iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	87.05	0.00e+00	1347.00	IUUC-Hsa-046682

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

Protein Sequence
(Fasta)

MEEEVQQHSH CVNCVSRRCM TRPEPGVSCD LIGCPLVCGA VFHSCKADEH RLLCPFERVP 60
CLNSNFGCPF TLARNKVAEH LEMCPASVVC CTMEWNRWPV SYSDRKSYES LSRDADEVSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGGCCCA GGGGGCGGCG GGGCCGGTGG AGTCGGCGCA GCTCGGAGGC TCTCGTCCAG 60
CTCGCCCGGG CCTCGAATCG CGCCCGGCTG CCTGTGTGGC CCGCCCTTGA GGCTCCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR031890--Fbxo30/Fbxo40
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR001293--Znf_TRAF

PROSITE

PS50181--FBOX
PS50145--ZF_TRAF

Pfam

PF15966--F-box_4
PF15965--zf-TRAF_2

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding

KEGG

rno:308283

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001191	Ailuropoda melanoleuca	85.43	0.00e+00	1323.00
IUUC-Apl-003279	Anas platyrhynchos	72.20	0.00e+00	1110.00
IUUC-Aca-004293	Anolis carolinensis	70.09	0.00e+00	1056.00
IUUC-Ani-009450	Aspergillus nidulans	40.38	6.00e-03	35.00
IUUC-Ame-011141	Astyanax mexicanus	58.98	0.00e+00	825.00
IUUC-Bta-013004	Bos taurus	85.29	0.00e+00	1304.00
IUUC-Cel-018506	Caenorhabditis elegans	30.60	4.00e-11	62.80
IUUC-Cja-019129	Callithrix jacchus	86.23	0.00e+00	1339.00
IUUC-Cfa-020617	Canis familiaris	85.43	0.00e+00	1308.00
IUUC-Cpo-021712	Cavia porcellus	85.29	0.00e+00	1304.00
IUUC-Csa-023463	Chlorocebus sabaeus	86.90	0.00e+00	1344.00
IUUC-Cho-024287	Choloepus hoffmanni	80.08	0.00e+00	1217.00
IUUC-Dre-028739	Danio rerio	80.58	9.00e-166	577.00
IUUC-Dno-029454	Dasypus novemcinctus	82.89	0.00e+00	1252.00
IUUC-Dor-031145	Dipodomys ordii	87.03	0.00e+00	1347.00
IUUC-Ete-033085	Echinops telfairi	81.94	0.00e+00	1138.00
IUUC-Eca-034171	Equus caballus	85.96	0.00e+00	1335.00
IUUC-Eeu-034630	Erinaceus europaeus	81.02	0.00e+00	1235.00
IUUC-Fca-035665	Felis catus	85.77	0.00e+00	1304.00
IUUC-Fal-036615	Ficedula albicollis	69.44	0.00e+00	1068.00
IUUC-Gmo-039277	Gadus morhua	58.87	0.00e+00	847.00
IUUC-Gga-040427	Gallus gallus	71.41	0.00e+00	1090.00
IUUC-Gac-041803	Gasterosteus aculeatus	57.85	0.00e+00	838.00
IUUC-Ggo-044649	Gorilla gorilla	86.92	0.00e+00	1346.00
IUUC-Hsa-046682	Homo sapiens	87.05	0.00e+00	1347.00
IUUC-Itr-048787	Ictidomys tridecemlineatus	87.17	0.00e+00	1346.00
IUUC-Lch-049910	Latimeria chalumnae	66.23	0.00e+00	975.00
IUUC-Loc-052516	Lepisosteus oculatus	63.38	0.00e+00	936.00
IUUC-Laf-054464	Loxodonta africana	84.09	0.00e+00	1243.00
IUUC-Mcc-054771	Macaca mulatta	86.90	0.00e+00	1346.00
IUUC-Meu-056672	Macropus eugenii	92.39	6.00e-156	544.00
IUUC-Mga-059844	Meleagris gallopavo	71.37	0.00e+00	1082.00
IUUC-Mmr-060619	Microcebus murinus	86.23	0.00e+00	1343.00
IUUC-Mdo-062500	Monodelphis domestica	76.90	0.00e+00	1136.00
IUUC-Mmu-064149	Mus musculus	93.57	0.00e+00	1453.00
IUUC-Mpu-066049	Mustela putorius furo	85.70	0.00e+00	1306.00
IUUC-Mlu-067541	Myotis lucifugus	86.10	0.00e+00	1311.00
IUUC-Nle-069653	Nomascus leucogenys	86.78	0.00e+00	1345.00
IUUC-Opr-070824	Ochotona princeps	79.01	0.00e+00	1203.00
IUUC-Ont-072617	Oreochromis niloticus	60.46	0.00e+00	848.00
IUUC-Oan-073691	Ornithorhynchus anatinus	74.87	0.00e+00	1097.00
IUUC-Ocu-074793	Oryctolagus cuniculus	84.85	0.00e+00	1273.00
IUUC-Ola-087112	Oryzias latipes	61.97	1.00e-124	440.00
IUUC-Oga-088620	Otolemur garnettii	85.79	0.00e+00	1330.00
IUUC-Oar-090411	Ovis aries	85.70	0.00e+00	1283.00
IUUC-Ptr-091121	Pan troglodytes	86.92	0.00e+00	1345.00
IUUC-Pan-092257	Papio anubis	86.90	0.00e+00	1346.00
IUUC-Psi-094017	Pelodiscus sinensis	71.14	0.00e+00	955.00
IUUC-Pma-094673	Petromyzon marinus	50.00	2.00e-82	300.00
IUUC-Pfo-096058	Poecilia formosa	59.04	0.00e+00	827.00
IUUC-Pab-098470	Pongo abelii	82.11	0.00e+00	1245.00
IUUC-Pca-100432	Procavia capensis	83.29	0.00e+00	1255.00
IUUC-Pva-103197	Pteropus vampyrus	86.50	0.00e+00	1341.00
IUUC-Sha-106714	Sarcophilus harrisii	77.97	0.00e+00	1145.00
IUUC-Smo-109422	Selaginella moellendorffii	28.95	6.60e-02	32.70
IUUC-Sar-113544	Sorex araneus	83.69	0.00e+00	1280.00
IUUC-Ssc-115836	Sus scrofa	85.14	0.00e+00	1297.00
IUUC-Tgu-116548	Taeniopygia guttata	71.70	0.00e+00	1083.00
IUUC-Tru-118572	Takifugu rubripes	59.20	0.00e+00	839.00
IUUC-Tsy-119478	Tarsius syrichta	86.08	0.00e+00	1314.00
IUUC-Tni-120227	Tetraodon nigroviridis	58.86	5.00e-109	388.00
IUUC-Tbe-127566	Tupaia belangeri	83.59	0.00e+00	1004.00
IUUC-Vpa-130509	Vicugna pacos	85.03	0.00e+00	1301.00
IUUC-Xtr-132254	Xenopus tropicalis	63.14	0.00e+00	958.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence