iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049808

Ensembl Protein ID

ENSLACP00000016343.1

UniProt Accession

H3B372; H3B372_LATCH

Genbank Protein ID

ENSLACP00000016343

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01070829

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000014399.1	ENSLACT00000016457.1	ENSLACP00000016343.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.70e-82	276.3	3836	4167

Active Site

Position(s)	Description	Evidence
4136	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 3836 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakspLHMNMFRFLGVLLGIAIRTGSPL 3922
           4566****************************************9999*******999999999*********************** PP
   S: 89   dlplsksfyklllgkklsledlee..vdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
            l+l+++++k+l g +l++ dl+e  vd++++  l++i++n+ +  e +++ l f+     +++++ +++  +++ +++ +eN+ eY
   Q: 3923 SLNLAEPVWKQLAGMNLTIADLSEvkVDKDFIPGLMYIRDNEATAEEFEAMVLPFT-----VPSASGQDIQLSSKYTHIVQENRAEY 4004
           **********************973369*************877777788888887.....888999999***************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v+l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++   iqwFwev+e+fs++e
   Q: 4005 VRLAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTAALIQWFWEVMESFSNTE 4089
           ***********.**************************************************77.********************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           r+ fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4090 RSLFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4167
           ***************.8*************999988888***********************************99875 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

ILTCPLSPNE SFLRYLTLPQ DNDLAIDLRQ TAVVVMAHLD RLAVPCMPPQ CSSPTSHKGS 60
LQEVVGWGLL GWKYPANIHG PIQCEALANL GVTQIACAEK CFLILTRNGR VYMQAYNSNT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACTAACAT GCCCTCTGAG TCCAAATGAA AGTTTCCTGA GGTACTTGAC CTTGCCGCAG 60
GACAATGACT TGGCTATAGA CCTGCGGCAG ACAGCAGTGG TTGTCATGGC TCACTTAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50255--CYTOCHROME_B5_2
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00173--Cyt-b5
PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	87.51	0.00e+00	3375.00
IUUC-Apl-003983	Anas platyrhynchos	89.32	0.00e+00	3410.00
IUUC-Aca-004300	Anolis carolinensis	90.68	0.00e+00	3426.00
IUUC-Ath-007268	Arabidopsis thaliana	32.57	3.00e-27	117.00
IUUC-Ame-010621	Astyanax mexicanus	89.27	0.00e+00	3344.00
IUUC-Bta-013067	Bos taurus	87.02	0.00e+00	3328.00
IUUC-Bdi-014093	Brachypodium distachyon	35.38	8.00e-45	176.00
IUUC-Cja-019687	Callithrix jacchus	86.81	0.00e+00	3296.00
IUUC-Cfa-020672	Canis familiaris	87.31	0.00e+00	3373.00
IUUC-Cpo-021819	Cavia porcellus	84.42	0.00e+00	3222.00
IUUC-Csa-023817	Chlorocebus sabaeus	87.31	0.00e+00	3363.00
IUUC-Cho-024387	Choloepus hoffmanni	94.56	0.00e+00	752.00
IUUC-Cin-025709	Ciona intestinalis	58.82	0.00e+00	1430.00
IUUC-Csv-026336	Ciona savignyi	52.72	0.00e+00	1825.00
IUUC-Dre-027717	Danio rerio	86.58	0.00e+00	3308.00
IUUC-Dno-029296	Dasypus novemcinctus	87.76	0.00e+00	3387.00
IUUC-Dor-030979	Dipodomys ordii	95.07	0.00e+00	1066.00
IUUC-Dme-032171	Drosophila melanogaster	71.89	0.00e+00	1264.00
IUUC-Ete-032687	Echinops telfairi	76.55	0.00e+00	1565.00
IUUC-Eca-034046	Equus caballus	85.89	0.00e+00	3294.00
IUUC-Eeu-034859	Erinaceus europaeus	80.70	0.00e+00	1703.00
IUUC-Fca-036262	Felis catus	87.22	0.00e+00	3369.00
IUUC-Fal-037562	Ficedula albicollis	89.26	0.00e+00	3401.00
IUUC-Gmo-038739	Gadus morhua	92.38	0.00e+00	1047.00
IUUC-Gga-040359	Gallus gallus	91.13	0.00e+00	3413.00
IUUC-Gac-041879	Gasterosteus aculeatus	92.73	0.00e+00	1056.00
IUUC-Ggo-044692	Gorilla gorilla	87.11	0.00e+00	3352.00
IUUC-Hsa-045995	Homo sapiens	87.36	0.00e+00	3374.00
IUUC-Loc-052685	Lepisosteus oculatus	86.32	0.00e+00	3323.00
IUUC-Laf-053372	Loxodonta africana	87.27	0.00e+00	3359.00
IUUC-Mcc-054693	Macaca mulatta	87.36	0.00e+00	3366.00
IUUC-Meu-056660	Macropus eugenii	96.51	0.00e+00	1924.00
IUUC-Mga-059371	Meleagris gallopavo	87.65	0.00e+00	3313.00
IUUC-Mmr-060787	Microcebus murinus	87.51	0.00e+00	3397.00
IUUC-Mdo-062518	Monodelphis domestica	83.39	0.00e+00	3163.00
IUUC-Mmu-063690	Mus musculus	86.97	0.00e+00	3334.00
IUUC-Mpu-066478	Mustela putorius furo	86.35	0.00e+00	3314.00
IUUC-Mlu-067596	Myotis lucifugus	81.15	0.00e+00	2006.00
IUUC-Nle-069445	Nomascus leucogenys	74.23	0.00e+00	951.00
IUUC-Opr-070990	Ochotona princeps	94.66	0.00e+00	2315.00
IUUC-Ont-072285	Oreochromis niloticus	89.51	0.00e+00	3345.00
IUUC-Oan-072721	Ornithorhynchus anatinus	85.83	0.00e+00	3417.00
IUUC-Ocu-074273	Oryctolagus cuniculus	87.52	0.00e+00	3376.00
IUUC-Ola-087346	Oryzias latipes	93.84	0.00e+00	1207.00
IUUC-Oga-088742	Otolemur garnettii	86.77	0.00e+00	3336.00
IUUC-Oar-090093	Ovis aries	87.21	0.00e+00	3362.00
IUUC-Ptr-091034	Pan troglodytes	78.93	0.00e+00	2965.00
IUUC-Pan-092783	Papio anubis	87.27	0.00e+00	3360.00
IUUC-Psi-094027	Pelodiscus sinensis	88.73	0.00e+00	3402.00
IUUC-Pfo-096208	Poecilia formosa	80.11	0.00e+00	1899.00
IUUC-Pva-103147	Pteropus vampyrus	73.33	0.00e+00	932.00
IUUC-Rno-105458	Rattus norvegicus	86.97	0.00e+00	3328.00
IUUC-Sha-106959	Sarcophilus harrisii	81.91	0.00e+00	3038.00
IUUC-Sar-113532	Sorex araneus	82.09	0.00e+00	967.00
IUUC-Sbi-114352	Sorghum bicolor	31.75	7.00e-47	182.00
IUUC-Ssc-116304	Sus scrofa	94.84	0.00e+00	950.00
IUUC-Tgu-116789	Taeniopygia guttata	85.97	0.00e+00	3308.00
IUUC-Tru-118129	Takifugu rubripes	89.21	0.00e+00	3355.00
IUUC-Tsy-119302	Tarsius syrichta	68.27	0.00e+00	917.00
IUUC-Tni-120374	Tetraodon nigroviridis	88.78	0.00e+00	3334.00
IUUC-Tbe-128137	Tupaia belangeri	71.07	0.00e+00	1420.00
IUUC-Ttr-128273	Tursiops truncatus	79.86	0.00e+00	1818.00
IUUC-Vpa-130471	Vicugna pacos	68.38	0.00e+00	1230.00
IUUC-Xtr-132185	Xenopus tropicalis	87.80	0.00e+00	3388.00
IUUC-Xma-133233	Xiphophorus maculatus	89.20	0.00e+00	3319.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence