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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045722
Ensembl Protein ID ENSP00000466868.1
UniProt Accession B9TWZ6; B9TWZ6_HUMAN
Genbank Protein ID ACB88882.1
Protein Name Mediator complex subunit MED16 variant MED16_i3; Mediator of RNA polymerase II transcription subunit 16
Genbank Nucleotide ID AC112706
Gene Name MED16
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000175221.14 ENST00000395808.7 ENSP00000379153.1
ENSG00000175221.14 ENST00000312090.10 ENSP00000308528.4
ENSG00000175221.14 ENST00000621073.4 ENSP00000478286.1
ENSG00000175221.14 ENST00000607471.5 ENSP00000475725.1
ENSG00000175221.14 ENST00000589119.5 ENSP00000464810.1
ENSG00000175221.14 ENST00000606248.5 ENSP00000475528.1
ENSG00000175221.14 ENST00000592943.5 ENSP00000466868.1
ENSG00000175221.14 ENST00000586017.5 ENSP00000465762.1
ENSG00000175221.14 ENST00000606828.2 ENSP00000480766.1
ENSG00000175221.14 ENST00000592373.1 ENSP00000465823.1
ENSG00000175221.14 ENST00000616387.4 ENSP00000479411.1
ENSG00000175221.14 ENST00000617672.1 ENSP00000483533.1
ENSG00000175221.14 ENST00000269814.8 ENSP00000269814.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmiRTarBasemicroRNA
TRANSFACRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
HINTInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.10e-06 27.5 80 112
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           H + +tcl++  s+ +l+s+  Dg+ik+W++ +
   Q: 80   HHEAITCLEWdqSGSRLLSADADGQIKCWSMAD 112
           6677******965599*************9765 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 60
MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045722|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CAGAAGTCTT TGGGAGGCGG CCCCACGCCT CAGGCGACTG GTTGTTACCG AGGAAGATGG 60
CGGCGCCAGA CCCGAGGCGC TAGGGAAGAT CGCACCGCGG ACGCCCGCTG AGCTTGGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045722|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0853--WD repeat
Interpro

IPR021665--Mediator_Med16
IPR011041--Quinoprot_gluc/sorb_DH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF11635--Med16
SMART

SM00320--WD40
Gene Ontology

GO:0003824--F:catalytic activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ame-011407 Astyanax mexicanus 80.11 3.00e-175 608.00
IUUC-Bta-012729 Bos taurus 86.29 0.00e+00 803.00
IUUC-Cja-019000 Callithrix jacchus 99.49 5.00e-108 383.00
IUUC-Cfa-020876 Canis familiaris 91.31 0.00e+00 847.00
IUUC-Cpo-021655 Cavia porcellus 88.98 0.00e+00 823.00
IUUC-Dre-027473 Danio rerio 75.43 0.00e+00 701.00
IUUC-Dno-029564 Dasypus novemcinctus 88.61 0.00e+00 824.00
IUUC-Eca-033914 Equus caballus 94.69 0.00e+00 851.00
IUUC-Fca-036338 Felis catus 95.92 0.00e+00 842.00
IUUC-Fal-037249 Ficedula albicollis 86.32 0.00e+00 805.00
IUUC-Gmo-039447 Gadus morhua 72.31 7.00e-167 580.00
IUUC-Gga-041100 Gallus gallus 87.03 0.00e+00 721.00
IUUC-Gac-042603 Gasterosteus aculeatus 72.77 2.00e-159 556.00
IUUC-Ggo-044794 Gorilla gorilla 94.01 0.00e+00 899.00
IUUC-Itr-048948 Ictidomys tridecemlineatus 90.08 0.00e+00 837.00
IUUC-Loc-052871 Lepisosteus oculatus 78.67 0.00e+00 718.00
IUUC-Mcc-055201 Macaca mulatta 93.39 0.00e+00 891.00
IUUC-Mga-059807 Meleagris gallopavo 80.97 0.00e+00 733.00
IUUC-Mmr-060781 Microcebus murinus 91.97 0.00e+00 850.00
IUUC-Mpu-066388 Mustela putorius furo 90.68 0.00e+00 842.00
IUUC-Ont-072316 Oreochromis niloticus 78.57 0.00e+00 697.00
IUUC-Ola-086721 Oryzias latipes 74.51 0.00e+00 659.00
IUUC-Oga-088875 Otolemur garnettii 90.91 0.00e+00 863.00
IUUC-Oar-090444 Ovis aries 89.03 0.00e+00 835.00
IUUC-Ptr-091117 Pan troglodytes 99.04 0.00e+00 1019.00
IUUC-Pan-091807 Papio anubis 93.60 0.00e+00 892.00
IUUC-Pfo-097356 Poecilia formosa 77.46 0.00e+00 671.00
IUUC-Pab-097953 Pongo abelii 98.20 0.00e+00 860.00
IUUC-Pca-100896 Procavia capensis 88.89 0.00e+00 828.00
IUUC-Rno-105038 Rattus norvegicus 88.68 0.00e+00 825.00
IUUC-Tgu-116750 Taeniopygia guttata 84.82 0.00e+00 794.00
IUUC-Tru-118405 Takifugu rubripes 76.33 0.00e+00 696.00
IUUC-Tni-120217 Tetraodon nigroviridis 76.50 0.00e+00 701.00
IUUC-Ttr-129222 Tursiops truncatus 93.32 0.00e+00 841.00
IUUC-Xtr-132084 Xenopus tropicalis 80.72 0.00e+00 698.00
Created Date 25-Jun-2017

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