iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003907

Ensembl Protein ID

ENSAPLP00000010988.1

UniProt Accession

U3IUR5; U3IUR5_ANAPL

Genbank Protein ID

ENSAPLP00000010988

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADON01126420

Gene Name

BTK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000011155.1	ENSAPLT00000011708.1	ENSAPLP00000010988.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.10e-12	46.0	214	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++kv +lydy + n  +L+l+kG+  +++  ee    W+k+ ++ +g++G +P+n+v++ 
   Q: 214  EMKKVVALYDYLPMNAQDLQLQKGEEYFIL--EESHLPWWKA-RDKNGREGYIPSNYVTET 271
           689**************************9..888999****.5**************975 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MASVILESIF LKRSQQKKKT SPLNFKKRLF LLTESKLSYY EYDFERGRRG SKKGSVDIEK 60
ITCVETVVPE NNPPPERQVP KKGEDYNNME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCACGCAG CACCCCGGGG AGCACGGCGT CGAGGCAGCC GGGGTGGCCG ACATGGCCAG 60
CGTCATCCTG GAGAGCATCT TCCTGAAGCG CTCGCAGCAG AAGAAGAAGA CGTCGCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
IPR001562--Znf_Btk_motif

PROSITE

PS50003--PH_DOMAIN
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
PS51113--ZF_BTK

Pfam

PF00779--BTK
PF00169--PH
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00107--BTK
SM00233--PH
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0002344--P:B cell affinity maturation
GO:0048469--P:cell maturation
GO:0098761--P:cellular response to interleukin-7
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0030889--P:negative regulation of B cell proliferation
GO:0001818--P:negative regulation of cytokine production

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001365	Ailuropoda melanoleuca	86.65	0.00e+00	1160.00
IUUC-Aca-004978	Anolis carolinensis	78.32	0.00e+00	1060.00
IUUC-Bta-012467	Bos taurus	86.19	0.00e+00	1157.00
IUUC-Cja-018841	Callithrix jacchus	86.19	0.00e+00	1154.00
IUUC-Cfa-020983	Canis familiaris	86.19	0.00e+00	1127.00
IUUC-Cpo-021307	Cavia porcellus	86.80	0.00e+00	1160.00
IUUC-Csa-023508	Chlorocebus sabaeus	84.48	0.00e+00	845.00
IUUC-Dno-029828	Dasypus novemcinctus	85.50	0.00e+00	1129.00
IUUC-Dor-030102	Dipodomys ordii	78.29	0.00e+00	938.00
IUUC-Ete-032981	Echinops telfairi	79.36	0.00e+00	1035.00
IUUC-Eca-033594	Equus caballus	86.34	0.00e+00	1156.00
IUUC-Eeu-035281	Erinaceus europaeus	83.12	0.00e+00	915.00
IUUC-Fca-035495	Felis catus	85.74	0.00e+00	1125.00
IUUC-Fal-036719	Ficedula albicollis	95.14	0.00e+00	1284.00
IUUC-Gga-041193	Gallus gallus	95.71	0.00e+00	1255.00
IUUC-Hsa-045931	Homo sapiens	86.04	0.00e+00	1130.00
IUUC-Itr-048061	Ictidomys tridecemlineatus	86.49	0.00e+00	1157.00
IUUC-Lch-049868	Latimeria chalumnae	74.70	0.00e+00	962.00
IUUC-Laf-053516	Loxodonta africana	86.08	0.00e+00	1172.00
IUUC-Mcc-054795	Macaca mulatta	86.04	0.00e+00	1130.00
IUUC-Meu-056157	Macropus eugenii	76.33	0.00e+00	986.00
IUUC-Mga-059529	Meleagris gallopavo	95.59	0.00e+00	1070.00
IUUC-Mmr-060824	Microcebus murinus	82.09	0.00e+00	1057.00
IUUC-Mdo-063036	Monodelphis domestica	86.90	0.00e+00	1150.00
IUUC-Mmu-064047	Mus musculus	85.74	0.00e+00	1152.00
IUUC-Mpu-066810	Mustela putorius furo	86.34	0.00e+00	1157.00
IUUC-Mlu-067671	Myotis lucifugus	85.52	0.00e+00	1142.00
IUUC-Nle-069108	Nomascus leucogenys	86.04	0.00e+00	1131.00
IUUC-Opr-070505	Ochotona princeps	68.95	4.00e-175	607.00
IUUC-Oan-073495	Ornithorhynchus anatinus	86.15	0.00e+00	1173.00
IUUC-Ocu-074416	Oryctolagus cuniculus	86.04	0.00e+00	1152.00
IUUC-Oga-088995	Otolemur garnettii	84.89	0.00e+00	1120.00
IUUC-Oar-089632	Ovis aries	85.28	0.00e+00	1133.00
IUUC-Ptr-090941	Pan troglodytes	86.04	0.00e+00	1130.00
IUUC-Pan-091900	Papio anubis	83.61	0.00e+00	1088.00
IUUC-Psi-093048	Pelodiscus sinensis	89.01	0.00e+00	1148.00
IUUC-Pab-097587	Pongo abelii	86.04	0.00e+00	1131.00
IUUC-Pca-100374	Procavia capensis	75.33	9.00e-127	447.00
IUUC-Pva-102583	Pteropus vampyrus	86.56	0.00e+00	1128.00
IUUC-Rno-104868	Rattus norvegicus	81.42	0.00e+00	1070.00
IUUC-Sha-106744	Sarcophilus harrisii	86.26	0.00e+00	1161.00
IUUC-Sar-113041	Sorex araneus	85.45	0.00e+00	1008.00
IUUC-Ssc-115294	Sus scrofa	86.19	0.00e+00	1155.00
IUUC-Tsy-118945	Tarsius syrichta	85.71	0.00e+00	777.00
IUUC-Ttr-128769	Tursiops truncatus	77.54	0.00e+00	1025.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence