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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047032
UUCD1 version UUC-HoS-00993
Ensembl Protein ID ENSP00000264555.5
UniProt Accession Q9P1Y6; A6H8W1; B7ZM64; B9EGP0; C9JS82; Q6PJP2; Q8IVY2; Q8N2Y7; Q9BSM2; PHRF1_HUMAN
Genbank Protein ID BAA96066.1; AAH04950.1; AAH13381.1; AAH29651.1; AAH41631.1; AAI36616.1; AAI44294.1; AAI46772.1
Protein Name PHD and RING finger domain-containing protein 1
Genbank Nucleotide ID AB040975; AP006284; BC013381; BC029651; BC041631; BC136615; BC144293; BC146771
Gene Name PHRF1; KIAA1542
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000070047.11 ENST00000534320.5 ENSP00000435360.1
ENSG00000070047.11 ENST00000264555.9 ENSP00000264555.5
ENSG00000070047.11 ENST00000533464.5 ENSP00000431870.1
ENSG00000070047.11 ENST00000413872.6 ENSP00000388589.2
ENSG00000070047.11 ENST00000416188.2 ENSP00000410626.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 23911286
E3 activity/RING/PHD PHD 23911286
Classification
Family E-value Score Start End
E3 activity/RING/PHD 1.50e-09 39.5 184 231
E3 activity/RING/RING 4.00e-07 32.1 108 149
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C vCg++++++  l+ C+ C+  +H +Cl ++  +e+p +e w+Cp+C 
   Q: 184  TFCEVCGRSDRED-RLLLCDGCDAGYHMECLDPP-LQEVPVDE-WFCPECA 231
           69*********88.5*******************.*******8.******7 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlp..CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ f+d+ + +p  C H f++dC+  w      s+++ +CP++r
   Q: 108  CPICLNAFRDQAVGTPenCAHYFCLDCIVEW------SKNANSCPVDR 149
           ********9999989999*************......********987 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MDDDSLDELV ARSPGPDGHP QVGPADPAGD FEESSVGSSG DSGDDSDSEH GDGTDGEDEG 60
ASEEEDLEDR SGSEDSEDDG ETLLEVAGTQ GKLEAAGSFN SDDDAESCPI CLNAFRDQAV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047032|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCGCACGG CGGCGGCAGA GGCGGCGGCG GCCGGGCCTA GGAGCGACTC TCGGTCGTGC 60
AGCGGCGGCG AGCGCTCGCG AGCGGCTGCG GGACGCGAGG TTTCCGGGTA AGTGCGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047032|E3,RING;E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR015970--P40_nucleoprot_sub2_BD-vir
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00628--PHD
PF13639--zf-RING_2
SMART

SM00249--PHD
SM00184--RING
Gene Ontology

GO:0016020--C:membrane
GO:0070063--F:RNA polymerase binding
GO:0008270--F:zinc ion binding
GO:0006397--P:mRNA processing
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:57661
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-004929 Anolis carolinensis 57.55 0.00e+00 780.00
IUUC-Ani-009406 Aspergillus nidulans 32.77 1.00e-15 78.20
IUUC-Bgr-012184 Blumeria graminis 32.77 3.00e-21 97.10
IUUC-Cfa-021078 Canis familiaris 67.72 0.00e+00 1040.00
IUUC-Cpo-022518 Cavia porcellus 68.81 0.00e+00 992.00
IUUC-Cgl-026545 Colletotrichum gloeosporioides 35.11 5.00e-18 86.70
IUUC-Dre-028443 Danio rerio 44.97 3.00e-99 357.00
IUUC-Dno-029298 Dasypus novemcinctus 64.95 0.00e+00 833.00
IUUC-Dme-031664 Drosophila melanogaster 38.46 2.00e-38 156.00
IUUC-Eca-033870 Equus caballus 68.17 0.00e+00 976.00
IUUC-Fox-037887 Fusarium oxysporum 30.47 3.00e-16 80.50
IUUC-Ggr-039838 Gaeumannomyces graminis 34.65 7.00e-19 89.40
IUUC-Gac-042138 Gasterosteus aculeatus 50.10 2.00e-112 401.00
IUUC-Gma-043193 Glycine max 31.49 3.00e-14 73.90
IUUC-Hvu-047154 Hordeum vulgare 34.03 3.00e-14 74.30
IUUC-Itr-048665 Ictidomys tridecemlineatus 74.55 0.00e+00 1140.00
IUUC-Lch-049602 Latimeria chalumnae 62.75 5.00e-144 506.00
IUUC-Loc-052887 Lepisosteus oculatus 46.37 7.00e-136 479.00
IUUC-Mor-056964 Magnaporthe oryzae 35.71 3.00e-19 90.50
IUUC-Mga-059236 Meleagris gallopavo 54.97 0.00e+00 776.00
IUUC-Mdo-061937 Monodelphis domestica 61.20 0.00e+00 895.00
IUUC-Mpu-066615 Mustela putorius furo 70.88 0.00e+00 936.00
IUUC-Mlu-067670 Myotis lucifugus 68.32 0.00e+00 925.00
IUUC-Ocu-073818 Oryctolagus cuniculus 68.27 0.00e+00 927.00
IUUC-Ome-081535 Oryza meridionalis 30.07 7.00e-14 73.60
IUUC-Oar-090046 Ovis aries 60.43 0.00e+00 850.00
IUUC-Pma-094431 Petromyzon marinus 43.04 2.00e-82 300.00
IUUC-Pfo-096523 Poecilia formosa 54.24 5.00e-120 426.00
IUUC-Pva-102835 Pteropus vampyrus 64.58 0.00e+00 828.00
IUUC-Rno-106007 Rattus norvegicus 70.42 0.00e+00 1078.00
IUUC-Sja-107848 Schizosaccharomyces japonicus 38.19 1.00e-22 102.00
IUUC-Spo-108141 Schizosaccharomyces pombe 38.26 1.00e-19 91.70
IUUC-Ttr-129201 Tursiops truncatus 68.12 0.00e+00 926.00
Created Date 25-Jun-2017

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