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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105812
Ensembl Protein ID ENSRNOP00000069034.1
UniProt Accession Q8R5M4; Q5PQX8; OPTN_RAT
Genbank Protein ID BAB84696.2; AAH86976.1
Protein Name Optineurin; FIP-2-like protein
Genbank Nucleotide ID AB069907; BC086976
Gene Name Optn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000017941.8 ENSRNOT00000042881.6 ENSRNOP00000045795.4
ENSRNOG00000017941.8 ENSRNOT00000083342.1 ENSRNOP00000069034.1
ENSRNOG00000017941.8 ENSRNOT00000024162.7 ENSRNOP00000024162.3
ENSRNOG00000017941.8 ENSRNOT00000091561.1 ENSRNOP00000072832.1
ENSRNOG00000017941.8 ENSRNOT00000081940.1 ENSRNOP00000068551.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBAN UBAN 21059646
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBAN 8.80e-24 83.6 458 514
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBAN
   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndsl 57
           +ee+let+ vL++Q+e+Y++DF+aERa+RE+++eeke+L+ q++ l+k+++ ++d++
   Q: 458  QEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDFEDGG 514
           79****************************************************986 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
 Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as of transferrin receptor (TFRC/TfR); regulates Rab8 recruitnment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family; targets ubiquitin-coated bacteria (xenophagy) and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52.
Protein Sequence
(Fasta)
MSHQPLSCLT EKGDSSCETP GNGPSNMVHP NLDTFTPEEL LQQMKELLVE NHQLKEAMKL 60
NNQAMKGRFE ELSAWTEKQK EERQLFEIQS KEAKERLKAL SHENERLKEE LGKLKEKSER 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105812|UBD,UBAN|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCGAGGCCG CGCGTCACCG TCCAGCTGCC CGGTCGCCGC CCCCTGGCCG GTCCCTGGCG 60
GGCGTCGGCA TCCAGAGCTT TGGGACAAGA TGCCAACGAA GCAGTGACCT GAGAGGAGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105812|UBD,UBAN|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR032939--Optineurin
IPR034735--ZF_CCHC_NOA
PROSITE

PS51801--ZF_CCHC_NOA
Pfam

PF16516--CC2-LZ
PF11577--NEMO
Gene Ontology

GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0031410--C:cytoplasmic vesicle
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0055037--C:recycling endosome
GO:0005802--C:trans-Golgi network
GO:0042802--F:identical protein binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0001155--F:TFIIIA-class transcription factor binding
GO:0043130--F:ubiquitin binding
GO:0006914--P:autophagy
GO:0034620--P:cellular response to unfolded protein
GO:0050663--P:cytokine secretion
GO:0007030--P:Golgi organization
GO:0090161--P:Golgi ribbon formation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0008284--P:positive regulation of cell proliferation
GO:0051260--P:protein homooligomerization
GO:0000042--P:protein targeting to Golgi
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0042060--P:wound healing
KEGG rno:246294
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002037 Ailuropoda melanoleuca 77.74 0.00e+00 742.00
IUUC-Apl-003812 Anas platyrhynchos 54.47 9.00e-141 493.00
IUUC-Aca-004625 Anolis carolinensis 52.47 1.00e-138 486.00
IUUC-Aly-005781 Arabidopsis lyrata 34.29 9.00e-04 38.10
IUUC-Ame-011116 Astyanax mexicanus 35.99 5.00e-65 241.00
IUUC-Bta-013240 Bos taurus 79.01 0.00e+00 865.00
IUUC-Cja-019911 Callithrix jacchus 78.72 0.00e+00 805.00
IUUC-Cfa-020330 Canis familiaris 79.86 0.00e+00 796.00
IUUC-Cpo-021753 Cavia porcellus 75.51 0.00e+00 776.00
IUUC-Csa-023662 Chlorocebus sabaeus 79.22 0.00e+00 801.00
IUUC-Cho-024574 Choloepus hoffmanni 62.88 4.00e-119 421.00
IUUC-Cme-027299 Cyanidioschyzon merolae 35.96 3.00e-03 36.60
IUUC-Dre-027720 Danio rerio 39.79 2.00e-88 319.00
IUUC-Dno-029079 Dasypus novemcinctus 75.60 0.00e+00 734.00
IUUC-Dor-030890 Dipodomys ordii 77.16 0.00e+00 815.00
IUUC-Dme-032072 Drosophila melanogaster 27.01 8.00e-04 38.10
IUUC-Ete-032568 Echinops telfairi 76.54 0.00e+00 692.00
IUUC-Eca-033528 Equus caballus 80.72 0.00e+00 825.00
IUUC-Eeu-035219 Erinaceus europaeus 70.12 0.00e+00 749.00
IUUC-Fca-035852 Felis catus 79.56 0.00e+00 798.00
IUUC-Fal-036862 Ficedula albicollis 52.44 3.00e-128 452.00
IUUC-Gmo-038735 Gadus morhua 38.01 2.00e-69 256.00
IUUC-Gga-040939 Gallus gallus 50.34 8.00e-132 464.00
IUUC-Gac-041580 Gasterosteus aculeatus 42.21 6.00e-90 324.00
IUUC-Gma-044378 Glycine max 38.46 1.20e-01 30.80
IUUC-Ggo-045034 Gorilla gorilla 71.33 0.00e+00 736.00
IUUC-Hsa-046624 Homo sapiens 79.05 0.00e+00 820.00
IUUC-Itr-048288 Ictidomys tridecemlineatus 71.55 0.00e+00 751.00
IUUC-Lch-049720 Latimeria chalumnae 47.49 1.00e-80 293.00
IUUC-Loc-052185 Lepisosteus oculatus 43.92 1.00e-96 347.00
IUUC-Laf-054079 Loxodonta africana 78.72 0.00e+00 797.00
IUUC-Mcc-055674 Macaca mulatta 80.03 0.00e+00 801.00
IUUC-Meu-056769 Macropus eugenii 82.25 9.00e-69 254.00
IUUC-Mga-060203 Meleagris gallopavo 53.07 4.00e-131 461.00
IUUC-Mmr-061492 Microcebus murinus 78.84 0.00e+00 786.00
IUUC-Mdo-063051 Monodelphis domestica 71.31 0.00e+00 753.00
IUUC-Mmu-063409 Mus musculus 89.57 0.00e+00 1027.00
IUUC-Mpu-065907 Mustela putorius furo 76.40 0.00e+00 790.00
IUUC-Mlu-066957 Myotis lucifugus 77.13 0.00e+00 729.00
IUUC-Nle-069973 Nomascus leucogenys 79.39 0.00e+00 818.00
IUUC-Opr-071049 Ochotona princeps 73.60 0.00e+00 699.00
IUUC-Ont-071915 Oreochromis niloticus 41.29 4.00e-86 311.00
IUUC-Oan-072965 Ornithorhynchus anatinus 70.29 0.00e+00 733.00
IUUC-Ocu-074029 Oryctolagus cuniculus 72.11 0.00e+00 654.00
IUUC-Ola-087019 Oryzias latipes 41.41 6.00e-89 321.00
IUUC-Oga-088613 Otolemur garnettii 78.25 0.00e+00 800.00
IUUC-Oar-090386 Ovis aries 78.33 0.00e+00 858.00
IUUC-Ptr-091619 Pan troglodytes 78.72 0.00e+00 817.00
IUUC-Pan-092178 Papio anubis 78.66 0.00e+00 785.00
IUUC-Psi-093214 Pelodiscus sinensis 58.53 2.00e-155 542.00
IUUC-Pfo-096901 Poecilia formosa 37.96 8.00e-77 281.00
IUUC-Pab-097560 Pongo abelii 72.01 0.00e+00 699.00
IUUC-Pca-100853 Procavia capensis 67.06 7.00e-109 387.00
IUUC-Pva-102255 Pteropus vampyrus 74.66 0.00e+00 706.00
IUUC-Sha-107225 Sarcophilus harrisii 75.60 5.00e-148 517.00
IUUC-Sar-113736 Sorex araneus 70.08 9.00e-125 440.00
IUUC-Ssc-115422 Sus scrofa 78.16 0.00e+00 832.00
IUUC-Tgu-116924 Taeniopygia guttata 54.05 8.00e-137 480.00
IUUC-Tru-117695 Takifugu rubripes 38.55 4.00e-88 318.00
IUUC-Tsy-119090 Tarsius syrichta 75.82 2.00e-141 495.00
IUUC-Tni-120645 Tetraodon nigroviridis 41.01 2.00e-90 326.00
IUUC-Tbe-127970 Tupaia belangeri 83.97 1.00e-118 420.00
IUUC-Ttr-129244 Tursiops truncatus 76.70 0.00e+00 767.00
IUUC-Vpa-130313 Vicugna pacos 75.34 0.00e+00 735.00
IUUC-Xtr-132115 Xenopus tropicalis 44.34 1.00e-97 350.00
IUUC-Xma-133867 Xiphophorus maculatus 38.49 5.00e-80 291.00
Created Date 25-Jun-2017

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