Equus caballus	46.73	9.00e-98	348.00
IUUC-Eeu-034984	Erinaceus europaeus	43.41	6.00e-90	322.00
IUUC-Fca-036498	Felis catus	46.81	3.00e-101	360.00
IUUC-Fal-036920	Ficedula albicollis	46.81	3.00e-101	360.00
IUUC-Fox-037996	Fusarium oxysporum	71.65	0.00e+00	681.00
IUUC-Fso-038160	Fusarium solani	71.49	0.00e+00	664.00
IUUC-Gmo-038983	Gadus morhua	47.52	5.00e-103	365.00
IUUC-Ggr-040051	Gaeumannomyces graminis	70.04	0.00e+00	647.00
IUUC-Gga-040623	Gallus gallus	46.81	3.00e-101	360.00
IUUC-Gac-041613	Gasterosteus aculeatus	47.37	6.00e-101	359.00
IUUC-Ggo-045410	Gorilla gorilla	43.67	8.00e-82	295.00
IUUC-Hsa-046358	Homo sapiens	46.81	2.00e-101	360.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	46.81	3.00e-101	360.00
IUUC-Kpa-049351	Komagataella pastoris	30.23	1.00e-41	162.00
IUUC-Lch-049936	Latimeria chalumnae	46.57	3.00e-101	360.00
IUUC-Loc-052476	Lepisosteus oculatus	47.22	3.00e-98	350.00
IUUC-Lma-053170	Leptosphaeria maculans	75.54	0.00e+00	675.00
IUUC-Laf-053713	Loxodonta africana	45.99	9.00e-99	351.00
IUUC-Mcc-054628	Macaca mulatta	46.81	4.00e-101	359.00
IUUC-Meu-055927	Macropus eugenii	40.14	9.00e-51	191.00
IUUC-Mor-056962	Magnaporthe oryzae	71.71	0.00e+00	665.00
IUUC-Mpo-057583	Magnaporthe poae	71.12	0.00e+00	630.00
IUUC-Mla-058819	Melampsora laricipopulina	48.61	2.00e-115	407.00
IUUC-Mga-059945	Meleagris gallopavo	46.57	6.00e-101	358.00
IUUC-Mvi-060403	Microbotryum violaceum	49.68	8.00e-124	435.00
IUUC-Mmr-061289	Microcebus murinus	46.32	6.00e-98	348.00
IUUC-Mdo-061912	Monodelphis domestica	46.57	2.00e-100	357.00
IUUC-Mmu-063253	Mus musculus	46.81	3.00e-101	360.00
IUUC-Mpu-066638	Mustela putorius furo	46.81	3.00e-101	360.00
IUUC-Mlu-067267	Myotis lucifugus	45.97	4.00e-98	349.00
IUUC-Nfi-068571	Neosartorya fischeri	68.88	0.00e+00	640.00
IUUC-Ncr-068895	Neurospora crassa	76.77	0.00e+00	691.00
IUUC-Nle-069087	Nomascus leucogenys	45.96	4.00e-82	296.00
IUUC-Opr-070579	Ochotona princeps	46.81	3.00e-101	360.00
IUUC-Ont-072432	Oreochromis niloticus	46.32	1.00e-100	358.00
IUUC-Oan-073072	Ornithorhynchus anatinus	46.81	3.00e-101	360.00
IUUC-Ocu-074180	Oryctolagus cuniculus	46.81	3.00e-101	360.00
IUUC-Ola-086772	Oryzias latipes	47.03	3.00e-101	360.00
IUUC-Oga-088219	Otolemur garnettii	45.75	1.00e-98	351.00
IUUC-Oar-090394	Ovis aries	46.81	3.00e-101	360.00
IUUC-Ptr-091517	Pan troglodytes	46.81	3.00e-101	360.00
IUUC-Pan-092421	Papio anubis	46.81	4.00e-101	359.00
IUUC-Psi-093370	Pelodiscus sinensis	46.81	5.00e-101	359.00
IUUC-Pma-094319	Petromyzon marinus	47.95	1.00e-86	311.00
IUUC-Pno-094815	Phaeosphaeria nodorum	75.86	0.00e+00	700.00
IUUC-Pfo-097089	Poecilia formosa	47.51	6.00e-103	365.00
IUUC-Pab-098421	Pongo abelii	46.81	3.00e-101	360.00
IUUC-Pca-100120	Procavia capensis	38.75	2.00e-58	218.00
IUUC-Pva-102960	Pteropus vampyrus	46.57	6.00e-100	355.00
IUUC-Pgr-103538	Puccinia graminis	48.83	8.00e-118	415.00
IUUC-Ptt-103990	Puccinia triticina	41.54	1.00e-38	152.00
IUUC-Pte-104261	Pyrenophora teres	75.16	0.00e+00	697.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	75.38	0.00e+00	699.00
IUUC-Rno-105123	Rattus norvegicus	46.81	3.00e-101	360.00
IUUC-Sce-106208	Saccharomyces cerevisiae	28.43	9.00e-33	132.00
IUUC-Sha-107010	Sarcophilus harrisii	46.57	2.00e-100	357.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	36.25	3.00e-66	243.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	77.22	0.00e+00	681.00
IUUC-Sar-113309	Sorex araneus	46.25	3.00e-95	340.00
IUUC-Sre-115003	Sporisorium reilianum	49.68	5.00e-123	432.00
IUUC-Ssc-116148	Sus scrofa	46.81	3.00e-101	360.00
IUUC-Tgu-117299	Taeniopygia guttata	46.81	2.00e-101	360.00
IUUC-Tru-117721	Takifugu rubripes	46.56	2.00e-101	360.00
IUUC-Tsy-119493	Tarsius syrichta	47.04	2.00e-100	357.00
IUUC-Tni-120355	Tetraodon nigroviridis	46.63	2.00e-100	357.00
IUUC-Tre-121977	Trichoderma reesei	66.88	3.00e-178	616.00
IUUC-Tvi-122661	Trichoderma virens	68.31	6.00e-177	611.00
IUUC-Tme-127031	Tuber melanosporum	68.34	3.00e-179	619.00
IUUC-Tbe-127492	Tupaia belangeri	41.76	6.00e-48	182.00
IUUC-Ttr-128929	Tursiops truncatus	46.81	7.00e-101	358.00
IUUC-Uma-129347	Ustilago maydis	50.00	2.00e-121	427.00
IUUC-Vda-129837	Verticillium dahliae	80.60	0.00e+00	699.00
IUUC-Vpa-130532	Vicugna pacos	40.79	2.00e-80	290.00
IUUC-Xtr-131985	Xenopus tropicalis	46.57	7.00e-101	358.00
IUUC-Xma-133314	Xiphophorus maculatus	47.27	1.00e-102	364.00
IUUC-Yli-134403	Yarrowia lipolytica	41.32	3.00e-93	333.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence