iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
ArrayExpress
Protein-protein Interaction
IID	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	5.90e-06	27.9	11	77
E3 activity/RING/RING	2.30e-08	36.1	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 3    peeflCpIslelMrdPvvlpsGitydrssIekwlasggk...tcPvtrqplteedlvPnltlrrliqa 67
            ee +CpI l++ + Pv++ +G+ +  ++I + + +      +cP+++++++++ +  n  lr+l+++
   Q: 11   QEEVICPICLDILQKPVTIDCGHNFCLKCITQ-IGETSCgffKCPLCKTSVRKNAIRFNSLLRNLVEK 77
           5899**************************88.433333689**********************9987 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ +++ p++ +CgH f+++C+ ++      s+++f+CPlC+
   Q: 16   CPICLDILQK-PVTIDCGHNFCLKCITQI---GETSCGFFKCPLCK 57
           **********.999************888...555**********7 PP

Organism

Homo sapiens

Functional Description
(View)

Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.

Protein Sequence
(Fasta)

MASGQFVNKL QEEVICPICL DILQKPVTID CGHNFCLKCI TQIGETSCGF FKCPLCKTSV 60
RKNAIRFNSL LRNLVEKIQA LQASEVQSKR KEATCPRHQE MFHYFCEDDG KFLCFVCRES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTACACATT CAAAGTATCC ATTTGTTCTC AAGAGGTAGC AAGGTAGGAC TGCCCATCTG 60
TTTTCCTCTC TTTATAATAT TTTCTAGATC CTAAATTTTA CGCTTTTCTA TCATTTCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0046597--P:negative regulation of viral entry into host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0016567--P:protein ubiquitination
GO:1902186--P:regulation of viral release from host cell

KEGG

hsa:11074

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-023297	Chlorocebus sabaeus	88.28	6.00e-75	272.00
IUUC-Dno-029706	Dasypus novemcinctus	60.94	1.00e-113	403.00
IUUC-Ete-032890	Echinops telfairi	57.06	4.00e-49	188.00
IUUC-Ggo-045224	Gorilla gorilla	98.35	0.00e+00	736.00
IUUC-Laf-053632	Loxodonta africana	63.00	1.00e-100	360.00
IUUC-Mmu-063149	Mus musculus	53.87	2.00e-96	346.00
IUUC-Nle-069068	Nomascus leucogenys	94.13	0.00e+00	730.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence