iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066342

Ensembl Protein ID

ENSMPUP00000018006.1

UniProt Accession

M3Z344; M3Z344_MUSPF

Genbank Protein ID

ENSMPUP00000018006

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01082127

Gene Name

Usp18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000018118.1	ENSMPUT00000018269.1	ENSMPUP00000018006.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-61	206.9	56	370

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+L++   +++ l++    ++++   +e+  ++  +l  l+e++++s++kav+p el  +l+k+++    + q
   Q: 56   VGLHNIGQTCCLNSLIQVLIMNVGFTKILKR---ITVPRGT-EEQRRSVPFQLLLLLEKMQDSRQKAVQPMELAYCLQKYNVP--MFVQ 138
           6******************************...4444432.466789*********************************98..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          ++    + ++ l+ +++k++++clec  + sr++++l+l+lp+ +
   Q: 139  HDAAQLYLTVWNLIKDQI--------------------------TDVDLVERLQALYTIRVKESLVCLECTVERSRNSSMLTLPLPLFD 201
           ******************..........................66778899************************************9 PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f+++ el g+ k++cekc kk+  ++ lkl++lP++L++hL Rfs ++  ++ eki  +++fp++Ldls++++ 
   Q: 202  MDSKPLKTLEDALRCFFQPRELSGKSKCFCEKCGKKTCGKQVLKLTHLPQTLTIHLLRFSIRN--SQTEKICHSLYFPQTLDLSQVLVI 288
           99999******************************************************7655..7899***************85544 PP
   S: 268  peekqke....kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......staYvlfYkr 337
           +e   +      ++YeL+av+ H+G ++ GHY+ay++n  +gkW++f+Ds+V+ v++e+++ + g       +taY+l+Y++
   Q: 289  EEGLCNAeeqlGRQYELFAVIAHMGAADFGHYCAYIQNsVDGKWFCFNDSNVSWVSWEDIQCTYGnhnyrwrETAYLLVYMK 370
           3322222344599*************************45677*******************888***************98 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

NESGAGVSEE ICLCILAETQ HFSAEPIEKK EENNMKRKKE QLKERLSAWD SPHGLVGLHN 60
IGQTCCLNSL IQVLIMNVGF TKILKRITVP RGTEEQRRSV PFQLLLLLEK MQDSRQKAVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGAGTCAG GTGCTGGAGT GTCTGAGGAA ATTTGCCTGT GCATCCTGGC TGAGACTCAG 60
CATTTCTCAG CAGAACCCAT TGAGAAGAAG GAAGAGAACA ACATGAAGAG GAAGAAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	94.71	0.00e+00	682.00
IUUC-Apl-004006	Anas platyrhynchos	57.50	1.00e-108	385.00
IUUC-Aca-005088	Anolis carolinensis	53.31	2.00e-90	326.00
IUUC-Ame-010606	Astyanax mexicanus	32.49	2.00e-41	162.00
IUUC-Bta-013036	Bos taurus	81.56	2.00e-158	551.00
IUUC-Cja-019052	Callithrix jacchus	76.09	1.00e-144	505.00
IUUC-Cfa-020554	Canis familiaris	94.40	0.00e+00	671.00
IUUC-Cpo-022421	Cavia porcellus	73.66	8.00e-158	549.00
IUUC-Csa-023737	Chlorocebus sabaeus	79.21	7.00e-96	342.00
IUUC-Cho-024807	Choloepus hoffmanni	70.56	4.00e-71	261.00
IUUC-Dre-027408	Danio rerio	34.15	5.00e-48	184.00
IUUC-Dno-029813	Dasypus novemcinctus	66.22	3.00e-124	437.00
IUUC-Dor-030532	Dipodomys ordii	76.26	2.00e-161	561.00
IUUC-Ete-032254	Echinops telfairi	70.25	5.00e-152	530.00
IUUC-Eca-033482	Equus caballus	86.56	2.00e-167	581.00
IUUC-Eeu-034451	Erinaceus europaeus	77.36	9.00e-100	355.00
IUUC-Fca-036313	Felis catus	92.18	0.00e+00	679.00
IUUC-Fal-037216	Ficedula albicollis	53.50	3.00e-106	378.00
IUUC-Gmo-038649	Gadus morhua	33.33	5.00e-40	157.00
IUUC-Gga-041082	Gallus gallus	55.49	7.00e-96	343.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.85	9.00e-51	193.00
IUUC-Ggo-044957	Gorilla gorilla	81.99	2.00e-135	474.00
IUUC-Hsa-046381	Homo sapiens	79.08	7.00e-174	602.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	78.32	9.00e-171	592.00
IUUC-Loc-052688	Lepisosteus oculatus	32.61	1.00e-45	177.00
IUUC-Laf-054109	Loxodonta africana	79.13	3.00e-177	613.00
IUUC-Mcc-054814	Macaca mulatta	77.99	2.00e-174	604.00
IUUC-Meu-056253	Macropus eugenii	69.34	4.00e-111	394.00
IUUC-Mmr-061613	Microcebus murinus	80.83	2.00e-166	578.00
IUUC-Mdo-061890	Monodelphis domestica	65.88	2.00e-128	451.00
IUUC-Mmu-064329	Mus musculus	71.08	8.00e-150	523.00
IUUC-Mlu-067010	Myotis lucifugus	80.70	0.00e+00	636.00
IUUC-Nle-069148	Nomascus leucogenys	78.21	3.00e-168	583.00
IUUC-Opr-070988	Ochotona princeps	69.43	3.00e-64	238.00
IUUC-Ont-072039	Oreochromis niloticus	34.05	1.00e-48	186.00
IUUC-Oan-073740	Ornithorhynchus anatinus	58.78	2.00e-78	285.00
IUUC-Ocu-074498	Oryctolagus cuniculus	79.02	2.00e-156	544.00
IUUC-Ola-086753	Oryzias latipes	35.67	2.00e-51	196.00
IUUC-Oga-088497	Otolemur garnettii	79.66	7.00e-170	589.00
IUUC-Oar-089505	Ovis aries	80.00	2.00e-155	541.00
IUUC-Ptr-091656	Pan troglodytes	78.53	4.00e-173	600.00
IUUC-Pan-092498	Papio anubis	77.99	3.00e-173	600.00
IUUC-Psi-093409	Pelodiscus sinensis	53.09	1.00e-107	382.00
IUUC-Pfo-096507	Poecilia formosa	35.45	2.00e-50	192.00
IUUC-Pab-097828	Pongo abelii	81.06	8.00e-158	549.00
IUUC-Pca-100299	Procavia capensis	75.21	2.00e-102	365.00
IUUC-Pva-102972	Pteropus vampyrus	79.78	1.00e-170	592.00
IUUC-Rno-105738	Rattus norvegicus	69.73	8.00e-154	536.00
IUUC-Sha-107309	Sarcophilus harrisii	64.60	3.00e-120	424.00
IUUC-Sar-112983	Sorex araneus	68.98	3.00e-133	468.00
IUUC-Ssc-116049	Sus scrofa	84.06	2.00e-164	571.00
IUUC-Tgu-117115	Taeniopygia guttata	55.70	4.00e-103	367.00
IUUC-Tru-118022	Takifugu rubripes	32.71	8.00e-43	167.00
IUUC-Tsy-118986	Tarsius syrichta	64.97	5.00e-63	234.00
IUUC-Tni-120306	Tetraodon nigroviridis	32.91	4.00e-41	161.00
IUUC-Tbe-127768	Tupaia belangeri	59.78	4.00e-115	407.00
IUUC-Ttr-128686	Tursiops truncatus	76.06	4.00e-159	553.00
IUUC-Xtr-132032	Xenopus tropicalis	44.86	5.00e-73	267.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence