iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000012934.8	ENSRNOT00000043449.6	ENSRNOP00000043761.5
ENSRNOG00000012934.8	ENSRNOT00000017947.4	ENSRNOP00000017947.4

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-14	54.4	167	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 167  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREIK 221
           78999*********************7..999*******..8**************996 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEVF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RNESECLSNI REFLRACGAS LRLETFDAND LYQGQNFNKV LSSLVTLNKV TADIGLGSDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGATCGCGCG CGGCGCCCCC TCTGTGCGCG CAGCCCGAGC CGCCGCAGCG ATGAATTCTG 60
CCGAGCAGAC CGTTACGTGG CTCATCACCC TGGGCGTGCT GGAGTCGCCC AAGAAAACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	90.70	0.00e+00	1263.00
IUUC-Aca-004591	Anolis carolinensis	91.07	0.00e+00	1366.00
IUUC-Ame-010759	Astyanax mexicanus	76.27	0.00e+00	1267.00
IUUC-Bta-013328	Bos taurus	92.23	0.00e+00	1464.00
IUUC-Bci-013864	Botrytis cinerea	40.00	9.00e-11	63.20
IUUC-Cja-018742	Callithrix jacchus	92.92	0.00e+00	1145.00
IUUC-Cfa-020756	Canis familiaris	93.04	0.00e+00	1102.00
IUUC-Cpo-021284	Cavia porcellus	94.91	0.00e+00	1448.00
IUUC-Csa-023162	Chlorocebus sabaeus	94.78	0.00e+00	1494.00
IUUC-Cho-024736	Choloepus hoffmanni	72.42	1.00e-164	573.00
IUUC-Cin-025535	Ciona intestinalis	40.30	5.00e-95	341.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	44.29	7.00e-12	66.60
IUUC-Cne-026866	Cryptococcus neoformans	50.79	5.00e-13	70.50
IUUC-Dre-028646	Danio rerio	76.04	0.00e+00	1249.00
IUUC-Dno-029461	Dasypus novemcinctus	94.32	0.00e+00	1484.00
IUUC-Dor-030623	Dipodomys ordii	82.50	0.00e+00	1059.00
IUUC-Dse-031165	Dothistroma septosporum	37.66	2.00e-11	65.50
IUUC-Dme-032219	Drosophila melanogaster	46.25	1.00e-97	351.00
IUUC-Ete-032236	Echinops telfairi	78.82	0.00e+00	765.00
IUUC-Eca-034137	Equus caballus	94.61	0.00e+00	1319.00
IUUC-Fca-035742	Felis catus	91.50	0.00e+00	1104.00
IUUC-Fal-037205	Ficedula albicollis	92.34	0.00e+00	1152.00
IUUC-Fox-037757	Fusarium oxysporum	41.67	6.00e-12	67.00
IUUC-Fso-038433	Fusarium solani	41.67	6.00e-12	67.00
IUUC-Gmo-039475	Gadus morhua	69.41	0.00e+00	1053.00
IUUC-Gga-040539	Gallus gallus	90.99	0.00e+00	931.00
IUUC-Gac-042615	Gasterosteus aculeatus	65.28	0.00e+00	949.00
IUUC-Ggo-044470	Gorilla gorilla	88.72	0.00e+00	1251.00
IUUC-Hsa-046398	Homo sapiens	91.79	0.00e+00	1301.00
IUUC-Loc-052146	Lepisosteus oculatus	85.17	0.00e+00	1356.00
IUUC-Laf-053891	Loxodonta africana	90.72	0.00e+00	1431.00
IUUC-Mcc-055483	Macaca mulatta	91.54	0.00e+00	1297.00
IUUC-Mga-059410	Meleagris gallopavo	90.59	0.00e+00	1294.00
IUUC-Mmr-060758	Microcebus murinus	94.16	0.00e+00	1258.00
IUUC-Mdo-061900	Monodelphis domestica	91.71	0.00e+00	1240.00
IUUC-Mmu-063849	Mus musculus	98.96	0.00e+00	1367.00
IUUC-Mpu-065876	Mustela putorius furo	92.87	0.00e+00	1094.00
IUUC-Mlu-067970	Myotis lucifugus	94.61	0.00e+00	1321.00
IUUC-Nle-069685	Nomascus leucogenys	90.27	0.00e+00	990.00
IUUC-Opr-071132	Ochotona princeps	63.03	0.00e+00	696.00
IUUC-Ont-071815	Oreochromis niloticus	76.27	0.00e+00	1245.00
IUUC-Oan-073057	Ornithorhynchus anatinus	91.77	0.00e+00	1167.00
IUUC-Ola-086663	Oryzias latipes	73.33	0.00e+00	1063.00
IUUC-Oga-088103	Otolemur garnettii	93.62	0.00e+00	1268.00
IUUC-Ptr-091162	Pan troglodytes	90.81	0.00e+00	1192.00
IUUC-Pan-092093	Papio anubis	86.06	0.00e+00	1360.00
IUUC-Pma-094701	Petromyzon marinus	62.89	1.00e-132	466.00
IUUC-Pfo-096736	Poecilia formosa	68.71	0.00e+00	1073.00
IUUC-Pab-097641	Pongo abelii	93.96	0.00e+00	1257.00
IUUC-Pva-102819	Pteropus vampyrus	91.18	0.00e+00	1244.00
IUUC-Sha-106845	Sarcophilus harrisii	90.66	0.00e+00	1078.00
IUUC-Ssc-116036	Sus scrofa	92.38	0.00e+00	1076.00
IUUC-Tgu-117498	Taeniopygia guttata	89.21	0.00e+00	1387.00
IUUC-Tru-118278	Takifugu rubripes	72.26	0.00e+00	1060.00
IUUC-Tsy-118990	Tarsius syrichta	91.85	0.00e+00	922.00
IUUC-Tni-120852	Tetraodon nigroviridis	74.51	0.00e+00	981.00
IUUC-Tre-121917	Trichoderma reesei	44.12	1.00e-11	66.20
IUUC-Tvi-122534	Trichoderma virens	44.12	8.00e-12	66.60
IUUC-Ttr-128922	Tursiops truncatus	86.28	0.00e+00	1083.00
IUUC-Xtr-132012	Xenopus tropicalis	84.82	0.00e+00	1230.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence