iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000085433.15	ENST00000400794.7	ENSP00000383599.3
ENSG00000085433.15	ENST00000369962.7	ENSP00000358979.3
ENSG00000085433.15	ENST00000361054.7	ENSP00000354339.3
ENSG00000085433.15	ENST00000369965.8	ENSP00000358982.4
ENSG00000085433.15	ENST00000357672.7	ENSP00000350301.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
InWeb_IM
Disease-associated Variation
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-27	96.5	761	797
UBD/Beta-Prp	1.40e-57	196.8	665	923

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcla.fsdtllvsGsdDgtikvWDlrtgvll 36
           gHt+ + +l  +s+++++sGs D+t++ WDlr   ++
   Q: 761  GHTGHILALYtWSGWMIASGSQDKTVRFWDLRVPSCV 797
           89999***966977*****************988887 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.....lrslsgheaevtavkfspdgk....ilvtgse.Drtikvwdlstgkcv 87
           ++hhk+ i+cv++sp ++llatgs d+ +kv  +  +++       ++s h+++++++ f +  +    il++++  D +i+  d + g+ +
   Q: 665  NKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCnatgpDLEFSMHDGTIRDLAFMEGPEsggaILISAGAgDCNIYTTDCQRGQGL 756
           68*****************************99999999889888899************987667778777765516788888******** PP
   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
           h+l+gh+  +l+l     g  ++sGs+d+t+r wdl+  +c++    t+ g+ ++v +v+v+p+g+ll++G  D+ ++l+d++ g++++   
   Q: 757  HALSGHTGHILALYTWS-GWMIASGSQDKTVRFWDLRVPSCVRVvgtTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH 847
           ***********997777.9***********************99999********************************************9 PP
   S: 177  gghtdsvyslsfdsngkelvsgsldgtvklwdlq....tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
             h ++v+s+ f++   +l++gs+d ++k+ dlq    ++  ++ + +h+d v + r + +d  ++s s+D+++ +W
   Q: 848  P-HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQgdltKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           8.********************************99977788*********************************** PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTAEETVNVK EVEIIKLILD FLNSKKLHIS MLALEKESGV INGLFSDDML FLRQLILDGQ 60
WDEVLQFIQP LECMEKFDKK RFRYIILKQK FLEALCVNNA MSAEDEPQHV RFLFLKLEFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTGACAAC CGCAGTCTGC AAGAGGCTGA GCTGAGGAGT CGCTGGGCCG GGAGGGGCGG 60
ACGTGAGAAG GACGGATTGA CGAACTGATG GATTGACGCG CGGGCGGTAG GAGGGAGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR006595--CTLH_C
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50897--CTLH
PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00668--CTLH
SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0007275--P:multicellular organism development

KEGG

hsa:22911

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001519	Ailuropoda melanoleuca	98.06	0.00e+00	1684.00
IUUC-Apl-003954	Anas platyrhynchos	90.65	0.00e+00	1564.00
IUUC-Aca-004766	Anolis carolinensis	88.69	0.00e+00	1503.00
IUUC-Ame-010725	Astyanax mexicanus	69.72	0.00e+00	1122.00
IUUC-Bta-013072	Bos taurus	95.04	0.00e+00	1609.00
IUUC-Cel-018667	Caenorhabditis elegans	48.63	2.00e-94	340.00
IUUC-Cja-018835	Callithrix jacchus	99.14	0.00e+00	1692.00
IUUC-Cfa-020380	Canis familiaris	95.42	0.00e+00	1017.00
IUUC-Cpo-021883	Cavia porcellus	95.47	0.00e+00	1594.00
IUUC-Csa-023467	Chlorocebus sabaeus	98.60	0.00e+00	1680.00
IUUC-Cho-024342	Choloepus hoffmanni	86.83	0.00e+00	1485.00
IUUC-Cin-025112	Ciona intestinalis	44.20	8.00e-73	266.00
IUUC-Dre-027530	Danio rerio	76.29	0.00e+00	1259.00
IUUC-Dno-029290	Dasypus novemcinctus	96.55	0.00e+00	1644.00
IUUC-Dor-030258	Dipodomys ordii	82.54	0.00e+00	1359.00
IUUC-Dme-032040	Drosophila melanogaster	52.42	2.00e-102	365.00
IUUC-Ete-032248	Echinops telfairi	89.15	0.00e+00	787.00
IUUC-Eca-033623	Equus caballus	97.09	0.00e+00	1654.00
IUUC-Fca-036425	Felis catus	95.19	0.00e+00	1459.00
IUUC-Fal-036661	Ficedula albicollis	89.77	0.00e+00	1529.00
IUUC-Gmo-039527	Gadus morhua	73.43	0.00e+00	1227.00
IUUC-Gga-041177	Gallus gallus	89.66	0.00e+00	1530.00
IUUC-Gac-042049	Gasterosteus aculeatus	73.58	0.00e+00	1243.00
IUUC-Ggo-044833	Gorilla gorilla	99.78	0.00e+00	1712.00
IUUC-Lch-050313	Latimeria chalumnae	80.17	0.00e+00	1401.00
IUUC-Loc-051790	Lepisosteus oculatus	81.30	0.00e+00	1409.00
IUUC-Laf-053521	Loxodonta africana	95.91	0.00e+00	1625.00
IUUC-Mcc-055053	Macaca mulatta	98.60	0.00e+00	1680.00
IUUC-Meu-056734	Macropus eugenii	92.20	0.00e+00	689.00
IUUC-Mga-059381	Meleagris gallopavo	90.01	0.00e+00	1547.00
IUUC-Mmr-060859	Microcebus murinus	97.84	0.00e+00	1672.00
IUUC-Mdo-062501	Monodelphis domestica	91.26	0.00e+00	1476.00
IUUC-Mmu-063126	Mus musculus	94.82	0.00e+00	1597.00
IUUC-Mpu-066718	Mustela putorius furo	96.60	0.00e+00	1306.00
IUUC-Mlu-067246	Myotis lucifugus	95.90	0.00e+00	1632.00
IUUC-Nle-069807	Nomascus leucogenys	99.57	0.00e+00	1709.00
IUUC-Opr-070862	Ochotona princeps	87.94	3.00e-69	256.00
IUUC-Ont-072519	Oreochromis niloticus	75.85	0.00e+00	1261.00
IUUC-Oan-072740	Ornithorhynchus anatinus	89.16	0.00e+00	798.00
IUUC-Ocu-074898	Oryctolagus cuniculus	97.09	0.00e+00	1623.00
IUUC-Ola-086396	Oryzias latipes	75.98	0.00e+00	1295.00
IUUC-Oga-088563	Otolemur garnettii	97.95	0.00e+00	1674.00
IUUC-Oar-089926	Ovis aries	96.44	0.00e+00	1642.00
IUUC-Ptr-090706	Pan troglodytes	99.89	0.00e+00	1711.00
IUUC-Pan-091740	Papio anubis	98.71	0.00e+00	1681.00
IUUC-Psi-093938	Pelodiscus sinensis	89.83	0.00e+00	1549.00
IUUC-Pfo-096531	Poecilia formosa	76.36	0.00e+00	1261.00
IUUC-Pab-098312	Pongo abelii	98.81	0.00e+00	1685.00
IUUC-Pca-101100	Procavia capensis	90.05	0.00e+00	731.00
IUUC-Pva-102734	Pteropus vampyrus	86.07	0.00e+00	1197.00
IUUC-Rno-105625	Rattus norvegicus	94.72	0.00e+00	1564.00
IUUC-Sha-106999	Sarcophilus harrisii	89.78	0.00e+00	1501.00
IUUC-Sar-112988	Sorex araneus	84.78	0.00e+00	1190.00
IUUC-Ssc-115384	Sus scrofa	96.34	0.00e+00	1609.00
IUUC-Tgu-116808	Taeniopygia guttata	89.68	0.00e+00	1523.00
IUUC-Tru-118233	Takifugu rubripes	75.59	0.00e+00	1228.00
IUUC-Tsy-119509	Tarsius syrichta	97.40	0.00e+00	674.00
IUUC-Tni-120473	Tetraodon nigroviridis	73.94	0.00e+00	1252.00
IUUC-Tbe-127447	Tupaia belangeri	89.12	2.00e-144	506.00
IUUC-Ttr-128459	Tursiops truncatus	93.75	0.00e+00	1505.00
IUUC-Vpa-130258	Vicugna pacos	91.08	0.00e+00	1014.00
IUUC-Xtr-132609	Xenopus tropicalis	78.42	0.00e+00	1323.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence