iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098079

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01180084

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003621.2	ENSPPYT00000004312.2	ENSPPYP00000004143.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	8.40e-10	39.1	16	55
E3 activity/RING/U-box	1.70e-09	37.7	12	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f++ p++  CgH f+++C+ ++      + +   CP+Cr
   Q: 16   CPICLDPFME-PVSIECGHSFCQECISQV-----GKGGGSVCPVCR 55
           **********.***************999.....6788888****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  CpI l+++ +Pv +++G+++ +++I +  + gg+ cPv+rq++  ++l Pn  l ++++
   Q: 12   EEVTCPICLDPFMEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVN 74
           6889***************************9999999******************9988875 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPICL DPFMEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 60
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTTCCTCT CAGACTTGCC TCTGAGCGGA AACTGAAAGT GAAATAGGGA GCTGGCTACC 60
AGCGCTGAGT CCCCTGCAAA GGTGAGTGAA CCCCACTAGA TCAAGGGACC CCTGCCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	75.35	4.00e-155	541.00
IUUC-Bta-013083	Bos taurus	67.80	1.00e-126	446.00
IUUC-Bol-016562	Brassica oleracea	45.10	5.00e-09	53.90
IUUC-Cel-018124	Caenorhabditis elegans	21.13	1.00e-12	67.00
IUUC-Cja-019002	Callithrix jacchus	88.95	1.00e-177	615.00
IUUC-Cfa-020415	Canis familiaris	71.84	1.00e-144	506.00
IUUC-Cpo-021948	Cavia porcellus	68.64	5.00e-132	464.00
IUUC-Csa-023135	Chlorocebus sabaeus	91.78	1.00e-162	565.00
IUUC-Cho-024493	Choloepus hoffmanni	65.40	9.00e-99	352.00
IUUC-Dno-030061	Dasypus novemcinctus	68.30	5.00e-141	494.00
IUUC-Dor-030451	Dipodomys ordii	70.85	1.00e-84	306.00
IUUC-Ete-033168	Echinops telfairi	69.41	3.00e-144	504.00
IUUC-Eca-033578	Equus caballus	76.49	8.00e-150	523.00
IUUC-Eeu-034749	Erinaceus europaeus	54.19	6.00e-85	307.00
IUUC-Fca-035468	Felis catus	69.05	1.00e-138	486.00
IUUC-Ggo-045190	Gorilla gorilla	94.90	3.00e-180	624.00
IUUC-Hsa-046583	Homo sapiens	95.18	0.00e+00	628.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	73.80	8.00e-152	530.00
IUUC-Kpa-049137	Komagataella pastoris	29.47	7.00e-09	55.10
IUUC-Laf-053455	Loxodonta africana	71.39	2.00e-140	491.00
IUUC-Mcc-054609	Macaca mulatta	91.22	7.00e-161	560.00
IUUC-Mmr-061369	Microcebus murinus	74.01	1.00e-125	442.00
IUUC-Mmu-063166	Mus musculus	66.08	2.00e-125	442.00
IUUC-Mpu-066889	Mustela putorius furo	72.24	8.00e-150	523.00
IUUC-Mlu-067647	Myotis lucifugus	74.79	2.00e-131	462.00
IUUC-Nle-069567	Nomascus leucogenys	93.20	1.00e-177	615.00
IUUC-Opr-071178	Ochotona princeps	60.92	5.00e-110	390.00
IUUC-Ocu-074104	Oryctolagus cuniculus	65.60	1.00e-69	255.00
IUUC-Olu-087666	Ostreococcus lucimarinus	32.95	2.00e-11	63.50
IUUC-Oga-088611	Otolemur garnettii	70.08	4.00e-92	330.00
IUUC-Oar-090413	Ovis aries	72.52	3.00e-132	465.00
IUUC-Ptr-091187	Pan troglodytes	95.18	0.00e+00	628.00
IUUC-Pan-092231	Papio anubis	91.78	9.00e-162	563.00
IUUC-Pca-100639	Procavia capensis	73.26	8.00e-142	496.00
IUUC-Pva-102476	Pteropus vampyrus	74.22	3.00e-144	504.00
IUUC-Rno-105054	Rattus norvegicus	64.84	1.00e-104	372.00
IUUC-Sar-113204	Sorex araneus	70.62	4.00e-124	438.00
IUUC-Ssc-116291	Sus scrofa	73.09	1.00e-139	489.00
IUUC-Tsy-118803	Tarsius syrichta	73.73	4.00e-73	268.00
IUUC-Ttr-128914	Tursiops truncatus	72.24	2.00e-120	426.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence