iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089698

Ensembl Protein ID

ENSOARP00000003874.1

UniProt Accession

W5P0C6; W5P0C6_SHEEP

Genbank Protein ID

ENSOARP00000003874

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AMGL01028346

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000003625.1	ENSOART00000003942.1	ENSOARP00000003874.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-135	451.6	537	869

Active Site

Position(s)	Description	Evidence
838	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 624
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 625  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 710
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 711  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDLSDWQKHTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 798
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyA+eet+gF++
   Q: 799  TGTCRLPVGGFTELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAVEETEGFGQ 869
           *********************************************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MASASSSRAG VALPFEKSQL ILKVVSAKPK VHSRQPRINS FVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTCCTGGTG ATGACATGGC ATCTGCCAGC TCCAGCCGGG CAGGGGTGGC CCTGCCTTTT 60
GAGAAGTCTC AGCTTATCCT GAAAGGTGAG TGGCATGGTA TGAAGTTTAT CATTTAAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

KEGG

oas:101122376

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	96.22	0.00e+00	1643.00
IUUC-Apl-003912	Anas platyrhynchos	76.39	0.00e+00	1231.00
IUUC-Aca-004291	Anolis carolinensis	80.32	0.00e+00	1429.00
IUUC-Bta-013231	Bos taurus	99.54	0.00e+00	1646.00
IUUC-Cja-019455	Callithrix jacchus	95.06	0.00e+00	1636.00
IUUC-Cfa-021017	Canis familiaris	96.55	0.00e+00	1627.00
IUUC-Cpo-021988	Cavia porcellus	94.83	0.00e+00	1623.00
IUUC-Csa-023549	Chlorocebus sabaeus	95.17	0.00e+00	1647.00
IUUC-Dre-028513	Danio rerio	91.59	0.00e+00	1130.00
IUUC-Dno-028976	Dasypus novemcinctus	95.41	0.00e+00	1623.00
IUUC-Dor-030176	Dipodomys ordii	91.84	0.00e+00	1489.00
IUUC-Eca-033949	Equus caballus	96.78	0.00e+00	1635.00
IUUC-Eeu-034529	Erinaceus europaeus	88.48	0.00e+00	1350.00
IUUC-Fca-036236	Felis catus	96.09	0.00e+00	1661.00
IUUC-Fal-036948	Ficedula albicollis	95.47	0.00e+00	1168.00
IUUC-Gmo-038842	Gadus morhua	89.42	0.00e+00	1071.00
IUUC-Gga-040617	Gallus gallus	79.78	0.00e+00	1415.00
IUUC-Gac-041338	Gasterosteus aculeatus	89.35	0.00e+00	1075.00
IUUC-Ggo-045278	Gorilla gorilla	95.63	0.00e+00	1651.00
IUUC-Hsa-046148	Homo sapiens	95.63	0.00e+00	1652.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	98.13	0.00e+00	1117.00
IUUC-Lch-050663	Latimeria chalumnae	78.37	0.00e+00	1377.00
IUUC-Loc-052604	Lepisosteus oculatus	75.96	0.00e+00	1298.00
IUUC-Laf-053944	Loxodonta africana	95.29	0.00e+00	1640.00
IUUC-Mcc-055655	Macaca mulatta	95.29	0.00e+00	1648.00
IUUC-Meu-055953	Macropus eugenii	80.05	0.00e+00	1362.00
IUUC-Mga-060190	Meleagris gallopavo	80.05	0.00e+00	1415.00
IUUC-Mmr-060896	Microcebus murinus	95.26	0.00e+00	1607.00
IUUC-Mdo-062536	Monodelphis domestica	90.83	0.00e+00	1585.00
IUUC-Mmu-064017	Mus musculus	94.60	0.00e+00	1600.00
IUUC-Mpu-066608	Mustela putorius furo	93.81	0.00e+00	1575.00
IUUC-Mlu-067623	Myotis lucifugus	93.11	0.00e+00	1568.00
IUUC-Nle-069496	Nomascus leucogenys	93.57	0.00e+00	1602.00
IUUC-Opr-071054	Ochotona princeps	83.27	0.00e+00	1391.00
IUUC-Ont-071279	Oreochromis niloticus	73.74	0.00e+00	1268.00
IUUC-Oan-073512	Ornithorhynchus anatinus	88.53	0.00e+00	1493.00
IUUC-Ocu-074271	Oryctolagus cuniculus	94.75	0.00e+00	1589.00
IUUC-Ola-087237	Oryzias latipes	86.27	0.00e+00	1041.00
IUUC-Oga-088164	Otolemur garnettii	96.09	0.00e+00	1639.00
IUUC-Ptr-091306	Pan troglodytes	94.37	0.00e+00	1621.00
IUUC-Pan-092814	Papio anubis	91.63	0.00e+00	1556.00
IUUC-Pfo-096709	Poecilia formosa	90.38	0.00e+00	1080.00
IUUC-Pab-098494	Pongo abelii	90.39	0.00e+00	1551.00
IUUC-Pca-100596	Procavia capensis	83.45	0.00e+00	1345.00
IUUC-Pva-103154	Pteropus vampyrus	90.96	0.00e+00	1523.00
IUUC-Rno-104954	Rattus norvegicus	94.19	0.00e+00	1391.00
IUUC-Sha-106781	Sarcophilus harrisii	91.28	0.00e+00	1610.00
IUUC-Ssc-116307	Sus scrofa	84.13	0.00e+00	1438.00
IUUC-Tgu-116530	Taeniopygia guttata	75.86	0.00e+00	1182.00
IUUC-Tru-118287	Takifugu rubripes	89.46	0.00e+00	1062.00
IUUC-Tsy-119097	Tarsius syrichta	81.82	0.00e+00	1195.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.36	0.00e+00	1172.00
IUUC-Tbe-127793	Tupaia belangeri	83.33	0.00e+00	1377.00
IUUC-Ttr-128275	Tursiops truncatus	93.10	0.00e+00	1567.00
IUUC-Xtr-132866	Xenopus tropicalis	89.25	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence