iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088497

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03128225

Gene Name

USP18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000014792.2	ENSOGAT00000014796.2	ENSOGAP00000013251.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.80e-58	196.9	56	357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +Gl+N+g tC +NS++Q+ ++ +++++ l++    ++++ + +e+  ++  +l  l+e++++s++kav p e+  +l+k+++    + q
   Q: 56   VGLHNIGQTCCLNSLIQVFIMNRDFTKILKR---ITVPRGD-EEQRRSVPFQLLLLLEKMQDSRQKAVRPLEFAYCLRKYKVP--MFVQ 138
           6******************************...5666554.578899********************************998..79** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da  +   + + +++++                          ++    + +  l+ +++k++++cl+c  +ssr+++ l+l+l++ g
   Q: 139  HDAAQLYLTIWNLIKDQI--------------------------TDVDLVERLRSLYTIETKESLVCLDCTMESSRNSSLLTLPLSLFG 201
           ******************..........................5677889999*********************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
            +++ +++l+d+L+ f++++el +  k++c++c kk++ ++ lkl++lP++L++hL+Rfs ++  ++ +k+  +++fp++Ld s+++++
   Q: 202  ADSKPLKTLEDALQYFFQPKELSSTSKCFCQNCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRN--SQTKKVCHSLYFPQSLDFSQVLQT 288
           ***********************************************************7655..7899***************98777 PP
   S: 268  ....peekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaY 331
               ++e++++  +YeL+av+ H+G +++GHY+ay++n  +gkW++f+Ds+V  v++e+++ + g+  Y
   Q: 289  kqdlSDEEEQSGGQYELFAVIAHMGRANCGHYCAYIRNsMDGKWFCFNDSNVCWVSWEDIQCTYGNGTY 357
           4444223333499*************************44666*****************987666666 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

TGNVFGFLRG IFQSTLAESQ QLPAEPAEEK EENTMKRDKE QLREHLSAWD YPHGLVGLHN 60
IGQTCCLNSL IQVFIMNRDF TKILKRITVP RGDEEQRRSV PFQLLLLLEK MQDSRQKAVR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGGCAACG TGTTTGGGTT TCTCAGGGGA ATCTTTCAGT CGACCCTGGC TGAGTCTCAG 60
CAGCTCCCGG CAGAACCTGC TGAGGAGAAG GAAGAGAACA CTATGAAGAG GGACAAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0019785--F:ISG15-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0035634--P:response to stilbenoid
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001615	Ailuropoda melanoleuca	79.66	1.00e-154	538.00
IUUC-Apl-004006	Anas platyrhynchos	55.99	8.00e-96	343.00
IUUC-Aca-005088	Anolis carolinensis	52.73	2.00e-81	296.00
IUUC-Ame-010606	Astyanax mexicanus	34.80	1.00e-36	146.00
IUUC-Bta-013036	Bos taurus	75.49	2.00e-134	471.00
IUUC-Cja-019052	Callithrix jacchus	78.52	5.00e-137	480.00
IUUC-Cfa-020554	Canis familiaris	81.54	4.00e-155	540.00
IUUC-Cpo-022421	Cavia porcellus	73.48	2.00e-143	502.00
IUUC-Csa-023737	Chlorocebus sabaeus	77.78	4.00e-84	303.00
IUUC-Cho-024807	Choloepus hoffmanni	66.84	6.00e-62	231.00
IUUC-Dre-027408	Danio rerio	33.98	9.00e-42	163.00
IUUC-Dno-029813	Dasypus novemcinctus	64.53	5.00e-112	397.00
IUUC-Dor-030532	Dipodomys ordii	73.46	8.00e-148	516.00
IUUC-Ete-032254	Echinops telfairi	69.08	2.00e-136	478.00
IUUC-Eca-033482	Equus caballus	82.35	6.00e-146	509.00
IUUC-Eeu-034451	Erinaceus europaeus	70.71	4.00e-78	283.00
IUUC-Fca-036313	Felis catus	77.93	2.00e-150	524.00
IUUC-Fal-037216	Ficedula albicollis	54.29	5.00e-97	347.00
IUUC-Gmo-038649	Gadus morhua	32.89	7.00e-39	154.00
IUUC-Gga-041082	Gallus gallus	53.97	4.00e-90	324.00
IUUC-Gac-042439	Gasterosteus aculeatus	35.79	2.00e-45	176.00
IUUC-Ggo-044957	Gorilla gorilla	81.99	3.00e-130	457.00
IUUC-Hsa-046381	Homo sapiens	79.39	3.00e-161	561.00
IUUC-Itr-047918	Ictidomys tridecemlineatus	75.98	3.00e-153	534.00
IUUC-Loc-052688	Lepisosteus oculatus	33.55	1.00e-44	173.00
IUUC-Laf-054109	Loxodonta africana	77.99	1.00e-158	551.00
IUUC-Mcc-054814	Macaca mulatta	78.27	6.00e-162	563.00
IUUC-Meu-056253	Macropus eugenii	66.55	5.00e-101	360.00
IUUC-Mmr-061613	Microcebus murinus	82.77	8.00e-159	552.00
IUUC-Mdo-061890	Monodelphis domestica	65.03	2.00e-116	411.00
IUUC-Mmu-064329	Mus musculus	70.67	7.00e-140	489.00
IUUC-Mpu-066342	Mustela putorius furo	79.66	2.00e-154	538.00
IUUC-Mlu-067010	Myotis lucifugus	74.64	9.00e-148	516.00
IUUC-Nle-069148	Nomascus leucogenys	78.21	4.00e-159	553.00
IUUC-Opr-070988	Ochotona princeps	78.00	2.00e-66	246.00
IUUC-Ont-072039	Oreochromis niloticus	34.33	3.00e-42	165.00
IUUC-Oan-073740	Ornithorhynchus anatinus	55.64	9.00e-67	246.00
IUUC-Ocu-074498	Oryctolagus cuniculus	76.82	6.00e-139	486.00
IUUC-Ola-086753	Oryzias latipes	34.29	8.00e-43	167.00
IUUC-Oar-089505	Ovis aries	75.16	1.00e-134	472.00
IUUC-Ptr-091656	Pan troglodytes	79.11	7.00e-161	559.00
IUUC-Pan-092498	Papio anubis	77.72	7.00e-163	566.00
IUUC-Psi-093409	Pelodiscus sinensis	52.08	4.00e-96	344.00
IUUC-Pfo-096507	Poecilia formosa	35.23	1.00e-42	166.00
IUUC-Pab-097828	Pongo abelii	80.91	3.00e-146	510.00
IUUC-Pca-100299	Procavia capensis	75.62	6.00e-93	333.00
IUUC-Pva-102972	Pteropus vampyrus	74.02	9.00e-147	513.00
IUUC-Rno-105738	Rattus norvegicus	68.44	1.00e-137	483.00
IUUC-Sha-107309	Sarcophilus harrisii	64.17	2.00e-113	401.00
IUUC-Sar-112983	Sorex araneus	65.72	9.00e-110	390.00
IUUC-Ssc-116049	Sus scrofa	76.47	2.00e-137	481.00
IUUC-Tgu-117115	Taeniopygia guttata	55.41	5.00e-96	343.00
IUUC-Tru-118022	Takifugu rubripes	34.09	3.00e-40	159.00
IUUC-Tsy-118986	Tarsius syrichta	62.86	2.00e-58	219.00
IUUC-Tni-120306	Tetraodon nigroviridis	34.21	2.00e-35	142.00
IUUC-Tbe-127768	Tupaia belangeri	68.69	5.00e-105	374.00
IUUC-Ttr-128686	Tursiops truncatus	74.68	2.00e-134	471.00
IUUC-Xtr-132032	Xenopus tropicalis	44.37	7.00e-65	240.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence