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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046398
Ensembl Protein ID ENSP00000364893.2
UniProt Accession Q14155; B1ALK6; B1ALK8; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1; ARHG7_HUMAN
Genbank Protein ID BAA09763.2; CAD38906.1; CAI12461.1; CAI12461.1; CAI14671.1; CAI14671.1; CAM13628.1; CAM13628.1; CAM20788.1; CAM20788.1; EAX09143.1; AAH33905.1; AAH50521.1; AAH60776.1; BAD66827.1; BAE45764.1
Protein Name Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
Genbank Nucleotide ID D63476; AL834228; AL390754; AL139086; AL139086; AL390754; AL390754; AL139086; AL139086; AL390754; CH471085; BC033905; BC050521; BC060776; AB177849; AB075521
Gene Name ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102606.17 ENST00000317133.9 ENSP00000325994.5
ENSG00000102606.17 ENST00000469877.5 ENSP00000418235.1
ENSG00000102606.17 ENST00000218789.9 ENSP00000218789.5
ENSG00000102606.17 ENST00000375736.8 ENSP00000364888.4
ENSG00000102606.17 ENST00000426768.2 ENSP00000389890.2
ENSG00000102606.17 ENST00000478679.5 ENSP00000417596.1
ENSG00000102606.17 ENST00000544132.2 ENSP00000445384.2
ENSG00000102606.17 ENST00000375739.6 ENSP00000364891.2
ENSG00000102606.17 ENST00000375741.6 ENSP00000364893.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 6.40e-15 56.5 188 242
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 188  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 242
           78999*********************7..999*******..8**************996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
 Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Protein Sequence
(Fasta)
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046398|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTGCCGTC TGGGCTCTCC AGGTTCGGCC TGCTGCTTTC ACAGCCCAGA TCTTCGGCGT 60
CCCCGAGACG CAGCCAGGCG CCCGGCCCGG CCCGGCCCGG CCCTCTGCAC AGCCCCACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046398|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0344--Guanine-nucleotide releasing factor
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2
PRINTS

PR00452--SH3DOMAIN
SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3
Gene Ontology

GO:0005938--C:cell cortex
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0001726--C:ruffle
GO:0000322--C:storage vacuole
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0019901--F:protein kinase binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048013--P:ephrin receptor signaling pathway
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007399--P:nervous system development
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:0043547--P:positive regulation of GTPase activity
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction
KEGG hsa:8874
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001259 Ailuropoda melanoleuca 91.99 0.00e+00 1335.00
IUUC-Aca-004591 Anolis carolinensis 89.52 0.00e+00 1252.00
IUUC-Ago-008003 Ashbya gossypii 25.00 5.00e-15 76.60
IUUC-Ame-010759 Astyanax mexicanus 74.59 0.00e+00 1134.00
IUUC-Bta-013328 Bos taurus 90.53 0.00e+00 1321.00
IUUC-Bci-013864 Botrytis cinerea 41.54 1.00e-11 66.20
IUUC-Cja-018742 Callithrix jacchus 96.71 0.00e+00 1273.00
IUUC-Cfa-020756 Canis familiaris 93.99 0.00e+00 1135.00
IUUC-Cpo-021284 Cavia porcellus 90.38 0.00e+00 1242.00
IUUC-Csa-023162 Chlorocebus sabaeus 97.22 0.00e+00 1412.00
IUUC-Cho-024736 Choloepus hoffmanni 73.62 2.00e-173 602.00
IUUC-Cin-025535 Ciona intestinalis 39.92 3.00e-94 339.00
IUUC-Cgl-026676 Colletotrichum gloeosporioides 41.43 2.00e-11 65.50
IUUC-Cne-026866 Cryptococcus neoformans 50.79 2.00e-13 72.40
IUUC-Dre-028646 Danio rerio 74.72 0.00e+00 1126.00
IUUC-Dno-029461 Dasypus novemcinctus 93.31 0.00e+00 1351.00
IUUC-Dor-030623 Dipodomys ordii 82.35 0.00e+00 1081.00
IUUC-Dme-032219 Drosophila melanogaster 46.51 5.00e-103 369.00
IUUC-Ete-032236 Echinops telfairi 80.24 0.00e+00 805.00
IUUC-Eca-034137 Equus caballus 96.22 0.00e+00 1191.00
IUUC-Fca-035742 Felis catus 95.08 0.00e+00 1115.00
IUUC-Fal-037205 Ficedula albicollis 93.81 0.00e+00 1025.00
IUUC-Fox-037757 Fusarium oxysporum 38.89 2.00e-11 65.50
IUUC-Gmo-039475 Gadus morhua 74.49 0.00e+00 995.00
IUUC-Gga-040539 Gallus gallus 93.15 0.00e+00 974.00
IUUC-Gac-042615 Gasterosteus aculeatus 71.64 0.00e+00 932.00
IUUC-Ggo-044470 Gorilla gorilla 98.43 0.00e+00 1251.00
IUUC-Loc-052146 Lepisosteus oculatus 83.10 0.00e+00 1218.00
IUUC-Laf-053891 Loxodonta africana 89.02 0.00e+00 1290.00
IUUC-Mcc-055483 Macaca mulatta 99.38 0.00e+00 1476.00
IUUC-Mga-059410 Meleagris gallopavo 93.20 0.00e+00 1162.00
IUUC-Mmr-060758 Microcebus murinus 94.52 0.00e+00 1341.00
IUUC-Mdo-061900 Monodelphis domestica 90.86 0.00e+00 1276.00
IUUC-Mmu-063849 Mus musculus 92.03 0.00e+00 1312.00
IUUC-Mpu-065876 Mustela putorius furo 94.11 0.00e+00 1126.00
IUUC-Mlu-067970 Myotis lucifugus 95.63 0.00e+00 1186.00
IUUC-Nle-069685 Nomascus leucogenys 96.04 0.00e+00 1071.00
IUUC-Opr-071132 Ochotona princeps 64.61 0.00e+00 731.00
IUUC-Ont-071815 Oreochromis niloticus 75.44 0.00e+00 1124.00
IUUC-Oan-073057 Ornithorhynchus anatinus 92.35 0.00e+00 1035.00
IUUC-Ola-086663 Oryzias latipes 73.14 0.00e+00 957.00
IUUC-Oga-088103 Otolemur garnettii 94.79 0.00e+00 1143.00
IUUC-Ptr-091162 Pan troglodytes 96.81 0.00e+00 1328.00
IUUC-Pan-092093 Papio anubis 86.27 0.00e+00 1256.00
IUUC-Pma-094701 Petromyzon marinus 61.40 2.00e-131 462.00
IUUC-Pfo-096736 Poecilia formosa 71.19 0.00e+00 1025.00
IUUC-Pab-097641 Pongo abelii 96.73 0.00e+00 1347.00
IUUC-Pva-102819 Pteropus vampyrus 90.41 0.00e+00 1301.00
IUUC-Pgr-103400 Puccinia graminis 27.00 5.00e-20 94.00
IUUC-Pte-104123 Pyrenophora teres 42.86 2.00e-10 61.60
IUUC-Pyt-104567 Pyrenophora triticirepentis 42.86 2.00e-10 61.60
IUUC-Rno-106099 Rattus norvegicus 91.79 0.00e+00 1284.00
IUUC-Sha-106845 Sarcophilus harrisii 92.41 0.00e+00 1119.00
IUUC-Stu-112434 Solanum tuberosum 46.15 1.00e-09 57.40
IUUC-Ssc-116036 Sus scrofa 94.27 0.00e+00 1115.00
IUUC-Tgu-117498 Taeniopygia guttata 87.75 0.00e+00 1249.00
IUUC-Tru-118278 Takifugu rubripes 72.33 0.00e+00 962.00
IUUC-Tsy-118990 Tarsius syrichta 93.54 0.00e+00 988.00
IUUC-Tni-120852 Tetraodon nigroviridis 73.57 0.00e+00 1009.00
IUUC-Ttr-128922 Tursiops truncatus 88.35 0.00e+00 1159.00
IUUC-Xtr-132012 Xenopus tropicalis 82.85 0.00e+00 1096.00
Created Date 25-Jun-2017

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