iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063779

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2 D1; (E3-independent) E2 ubiquitin-conjugating enzyme D1; E2 ubiquitin-conjugating enzyme D1; Ubiquitin carrier protein D1; Ubiquitin-conjugating enzyme E2(17)KB 1; Ubiquitin-conjugating enzyme E2-17 kDa 1; Ubiquitin-protein ligase D1

Genbank Nucleotide ID

BC019464

Gene Name

Ube2d1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000019927.6	ENSMUST00000020085.6	ENSMUSP00000020085.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.70e-56	190.3	5	139
UBD/UBC-like/UBD_UBC	5.90e-84	280.2	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+ Y+ggvF l+++fp+dYPfkPPk+ f+tki+hPn+++nG++Cl+il+  
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGD-DLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILR-- 90
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wspal+v++vllsi+sll++pnp++pl  ++a+++k+++e+y++++r
   Q: 91   SQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAR 139
           *********************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqw 89
           ri+kel+dl+rd++a++sa++v+ddlf+++ati+gppds+y+ggvfflt+++ptdypfkppk+af+tkiyhpninsngsicldilrsqw
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQW 93
           8**************************************************************************************** PP
   S: 90   saaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           s+alt+skvlls+csll+d++pddplv++ia+iyk+dkeky+r+arewt
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWT 142
           ************************************************8 PP

Organism

Mus musculus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Protein Sequence
(Fasta)

MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY 60
PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAAGCGAA GGCGGAAACA AAAGAGTCCG GCGCCGCCGC CCGCACACTC GCGCACCGCG 60
CCCGGGCGCA CACGGAGCAG CCCTGCGAGG CGGCAGCCCG GGACACGCGG ACACTCCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0031398--P:positive regulation of protein ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:216080

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001563	Ailuropoda melanoleuca	100.00	1.00e-85	308.00
IUUC-Apl-003639	Anas platyrhynchos	99.29	4.00e-81	292.00
IUUC-Aca-005254	Anolis carolinensis	100.00	1.00e-85	308.00
IUUC-Ame-011566	Astyanax mexicanus	94.56	6.00e-81	292.00
IUUC-Bta-013467	Bos taurus	100.00	1.00e-85	308.00
IUUC-Cja-019302	Callithrix jacchus	100.00	1.00e-85	308.00
IUUC-Cfa-021087	Canis familiaris	100.00	1.00e-85	308.00
IUUC-Csa-023668	Chlorocebus sabaeus	100.00	1.00e-85	308.00
IUUC-Cho-024987	Choloepus hoffmanni	100.00	1.00e-85	308.00
IUUC-Cme-027220	Cyanidioschyzon merolae	81.63	2.00e-71	261.00
IUUC-Dre-028568	Danio rerio	94.56	6.00e-81	292.00
IUUC-Dno-030067	Dasypus novemcinctus	100.00	1.00e-85	308.00
IUUC-Dor-030474	Dipodomys ordii	100.00	1.00e-85	308.00
IUUC-Ete-032540	Echinops telfairi	100.00	1.00e-85	308.00
IUUC-Eca-034167	Equus caballus	100.00	1.00e-85	308.00
IUUC-Gmo-038775	Gadus morhua	91.84	1.00e-78	284.00
IUUC-Gga-040873	Gallus gallus	100.00	1.00e-85	308.00
IUUC-Hsa-045951	Homo sapiens	100.00	1.00e-85	308.00
IUUC-Itr-048743	Ictidomys tridecemlineatus	100.00	1.00e-85	308.00
IUUC-Loc-051773	Lepisosteus oculatus	94.56	9.00e-81	291.00
IUUC-Laf-053673	Loxodonta africana	99.29	3.00e-81	293.00
IUUC-Mcc-055719	Macaca mulatta	100.00	1.00e-85	308.00
IUUC-Mga-060138	Meleagris gallopavo	99.29	4.00e-81	292.00
IUUC-Mmr-061212	Microcebus murinus	100.00	1.00e-85	308.00
IUUC-Mdo-062402	Monodelphis domestica	100.00	1.00e-81	294.00
IUUC-Mpu-065724	Mustela putorius furo	100.00	1.00e-85	308.00
IUUC-Mlu-067573	Myotis lucifugus	99.29	4.00e-81	292.00
IUUC-Nle-069950	Nomascus leucogenys	100.00	1.00e-85	308.00
IUUC-Oan-073149	Ornithorhynchus anatinus	95.92	4.00e-82	296.00
IUUC-Oga-088915	Otolemur garnettii	100.00	1.00e-85	308.00
IUUC-Oar-090418	Ovis aries	97.95	3.00e-83	300.00
IUUC-Ptr-091575	Pan troglodytes	100.00	1.00e-85	308.00
IUUC-Pan-092922	Papio anubis	100.00	1.00e-85	308.00
IUUC-Pab-098137	Pongo abelii	100.00	1.00e-85	308.00
IUUC-Pca-100678	Procavia capensis	100.00	1.00e-85	308.00
IUUC-Pva-102770	Pteropus vampyrus	100.00	1.00e-85	308.00
IUUC-Rno-106124	Rattus norvegicus	100.00	1.00e-85	308.00
IUUC-Sha-106489	Sarcophilus harrisii	95.86	8.00e-82	295.00
IUUC-Sar-113557	Sorex araneus	100.00	7.00e-81	291.00
IUUC-Tgu-117399	Taeniopygia guttata	100.00	6.00e-84	302.00
IUUC-Ttr-128363	Tursiops truncatus	100.00	1.00e-85	308.00
IUUC-Vpa-130352	Vicugna pacos	92.81	1.00e-67	248.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence