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Tag Content
UUCD2 ID IUUC-Tgu-117302
UUCD1 version UUC-TaG-00481
Ensembl Protein ID ENSTGUP00000009081.1
UniProt Accession H0ZER9; H0ZER9_TAEGU
Genbank Protein ID ENSTGUP00000009081
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID ABQF01015705
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSTGUG00000008761.1 ENSTGUT00000009178.1 ENSTGUP00000009081.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-63 206.7 740 779
UBD/Beta-Prp 1.80e-119 398.2 613 870
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllks 38
           gH++sv+ ++f  +d +++s+s Dgt+k+W+ r+g+ lks
   Q: 740  GHENSVNHCRFspNDEYVASCSTDGTVKLWESRSGNELKS 779
           8***********666*******************998875 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h + ++  +fs+dk+ +a+ ++d+t++v+++++g  l ++  h++e+ +++fs dg++ +t+s+D+ +kvw+ +tg+c  ++++h+++v
   Q: 613  HRDAVYHACFSKDKQRIASCGADKTLQVFKAESGERLLEINAHDDEILCCTFSADGEFVATCSSDKKVKVWNSRTGQCRCVYEEHSEQV 701
           44555669********************************************************************************* PP
   S: 98   lslsfsp.sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl......... 175
            +++f+  sg + l++ s+d  i++wdl++++c + t  gh+ +vn+ +++p++ +++s+s+D+tv+lW +++g+ l+           
   Q: 702  NCCQFNNkSGqYLLATCSNDTFIKIWDLNKKYCRN-TMIGHENSVNHCRFSPNDEYVASCSTDGTVKLWESRSGNELKSIeikdffkna 789
           *******877788999*******************.***********************************999999999999999995 PP
   S: 176  tgghtdsvysls....fdsngkelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
             ++ d+v+ l     +++ng  ++ +++++ + l+d+   g   +    h ++++  +f+p de+++++ s+ s+ +W+++s
   Q: 790  D-EQPDDVEVLVkccsWSRNGDKILVVAKNK-LLLFDINtCGLLTQVIVSHHSTIQYCDFCPGDELVAVALSHCSVELWNIKS 870
           3.47888877777888*********999875.7799**955777888889******************************986 PP
   
Organism Taeniopygia guttata
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
NMDVKSRNYL LMNRQALEND IKTSYIMDRM ISDEVLTLQE EERVKQQNTQ KERAAMLINI 60
ILTKDNNSYR SFYNALLHEG YRDLAALLQD GIPAVSSGNR KSSMDGMTSY VKTILCEGGV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Tgu-117302|E3,WD_repeat;UBD,Beta-Prp|Taeniopygia guttata
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATATGGATG TCAAGAGTAG AAACTATTTG CTTATGAATC GTCAAGCACT GGAAAATGAC 60
ATCAAGACTT CTTATATTAT GGATCGTATG ATTTCTGATG AAGTATTGAC ATTACAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Tgu-117302|E3,WD_repeat;UBD,Beta-Prp|Taeniopygia guttata
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 70.93 0.00e+00 1836.00
IUUC-Apl-004201 Anas platyrhynchos 90.54 0.00e+00 2315.00
IUUC-Aca-004638 Anolis carolinensis 70.88 0.00e+00 1879.00
IUUC-Ani-009285 Aspergillus nidulans 26.16 6.00e-67 249.00
IUUC-Ame-011062 Astyanax mexicanus 54.33 0.00e+00 1373.00
IUUC-Bta-012865 Bos taurus 70.62 0.00e+00 1870.00
IUUC-Cel-018376 Caenorhabditis elegans 21.47 5.00e-27 117.00
IUUC-Cja-018815 Callithrix jacchus 65.20 0.00e+00 1664.00
IUUC-Cfa-020222 Canis familiaris 67.51 0.00e+00 1711.00
IUUC-Cpo-021524 Cavia porcellus 69.98 0.00e+00 1832.00
IUUC-Cre-022868 Chlamydomonas reinhardtii 23.67 3.00e-39 157.00
IUUC-Csa-023861 Chlorocebus sabaeus 70.94 0.00e+00 1846.00
IUUC-Cho-024484 Choloepus hoffmanni 60.08 0.00e+00 916.00
IUUC-Dre-028006 Danio rerio 52.93 0.00e+00 1274.00
IUUC-Dno-029591 Dasypus novemcinctus 71.74 0.00e+00 1883.00
IUUC-Dor-030237 Dipodomys ordii 57.71 0.00e+00 816.00
IUUC-Ete-032620 Echinops telfairi 67.58 0.00e+00 865.00
IUUC-Eca-033569 Equus caballus 70.94 0.00e+00 1843.00
IUUC-Eeu-035354 Erinaceus europaeus 50.73 4.00e-135 475.00
IUUC-Fca-036337 Felis catus 70.40 0.00e+00 1858.00
IUUC-Fal-037077 Ficedula albicollis 97.12 0.00e+00 2494.00
IUUC-Gmo-039687 Gadus morhua 48.89 0.00e+00 898.00
IUUC-Ggr-039828 Gaeumannomyces graminis 23.85 6.00e-44 173.00
IUUC-Gga-040299 Gallus gallus 87.89 0.00e+00 2295.00
IUUC-Gac-041762 Gasterosteus aculeatus 51.90 0.00e+00 1271.00
IUUC-Ggo-045563 Gorilla gorilla 71.10 0.00e+00 1856.00
IUUC-Hsa-046771 Homo sapiens 70.94 0.00e+00 1852.00
IUUC-Lch-050200 Latimeria chalumnae 65.12 0.00e+00 1635.00
IUUC-Loc-052090 Lepisosteus oculatus 59.08 0.00e+00 1538.00
IUUC-Laf-053861 Loxodonta africana 70.48 0.00e+00 1840.00
IUUC-Mcc-055543 Macaca mulatta 70.86 0.00e+00 1842.00
IUUC-Meu-056688 Macropus eugenii 69.66 0.00e+00 1787.00
IUUC-Mga-059243 Meleagris gallopavo 88.78 0.00e+00 2320.00
IUUC-Mmr-061134 Microcebus murinus 67.49 0.00e+00 1583.00
IUUC-Mdo-062913 Monodelphis domestica 69.34 0.00e+00 1804.00
IUUC-Mmu-063811 Mus musculus 70.14 0.00e+00 1851.00
IUUC-Mpu-066780 Mustela putorius furo 71.04 0.00e+00 1824.00
IUUC-Mlu-067276 Myotis lucifugus 70.88 0.00e+00 1865.00
IUUC-Nle-069129 Nomascus leucogenys 70.70 0.00e+00 1842.00
IUUC-Opr-071007 Ochotona princeps 51.99 0.00e+00 850.00
IUUC-Ont-071348 Oreochromis niloticus 54.78 0.00e+00 1407.00
IUUC-Oan-072717 Ornithorhynchus anatinus 73.02 0.00e+00 1909.00
IUUC-Ocu-074286 Oryctolagus cuniculus 70.56 0.00e+00 1562.00
IUUC-Ola-086895 Oryzias latipes 50.00 0.00e+00 1199.00
IUUC-Oga-088678 Otolemur garnettii 70.14 0.00e+00 1827.00
IUUC-Oar-089359 Ovis aries 70.78 0.00e+00 1863.00
IUUC-Ptr-091062 Pan troglodytes 71.10 0.00e+00 1858.00
IUUC-Pan-092528 Papio anubis 75.79 0.00e+00 1142.00
IUUC-Psi-093430 Pelodiscus sinensis 79.38 0.00e+00 2043.00
IUUC-Pma-094690 Petromyzon marinus 36.61 7.00e-144 504.00
IUUC-Pfo-097204 Poecilia formosa 53.90 0.00e+00 1381.00
IUUC-Pab-097690 Pongo abelii 71.10 0.00e+00 1854.00
IUUC-Pca-100778 Procavia capensis 54.68 0.00e+00 896.00
IUUC-Pva-102870 Pteropus vampyrus 68.92 0.00e+00 1663.00
IUUC-Pyt-104620 Pyrenophora triticirepentis 27.44 1.00e-65 245.00
IUUC-Rno-104889 Rattus norvegicus 70.06 0.00e+00 1821.00
IUUC-Sha-107465 Sarcophilus harrisii 70.13 0.00e+00 1848.00
IUUC-Sar-113268 Sorex araneus 67.81 1.00e-143 504.00
IUUC-Ssc-115654 Sus scrofa 70.22 0.00e+00 1856.00
IUUC-Tru-118363 Takifugu rubripes 54.07 0.00e+00 1372.00
IUUC-Tsy-119007 Tarsius syrichta 69.02 0.00e+00 1785.00
IUUC-Tni-120910 Tetraodon nigroviridis 52.31 0.00e+00 1316.00
IUUC-Tbe-127413 Tupaia belangeri 60.84 0.00e+00 1104.00
IUUC-Ttr-129213 Tursiops truncatus 65.25 0.00e+00 1672.00
IUUC-Vpa-130146 Vicugna pacos 66.13 0.00e+00 1259.00
IUUC-Xtr-132559 Xenopus tropicalis 60.16 0.00e+00 1564.00
Created Date 25-Jun-2017

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