iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bol-016263

Ensembl Protein ID

Bo6g074420.1

UniProt Accession

A0A0D3CUH4; A0A0D3CUH4_BRAOL

Protein Name

E3 ubiquitin-protein ligase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bo6g074420	Bo6g074420.1	Bo6g074420.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	33.57	5.00e-41	166.00	IUUC-Hsa-046357
E3 activity/RING/RING	36.36	6.00e-41	165.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Brassica oleracea

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MAPGGSALKE VLESTSTGMD YEVKMAKAEV NNNKPTKSGS AGVGKYGMHS NNGVYELLEC 60
PVCTNLMYPP IHQCPNGHTL CSNCKARVQN TCPTCRYELG NIRCLALEKV AESLEVPCRY 120

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Nucleotide Sequence
(Fasta)

ATGGCTCCTG GAGGCAGTGC TTTGAAAGAA GTCCTTGAAT CTACTTCCAC AGGAATGGAC 60
TACGAAGTTA AAATGGCGAA AGCCGAAGTT AATAATAACA AACCTACAAA GTCAGGGAGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001186	Ailuropoda melanoleuca	33.45	6.00e-43	167.00
IUUC-Apl-003813	Anas platyrhynchos	36.36	3.00e-42	165.00
IUUC-Aly-006207	Arabidopsis lyrata	95.79	0.00e+00	625.00
IUUC-Ath-007049	Arabidopsis thaliana	96.43	0.00e+00	630.00
IUUC-Bta-012887	Bos taurus	33.45	7.00e-43	167.00
IUUC-Bra-016847	Brassica rapa	83.77	1.00e-158	551.00
IUUC-Cja-019796	Callithrix jacchus	33.57	2.00e-42	166.00
IUUC-Csa-023974	Chlorocebus sabaeus	33.57	2.00e-42	166.00
IUUC-Cin-025674	Ciona intestinalis	34.15	2.00e-39	155.00
IUUC-Csv-026233	Ciona savignyi	34.14	2.00e-39	155.00
IUUC-Dno-029764	Dasypus novemcinctus	33.45	2.00e-42	166.00
IUUC-Eca-033536	Equus caballus	36.36	3.00e-42	165.00
IUUC-Fca-035362	Felis catus	33.45	6.00e-43	167.00
IUUC-Fal-037487	Ficedula albicollis	32.89	6.00e-43	167.00
IUUC-Gga-040269	Gallus gallus	36.36	3.00e-42	165.00
IUUC-Gac-042282	Gasterosteus aculeatus	33.81	1.00e-42	166.00
IUUC-Ggo-045444	Gorilla gorilla	33.57	2.00e-42	166.00
IUUC-Hsa-046357	Homo sapiens	33.57	2.00e-42	166.00
IUUC-Laf-053668	Loxodonta africana	36.36	3.00e-42	165.00
IUUC-Mcc-054640	Macaca mulatta	33.57	2.00e-42	166.00
IUUC-Mtr-057852	Medicago truncatula	78.39	1.00e-145	508.00
IUUC-Mga-059503	Meleagris gallopavo	33.57	1.00e-42	166.00
IUUC-Mmu-064129	Mus musculus	36.36	2.00e-42	165.00
IUUC-Mpu-066488	Mustela putorius furo	33.45	6.00e-43	167.00
IUUC-Nle-069706	Nomascus leucogenys	33.57	2.00e-42	166.00
IUUC-Ont-071849	Oreochromis niloticus	33.80	6.00e-43	167.00
IUUC-Ocu-074876	Oryctolagus cuniculus	33.22	5.00e-43	167.00
IUUC-Ola-086814	Oryzias latipes	33.81	1.00e-42	166.00
IUUC-Oar-089323	Ovis aries	33.45	6.00e-43	167.00
IUUC-Pan-092012	Papio anubis	33.57	2.00e-42	166.00
IUUC-Psi-093687	Pelodiscus sinensis	33.22	4.00e-43	167.00
IUUC-Pfo-097134	Poecilia formosa	33.81	1.00e-42	166.00
IUUC-Pab-097555	Pongo abelii	33.57	2.00e-42	166.00
IUUC-Ppe-101760	Prunus persica	73.62	1.00e-139	488.00
IUUC-Rno-104866	Rattus norvegicus	36.36	2.00e-42	165.00
IUUC-Sha-106547	Sarcophilus harrisii	33.57	2.00e-42	166.00
IUUC-Sly-111117	Solanum lycopersicum	72.64	1.00e-137	481.00
IUUC-Tgu-116579	Taeniopygia guttata	36.36	3.00e-42	165.00
IUUC-Tru-118250	Takifugu rubripes	35.02	7.00e-41	160.00
IUUC-Tni-120488	Tetraodon nigroviridis	33.45	5.00e-40	157.00
IUUC-Vvi-131233	Vitis vinifera	83.06	6.00e-154	536.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence