iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040611

Ensembl Protein ID

ENSGALP00000051910.1

UniProt Accession

Q5SDR3; BMI1_CHICK

Genbank Protein ID

AAU25821.1

Protein Name

Polycomb complex protein BMI-1; Polycomb group RING finger protein 4

Genbank Nucleotide ID

AY616032

Gene Name

BMI1; PCGF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000041267.1	ENSGALT00000047281.1	ENSGALP00000051910.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.30e-06	27.9	18	57
ULD/UDP/UFD/RAWUL	2.00e-30	105.5	131	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C   f d + +  C H f+++C+ ++        ++ +CP+C+
   Q: 18   CVLCGGYFIDATTIIECLHSFCKTCIVRY------LETSKYCPICD 57
           ********99999****************......**********5 PP

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk..........lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwkkeg 79
           isls+e++++n+ +++ +          ++k+ylrc+a++tV+hl+kfl++k+++++++++d+++e+e+L+d++tL++i+yi++w+++g
   Q: 131  ISLSIEFFDQNRLERKGNkekekskeevNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNG 219
           6788888888877665555677788999************************************************************* PP
   S: 80   pLvLqYr 86
           pL+L+Yr
   Q: 220  PLPLKYR 226
           ******9 PP

Organism

Gallus gallus

Functional Description
(View)

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).

Protein Sequence
(Fasta)

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 60
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGCGGGG AGGCGGCGGC GAAAAGGAGG CATCGGCGGC GCGCGGGCGG GCGCGTGCAG 60
GGCCGGGGGG AGGGGAGGGG GCGGCGGGGG GGGGCGGGGG GAAGCGGGGG AGGAGGAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0000792--C:heterochromatin
GO:0016604--C:nuclear body
GO:0031519--C:PcG protein complex
GO:0000151--C:ubiquitin ligase complex
GO:1990841--F:promoter-specific chromatin binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0006306--P:DNA methylation
GO:0048704--P:embryonic skeletal system morphogenesis
GO:0016573--P:histone acetylation
GO:0016574--P:histone ubiquitination
GO:0006959--P:humoral immune response
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030890--P:positive regulation of B cell proliferation
GO:0033092--P:positive regulation of immature T cell proliferation in thymus
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0021903--P:rostrocaudal neural tube patterning
GO:0048103--P:somatic stem cell division
GO:0006351--P:transcription, DNA-templated

KEGG

gga:493647

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001498	Ailuropoda melanoleuca	95.09	2.00e-160	557.00
IUUC-Atr-002463	Amborella trichopoda	35.79	9.00e-12	64.30
IUUC-Apl-004208	Anas platyrhynchos	98.61	4.00e-138	483.00
IUUC-Aca-004661	Anolis carolinensis	85.58	7.00e-141	493.00
IUUC-Ame-010610	Astyanax mexicanus	71.12	9.00e-134	469.00
IUUC-Bta-012606	Bos taurus	95.71	4.00e-161	560.00
IUUC-Bol-015090	Brassica oleracea	36.73	4.00e-13	68.90
IUUC-Cja-019482	Callithrix jacchus	95.22	2.00e-168	583.00
IUUC-Cfa-020482	Canis familiaris	95.09	2.00e-160	557.00
IUUC-Cpo-022061	Cavia porcellus	95.22	2.00e-168	584.00
IUUC-Csa-024102	Chlorocebus sabaeus	95.54	6.00e-170	590.00
IUUC-Cho-025081	Choloepus hoffmanni	79.12	4.00e-104	370.00
IUUC-Cin-025612	Ciona intestinalis	48.58	7.00e-52	197.00
IUUC-Dre-027929	Danio rerio	80.43	4.00e-140	490.00
IUUC-Dno-029797	Dasypus novemcinctus	95.86	7.00e-177	612.00
IUUC-Dor-030256	Dipodomys ordii	92.68	5.00e-162	563.00
IUUC-Dme-031904	Drosophila melanogaster	44.30	6.00e-52	200.00
IUUC-Ete-033148	Echinops telfairi	63.87	6.00e-82	296.00
IUUC-Eca-033318	Equus caballus	95.71	3.00e-161	560.00
IUUC-Eeu-034547	Erinaceus europaeus	82.80	9.00e-139	485.00
IUUC-Fca-035866	Felis catus	95.40	6.00e-161	559.00
IUUC-Fal-036660	Ficedula albicollis	98.47	7.00e-162	562.00
IUUC-Gmo-039341	Gadus morhua	82.31	1.00e-125	441.00
IUUC-Gac-041888	Gasterosteus aculeatus	72.19	3.00e-129	454.00
IUUC-Gma-042798	Glycine max	39.02	4.00e-12	65.50
IUUC-Ggo-045027	Gorilla gorilla	95.54	6.00e-169	586.00
IUUC-Hsa-045665	Homo sapiens	95.54	1.00e-169	589.00
IUUC-Itr-049045	Ictidomys tridecemlineatus	93.95	2.00e-167	581.00
IUUC-Lch-049714	Latimeria chalumnae	86.54	4.00e-162	563.00
IUUC-Lpe-051490	Leersia perrieri	42.03	9.00e-12	64.30
IUUC-Loc-052161	Lepisosteus oculatus	83.18	8.00e-143	499.00
IUUC-Laf-054108	Loxodonta africana	93.40	3.00e-166	577.00
IUUC-Mcc-055562	Macaca mulatta	95.54	7.00e-170	589.00
IUUC-Meu-056709	Macropus eugenii	95.71	3.00e-164	570.00
IUUC-Mtr-058158	Medicago truncatula	43.42	3.00e-10	57.40
IUUC-Mga-060104	Meleagris gallopavo	98.39	4.00e-125	440.00
IUUC-Mmr-061191	Microcebus murinus	95.54	7.00e-170	589.00
IUUC-Mdo-062711	Monodelphis domestica	91.73	1.00e-145	508.00
IUUC-Mmu-064255	Mus musculus	92.04	4.00e-161	560.00
IUUC-Mpu-066466	Mustela putorius furo	94.79	5.00e-160	556.00
IUUC-Mlu-067622	Myotis lucifugus	94.90	8.00e-168	582.00
IUUC-Nle-069253	Nomascus leucogenys	95.54	6.00e-170	590.00
IUUC-Opr-070511	Ochotona princeps	95.54	4.00e-168	583.00
IUUC-Ont-072177	Oreochromis niloticus	85.06	9.00e-128	449.00
IUUC-Oan-073336	Ornithorhynchus anatinus	96.93	3.00e-164	570.00
IUUC-Ocu-074113	Oryctolagus cuniculus	94.90	6.00e-164	569.00
IUUC-Olo-080821	Oryza longistaminata	39.44	1.00e-10	60.80
IUUC-Ola-087057	Oryzias latipes	83.33	1.00e-122	432.00
IUUC-Oga-088346	Otolemur garnettii	95.54	6.00e-169	586.00
IUUC-Oar-089843	Ovis aries	95.71	4.00e-161	560.00
IUUC-Ptr-090486	Pan troglodytes	95.54	6.00e-169	586.00
IUUC-Pan-092667	Papio anubis	96.60	2.00e-151	528.00
IUUC-Psi-093469	Pelodiscus sinensis	98.16	4.00e-171	593.00
IUUC-Pma-094481	Petromyzon marinus	73.36	4.00e-89	320.00
IUUC-Ppa-095526	Physcomitrella patens	40.22	9.00e-10	58.20
IUUC-Pfo-097156	Poecilia formosa	80.41	6.00e-132	463.00
IUUC-Pab-097670	Pongo abelii	95.54	6.00e-169	586.00
IUUC-Pop-099100	Populus trichocarpa	37.65	2.00e-12	67.00
IUUC-Pva-102800	Pteropus vampyrus	95.54	6.00e-169	586.00
IUUC-Rno-105128	Rattus norvegicus	90.76	2.00e-159	554.00
IUUC-Sha-106747	Sarcophilus harrisii	96.01	1.00e-160	558.00
IUUC-Sly-111012	Solanum lycopersicum	45.07	6.00e-13	68.60
IUUC-Stu-112047	Solanum tuberosum	45.07	9.00e-13	67.80
IUUC-Sar-113416	Sorex araneus	95.54	5.00e-168	583.00
IUUC-Sbi-114697	Sorghum bicolor	40.85	2.00e-10	60.50
IUUC-Ssc-115864	Sus scrofa	95.54	5.00e-169	586.00
IUUC-Tgu-116851	Taeniopygia guttata	97.57	7.00e-139	486.00
IUUC-Tru-117698	Takifugu rubripes	86.59	3.00e-122	431.00
IUUC-Tsy-119590	Tarsius syrichta	95.54	5.00e-169	586.00
IUUC-Tni-120170	Tetraodon nigroviridis	73.23	1.00e-126	445.00
IUUC-Tbe-127790	Tupaia belangeri	95.22	7.00e-169	585.00
IUUC-Ttr-129316	Tursiops truncatus	95.54	7.00e-170	589.00
IUUC-Vpa-130669	Vicugna pacos	95.71	3.00e-161	560.00
IUUC-Xtr-131912	Xenopus tropicalis	88.69	5.00e-147	513.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence