iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000042001.1	ENSGALT00000066953.1	ENSGALP00000047294.1
ENSGALG00000042001.1	ENSGALT00000068504.1	ENSGALP00000058345.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-72	244.7	734	1053

Active Site

Position(s)	Description	Evidence
1022	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           s++++ l+v f+gEeg +  G+ re +a  +kel++p+   f++ + ++  ++p + s      h + F ++G++ g+al+++   +
   Q: 734  SQFRHFLDVYFEGEEGEGV-GLCRELFAVAAKELCDPQSDVFRHFP-SRLIWFPTQVS-----SHDDTFLLVGTFFGMALYNHCQTP 813
           67788899***********.**********************7766.67888988877.....5889******************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
            p++++++k++ +++ +ledlee++p + ++lk i++  es+ + ++l++tf + e   +  +++eLk +G+ni Vt+ N++e+v+l
   Q: 814  FPFPRALFKKMRDVEPTLEDLEELMPAVGRNLKNILKE-ESEHKLESLHMTFVQME---EGGSVVELKKNGANILVTKHNRKEFVDL 896
           ************************************88.78999999*****8444...6778899********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v+y+l+e++++ +e f +Gf + +p e+ ++F + el+++++G +++d++ lkk+ ky   y++++++i++Fw v+ ++ +e++k+
   Q: 897  YVNYTLNESVRKPFEDFMRGFLRGCPVESWKIFLPDELQVVLMGPTNYDWHLLKKNVKYVY-YEASHQTIKNFWTVFYKLPEEKKKK 982
           ***********************************************************77.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL F+Tgs+r+ ++G+  +      i++   ++ d+++P + TC  +L LP+Ysskeil+ekLl  ie+++gF+l
   Q: 983  FLAFLTGSDRVIPKGLHFVL----SIEDplcENPDNSYPFARTCSCTLFLPRYSSKEILEEKLLSVIEYSEGFGL 1053
           ************99987554....56667878899**************************************97 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MASALPLLSL QPRAKLPSPS AVEKSGCGSR GSGAGTLQPR SLAQFKKSEA QEEPFPLGTP 60
RGRRRRAGPP EHGQLSVSIS PSRRGRAERG GRPGSCPPGS GSRTPAGRRR GMAGGRQRQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCATCTG CTCTCCCTCT GCTATCACTG CAGCCCAGGG CAAAGCTCCC ATCGCCTTCT 60
GCGGTAGAAA AGTCGGGATG TGGCAGCCGG GGTTCCGGAG CTGGGACTCT CCAGCCACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005342	Anolis carolinensis	47.32	0.00e+00	803.00
IUUC-Dor-030862	Dipodomys ordii	46.58	6.00e-77	282.00
IUUC-Fal-037529	Ficedula albicollis	60.76	0.00e+00	1019.00
IUUC-Loc-052283	Lepisosteus oculatus	40.77	2.00e-173	602.00
IUUC-Mga-059605	Meleagris gallopavo	70.79	0.00e+00	1165.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence