iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013138.3	ENSMMUT00000043005.2	ENSMMUP00000036020.2
ENSMMUG00000013138.3	ENSMMUT00000019337.3	ENSMMUP00000018108.3
ENSMMUG00000013138.3	ENSMMUT00000018434.3	ENSMMUP00000017261.3
ENSMMUG00000013138.3	ENSMMUT00000043004.2	ENSMMUP00000036019.2
ENSMMUG00000013138.3	ENSMMUT00000018435.3	ENSMMUP00000017262.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.60e-15	56.4	188	242

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 188  VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--TLNGRTGWFPSNYVREVK 242
           78999*********************7..999*******..8**************996 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP 60
RSESECLSNI REFLRGCGAS LRLELLFPPS QPLQHLVTTI LFSASTFDAN DLYQGQNFNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGGCCGGG GGGGCGGCGC GGGCGCCCGC AGGTTCGAGC CGCCCTGAGA AAGCGCCTGA 60
CAGCGGGCCG GGGCGCACGG AGGAGCGGGC CGGGCCGGAC CTGCTGGGCC GCGCCGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	91.86	0.00e+00	1335.00
IUUC-Aca-004591	Anolis carolinensis	89.14	0.00e+00	1249.00
IUUC-Ago-008003	Ashbya gossypii	25.00	4.00e-15	76.60
IUUC-Ame-010759	Astyanax mexicanus	74.34	0.00e+00	1133.00
IUUC-Bta-013328	Bos taurus	90.40	0.00e+00	1320.00
IUUC-Bci-013864	Botrytis cinerea	43.08	4.00e-12	67.40
IUUC-Cja-018742	Callithrix jacchus	96.44	0.00e+00	1272.00
IUUC-Cfa-020756	Canis familiaris	93.99	0.00e+00	1136.00
IUUC-Cpo-021284	Cavia porcellus	90.17	0.00e+00	1244.00
IUUC-Csa-023162	Chlorocebus sabaeus	97.10	0.00e+00	1410.00
IUUC-Cho-024736	Choloepus hoffmanni	73.14	2.00e-172	599.00
IUUC-Cin-025535	Ciona intestinalis	39.92	7.00e-94	337.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	41.43	2.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	50.79	2.00e-13	72.40
IUUC-Dre-028646	Danio rerio	74.21	0.00e+00	1126.00
IUUC-Dno-029461	Dasypus novemcinctus	93.31	0.00e+00	1352.00
IUUC-Dor-030623	Dipodomys ordii	82.35	0.00e+00	1081.00
IUUC-Dme-032219	Drosophila melanogaster	46.25	2.00e-102	367.00
IUUC-Ete-032236	Echinops telfairi	80.24	0.00e+00	805.00
IUUC-Eca-034137	Equus caballus	96.07	0.00e+00	1189.00
IUUC-Fca-035742	Felis catus	94.92	0.00e+00	1113.00
IUUC-Fal-037205	Ficedula albicollis	93.65	0.00e+00	1025.00
IUUC-Fox-037757	Fusarium oxysporum	38.89	2.00e-11	65.10
IUUC-Gmo-039475	Gadus morhua	73.94	0.00e+00	991.00
IUUC-Gga-040539	Gallus gallus	92.97	0.00e+00	973.00
IUUC-Gac-042615	Gasterosteus aculeatus	71.51	0.00e+00	931.00
IUUC-Ggo-044470	Gorilla gorilla	98.14	0.00e+00	1249.00
IUUC-Hsa-046398	Homo sapiens	99.38	0.00e+00	1476.00
IUUC-Loc-052146	Lepisosteus oculatus	82.98	0.00e+00	1219.00
IUUC-Laf-053891	Loxodonta africana	88.89	0.00e+00	1288.00
IUUC-Mga-059410	Meleagris gallopavo	92.91	0.00e+00	1161.00
IUUC-Mmr-060758	Microcebus murinus	94.40	0.00e+00	1340.00
IUUC-Mdo-061900	Monodelphis domestica	90.72	0.00e+00	1275.00
IUUC-Mmu-063849	Mus musculus	91.78	0.00e+00	1310.00
IUUC-Mpu-065876	Mustela putorius furo	93.95	0.00e+00	1125.00
IUUC-Mlu-067970	Myotis lucifugus	95.49	0.00e+00	1186.00
IUUC-Nle-069685	Nomascus leucogenys	95.86	0.00e+00	1071.00
IUUC-Opr-071132	Ochotona princeps	64.33	0.00e+00	728.00
IUUC-Ont-071815	Oreochromis niloticus	75.19	0.00e+00	1125.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.18	0.00e+00	1035.00
IUUC-Ola-086663	Oryzias latipes	72.74	0.00e+00	956.00
IUUC-Oga-088103	Otolemur garnettii	95.08	0.00e+00	1147.00
IUUC-Ptr-091162	Pan troglodytes	96.54	0.00e+00	1324.00
IUUC-Pan-092093	Papio anubis	86.39	0.00e+00	1258.00
IUUC-Pma-094701	Petromyzon marinus	61.40	3.00e-131	461.00
IUUC-Pfo-096736	Poecilia formosa	70.68	0.00e+00	1023.00
IUUC-Pab-097641	Pongo abelii	96.59	0.00e+00	1346.00
IUUC-Pva-102819	Pteropus vampyrus	90.41	0.00e+00	1300.00
IUUC-Pgr-103400	Puccinia graminis	27.00	5.00e-20	93.60
IUUC-Pyt-104567	Pyrenophora triticirepentis	42.86	2.00e-10	61.60
IUUC-Rno-106099	Rattus norvegicus	91.54	0.00e+00	1282.00
IUUC-Sha-106845	Sarcophilus harrisii	92.83	0.00e+00	1118.00
IUUC-Sja-107728	Schizosaccharomyces japonicus	24.34	9.00e-11	62.80
IUUC-Ssl-108538	Sclerotinia sclerotiorum	41.54	3.00e-11	64.70
IUUC-Ssc-116036	Sus scrofa	93.67	0.00e+00	1116.00
IUUC-Tgu-117498	Taeniopygia guttata	87.63	0.00e+00	1247.00
IUUC-Tru-118278	Takifugu rubripes	71.93	0.00e+00	960.00
IUUC-Tsy-118990	Tarsius syrichta	93.84	0.00e+00	983.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.43	0.00e+00	1008.00
IUUC-Ttr-128922	Tursiops truncatus	88.22	0.00e+00	1157.00
IUUC-Xtr-132012	Xenopus tropicalis	82.85	0.00e+00	1098.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence