iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005306.3	ENSMMUT00000007473.3	ENSMMUP00000007022.3
ENSMMUG00000005306.3	ENSMMUT00000007472.3	ENSMMUP00000007021.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.30e-08	34.1	16	57
E3 activity/RING/U-box	5.00e-06	27.6	12	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+ f d p+ ++CgH f+++C+  +w     +  +   CP Cr
   Q: 16   CAICLDYFTD-PVMTDCGHNFCRECIrRCW----GQPEGPYACPECR 57
           **********.999************99**....66789999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggk..tcPvtrqplteedlvPnltl 61
           ee  C+I l+ ++dPv++ +G+ + r++I+++    +      cP +r+   +++l Pn  l
   Q: 12   EEATCAICLDYFTDPVMTDCGHNFCRECIRRCWgqPE--GpyACPECRELSPQRNLRPNRPL 71
           7889***************************995333..346*****************866 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS 60
PQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCPAHREPLA AFCGDELRLL CAACERSGEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCCC CCGACCTGTC CACCAACCTC CAGGAGGAGG CCACCTGCGC CATCTGCCTC 60
GACTACTTCA CGGATCCGGT GATGACCGAC TGCGGCCACA ACTTCTGCCG CGAGTGCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0050768--P:negative regulation of neurogenesis
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0046598--P:positive regulation of viral entry into host cell

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001800	Ailuropoda melanoleuca	72.06	1.00e-162	565.00
IUUC-Bta-012332	Bos taurus	90.38	0.00e+00	773.00
IUUC-Cja-019969	Callithrix jacchus	82.69	0.00e+00	677.00
IUUC-Cfa-020491	Canis familiaris	89.96	0.00e+00	781.00
IUUC-Cpo-021936	Cavia porcellus	87.82	0.00e+00	747.00
IUUC-Csa-024151	Chlorocebus sabaeus	97.86	0.00e+00	780.00
IUUC-Cho-024990	Choloepus hoffmanni	76.57	6.00e-111	393.00
IUUC-Dno-029580	Dasypus novemcinctus	79.67	0.00e+00	638.00
IUUC-Ete-032556	Echinops telfairi	68.60	2.00e-110	391.00
IUUC-Eca-033612	Equus caballus	73.91	4.00e-131	461.00
IUUC-Fca-035821	Felis catus	87.65	3.00e-145	507.00
IUUC-Ggo-044629	Gorilla gorilla	97.65	0.00e+00	777.00
IUUC-Hsa-046332	Homo sapiens	97.65	0.00e+00	776.00
IUUC-Itr-047946	Ictidomys tridecemlineatus	91.88	0.00e+00	756.00
IUUC-Laf-054350	Loxodonta africana	74.75	6.00e-141	493.00
IUUC-Meu-056122	Macropus eugenii	71.95	0.00e+00	644.00
IUUC-Mmr-061700	Microcebus murinus	91.01	0.00e+00	764.00
IUUC-Mdo-062921	Monodelphis domestica	63.68	1.00e-165	576.00
IUUC-Mmu-063762	Mus musculus	87.82	0.00e+00	719.00
IUUC-Mpu-065873	Mustela putorius furo	90.17	0.00e+00	785.00
IUUC-Mlu-067379	Myotis lucifugus	68.22	9.00e-168	583.00
IUUC-Nle-069440	Nomascus leucogenys	97.03	0.00e+00	773.00
IUUC-Opr-070901	Ochotona princeps	80.77	1.00e-175	609.00
IUUC-Oan-073401	Ornithorhynchus anatinus	44.20	3.00e-86	312.00
IUUC-Ocu-074038	Oryctolagus cuniculus	73.50	2.00e-158	551.00
IUUC-Oga-088948	Otolemur garnettii	87.55	0.00e+00	745.00
IUUC-Oar-090242	Ovis aries	83.68	0.00e+00	726.00
IUUC-Ptr-090615	Pan troglodytes	99.53	1.00e-103	369.00
IUUC-Pan-092626	Papio anubis	98.29	0.00e+00	782.00
IUUC-Pab-097895	Pongo abelii	90.81	0.00e+00	778.00
IUUC-Pca-100435	Procavia capensis	87.79	0.00e+00	729.00
IUUC-Pva-102288	Pteropus vampyrus	81.62	0.00e+00	677.00
IUUC-Pgr-103696	Puccinia graminis	34.78	2.00e-06	46.20
IUUC-Rno-105938	Rattus norvegicus	88.46	0.00e+00	729.00
IUUC-Sha-107354	Sarcophilus harrisii	73.82	0.00e+00	655.00
IUUC-Tbe-127733	Tupaia belangeri	93.76	0.00e+00	763.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence