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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106364
UUCD1 version UUC-SaC-00133
Ensembl Protein ID YEL056W
UniProt Accession P39984; D3DLJ4; HAT2_YEAST
Genbank Protein ID AAB65031.1; DAA07598.1
Protein Name Histone acetyltransferase type B subunit 2
Genbank Nucleotide ID U18795; BK006939
Gene Name HAT2; YEL056W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YEL056W YEL056W YEL056W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-21 74.4 293 330
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gH+d v+ l+f    d+ +vs++ D+ +++WDl++   
   Q: 293  GHEDAVNNLEFsthVDGVVVSSGSDNRLMMWDLKQIGA 330
           8**********97655899*************987665 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. HAT2 is required for high affinity binding of the acetyltransferase to histone H4, for the nuclear location of HAT1 and for the HAT1-HIF1 interaction. Alone, it is unable to bind to H4, requiring HAT1 for high affinity interaction with the histone tail. HAT2 has also a HAT1 independent function in life-span regulation.
 Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. HAT2 is required for high affinity binding of the acetyltransferase to histone H4, for the nuclear location of HAT1 and for the HAT1-HIF1 interaction. Alone, it is unable to bind to H4, requiring HAT1 for high affinity interaction with the histone tail. HAT2 has also a HAT1 independent function in life-span regulation.
Protein Sequence
(Fasta)
MENQEKPLSV DEEYDLWKSN VPLMYDFVSE TRLTWPSLTV QWLPTPVQEL DGGFIKQELI 60
IGTHTSGEEE NYLKFAEINL PKEILSNEDP QEEAGEEYQS SLPAPRSNIR ITAKYEHEEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106364|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGAAAACC AAGAGAAACC GCTTTCTGTA GACGAGGAGT ACGATTTATG GAAATCCAAT 60
GTTCCATTAA TGTATGACTT TGTTAGCGAG ACACGTTTAA CATGGCCATC TTTAACCGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106364|E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0006333--P:chromatin assembly or disassembly
GO:0006348--P:chromatin silencing at telomere
GO:0016573--P:histone acetylation
KEGG sce:YEL056W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 36.29 7.00e-65 239.00
IUUC-Aml-001256 Ailuropoda melanoleuca 36.20 9.00e-74 268.00
IUUC-Atr-003075 Amborella trichopoda 36.22 1.00e-70 258.00
IUUC-Apl-003952 Anas platyrhynchos 37.84 1.00e-75 274.00
IUUC-Aca-004508 Anolis carolinensis 37.84 2.00e-75 274.00
IUUC-Aly-006342 Arabidopsis lyrata 34.95 2.00e-67 247.00
IUUC-Ath-006855 Arabidopsis thaliana 35.20 1.00e-67 248.00
IUUC-Ago-007892 Ashbya gossypii 53.65 2.00e-123 433.00
IUUC-Acl-008163 Aspergillus clavatus 38.69 2.00e-75 273.00
IUUC-Afl-008645 Aspergillus flavus 38.81 2.00e-74 271.00
IUUC-Afu-009091 Aspergillus fumigatus 38.19 7.00e-74 269.00
IUUC-Ani-009478 Aspergillus nidulans 36.53 1.00e-59 221.00
IUUC-Ang-009707 Aspergillus niger 39.45 1.00e-73 268.00
IUUC-Aor-010028 Aspergillus oryzae 38.81 2.00e-74 271.00
IUUC-Ate-010416 Aspergillus terreus 38.69 5.00e-76 276.00
IUUC-Ame-010598 Astyanax mexicanus 37.59 6.00e-75 272.00
IUUC-Bgr-012001 Blumeria graminis 36.27 4.00e-64 236.00
IUUC-Bta-012851 Bos taurus 37.84 1.00e-75 274.00
IUUC-Bci-013815 Botrytis cinerea 38.40 1.00e-74 271.00
IUUC-Bdi-014926 Brachypodium distachyon 36.48 5.00e-68 249.00
IUUC-Bol-015856 Brassica oleracea 34.76 7.00e-67 246.00
IUUC-Bra-016725 Brassica rapa 34.24 1.00e-67 248.00
IUUC-Cel-018587 Caenorhabditis elegans 34.96 2.00e-67 248.00
IUUC-Cja-019884 Callithrix jacchus 37.84 1.00e-75 274.00
IUUC-Cfa-020343 Canis familiaris 37.84 1.00e-75 274.00
IUUC-Cpo-021591 Cavia porcellus 37.84 1.00e-75 274.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 38.35 9.00e-73 265.00
IUUC-Csa-023738 Chlorocebus sabaeus 36.20 6.00e-74 269.00
IUUC-Cho-024506 Choloepus hoffmanni 37.84 1.00e-73 268.00
IUUC-Cin-025589 Ciona intestinalis 35.25 3.00e-71 259.00
IUUC-Csv-026216 Ciona savignyi 35.75 3.00e-72 263.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 38.31 4.00e-75 273.00
IUUC-Cne-026792 Cryptococcus neoformans 38.35 2.00e-72 263.00
IUUC-Cme-027307 Cyanidioschyzon merolae 34.97 9.00e-66 242.00
IUUC-Dre-028742 Danio rerio 37.84 2.00e-75 273.00
IUUC-Dno-028971 Dasypus novemcinctus 37.84 2.00e-75 274.00
IUUC-Dor-030733 Dipodomys ordii 42.42 9.00e-32 129.00
IUUC-Dse-031282 Dothistroma septosporum 36.09 8.00e-65 239.00
IUUC-Dme-032126 Drosophila melanogaster 36.46 3.00e-73 266.00
IUUC-Ete-032731 Echinops telfairi 37.84 1.00e-75 274.00
IUUC-Eca-033533 Equus caballus 38.19 1.00e-75 275.00
IUUC-Eeu-034644 Erinaceus europaeus 34.76 2.00e-26 111.00
IUUC-Fca-036202 Felis catus 37.84 1.00e-75 274.00
IUUC-Fal-037084 Ficedula albicollis 37.84 1.00e-75 274.00
IUUC-Fox-037974 Fusarium oxysporum 38.60 3.00e-75 273.00
IUUC-Fso-038246 Fusarium solani 38.36 2.00e-70 257.00
IUUC-Gmo-038593 Gadus morhua 38.10 2.00e-76 277.00
IUUC-Ggr-039741 Gaeumannomyces graminis 40.25 1.00e-76 278.00
IUUC-Gga-040396 Gallus gallus 37.84 1.00e-75 274.00
IUUC-Gac-041389 Gasterosteus aculeatus 38.50 2.00e-75 273.00
IUUC-Gma-042791 Glycine max 36.22 8.00e-69 251.00
IUUC-Ggo-045422 Gorilla gorilla 37.31 2.00e-66 243.00
IUUC-Hsa-045683 Homo sapiens 37.84 1.00e-75 274.00
IUUC-Hvu-047457 Hordeum vulgare 37.50 5.00e-32 128.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 37.84 1.00e-75 274.00
IUUC-Kpa-049258 Komagataella pastoris 41.24 2.00e-82 297.00
IUUC-Lch-050545 Latimeria chalumnae 37.34 1.00e-74 271.00
IUUC-Lpe-051337 Leersia perrieri 35.97 1.00e-66 244.00
IUUC-Loc-052473 Lepisosteus oculatus 37.84 2.00e-75 274.00
IUUC-Lma-053275 Leptosphaeria maculans 32.81 2.00e-34 137.00
IUUC-Laf-054114 Loxodonta africana 37.84 1.00e-75 274.00
IUUC-Mcc-055648 Macaca mulatta 37.84 1.00e-75 274.00
IUUC-Meu-056490 Macropus eugenii 37.84 1.00e-75 274.00
IUUC-Mor-056947 Magnaporthe oryzae 39.10 2.00e-74 270.00
IUUC-Mpo-057602 Magnaporthe poae 39.50 2.00e-75 273.00
IUUC-Mtr-057853 Medicago truncatula 35.05 3.00e-66 243.00
IUUC-Mla-058884 Melampsora laricipopulina 36.72 4.00e-69 253.00
IUUC-Mga-059452 Meleagris gallopavo 37.84 1.00e-75 274.00
IUUC-Mvi-060450 Microbotryum violaceum 34.34 6.00e-63 232.00
IUUC-Mmr-060678 Microcebus murinus 38.32 1.00e-75 274.00
IUUC-Mdo-062450 Monodelphis domestica 38.32 2.00e-75 274.00
IUUC-Mmu-063282 Mus musculus 37.84 1.00e-75 274.00
IUUC-Mac-065480 Musa acuminata 36.22 4.00e-68 249.00
IUUC-Mpu-066529 Mustela putorius furo 37.34 2.00e-74 270.00
IUUC-Mlu-068072 Myotis lucifugus 37.84 1.00e-75 274.00
IUUC-Nfi-068374 Neosartorya fischeri 38.19 8.00e-72 262.00
IUUC-Ncr-068794 Neurospora crassa 37.19 5.00e-73 266.00
IUUC-Nle-069577 Nomascus leucogenys 37.84 1.00e-75 274.00
IUUC-Opr-070245 Ochotona princeps 35.17 3.00e-39 154.00
IUUC-Ont-072590 Oreochromis niloticus 37.75 2.00e-76 277.00
IUUC-Oan-072839 Ornithorhynchus anatinus 38.00 3.00e-75 273.00
IUUC-Ocu-074778 Oryctolagus cuniculus 36.20 5.00e-74 269.00
IUUC-Oba-075719 Oryza barthii 34.77 7.00e-58 216.00
IUUC-Obr-076859 Oryza brachyantha 36.13 5.00e-67 246.00
IUUC-Ogl-077920 Oryza glaberrima 35.97 3.00e-67 246.00
IUUC-Ogu-078437 Oryza glumaepatula 35.17 6.00e-59 219.00
IUUC-Oin-079872 Oryza indica 35.43 1.00e-59 221.00
IUUC-Olo-080553 Oryza longistaminata 33.18 3.00e-54 204.00
IUUC-Ome-081835 Oryza meridionalis 35.97 5.00e-67 246.00
IUUC-Oni-082852 Oryza nivara 35.43 1.00e-59 221.00
IUUC-Opu-083343 Oryza punctata 35.70 3.00e-59 220.00
IUUC-Oru-084666 Oryza rufipogon 35.97 3.00e-67 246.00
IUUC-Osa-085884 Oryza sativa 35.97 3.00e-67 246.00
IUUC-Ola-086664 Oryzias latipes 37.59 5.00e-75 272.00
IUUC-Olu-087579 Ostreococcus lucimarinus 37.69 1.00e-73 268.00
IUUC-Oga-088364 Otolemur garnettii 35.28 6.00e-70 255.00
IUUC-Oar-089652 Ovis aries 37.84 1.00e-75 274.00
IUUC-Ptr-091598 Pan troglodytes 36.20 5.00e-74 269.00
IUUC-Pan-092412 Papio anubis 36.20 6.00e-74 269.00
IUUC-Psi-093300 Pelodiscus sinensis 37.50 4.00e-68 249.00
IUUC-Pma-094307 Petromyzon marinus 37.50 6.00e-74 269.00
IUUC-Pno-095153 Phaeosphaeria nodorum 33.58 2.00e-60 224.00
IUUC-Ppa-095800 Physcomitrella patens 38.68 9.00e-72 261.00
IUUC-Pfo-097240 Poecilia formosa 38.60 4.00e-76 276.00
IUUC-Pab-097697 Pongo abelii 37.84 1.00e-75 274.00
IUUC-Pop-100045 Populus trichocarpa 35.35 6.00e-68 249.00
IUUC-Pca-100642 Procavia capensis 32.99 4.00e-57 213.00
IUUC-Ppe-101212 Prunus persica 36.73 5.00e-70 256.00
IUUC-Pva-102253 Pteropus vampyrus 37.84 1.00e-75 274.00
IUUC-Pgr-103441 Puccinia graminis 35.25 1.00e-62 231.00
IUUC-Pte-104332 Pyrenophora teres 33.00 2.00e-60 224.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 33.00 2.00e-60 224.00
IUUC-Rno-105678 Rattus norvegicus 37.84 1.00e-75 274.00
IUUC-Sha-106663 Sarcophilus harrisii 37.84 1.00e-75 274.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 36.29 2.00e-70 257.00
IUUC-Spo-108145 Schizosaccharomyces pombe 36.71 7.00e-73 265.00
IUUC-Smo-109400 Selaginella moellendorffii 38.44 4.00e-74 269.00
IUUC-Sit-110144 Setaria italica 36.10 1.00e-67 248.00
IUUC-Sly-111680 Solanum lycopersicum 35.97 1.00e-68 251.00
IUUC-Stu-111931 Solanum tuberosum 35.97 7.00e-69 252.00
IUUC-Sar-113236 Sorex araneus 33.67 8.00e-58 215.00
IUUC-Sbi-114637 Sorghum bicolor 35.85 3.00e-66 243.00
IUUC-Sre-114980 Sporisorium reilianum 36.61 2.00e-72 264.00
IUUC-Ssc-116352 Sus scrofa 36.20 8.00e-74 268.00
IUUC-Tgu-116925 Taeniopygia guttata 37.59 4.00e-75 273.00
IUUC-Tru-117912 Takifugu rubripes 37.40 4.00e-76 276.00
IUUC-Tsy-118854 Tarsius syrichta 36.20 5.00e-74 269.00
IUUC-Tni-120415 Tetraodon nigroviridis 37.56 1.00e-75 274.00
IUUC-Tca-121841 Theobroma cacao 36.11 3.00e-69 253.00
IUUC-Tre-122190 Trichoderma reesei 37.34 1.00e-66 244.00
IUUC-Tvi-122304 Trichoderma virens 37.59 3.00e-76 276.00
IUUC-Tae-124648 Triticum aestivum 36.22 9.00e-68 248.00
IUUC-Tur-126850 Triticum urartu 34.84 5.00e-46 176.00
IUUC-Tme-126949 Tuber melanosporum 38.75 1.00e-77 281.00
IUUC-Tbe-128010 Tupaia belangeri 32.23 8.00e-60 222.00
IUUC-Ttr-128558 Tursiops truncatus 37.84 2.00e-56 211.00
IUUC-Uma-129424 Ustilago maydis 36.36 2.00e-71 261.00
IUUC-Vda-129873 Verticillium dahliae 39.75 2.00e-78 284.00
IUUC-Vpa-130079 Vicugna pacos 37.59 5.00e-74 269.00
IUUC-Vvi-131585 Vitis vinifera 35.97 4.00e-68 249.00
IUUC-Xtr-132005 Xenopus tropicalis 37.09 5.00e-74 269.00
IUUC-Xma-133485 Xiphophorus maculatus 38.50 1.00e-76 278.00
IUUC-Yli-134625 Yarrowia lipolytica 33.25 4.00e-54 202.00
IUUC-Zma-135710 Zea mays 35.94 4.00e-67 246.00
Created Date 25-Jun-2017

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