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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Mmu-063209
UUCD1 version UUC-MuM-00608
Ensembl Protein ID ENSMUSP00000119124.1
UniProt Accession Q9EPX5; Q3UVH7; Q8CDX0; Q9CY04; Q9QZN5; FXL12_MOUSE
Genbank Protein ID AAF09134.1; AAG37272.1; BAB27385.1; BAC26448.1; BAC27180.1; BAE23292.1; AAH05699.1; AAH54471.1
Protein Name F-box/LRR-repeat protein 12; F-box and leucine-rich repeat protein 12; F-box protein FBL12
Genbank Nucleotide ID AF176525; AF313405; AK011081; AK029429; AK030910; AK137282; BC005699; BC054471
Gene Name Fbxl12; Fbl12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000066892.14 ENSMUST00000155301.7 ENSMUSP00000118369.1
ENSMUSG00000066892.14 ENSMUST00000148631.7 ENSMUSP00000119124.1
ENSMUSG00000066892.14 ENSMUST00000151861.8 ENSMUSP00000121429.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 93.25 2.00e-176 615.00 IUUC-Hsa-046340
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description



     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity).
Protein Sequence
(Fasta)
MATLFDLPDL VLLEIFSYLP VRDRIRISRV CHRWKRLVDD RWLWRHVDLT LYTMRPKVMW 60
HLLRRYMASR LYSLRMGGYL FSGSQAPQLS PALMRALGQK CPNLKRLCLH VADLSMVPIT 120
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Protein Fasta Sequence



>IUUC-Mmu-063209|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTTCCGGGC TAGGATTTGC GATTCTGTTG CGCAGTGTGG ATGAGCTGGG ACTTGCTAAG 60
AATGGATTTA CAGCGGACGT TGGAACTGGT GTTGGAGATT CCTTCATCAT GGAAGAAACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063209|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG mmu:30843
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001419 Ailuropoda melanoleuca 92.33 4.00e-174 603.00
IUUC-Aca-004405 Anolis carolinensis 37.91 7.00e-48 184.00
IUUC-Aly-006243 Arabidopsis lyrata 28.32 1.00e-05 44.70
IUUC-Ame-011583 Astyanax mexicanus 41.15 6.00e-15 75.10
IUUC-Bta-013334 Bos taurus 89.88 1.00e-170 592.00
IUUC-Cja-019257 Callithrix jacchus 92.94 4.00e-177 613.00
IUUC-Cfa-020655 Canis familiaris 93.25 4.00e-176 610.00
IUUC-Cpo-021946 Cavia porcellus 83.74 2.00e-151 528.00
IUUC-Csa-024146 Chlorocebus sabaeus 93.25 8.00e-178 615.00
IUUC-Cho-024674 Choloepus hoffmanni 44.50 6.00e-38 150.00
IUUC-Cin-025189 Ciona intestinalis 25.00 2.00e-21 96.30
IUUC-Csv-025971 Ciona savignyi 25.68 5.00e-14 71.60
IUUC-Dno-028860 Dasypus novemcinctus 86.50 7.00e-167 579.00
IUUC-Eca-034376 Equus caballus 91.41 3.00e-174 603.00
IUUC-Eeu-035297 Erinaceus europaeus 61.47 7.00e-109 386.00
IUUC-Fca-036044 Felis catus 91.41 2.00e-172 598.00
IUUC-Fal-036630 Ficedula albicollis 32.84 8.00e-29 120.00
IUUC-Fox-037910 Fusarium oxysporum 43.90 4.00e-04 40.00
IUUC-Gmo-039360 Gadus morhua 33.14 2.00e-25 110.00
IUUC-Gga-040461 Gallus gallus 40.67 1.00e-22 100.00
IUUC-Gac-041737 Gasterosteus aculeatus 39.35 2.00e-24 106.00
IUUC-Ggo-044537 Gorilla gorilla 93.56 6.00e-178 616.00
IUUC-Hsa-046340 Homo sapiens 93.25 8.00e-178 615.00
IUUC-Itr-048279 Ictidomys tridecemlineatus 92.33 9.00e-176 608.00
IUUC-Lch-050320 Latimeria chalumnae 41.48 3.00e-60 225.00
IUUC-Laf-054250 Loxodonta africana 91.10 5.00e-174 603.00
IUUC-Mcc-055154 Macaca mulatta 93.56 6.00e-178 616.00
IUUC-Mmr-060928 Microcebus murinus 92.67 2.00e-146 511.00
IUUC-Mdo-062488 Monodelphis domestica 49.33 2.00e-55 208.00
IUUC-Mac-065258 Musa acuminata 31.07 1.00e-05 44.30
IUUC-Mpu-066145 Mustela putorius furo 92.64 4.00e-175 607.00
IUUC-Nle-069785 Nomascus leucogenys 93.25 8.00e-178 615.00
IUUC-Opr-070335 Ochotona princeps 86.81 7.00e-153 533.00
IUUC-Ont-071234 Oreochromis niloticus 39.91 1.00e-26 114.00
IUUC-Ocu-073801 Oryctolagus cuniculus 90.94 6.00e-158 549.00
IUUC-Oni-082319 Oryza nivara 36.47 3.00e-05 45.10
IUUC-Ola-087439 Oryzias latipes 41.88 3.00e-31 129.00
IUUC-Oga-088576 Otolemur garnettii 92.33 3.00e-176 610.00
IUUC-Oar-090342 Ovis aries 89.88 1.00e-170 592.00
IUUC-Ptr-090775 Pan troglodytes 93.25 8.00e-178 615.00
IUUC-Pan-092039 Papio anubis 93.56 6.00e-178 616.00
IUUC-Psi-093821 Pelodiscus sinensis 38.46 3.00e-44 172.00
IUUC-Pma-094751 Petromyzon marinus 33.44 2.00e-29 122.00
IUUC-Pfo-097122 Poecilia formosa 41.88 2.00e-27 116.00
IUUC-Pab-098147 Pongo abelii 92.94 5.00e-177 613.00
IUUC-Pca-101020 Procavia capensis 90.49 2.00e-172 597.00
IUUC-Pva-102723 Pteropus vampyrus 90.80 1.00e-172 598.00
IUUC-Rno-104905 Rattus norvegicus 97.80 4.00e-155 540.00
IUUC-Sha-107634 Sarcophilus harrisii 47.26 6.00e-57 213.00
IUUC-Ssc-115703 Sus scrofa 93.25 9.00e-177 612.00
IUUC-Tsy-118925 Tarsius syrichta 88.28 1.00e-141 495.00
IUUC-Tni-119768 Tetraodon nigroviridis 38.79 5.00e-29 121.00
IUUC-Tbe-127446 Tupaia belangeri 88.57 7.00e-121 426.00
IUUC-Xtr-132349 Xenopus tropicalis 36.36 5.00e-47 181.00
Created Date 25-Jun-2017

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