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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064384
Ensembl Protein ID ENSMUSP00000031081.4
UniProt Accession Q8CBQ5; Q91Z30; Q9D072; Q9D471; P4K2B_MOUSE
Genbank Protein ID AAL04155.1; AAN37399.1; BAB27819.1; BAB30411.1; BAC29091.1; BAE41986.1; AAH10257.1; AAH62144.1
Protein Name Phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta
Genbank Nucleotide ID AF411321; AY148879; AK011751; AK016754; AK035523; AK170730; BC010257; BC062144
Gene Name Pi4k2b
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029186.12 ENSMUST00000031081.10 ENSMUSP00000031081.4
ENSMUSG00000029186.12 ENSMUST00000131526.1 ENSMUSP00000142802.1
ENSMUSG00000029186.12 ENSMUST00000031082.7 ENSMUSP00000031082.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UFD/MUB 28.47 4.00e-18 89.70 IUUC-Ath-007357
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).
 Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking (By similarity).
Protein Sequence
(Fasta)
MAEACEPTRP SEDEDEEREP LLPRVAWAQP RRVAPGSAVR MQADEGADVL REPATDEPPA 60
VSGEGSISAS LSTELDRTRT TSSETNTFLE DPEFADIVLK AEQAIEIGVF PERISQGSSG 120
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Protein Fasta Sequence


>IUUC-Mmu-064384|ULD,MUB|Mus musculus
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Nucleotide Sequence
(Fasta)
GTGGCCGGCG GCTGGGCGTG GCCGGCGCGG GCTGGTGGAC TGGTGAGGTG GCGTCGGTGG 60
GAGCAGTCCC CCGCGGTTTG GCGTGATGCT GGGGTCCCAG TCCGGAGCCC GGCGGCTCTG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064384|ULD,MUB|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR000403--PI3/4_kinase_cat_dom
Pfam

PF00454--PI3_PI4_kinase
Gene Ontology

GO:0005768--C:endosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0046854--P:phosphatidylinositol phosphorylation
KEGG mmu:67073
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000880 Aegilops tauschii 27.18 2.00e-15 77.40
IUUC-Aml-002168 Ailuropoda melanoleuca 77.64 0.00e+00 754.00
IUUC-Atr-002849 Amborella trichopoda 24.74 4.00e-14 73.20
IUUC-Apl-003641 Anas platyrhynchos 80.57 0.00e+00 671.00
IUUC-Aca-004310 Anolis carolinensis 72.37 0.00e+00 676.00
IUUC-Aly-005869 Arabidopsis lyrata 27.97 2.00e-17 84.30
IUUC-Ath-007357 Arabidopsis thaliana 29.02 4.00e-19 89.70
IUUC-Ago-007834 Ashbya gossypii 37.53 2.00e-60 226.00
IUUC-Acl-008056 Aspergillus clavatus 40.15 4.00e-48 186.00
IUUC-Afl-008443 Aspergillus flavus 39.25 3.00e-46 180.00
IUUC-Afu-008894 Aspergillus fumigatus 32.64 4.00e-52 199.00
IUUC-Ani-009242 Aspergillus nidulans 33.19 2.00e-64 240.00
IUUC-Ang-009698 Aspergillus niger 36.65 2.00e-72 267.00
IUUC-Aor-010129 Aspergillus oryzae 39.25 3.00e-46 180.00
IUUC-Ate-010366 Aspergillus terreus 39.53 8.00e-45 175.00
IUUC-Ame-011505 Astyanax mexicanus 60.50 3.00e-138 484.00
IUUC-Bgr-012207 Blumeria graminis 34.27 1.00e-64 241.00
IUUC-Bta-013130 Bos taurus 74.64 0.00e+00 721.00
IUUC-Bci-013857 Botrytis cinerea 43.75 9.00e-43 168.00
IUUC-Bdi-014227 Brachypodium distachyon 27.53 2.00e-15 77.80
IUUC-Bol-015769 Brassica oleracea 28.67 2.00e-19 90.50
IUUC-Bra-017779 Brassica rapa 28.92 2.00e-18 87.40
IUUC-Cel-018333 Caenorhabditis elegans 40.23 1.00e-63 236.00
IUUC-Cja-019512 Callithrix jacchus 78.17 0.00e+00 775.00
IUUC-Cfa-020046 Canis familiaris 86.98 0.00e+00 709.00
IUUC-Cpo-022524 Cavia porcellus 85.71 0.00e+00 676.00
IUUC-Cre-022842 Chlamydomonas reinhardtii 23.44 1.00e-04 40.00
IUUC-Csa-024215 Chlorocebus sabaeus 79.20 0.00e+00 748.00
IUUC-Cho-024651 Choloepus hoffmanni 74.26 3.00e-166 577.00
IUUC-Cin-025197 Ciona intestinalis 59.14 2.00e-146 512.00
IUUC-Csv-026330 Ciona savignyi 63.45 1.00e-148 519.00
IUUC-Cgl-026422 Colletotrichum gloeosporioides 34.89 3.00e-66 246.00
IUUC-Dre-028161 Danio rerio 76.24 0.00e+00 653.00
IUUC-Dno-029087 Dasypus novemcinctus 75.32 0.00e+00 731.00
IUUC-Dor-031108 Dipodomys ordii 72.31 0.00e+00 668.00
IUUC-Dse-031283 Dothistroma septosporum 33.33 6.00e-64 239.00
IUUC-Dme-032030 Drosophila melanogaster 66.37 1.00e-86 313.00
IUUC-Ete-032358 Echinops telfairi 70.83 8.00e-110 390.00
IUUC-Eca-034170 Equus caballus 84.54 0.00e+00 693.00
IUUC-Eeu-034549 Erinaceus europaeus 82.97 1.00e-91 330.00
IUUC-Fca-035541 Felis catus 78.41 0.00e+00 726.00
IUUC-Fal-037138 Ficedula albicollis 80.67 0.00e+00 669.00
IUUC-Fox-037982 Fusarium oxysporum 34.23 5.00e-62 232.00
IUUC-Fso-038407 Fusarium solani 44.44 6.00e-41 162.00
IUUC-Gmo-039406 Gadus morhua 66.58 2.00e-159 555.00
IUUC-Ggr-040017 Gaeumannomyces graminis 45.65 2.00e-39 157.00
IUUC-Gga-040594 Gallus gallus 79.79 0.00e+00 666.00
IUUC-Gac-041355 Gasterosteus aculeatus 76.47 0.00e+00 639.00
IUUC-Gma-043772 Glycine max 27.53 4.00e-16 80.10
IUUC-Ggo-044615 Gorilla gorilla 79.82 0.00e+00 743.00
IUUC-Hsa-046453 Homo sapiens 80.04 0.00e+00 748.00
IUUC-Hvu-047413 Hordeum vulgare 27.87 2.00e-15 77.80
IUUC-Itr-048839 Ictidomys tridecemlineatus 86.41 0.00e+00 724.00
IUUC-Kpa-049368 Komagataella pastoris 37.85 3.00e-69 256.00
IUUC-Lch-049861 Latimeria chalumnae 78.93 0.00e+00 659.00
IUUC-Lpe-051162 Leersia perrieri 26.30 4.00e-14 73.60
IUUC-Loc-052304 Lepisosteus oculatus 79.12 0.00e+00 659.00
IUUC-Lma-053303 Leptosphaeria maculans 34.41 1.00e-65 244.00
IUUC-Laf-053826 Loxodonta africana 79.33 0.00e+00 738.00
IUUC-Mcc-055372 Macaca mulatta 87.24 0.00e+00 719.00
IUUC-Meu-056312 Macropus eugenii 75.77 7.00e-174 603.00
IUUC-Mor-056958 Magnaporthe oryzae 45.95 1.00e-39 158.00
IUUC-Mpo-057554 Magnaporthe poae 44.86 1.00e-40 161.00
IUUC-Mtr-058162 Medicago truncatula 27.65 1.00e-16 82.00
IUUC-Mla-059000 Melampsora laricipopulina 38.40 3.00e-51 196.00
IUUC-Mga-059856 Meleagris gallopavo 79.64 0.00e+00 665.00
IUUC-Mvi-060280 Microbotryum violaceum 44.20 4.00e-34 140.00
IUUC-Mmr-061773 Microcebus murinus 86.15 0.00e+00 721.00
IUUC-Mdo-061817 Monodelphis domestica 84.54 0.00e+00 680.00
IUUC-Mac-064944 Musa acuminata 24.00 9.00e-13 68.60
IUUC-Mpu-066590 Mustela putorius furo 76.28 0.00e+00 744.00
IUUC-Mlu-067287 Myotis lucifugus 74.68 0.00e+00 699.00
IUUC-Nfi-068333 Neosartorya fischeri 40.53 4.00e-47 183.00
IUUC-Ncr-068800 Neurospora crassa 32.60 1.00e-61 231.00
IUUC-Nle-069534 Nomascus leucogenys 80.04 0.00e+00 749.00
IUUC-Opr-071136 Ochotona princeps 66.67 7.00e-171 593.00
IUUC-Ont-071667 Oreochromis niloticus 78.77 0.00e+00 660.00
IUUC-Oan-073489 Ornithorhynchus anatinus 83.16 0.00e+00 672.00
IUUC-Ocu-074482 Oryctolagus cuniculus 87.44 0.00e+00 729.00
IUUC-Oba-075382 Oryza barthii 26.64 3.00e-15 77.00
IUUC-Obr-076060 Oryza brachyantha 27.18 4.00e-17 83.60
IUUC-Ogl-077532 Oryza glaberrima 28.21 4.00e-16 80.10
IUUC-Ogu-078353 Oryza glumaepatula 26.64 2.00e-15 77.80
IUUC-Oin-079936 Oryza indica 26.64 2.00e-15 77.40
IUUC-Olo-080229 Oryza longistaminata 28.72 1.00e-17 84.70
IUUC-Ome-081235 Oryza meridionalis 27.15 8.00e-16 78.60
IUUC-Oni-082917 Oryza nivara 26.64 2.00e-15 77.40
IUUC-Opu-084094 Oryza punctata 28.06 2.00e-17 84.00
IUUC-Oru-084647 Oryza rufipogon 26.64 3.00e-15 77.00
IUUC-Osa-086157 Oryza sativa 26.64 2.00e-15 77.40
IUUC-Ola-086957 Oryzias latipes 78.44 0.00e+00 640.00
IUUC-Olu-087862 Ostreococcus lucimarinus 24.34 3.00e-10 58.50
IUUC-Oga-088698 Otolemur garnettii 78.35 0.00e+00 744.00
IUUC-Oar-090389 Ovis aries 74.85 0.00e+00 721.00
IUUC-Ptr-090638 Pan troglodytes 79.31 0.00e+00 759.00
IUUC-Pan-092030 Papio anubis 71.21 0.00e+00 647.00
IUUC-Psi-093599 Pelodiscus sinensis 79.18 0.00e+00 673.00
IUUC-Pma-094719 Petromyzon marinus 65.98 9.00e-136 476.00
IUUC-Pno-094843 Phaeosphaeria nodorum 31.13 2.00e-53 204.00
IUUC-Pfo-096221 Poecilia formosa 80.10 0.00e+00 664.00
IUUC-Pab-097653 Pongo abelii 80.04 0.00e+00 753.00
IUUC-Pop-099957 Populus trichocarpa 26.60 3.00e-16 80.50
IUUC-Pca-100747 Procavia capensis 73.14 1.00e-69 257.00
IUUC-Ppe-101716 Prunus persica 26.87 2.00e-15 77.40
IUUC-Pva-102926 Pteropus vampyrus 74.27 0.00e+00 732.00
IUUC-Pte-104342 Pyrenophora teres 44.91 6.00e-38 152.00
IUUC-Rno-105311 Rattus norvegicus 94.88 0.00e+00 900.00
IUUC-Sce-106456 Saccharomyces cerevisiae 34.40 9.00e-60 224.00
IUUC-Sha-106794 Sarcophilus harrisii 84.24 0.00e+00 692.00
IUUC-Sja-107883 Schizosaccharomyces japonicus 38.04 2.00e-60 226.00
IUUC-Spo-108111 Schizosaccharomyces pombe 35.46 3.00e-60 226.00
IUUC-Ssl-108516 Sclerotinia sclerotiorum 32.91 5.00e-62 232.00
IUUC-Smo-108951 Selaginella moellendorffii 29.11 6.00e-14 72.40
IUUC-Sit-110535 Setaria italica 28.57 6.00e-16 79.30
IUUC-Sly-111242 Solanum lycopersicum 26.28 1.00e-16 81.60
IUUC-Stu-111951 Solanum tuberosum 26.62 2.00e-16 80.90
IUUC-Sar-113055 Sorex araneus 82.90 0.00e+00 680.00
IUUC-Sbi-114147 Sorghum bicolor 28.11 7.00e-16 79.00
IUUC-Sre-114896 Sporisorium reilianum 44.74 1.00e-31 131.00
IUUC-Ssc-115853 Sus scrofa 68.91 6.00e-158 550.00
IUUC-Tgu-116711 Taeniopygia guttata 80.67 0.00e+00 672.00
IUUC-Tru-118416 Takifugu rubripes 69.23 0.00e+00 638.00
IUUC-Tsy-119014 Tarsius syrichta 84.86 0.00e+00 726.00
IUUC-Tni-120317 Tetraodon nigroviridis 64.79 0.00e+00 645.00
IUUC-Tca-121419 Theobroma cacao 26.86 1.00e-15 78.60
IUUC-Tre-122021 Trichoderma reesei 44.21 7.00e-40 159.00
IUUC-Tvi-122384 Trichoderma virens 42.63 4.00e-36 146.00
IUUC-Tae-122680 Triticum aestivum 27.53 7.00e-16 79.30
IUUC-Tur-126000 Triticum urartu 26.77 1.00e-13 71.60
IUUC-Tme-127049 Tuber melanosporum 38.56 8.00e-71 261.00
IUUC-Tbe-127365 Tupaia belangeri 76.67 9.00e-178 615.00
IUUC-Ttr-129032 Tursiops truncatus 77.09 0.00e+00 730.00
IUUC-Uma-129477 Ustilago maydis 44.08 3.00e-31 130.00
IUUC-Vda-129801 Verticillium dahliae 33.33 2.00e-65 243.00
IUUC-Vpa-130255 Vicugna pacos 80.67 0.00e+00 647.00
IUUC-Vvi-131314 Vitis vinifera 25.67 2.00e-17 84.30
IUUC-Xtr-132347 Xenopus tropicalis 73.14 0.00e+00 683.00
IUUC-Xma-133726 Xiphophorus maculatus 71.02 0.00e+00 660.00
IUUC-Yli-134389 Yarrowia lipolytica 38.77 2.00e-74 274.00
IUUC-Zma-134858 Zea mays 28.11 2.00e-14 74.30
Created Date 25-Jun-2017

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