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Tag Content
UUCD2 ID IUUC-Bta-012482
UUCD1 version UUC-BoT-01081
Ensembl Protein ID ENSBTAP00000004401.5
UniProt Accession A6QP16; ZRAN1_BOVIN
Genbank Protein ID AAI49100.1
Protein Name Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1
Genbank Nucleotide ID BC149099
Gene Name ZRANB1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000003395.5 ENSBTAT00000004401.5 ENSBTAP00000004401.5
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/OTU 4.10e-36 124.6 432 592
UBD/ZnF/NZF 2.10e-27 94.4 7 32
Active Site
Position(s) Description Evidence
443 Nucleophile ECO:0000250}
585 Proton acceptor ECO:0000250}
Domain Profile

   DUB/OTU
   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak 76
           l++l+++++G+CLl++v q+++g++d+ds l++al+++L++ +s+++    +++++++s+++  +        +++++f+ +l+++++ 
   Q: 432  LYALWNRTAGDCLLDSVLQATWGIYDKDSvLRKALHDSLHD-CSHWFytrwKDWESWYSQSFGLHfslreeqwQEDWAFILSLASQPGA 519
           6899*************************************.*****999999999999999999**********************77 PP
   S: 77   .geeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
             e++hif+La+iL+rpiiv+ v++++s         +++g++lpll++++  +k+pi+L+Y++gH++aLva+
   Q: 520  sLEQTHIFVLAHILRRPIIVYGVKYYKSfrgetlgytRFQGVYLPLLWEQSFcWKSPIALGYTRGHFSALVAM 592
           46********************************************************************986 PP
   

   UBD/ZnF/NZF
   S: 4    qWaCsaCTflNePeavkCemCsrpRg 29
           +WaC++CT++N+P+a+kC+mC  +R+
   Q: 7    KWACEYCTYENWPSAIKCTMCRAQRP 32
           7************************8 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity).
 Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity).
Protein Sequence
(Fasta)
MSERGIKWAC EYCTYENWPS AIKCTMCRAQ RPSGTIITED PFKSGSSDVG RDWDPSSTEG 60
GSSPLICPDS SARPRVKSSY SMENANKWSC HMCTYLNWPR AIRCTQCLSQ RRTRSPTESP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012482|DUB,OTU;UBD,NZF|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CATAACTCAC TTCAAGAAGT GCACAATGTC AGAACGTGGA ATTAAGTGGG CTTGTGAATA 60
CTGTACGTAT GAAAACTGGC CGTCTGCGAT CAAGTGTACC ATGTGTCGTG CCCAGAGACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012482|DUB,OTU;UBD,NZF|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR001876--Znf_RanBP2
PROSITE

PS50802--OTU
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF02338--OTU
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016477--P:cell migration
GO:0007010--P:cytoskeleton organization
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0022604--P:regulation of cell morphogenesis
GO:0016055--P:Wnt signaling pathway
KEGG bta:523338
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002329 Ailuropoda melanoleuca 99.43 0.00e+00 1410.00
IUUC-Apl-003612 Anas platyrhynchos 96.29 0.00e+00 1415.00
IUUC-Aca-004604 Anolis carolinensis 96.41 0.00e+00 1358.00
IUUC-Afl-008658 Aspergillus flavus 32.69 5.60e-02 32.00
IUUC-Afu-008779 Aspergillus fumigatus 36.36 3.00e-03 35.00
IUUC-Aor-009946 Aspergillus oryzae 32.69 5.60e-02 32.00
IUUC-Ame-011865 Astyanax mexicanus 78.09 0.00e+00 1115.00
IUUC-Cja-019268 Callithrix jacchus 99.43 0.00e+00 1412.00
IUUC-Cfa-021066 Canis familiaris 99.57 0.00e+00 1414.00
IUUC-Cpo-021479 Cavia porcellus 99.00 0.00e+00 1441.00
IUUC-Cre-022623 Chlamydomonas reinhardtii 29.70 3.00e-03 37.40
IUUC-Csa-023512 Chlorocebus sabaeus 99.28 0.00e+00 1412.00
IUUC-Cho-024615 Choloepus hoffmanni 90.11 0.00e+00 1140.00
IUUC-Cin-025238 Ciona intestinalis 44.03 6.00e-164 570.00
IUUC-Csv-026263 Ciona savignyi 54.55 1.00e-27 115.00
IUUC-Dre-028575 Danio rerio 78.24 0.00e+00 1131.00
IUUC-Dno-029309 Dasypus novemcinctus 98.13 0.00e+00 1394.00
IUUC-Dor-030895 Dipodomys ordii 91.02 4.00e-170 591.00
IUUC-Dse-031270 Dothistroma septosporum 26.13 9.00e-04 38.50
IUUC-Dme-032064 Drosophila melanogaster 42.88 4.00e-144 505.00
IUUC-Ete-032769 Echinops telfairi 96.99 0.00e+00 1385.00
IUUC-Eca-033523 Equus caballus 99.57 0.00e+00 1413.00
IUUC-Eeu-034672 Erinaceus europaeus 94.45 0.00e+00 1140.00
IUUC-Fca-036567 Felis catus 98.57 0.00e+00 1430.00
IUUC-Fal-037545 Ficedula albicollis 96.84 0.00e+00 1421.00
IUUC-Fox-037727 Fusarium oxysporum 34.92 1.30e-02 34.70
IUUC-Gmo-038762 Gadus morhua 82.55 0.00e+00 1177.00
IUUC-Gga-040857 Gallus gallus 96.84 0.00e+00 1423.00
IUUC-Gac-041663 Gasterosteus aculeatus 84.42 0.00e+00 1211.00
IUUC-Ggo-045078 Gorilla gorilla 99.14 0.00e+00 1410.00
IUUC-Hsa-046882 Homo sapiens 99.28 0.00e+00 1410.00
IUUC-Itr-048983 Ictidomys tridecemlineatus 99.77 0.00e+00 910.00
IUUC-Lch-050317 Latimeria chalumnae 94.27 0.00e+00 1257.00
IUUC-Loc-052922 Lepisosteus oculatus 91.29 0.00e+00 1310.00
IUUC-Laf-054134 Loxodonta africana 98.85 0.00e+00 1406.00
IUUC-Mcc-054889 Macaca mulatta 99.28 0.00e+00 1401.00
IUUC-Meu-056035 Macropus eugenii 96.70 0.00e+00 1357.00
IUUC-Mga-059653 Meleagris gallopavo 92.84 0.00e+00 1352.00
IUUC-Mmr-061487 Microcebus murinus 99.57 0.00e+00 1414.00
IUUC-Mdo-061945 Monodelphis domestica 96.99 0.00e+00 1384.00
IUUC-Mmu-063923 Mus musculus 99.14 0.00e+00 1410.00
IUUC-Mpu-066044 Mustela putorius furo 99.28 0.00e+00 1411.00
IUUC-Mlu-067031 Myotis lucifugus 98.13 0.00e+00 1313.00
IUUC-Nle-069600 Nomascus leucogenys 99.00 0.00e+00 1407.00
IUUC-Opr-070795 Ochotona princeps 90.82 0.00e+00 1212.00
IUUC-Ont-071422 Oreochromis niloticus 86.04 0.00e+00 1251.00
IUUC-Oan-072942 Ornithorhynchus anatinus 95.17 8.00e-164 569.00
IUUC-Ocu-074481 Oryctolagus cuniculus 95.01 0.00e+00 1369.00
IUUC-Obr-076679 Oryza brachyantha 23.58 7.00e-05 42.00
IUUC-Ola-087151 Oryzias latipes 83.01 0.00e+00 1203.00
IUUC-Olu-087626 Ostreococcus lucimarinus 28.00 4.20e-01 28.90
IUUC-Oga-089035 Otolemur garnettii 99.43 0.00e+00 1408.00
IUUC-Oar-089948 Ovis aries 99.71 0.00e+00 1410.00
IUUC-Ptr-091245 Pan troglodytes 99.14 0.00e+00 1410.00
IUUC-Pan-092797 Papio anubis 98.95 0.00e+00 947.00
IUUC-Psi-093759 Pelodiscus sinensis 96.01 0.00e+00 885.00
IUUC-Pfo-096859 Poecilia formosa 82.08 0.00e+00 1196.00
IUUC-Pab-098015 Pongo abelii 99.28 0.00e+00 1410.00
IUUC-Pca-100282 Procavia capensis 95.75 0.00e+00 1211.00
IUUC-Pva-102680 Pteropus vampyrus 98.74 0.00e+00 1281.00
IUUC-Pgr-103642 Puccinia graminis 22.73 6.00e-03 35.40
IUUC-Rno-105058 Rattus norvegicus 99.14 0.00e+00 1410.00
IUUC-Sha-106846 Sarcophilus harrisii 96.99 0.00e+00 1384.00
IUUC-Sar-113395 Sorex araneus 95.95 3.00e-143 502.00
IUUC-Ssc-116143 Sus scrofa 99.43 0.00e+00 1413.00
IUUC-Tgu-117173 Taeniopygia guttata 96.99 0.00e+00 1424.00
IUUC-Tru-118266 Takifugu rubripes 85.37 0.00e+00 1234.00
IUUC-Tsy-118947 Tarsius syrichta 92.25 0.00e+00 1251.00
IUUC-Tni-120090 Tetraodon nigroviridis 83.93 0.00e+00 1174.00
IUUC-Tbe-127522 Tupaia belangeri 98.12 0.00e+00 852.00
IUUC-Ttr-128170 Tursiops truncatus 99.28 0.00e+00 1410.00
IUUC-Vpa-130143 Vicugna pacos 91.35 0.00e+00 1161.00
IUUC-Xtr-132143 Xenopus tropicalis 89.96 0.00e+00 1266.00
Created Date 25-Jun-2017

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