iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118129

UUCD1 version

UUC-TaR-00485

Ensembl Protein ID

ENSTRUP00000023760.1

UniProt Accession

H2TGG2; H2TGG2_TAKRU

Protein Name

Uncharacterized protein

Gene Name

herc2; LOC101064050

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000009456.1	ENSTRUT00000023858.1	ENSTRUP00000023760.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-86	289.9	4462	4791

Active Site

Position(s)	Description	Evidence
4760	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4462 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakspLHMSMFRFLGVLLGIAIRTGSPL 4548
           4566****************************************9999*******999999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++ sl++i++n+ +  e ++++l f+     +++++ +++  +++  ++t eN+ eYv+
   Q: 4549 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPSLMYIRDNEATAEEFEAMTLPFT-----VPNASGQDIQLSSKYSHITLENRAEYVR 4630
           ***************************************998999999999998.....7889999999****************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++s  iqwFwev+e+fs++er+
   Q: 4631 LAINYRLHE-FDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-VEPTSALIQWFWEVMESFSNTERS 4715
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fv++     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4716 LFLRFVWGRTRLP-RTIADFRGRDFVVQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4791
           *************.8*************999988888***********************************99875 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MPSLSFTLDA QLRFHDKWLK IDLQRAFSPE GLSEMWNEMV IDEEITFNRE ESAHTGKVVH 60
PENCSSLSGT KKDETNDKEK KEDEDLLTSV HHSIIETWDW GRQPDESELK ECLAVLVEDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCTC TGTCTTTCAC CCTCGATGCT CAGCTAAGAT TCCATGACAA ATGGCTGAAG 60
ATAGATTTAC AGGTATGCAG TCTAAAAATT CTGTACTGTT ACTGTTTACT TTTCTGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR000859--CUB_dom
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	84.16	0.00e+00	6309.00
IUUC-Atr-003065	Amborella trichopoda	34.45	8.00e-51	196.00
IUUC-Apl-003983	Anas platyrhynchos	84.86	0.00e+00	7748.00
IUUC-Aca-004300	Anolis carolinensis	84.62	0.00e+00	7649.00
IUUC-Aly-006441	Arabidopsis lyrata	33.33	8.00e-44	172.00
IUUC-Ame-010621	Astyanax mexicanus	91.77	0.00e+00	7412.00
IUUC-Bta-013067	Bos taurus	82.05	0.00e+00	7401.00
IUUC-Bdi-014093	Brachypodium distachyon	33.51	1.00e-49	191.00
IUUC-Bol-015203	Brassica oleracea	34.55	3.00e-52	200.00
IUUC-Bra-016737	Brassica rapa	34.27	1.00e-47	184.00
IUUC-Cja-019687	Callithrix jacchus	81.58	0.00e+00	7296.00
IUUC-Cfa-020672	Canis familiaris	82.57	0.00e+00	7493.00
IUUC-Cpo-021819	Cavia porcellus	80.12	0.00e+00	7214.00
IUUC-Csa-023817	Chlorocebus sabaeus	82.48	0.00e+00	7431.00
IUUC-Cho-024387	Choloepus hoffmanni	84.68	0.00e+00	1711.00
IUUC-Cin-025709	Ciona intestinalis	54.69	0.00e+00	2233.00
IUUC-Csv-026336	Ciona savignyi	59.49	0.00e+00	1464.00
IUUC-Dre-027717	Danio rerio	89.31	0.00e+00	7885.00
IUUC-Dno-029296	Dasypus novemcinctus	83.11	0.00e+00	7452.00
IUUC-Dor-030979	Dipodomys ordii	77.93	0.00e+00	2505.00
IUUC-Dme-032171	Drosophila melanogaster	60.01	0.00e+00	1546.00
IUUC-Ete-032687	Echinops telfairi	76.26	0.00e+00	2321.00
IUUC-Eca-034046	Equus caballus	81.73	0.00e+00	7406.00
IUUC-Eeu-034859	Erinaceus europaeus	86.94	0.00e+00	1808.00
IUUC-Fca-036262	Felis catus	82.63	0.00e+00	7505.00
IUUC-Fal-037562	Ficedula albicollis	84.87	0.00e+00	7704.00
IUUC-Gmo-039054	Gadus morhua	90.58	0.00e+00	1134.00
IUUC-Gga-040359	Gallus gallus	85.01	0.00e+00	7716.00
IUUC-Gac-041879	Gasterosteus aculeatus	95.20	0.00e+00	1081.00
IUUC-Ggo-044692	Gorilla gorilla	89.69	0.00e+00	4051.00
IUUC-Hsa-045995	Homo sapiens	82.44	0.00e+00	7476.00
IUUC-Hvu-047529	Hordeum vulgare	34.82	1.00e-48	188.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	76.84	0.00e+00	1950.00
IUUC-Lch-049808	Latimeria chalumnae	89.21	0.00e+00	3344.00
IUUC-Lpe-051482	Leersia perrieri	33.94	2.00e-46	181.00
IUUC-Loc-052685	Lepisosteus oculatus	89.04	0.00e+00	7913.00
IUUC-Laf-053372	Loxodonta africana	82.29	0.00e+00	7401.00
IUUC-Mcc-054693	Macaca mulatta	82.44	0.00e+00	7462.00
IUUC-Meu-056660	Macropus eugenii	93.97	0.00e+00	1891.00
IUUC-Mga-059371	Meleagris gallopavo	86.64	0.00e+00	6811.00
IUUC-Mmr-060787	Microcebus murinus	82.63	0.00e+00	7513.00
IUUC-Mdo-062518	Monodelphis domestica	81.78	0.00e+00	7324.00
IUUC-Mmu-063690	Mus musculus	82.09	0.00e+00	7400.00
IUUC-Mpu-066478	Mustela putorius furo	81.96	0.00e+00	7424.00
IUUC-Mlu-067596	Myotis lucifugus	80.94	0.00e+00	3966.00
IUUC-Nle-069445	Nomascus leucogenys	79.08	0.00e+00	1750.00
IUUC-Opr-070990	Ochotona princeps	93.93	0.00e+00	2304.00
IUUC-Ont-072285	Oreochromis niloticus	94.13	0.00e+00	8272.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.00	0.00e+00	3363.00
IUUC-Ocu-074273	Oryctolagus cuniculus	81.92	0.00e+00	7391.00
IUUC-Oba-075573	Oryza barthii	33.16	3.00e-45	177.00
IUUC-Obr-076107	Oryza brachyantha	32.49	1.00e-50	195.00
IUUC-Ogl-077193	Oryza glaberrima	33.16	3.00e-45	177.00
IUUC-Ogu-078817	Oryza glumaepatula	33.16	3.00e-45	177.00
IUUC-Oin-079609	Oryza indica	32.24	9.00e-49	189.00
IUUC-Olo-080629	Oryza longistaminata	33.16	3.00e-45	177.00
IUUC-Ome-081686	Oryza meridionalis	33.16	8.00e-46	179.00
IUUC-Opu-084137	Oryza punctata	33.42	5.00e-46	179.00
IUUC-Oru-085013	Oryza rufipogon	33.16	3.00e-45	177.00
IUUC-Osa-085597	Oryza sativa	33.16	3.00e-45	177.00
IUUC-Ola-087346	Oryzias latipes	95.44	0.00e+00	1239.00
IUUC-Oga-088742	Otolemur garnettii	82.25	0.00e+00	7352.00
IUUC-Oar-090093	Ovis aries	82.14	0.00e+00	7405.00
IUUC-Ptr-091034	Pan troglodytes	79.65	0.00e+00	5040.00
IUUC-Pan-092783	Papio anubis	80.89	0.00e+00	7290.00
IUUC-Psi-094027	Pelodiscus sinensis	85.91	0.00e+00	7487.00
IUUC-Pfo-096208	Poecilia formosa	92.26	0.00e+00	6857.00
IUUC-Pab-097681	Pongo abelii	75.38	0.00e+00	2073.00
IUUC-Pop-099121	Populus trichocarpa	34.65	7.00e-51	196.00
IUUC-Pca-100705	Procavia capensis	87.62	0.00e+00	1090.00
IUUC-Pva-103147	Pteropus vampyrus	73.30	0.00e+00	2070.00
IUUC-Rno-105458	Rattus norvegicus	82.11	0.00e+00	7386.00
IUUC-Sha-106959	Sarcophilus harrisii	73.84	0.00e+00	4369.00
IUUC-Sit-109917	Setaria italica	35.76	2.00e-47	184.00
IUUC-Sly-110961	Solanum lycopersicum	34.51	5.00e-53	202.00
IUUC-Sar-113532	Sorex araneus	69.47	0.00e+00	1489.00
IUUC-Sbi-114352	Sorghum bicolor	32.56	2.00e-49	191.00
IUUC-Ssc-115337	Sus scrofa	76.04	0.00e+00	2434.00
IUUC-Tgu-116789	Taeniopygia guttata	84.84	0.00e+00	7735.00
IUUC-Tsy-119302	Tarsius syrichta	75.18	0.00e+00	1128.00
IUUC-Tni-120374	Tetraodon nigroviridis	95.84	0.00e+00	8517.00
IUUC-Tca-121094	Theobroma cacao	35.03	2.00e-53	204.00
IUUC-Tae-124157	Triticum aestivum	32.98	1.00e-48	188.00
IUUC-Tur-126300	Triticum urartu	34.45	4.00e-49	190.00
IUUC-Tbe-128137	Tupaia belangeri	73.89	0.00e+00	1908.00
IUUC-Ttr-128273	Tursiops truncatus	78.86	0.00e+00	4360.00
IUUC-Vpa-130471	Vicugna pacos	75.24	0.00e+00	1341.00
IUUC-Xtr-132185	Xenopus tropicalis	81.35	0.00e+00	7308.00
IUUC-Xma-133233	Xiphophorus maculatus	93.24	0.00e+00	8231.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence