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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045901
UUCD1 version UUC-HoS-00416
Ensembl Protein ID ENSP00000273480.3
UniProt Accession Q9UBF6; A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; Q9BXN8; Q9Y5M7; RBX2_HUMAN
Genbank Protein ID AAD55984.1; AAD30147.1; AAD25962.1; AAK37450.1; AAP36012.1; BAF82583.1; EAW78991.1; EAW78992.1; EAW78994.1; EAW78995.1; EAW78996.1; AAH05966.1; AAH08627.1
Protein Name RING-box protein 2; CKII beta-binding protein 1; RING finger protein 7; Regulator of cullins 2; Sensitive to apoptosis gene protein
Genbank Nucleotide ID AF164679; AF142060; AF092878; AF312226; BT007348; AK289894; DB272382; CH471052; CH471052; CH471052; CH471052; BC005966; BC008627
Gene Name RNF7; RBX2; ROC2; SAG
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114125.13 ENST00000273480.3 ENSP00000273480.3
ENSG00000114125.13 ENST00000480908.1 ENSP00000419084.1
ENSG00000114125.13 ENST00000393000.3 ENSP00000376725.3
ENSG00000114125.13 ENST00000477012.5 ENSP00000419339.1
ENSG00000114125.13 ENST00000477393.1 ENSP00000419979.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18258608; 20103673; 18258608; 19325126
Classification
Family E-value Score Start End
E3 activity/RING/RING 9.90e-05 24.5 50 103
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..............kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+                 ++ ++ + C+H fh  C   w       +++ rCPlC+
   Q: 50   CAICRVQVmdaclrcqaenkqeDCVVVWGECNHSFHNCCMSLW------VKQNNRCPLCQ 103
           999966554444555555554333466688*************......**********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
 Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (PubMed:10851089). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
Protein Sequence
(Fasta)
MADVEDGEET CALASHSGSS GSKSGGDKMF SLKKWNAVAM WSWDVECDTC AICRVQVMDA 60
CLRCQAENKQ EDCVVVWGEC NHSFHNCCMS LWVKQNNRCP LCQQDWVVQR IGK 113
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Protein Fasta Sequence


>IUUC-Hsa-045901|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGCAGCCGG GGTCTAGGCA CCACGGTGGC TGGCGGCCTG CGGGCGGCGC TGTGGCCCGT 60
CGGGCGGCTC CACAGAGCCG CCCTAGCCTT CCGCCTTCCC CAAGCCAACG TCTCCGCCGT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045901|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR024766--Znf_RING_H2
PROSITE

PS50089--ZF_RING_2
Pfam

PF12678--zf-rbx1
Gene Ontology

GO:0031466--C:Cul5-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005507--F:copper ion binding
GO:0097602--F:cullin family protein binding
GO:0019788--F:NEDD8 transferase activity
GO:0008270--F:zinc ion binding
GO:0045116--P:protein neddylation
GO:0016567--P:protein ubiquitination
GO:0051775--P:response to redox state
KEGG hsa:9616
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001959 Ailuropoda melanoleuca 97.25 7.00e-50 188.00
IUUC-Apl-003554 Anas platyrhynchos 96.49 1.00e-28 117.00
IUUC-Aca-004651 Anolis carolinensis 84.48 2.00e-48 184.00
IUUC-Ame-010935 Astyanax mexicanus 100.00 7.00e-47 178.00
IUUC-Bta-013315 Bos taurus 97.35 5.00e-52 195.00
IUUC-Cel-018286 Caenorhabditis elegans 68.97 9.00e-34 134.00
IUUC-Cja-019230 Callithrix jacchus 98.23 8.00e-51 191.00
IUUC-Cfa-020188 Canis familiaris 96.46 1.00e-51 194.00
IUUC-Cpo-021681 Cavia porcellus 96.46 5.00e-52 195.00
IUUC-Csa-023305 Chlorocebus sabaeus 100.00 3.00e-53 199.00
IUUC-Cho-024539 Choloepus hoffmanni 94.69 7.00e-50 188.00
IUUC-Cin-025216 Ciona intestinalis 82.56 3.00e-40 155.00
IUUC-Csv-026356 Ciona savignyi 85.53 2.00e-36 143.00
IUUC-Dre-027952 Danio rerio 92.04 2.00e-48 183.00
IUUC-Dno-029920 Dasypus novemcinctus 95.58 4.00e-50 189.00
IUUC-Dme-031722 Drosophila melanogaster 81.52 1.00e-40 157.00
IUUC-Ete-033111 Echinops telfairi 74.34 1.00e-36 144.00
IUUC-Eca-034329 Equus caballus 96.51 1.00e-44 170.00
IUUC-Fal-037052 Ficedula albicollis 97.75 1.00e-47 180.00
IUUC-Gmo-038573 Gadus morhua 90.18 4.00e-48 182.00
IUUC-Gga-040409 Gallus gallus 85.96 2.00e-50 190.00
IUUC-Gac-041808 Gasterosteus aculeatus 89.29 4.00e-48 182.00
IUUC-Ggo-045314 Gorilla gorilla 100.00 3.00e-53 199.00
IUUC-Itr-048540 Ictidomys tridecemlineatus 95.58 2.00e-51 193.00
IUUC-Lch-049958 Latimeria chalumnae 91.15 4.00e-49 186.00
IUUC-Loc-052481 Lepisosteus oculatus 90.27 1.00e-48 184.00
IUUC-Laf-054260 Loxodonta africana 94.69 2.00e-49 187.00
IUUC-Mcc-055092 Macaca mulatta 85.84 2.00e-41 159.00
IUUC-Meu-056081 Macropus eugenii 91.89 3.00e-28 116.00
IUUC-Mga-059532 Meleagris gallopavo 91.80 1.00e-28 117.00
IUUC-Mmr-061775 Microcebus murinus 84.07 7.00e-39 151.00
IUUC-Mdo-062083 Monodelphis domestica 94.69 4.00e-50 189.00
IUUC-Mmu-063421 Mus musculus 96.46 2.00e-51 194.00
IUUC-Mpu-066010 Mustela putorius furo 97.35 5.00e-52 195.00
IUUC-Mlu-067975 Myotis lucifugus 96.49 1.00e-28 117.00
IUUC-Nle-069723 Nomascus leucogenys 100.00 3.00e-53 199.00
IUUC-Opr-070339 Ochotona princeps 96.46 6.00e-54 201.00
IUUC-Ont-072072 Oreochromis niloticus 90.18 2.00e-49 186.00
IUUC-Oan-073574 Ornithorhynchus anatinus 85.09 4.00e-47 179.00
IUUC-Ola-087260 Oryzias latipes 87.50 5.00e-49 185.00
IUUC-Oga-089038 Otolemur garnettii 96.46 8.00e-51 191.00
IUUC-Oar-089945 Ovis aries 97.35 5.00e-52 195.00
IUUC-Ptr-091040 Pan troglodytes 100.00 3.00e-53 199.00
IUUC-Pan-092693 Papio anubis 100.00 3.00e-53 199.00
IUUC-Psi-093633 Pelodiscus sinensis 100.00 3.00e-47 179.00
IUUC-Pfo-096440 Poecilia formosa 91.07 5.00e-48 182.00
IUUC-Pab-098277 Pongo abelii 100.00 3.00e-53 199.00
IUUC-Pva-102548 Pteropus vampyrus 96.46 1.00e-51 194.00
IUUC-Rno-105855 Rattus norvegicus 96.46 2.00e-51 194.00
IUUC-Sha-107430 Sarcophilus harrisii 94.69 4.00e-50 189.00
IUUC-Sar-112957 Sorex araneus 85.84 3.00e-47 179.00
IUUC-Ssc-115606 Sus scrofa 86.15 2.00e-18 83.60
IUUC-Tgu-116519 Taeniopygia guttata 90.32 4.00e-29 119.00
IUUC-Tru-117658 Takifugu rubripes 85.09 3.00e-48 182.00
IUUC-Tsy-119251 Tarsius syrichta 97.35 8.00e-51 191.00
IUUC-Tni-120364 Tetraodon nigroviridis 87.61 3.00e-48 183.00
IUUC-Tbe-127256 Tupaia belangeri 84.07 1.00e-38 150.00
IUUC-Ttr-129140 Tursiops truncatus 97.35 5.00e-52 195.00
IUUC-Vpa-130670 Vicugna pacos 96.55 4.00e-44 168.00
IUUC-Xtr-132382 Xenopus tropicalis 100.00 3.00e-46 176.00
Created Date 25-Jun-2017

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