iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-81	275.7	445	949

Active Site

Position(s)	Description	Evidence
454	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
857	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl NlgNtCYmNSvLQ+L++ +e+r+++l+ + + +n         +l+k+lq+lf+ l +++++a++pr +++a +   + f+  +q
   Q: 445  TGLINLGNTCYMNSVLQALFMATEFRRQVLSLNLNGCN---------SLMKKLQHLFAFLAHTQREAYAPRIFFEASR--PPWFTPRSQ 522
           7******************************5555554.........7***************************998..777****** PP
   S: 90   qDaqEflaflldqleeelkk...eknkpkeeeeeedkselsde........aeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           qD++E+l+flld+l+ee k    +++++ +e  + +++ l++         ++  +  ++k+li+++F+g+l+++i cl+c+++s + e
   Q: 523  QDCSEYLRFLLDRLHEEEKIlrvQSSHKPSEGLDCAETCLQEVtskvavptESPGTGDSEKTLIEKMFGGKLRTHICCLNCGSTSHKVE 611
           ******************5577666666666666666666666899999988888999999**************************** PP
   S: 168  pfldlslpvpgkeetkke....................................................................... 185
            f+dlsl++  + + + +                                                                       
   Q: 612  AFTDLSLAFCPSPSVEDLsfqdtaslpsaqddglmqtsvadpeeepvvynpataafvcdsvvnqrvlgsppvefhcaesssvpeesaki 700
           *********98876544489999****************************************************************** PP
   S: 186  ................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
                           s++d+L+ f ++e l+gen+yyce+c ++q+aek++++++ Pe+Lil L Rfs++++ ++r+ki ++v++pl 
   Q: 701  liskdvpqnpggesttSVTDLLNYFLAPEVLTGENQYYCESCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLV 789
           ***************************************************************************************** PP
   S: 259  Ldlspfcts.....peekqke...............................kkkYeLiavvvHsG.slssGHYvayvkn......... 301
           L+l    t      +     +                                + Y L++vvvHsG s++sGHY++y++n         
   Q: 790  LELPVKRTAsfsslS-----QswsvdvdftdinenlpkklkpsgteeafcpkLVPYLLSSVVVHSGvSSESGHYYSYARNitgtessyq 873
           999965555344440.....244555555555555556666666666777779************************************ PP
   S: 302  ...................................ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                                               +++W+lf+Ds+Vt ++ ++v++ t+    +taYvl+Yk++
   Q: 874  mcpqseslalapsqscllgvespntvieqdlenkeMSQEWFLFNDSRVTFTSFQSVQKITSrfpkDTAYVLLYKKQ 949
           ************999999999999999988865433444*******************999************986 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.

Protein Sequence
(Fasta)

MDKILEGLVS SSHPLPLKRM IVRKVVEFAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 60
GHQVLEAYAR YHRPEFESFF NKTFVLGLLQ QGYHSVDRKD VAILDYIHNG LKLIMSCPSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTATTTCTG CTTCCGGGTT CAGGGTGTTC CGCGCCTCCG GCTCCTCTCC TTGGCAGATC 60
GAGGTACTCG CATTGACAGT GCCTCCTGAC TCAACCCAGG GCGACTTTTA ACTGCCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:74841

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002174	Ailuropoda melanoleuca	89.58	0.00e+00	1791.00
IUUC-Apl-003435	Anas platyrhynchos	74.44	0.00e+00	1224.00
IUUC-Aca-004556	Anolis carolinensis	69.80	0.00e+00	1252.00
IUUC-Ame-010616	Astyanax mexicanus	61.60	0.00e+00	1199.00
IUUC-Bta-013544	Bos taurus	89.06	0.00e+00	1764.00
IUUC-Cja-018745	Callithrix jacchus	88.43	0.00e+00	1785.00
IUUC-Cfa-020434	Canis familiaris	85.80	0.00e+00	1708.00
IUUC-Cpo-021666	Cavia porcellus	89.35	0.00e+00	1751.00
IUUC-Csa-023965	Chlorocebus sabaeus	90.50	0.00e+00	1862.00
IUUC-Cho-024809	Choloepus hoffmanni	79.95	0.00e+00	1208.00
IUUC-Cin-025604	Ciona intestinalis	38.70	2.00e-42	166.00
IUUC-Csv-026333	Ciona savignyi	45.14	1.00e-31	129.00
IUUC-Dre-028338	Danio rerio	62.18	0.00e+00	1206.00
IUUC-Dno-029372	Dasypus novemcinctus	88.48	0.00e+00	1780.00
IUUC-Dor-030752	Dipodomys ordii	86.87	0.00e+00	1209.00
IUUC-Ete-032588	Echinops telfairi	78.31	0.00e+00	1093.00
IUUC-Eca-034416	Equus caballus	90.02	0.00e+00	1833.00
IUUC-Eeu-035132	Erinaceus europaeus	71.71	0.00e+00	1334.00
IUUC-Fca-036137	Felis catus	90.02	0.00e+00	1809.00
IUUC-Fal-037297	Ficedula albicollis	74.02	0.00e+00	1417.00
IUUC-Gmo-038727	Gadus morhua	65.41	0.00e+00	1012.00
IUUC-Gga-041091	Gallus gallus	72.71	0.00e+00	1367.00
IUUC-Gac-042082	Gasterosteus aculeatus	61.67	0.00e+00	1118.00
IUUC-Ggo-045376	Gorilla gorilla	85.56	0.00e+00	1689.00
IUUC-Hsa-046444	Homo sapiens	90.12	0.00e+00	1825.00
IUUC-Itr-047976	Ictidomys tridecemlineatus	90.21	0.00e+00	1826.00
IUUC-Lch-050500	Latimeria chalumnae	70.82	0.00e+00	1393.00
IUUC-Loc-052625	Lepisosteus oculatus	64.09	0.00e+00	1254.00
IUUC-Laf-053689	Loxodonta africana	89.32	0.00e+00	1798.00
IUUC-Mcc-055286	Macaca mulatta	90.69	0.00e+00	1834.00
IUUC-Mga-059905	Meleagris gallopavo	72.92	0.00e+00	1199.00
IUUC-Mmr-061397	Microcebus murinus	90.60	0.00e+00	1820.00
IUUC-Mdo-062833	Monodelphis domestica	83.64	0.00e+00	1716.00
IUUC-Mpu-066434	Mustela putorius furo	90.31	0.00e+00	1824.00
IUUC-Mlu-068178	Myotis lucifugus	88.44	0.00e+00	1747.00
IUUC-Nle-070153	Nomascus leucogenys	89.64	0.00e+00	1781.00
IUUC-Ont-072330	Oreochromis niloticus	62.35	0.00e+00	1210.00
IUUC-Oan-072709	Ornithorhynchus anatinus	77.60	0.00e+00	1220.00
IUUC-Ocu-074832	Oryctolagus cuniculus	90.50	0.00e+00	1820.00
IUUC-Ola-087003	Oryzias latipes	56.70	1.00e-47	182.00
IUUC-Oga-088517	Otolemur garnettii	85.58	0.00e+00	1722.00
IUUC-Oar-089472	Ovis aries	85.70	0.00e+00	1687.00
IUUC-Ptr-090996	Pan troglodytes	89.92	0.00e+00	1821.00
IUUC-Pan-091837	Papio anubis	88.66	0.00e+00	1809.00
IUUC-Psi-093236	Pelodiscus sinensis	74.97	0.00e+00	1142.00
IUUC-Pma-094349	Petromyzon marinus	53.28	0.00e+00	954.00
IUUC-Pfo-097193	Poecilia formosa	61.29	0.00e+00	1144.00
IUUC-Pab-098710	Pongo abelii	89.92	0.00e+00	1841.00
IUUC-Pca-100794	Procavia capensis	79.29	0.00e+00	1565.00
IUUC-Pva-102722	Pteropus vampyrus	89.36	0.00e+00	1800.00
IUUC-Rno-105743	Rattus norvegicus	95.30	0.00e+00	1885.00
IUUC-Sha-106563	Sarcophilus harrisii	82.14	0.00e+00	1372.00
IUUC-Sar-113533	Sorex araneus	76.68	0.00e+00	1502.00
IUUC-Ssc-116259	Sus scrofa	80.86	0.00e+00	1529.00
IUUC-Tgu-117475	Taeniopygia guttata	73.71	0.00e+00	1287.00
IUUC-Tru-118623	Takifugu rubripes	62.20	0.00e+00	1136.00
IUUC-Tsy-119250	Tarsius syrichta	87.84	0.00e+00	1390.00
IUUC-Tni-120441	Tetraodon nigroviridis	58.29	0.00e+00	1053.00
IUUC-Tbe-127936	Tupaia belangeri	78.12	0.00e+00	1495.00
IUUC-Ttr-128483	Tursiops truncatus	76.40	0.00e+00	1334.00
IUUC-Vpa-130303	Vicugna pacos	96.25	0.00e+00	1061.00
IUUC-Xtr-132773	Xenopus tropicalis	71.66	0.00e+00	1379.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence