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Tag Content
UUCD2 ID IUUC-Bta-012914
UUCD1 version UUC-BoT-00840
Ensembl Protein ID ENSBTAP00000027965.3
UniProt Accession Q0VBY8; DDB2_BOVIN
Genbank Protein ID AAI20441.1
Protein Name DNA damage-binding protein 2; Damage-specific DNA-binding protein 2
Genbank Nucleotide ID BC120440
Gene Name DDB2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000020999.3 ENSBTAT00000027965.3 ENSBTAP00000027965.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.90e-11 42.9 240 273
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           H+ +vt +a+    d+ll+++s D t+k+WDlr+
   Q: 240  HKKKVTHVALnpcCDWLLATASVDQTVKIWDLRQ 273
           7888999999975559***************986 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity).
 Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER (By similarity).
Protein Sequence
(Fasta)
MAPRKRPENQ KTPEVVVRPK SKRNRSPREL EPEAKKLCVK GPGSSRRFDS GLWAGLASLR 60
VPPLCSSIVR ALHQHKLGTA AWPSLQQGLQ QSFLNSLASY RIFQKAAPFD RRATSLAWHP 120
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Protein Fasta Sequence


>IUUC-Bta-012914|E3,WD_repeat|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCTTTTCCT CGTCCCCGCC TTGTTCTCCC CAGAGGCTTC TTAATTCTTC CTCGGCATAG 60
GGCATAGTAC CCCTTCGCAC GGAGGACGCC ATGGCTCCCA GGAAACGCCC AGAAAACCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012914|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR033312--DDB2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0030054--C:cell junction
GO:0031465--C:Cul4B-RING E3 ubiquitin ligase complex
GO:0005654--C:nucleoplasm
GO:0043234--C:protein complex
GO:0003684--F:damaged DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035518--P:histone H2A monoubiquitination
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006290--P:pyrimidine dimer repair
GO:0070914--P:UV-damage excision repair
KEGG bta:519357
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000470 Aegilops tauschii 29.97 7.00e-32 132.00
IUUC-Aml-002203 Ailuropoda melanoleuca 91.75 0.00e+00 780.00
IUUC-Atr-002957 Amborella trichopoda 31.00 5.00e-37 149.00
IUUC-Apl-003832 Anas platyrhynchos 51.32 9.00e-124 437.00
IUUC-Aca-004358 Anolis carolinensis 51.89 2.00e-128 452.00
IUUC-Aly-006296 Arabidopsis lyrata 32.01 4.00e-38 152.00
IUUC-Ath-007115 Arabidopsis thaliana 32.01 1.00e-39 157.00
IUUC-Ame-010817 Astyanax mexicanus 55.22 6.00e-125 441.00
IUUC-Bdi-014261 Brachypodium distachyon 30.79 9.00e-33 134.00
IUUC-Bol-015317 Brassica oleracea 31.10 6.00e-37 148.00
IUUC-Bra-016848 Brassica rapa 31.00 4.00e-37 149.00
IUUC-Cja-018967 Callithrix jacchus 84.78 0.00e+00 726.00
IUUC-Cfa-021238 Canis familiaris 92.43 0.00e+00 752.00
IUUC-Cpo-022063 Cavia porcellus 79.48 0.00e+00 699.00
IUUC-Csa-023382 Chlorocebus sabaeus 84.31 0.00e+00 759.00
IUUC-Cho-024805 Choloepus hoffmanni 61.09 2.00e-92 331.00
IUUC-Dre-028732 Danio rerio 49.18 2.00e-109 389.00
IUUC-Dor-030461 Dipodomys ordii 75.97 2.00e-120 425.00
IUUC-Ete-033038 Echinops telfairi 74.47 0.00e+00 645.00
IUUC-Eca-033772 Equus caballus 89.93 0.00e+00 741.00
IUUC-Eeu-034662 Erinaceus europaeus 68.00 3.00e-71 262.00
IUUC-Fca-036095 Felis catus 90.63 0.00e+00 766.00
IUUC-Gmo-039683 Gadus morhua 50.14 3.00e-106 378.00
IUUC-Gga-040530 Gallus gallus 52.01 5.00e-125 441.00
IUUC-Gac-041517 Gasterosteus aculeatus 50.28 3.00e-98 352.00
IUUC-Gma-043378 Glycine max 31.33 2.00e-38 153.00
IUUC-Ggo-045364 Gorilla gorilla 85.01 0.00e+00 761.00
IUUC-Hsa-046354 Homo sapiens 84.78 0.00e+00 760.00
IUUC-Hvu-047151 Hordeum vulgare 31.29 4.00e-29 122.00
IUUC-Itr-048304 Ictidomys tridecemlineatus 87.11 0.00e+00 759.00
IUUC-Lpe-051256 Leersia perrieri 30.09 3.00e-31 129.00
IUUC-Loc-052398 Lepisosteus oculatus 60.78 4.00e-129 454.00
IUUC-Laf-053562 Loxodonta africana 85.95 0.00e+00 726.00
IUUC-Mcc-055197 Macaca mulatta 64.95 3.00e-153 534.00
IUUC-Meu-056151 Macropus eugenii 75.64 8.00e-122 429.00
IUUC-Mtr-057940 Medicago truncatula 31.40 4.00e-37 149.00
IUUC-Mga-059923 Meleagris gallopavo 51.79 4.00e-132 464.00
IUUC-Mmr-061465 Microcebus murinus 88.49 1.00e-150 525.00
IUUC-Mdo-063063 Monodelphis domestica 67.22 1.00e-159 555.00
IUUC-Mmu-064294 Mus musculus 78.69 0.00e+00 679.00
IUUC-Mac-065598 Musa acuminata 31.48 6.00e-34 138.00
IUUC-Mpu-066831 Mustela putorius furo 90.85 0.00e+00 779.00
IUUC-Mlu-067222 Myotis lucifugus 86.65 0.00e+00 764.00
IUUC-Nle-069581 Nomascus leucogenys 84.54 0.00e+00 761.00
IUUC-Opr-070644 Ochotona princeps 83.96 0.00e+00 717.00
IUUC-Ont-072605 Oreochromis niloticus 51.44 1.00e-116 413.00
IUUC-Oan-072973 Ornithorhynchus anatinus 71.93 6.00e-150 523.00
IUUC-Ocu-074615 Oryctolagus cuniculus 84.07 0.00e+00 742.00
IUUC-Oba-075283 Oryza barthii 29.97 1.00e-31 131.00
IUUC-Obr-076605 Oryza brachyantha 31.02 1.00e-33 137.00
IUUC-Ogl-077512 Oryza glaberrima 29.97 1.00e-31 131.00
IUUC-Ogu-078329 Oryza glumaepatula 29.97 1.00e-31 131.00
IUUC-Oin-079980 Oryza indica 29.97 1.00e-31 130.00
IUUC-Olo-080516 Oryza longistaminata 29.97 5.00e-32 132.00
IUUC-Ome-081415 Oryza meridionalis 29.97 1.00e-31 130.00
IUUC-Oni-082985 Oryza nivara 29.97 1.00e-31 130.00
IUUC-Opu-084159 Oryza punctata 30.89 2.00e-32 133.00
IUUC-Oru-085137 Oryza rufipogon 29.97 7.00e-32 132.00
IUUC-Osa-085614 Oryza sativa 29.97 7.00e-32 132.00
IUUC-Ola-087044 Oryzias latipes 48.22 4.00e-108 385.00
IUUC-Oga-088274 Otolemur garnettii 85.95 0.00e+00 751.00
IUUC-Oar-089826 Ovis aries 99.06 0.00e+00 876.00
IUUC-Ptr-091631 Pan troglodytes 84.78 0.00e+00 760.00
IUUC-Pan-092535 Papio anubis 84.78 0.00e+00 763.00
IUUC-Psi-093815 Pelodiscus sinensis 54.74 9.00e-124 437.00
IUUC-Pma-094474 Petromyzon marinus 49.12 3.00e-97 348.00
IUUC-Ppa-095414 Physcomitrella patens 28.74 6.00e-30 125.00
IUUC-Pfo-096559 Poecilia formosa 45.50 1.00e-101 363.00
IUUC-Pab-098528 Pongo abelii 84.78 0.00e+00 762.00
IUUC-Pop-100064 Populus trichocarpa 29.18 4.00e-35 142.00
IUUC-Pca-100803 Procavia capensis 83.84 0.00e+00 721.00
IUUC-Ppe-101966 Prunus persica 29.88 1.00e-35 144.00
IUUC-Pva-103213 Pteropus vampyrus 89.23 0.00e+00 744.00
IUUC-Rno-105087 Rattus norvegicus 78.92 0.00e+00 699.00
IUUC-Sha-107466 Sarcophilus harrisii 72.58 2.00e-157 548.00
IUUC-Smo-108958 Selaginella moellendorffii 27.51 1.00e-28 121.00
IUUC-Sit-109968 Setaria italica 29.55 6.00e-31 129.00
IUUC-Sly-111495 Solanum lycopersicum 30.49 3.00e-34 140.00
IUUC-Stu-111974 Solanum tuberosum 24.31 4.00e-11 63.50
IUUC-Sar-113272 Sorex araneus 80.24 3.00e-168 584.00
IUUC-Sbi-114706 Sorghum bicolor 28.10 2.00e-27 117.00
IUUC-Ssc-115437 Sus scrofa 90.87 0.00e+00 794.00
IUUC-Tgu-116602 Taeniopygia guttata 51.45 4.00e-122 431.00
IUUC-Tru-118698 Takifugu rubripes 49.58 2.00e-99 356.00
IUUC-Tsy-119027 Tarsius syrichta 83.68 0.00e+00 679.00
IUUC-Tni-119787 Tetraodon nigroviridis 49.16 7.00e-103 367.00
IUUC-Tca-121447 Theobroma cacao 29.13 2.00e-35 143.00
IUUC-Tae-125839 Triticum aestivum 30.18 2.00e-32 133.00
IUUC-Tur-126724 Triticum urartu 30.18 2.00e-32 133.00
IUUC-Tbe-127680 Tupaia belangeri 82.55 3.00e-135 474.00
IUUC-Ttr-128201 Tursiops truncatus 82.90 0.00e+00 691.00
IUUC-Vpa-130451 Vicugna pacos 77.29 1.00e-117 416.00
IUUC-Vvi-131001 Vitis vinifera 31.00 6.00e-38 152.00
IUUC-Xtr-132266 Xenopus tropicalis 62.25 3.00e-131 461.00
IUUC-Xma-133034 Xiphophorus maculatus 50.00 3.00e-114 405.00
Created Date 25-Jun-2017

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