iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046523

UUCD1 version

UUC-HoS-00287

Ensembl Protein ID

ENSP00000426103.2

UniProt Accession

Q96AX9; A2AGM5; A2AGM6; B3KV93; B3KVF4; B3KXY1; B4DZ57; E9PGU1; E9PHQ1; F8WA73; J3KNZ7; Q7Z437; Q8IY62; Q8N786; Q8N897; Q8N8R2; Q8N911; Q8NB36; Q8NCY1; Q8NG59; Q8NG60; Q8NG61; Q8NI59; Q8WYN1; MIB2_HUMAN

Genbank Protein ID

BAB92950.1; BAB82979.1; BAC00992.1; BAC00993.1; BAC00994.1; BAC77353.1; BAC03707.1; BAC04646.1; BAC04752.1; BAC04952.1; BAC05413.1; BAG53705.1; BAG53766.1; BAG54643.1; BAG63969.1; AAH16490.1; AAH37542.1; CAD39183.1

Protein Name

E3 ubiquitin-protein ligase MIB2; Mind bomb homolog 2; Novel zinc finger protein; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1

Genbank Nucleotide ID

AB074480; AB064367; AB076691; AB076692; AB076693; AB097000; AK091610; AK095914; AK096295; AK097106; AK098785; AK122751; AK122863; AK128167; AK302757; AL691432; BC037542; AL834527

Gene Name

MIB2; SKD; ZZANK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000197530.12	ENST00000520777.5	ENSP00000428660.1
ENSG00000197530.12	ENST00000355826.9	ENSP00000348081.5
ENSG00000197530.12	ENST00000518681.5	ENSP00000428264.1
ENSG00000197530.12	ENST00000505820.6	ENSP00000426103.2
ENSG00000197530.12	ENST00000489635.5	ENSP00000426007.1
ENSG00000197530.12	ENST00000514363.1	ENSP00000420935.1
ENSG00000197530.12	ENST00000487053.5	ENSP00000424615.1
ENSG00000197530.12	ENST00000502470.5	ENSP00000423221.1
ENSG00000197530.12	ENST00000378712.5	ENSP00000367984.1
ENSG00000197530.12	ENST00000378708.5	ENSP00000367980.1
ENSG00000197530.12	ENST00000506488.5	ENSP00000425032.1
ENSG00000197530.12	ENST00000514234.5	ENSP00000427680.1
ENSG00000197530.12	ENST00000486072.1	ENSP00000463504.1
ENSG00000197530.12	ENST00000483015.1	ENSP00000464106.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15920166

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	63.44	0.00e+00	1224.00	IUUC-Dre-028844

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Protein Sequence
(Fasta)

MAGALRRGRA LGSRPSGPTV SSRRSPQCPV AQEGLGARSR PRVAPRSLAR CGPSSRLMGW 60
KPSEARGQSQ SFQASGLQPR SLKAARRATG RPDRSRAARP TMDPSAHRSR AAPPNMDPDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCGGTG CTTGCCCTGC CCATCCCCGT GGCGGGGGCG TGGCCATGGC GGGGGCGCTC 60
CGGCGGGGGC GGGCCCTGGG CTCCCGCCCT TCGGGTCCCA CAGTTTCCAG CCGCCGCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0479--Metal-binding
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001370--BIR_rpt
IPR010606--Mib_Herc2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR000433--Znf_ZZ

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS51416--MIB_HERC2
PS50089--ZF_RING_2
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF12796--Ank_2
PF06701--MIB_HERC2
PF00569--ZZ

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00184--RING
SM00291--ZnF_ZZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0000151--C:ubiquitin ligase complex
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007219--P:Notch signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0000209--P:protein polyubiquitination

KEGG

hsa:142678

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000355	Aegilops tauschii	28.22	5.00e-21	97.80
IUUC-Aml-001839	Ailuropoda melanoleuca	86.86	0.00e+00	1282.00
IUUC-Apl-003333	Anas platyrhynchos	65.93	0.00e+00	1157.00
IUUC-Ame-011227	Astyanax mexicanus	59.73	0.00e+00	1184.00
IUUC-Bta-012993	Bos taurus	88.16	0.00e+00	1608.00
IUUC-Bdi-014301	Brachypodium distachyon	27.36	5.00e-20	94.40
IUUC-Cja-019653	Callithrix jacchus	97.28	0.00e+00	1785.00
IUUC-Cfa-020044	Canis familiaris	90.07	0.00e+00	1657.00
IUUC-Cpo-021836	Cavia porcellus	91.44	0.00e+00	1662.00
IUUC-Csa-023940	Chlorocebus sabaeus	98.43	0.00e+00	1808.00
IUUC-Dre-028844	Danio rerio	61.80	0.00e+00	1252.00
IUUC-Dno-030086	Dasypus novemcinctus	82.54	0.00e+00	1037.00
IUUC-Dor-030915	Dipodomys ordii	86.05	0.00e+00	789.00
IUUC-Dme-031821	Drosophila melanogaster	47.90	0.00e+00	652.00
IUUC-Ete-033045	Echinops telfairi	84.70	0.00e+00	1085.00
IUUC-Eca-034009	Equus caballus	92.98	0.00e+00	1297.00
IUUC-Eeu-035321	Erinaceus europaeus	93.36	6.00e-142	498.00
IUUC-Fal-036757	Ficedula albicollis	69.24	0.00e+00	1408.00
IUUC-Gmo-039304	Gadus morhua	60.42	0.00e+00	1124.00
IUUC-Gga-040651	Gallus gallus	68.61	0.00e+00	1405.00
IUUC-Gac-042061	Gasterosteus aculeatus	62.03	0.00e+00	1209.00
IUUC-Ggo-045409	Gorilla gorilla	72.13	0.00e+00	684.00
IUUC-Hvu-047502	Hordeum vulgare	26.90	3.00e-19	90.90
IUUC-Itr-048215	Ictidomys tridecemlineatus	91.28	0.00e+00	1629.00
IUUC-Lch-049427	Latimeria chalumnae	65.93	0.00e+00	1319.00
IUUC-Loc-052166	Lepisosteus oculatus	63.41	0.00e+00	1263.00
IUUC-Laf-054174	Loxodonta africana	83.73	0.00e+00	1110.00
IUUC-Mcc-055748	Macaca mulatta	97.63	0.00e+00	1956.00
IUUC-Meu-056351	Macropus eugenii	65.21	0.00e+00	631.00
IUUC-Mtr-058673	Medicago truncatula	30.18	2.00e-20	95.50
IUUC-Mga-059882	Meleagris gallopavo	54.80	0.00e+00	1035.00
IUUC-Mmr-061388	Microcebus murinus	86.52	0.00e+00	1505.00
IUUC-Mdo-061981	Monodelphis domestica	75.41	0.00e+00	1211.00
IUUC-Mmu-063153	Mus musculus	89.13	0.00e+00	1589.00
IUUC-Mac-065553	Musa acuminata	27.41	9.00e-17	82.80
IUUC-Mpu-066551	Mustela putorius furo	92.24	0.00e+00	1467.00
IUUC-Nle-069881	Nomascus leucogenys	88.51	0.00e+00	1704.00
IUUC-Opr-070624	Ochotona princeps	81.05	0.00e+00	828.00
IUUC-Ont-072414	Oreochromis niloticus	61.39	0.00e+00	1241.00
IUUC-Osa-085300	Oryza sativa	30.77	3.00e-17	83.60
IUUC-Ola-086715	Oryzias latipes	58.93	0.00e+00	1174.00
IUUC-Oga-088898	Otolemur garnettii	93.12	0.00e+00	1673.00
IUUC-Oar-089265	Ovis aries	80.85	0.00e+00	1013.00
IUUC-Pan-092360	Papio anubis	96.22	0.00e+00	1457.00
IUUC-Psi-093964	Pelodiscus sinensis	68.85	0.00e+00	1355.00
IUUC-Pma-094121	Petromyzon marinus	40.45	1.00e-156	547.00
IUUC-Pfo-096821	Poecilia formosa	62.33	0.00e+00	1227.00
IUUC-Pab-098440	Pongo abelii	77.18	0.00e+00	1139.00
IUUC-Pop-098784	Populus trichocarpa	29.13	3.00e-21	98.20
IUUC-Pca-100806	Procavia capensis	88.03	0.00e+00	1036.00
IUUC-Ppe-102003	Prunus persica	29.66	2.00e-21	99.40
IUUC-Pva-102667	Pteropus vampyrus	86.72	0.00e+00	1068.00
IUUC-Rno-105681	Rattus norvegicus	91.85	0.00e+00	1654.00
IUUC-Sha-106735	Sarcophilus harrisii	73.66	0.00e+00	652.00
IUUC-Sit-109898	Setaria italica	26.82	8.00e-21	97.10
IUUC-Sbi-114492	Sorghum bicolor	27.61	5.00e-20	94.70
IUUC-Ssc-116370	Sus scrofa	92.40	0.00e+00	1649.00
IUUC-Tgu-116853	Taeniopygia guttata	69.09	0.00e+00	1395.00
IUUC-Tru-118714	Takifugu rubripes	62.45	0.00e+00	1225.00
IUUC-Tni-119764	Tetraodon nigroviridis	62.32	0.00e+00	1230.00
IUUC-Tca-121711	Theobroma cacao	30.66	2.00e-20	95.90
IUUC-Tae-124169	Triticum aestivum	28.22	3.00e-21	98.20
IUUC-Ttr-128730	Tursiops truncatus	81.31	0.00e+00	858.00
IUUC-Vvi-131705	Vitis vinifera	28.71	6.00e-19	90.90
IUUC-Xtr-132967	Xenopus tropicalis	67.01	0.00e+00	1364.00
IUUC-Xma-133473	Xiphophorus maculatus	62.03	0.00e+00	1080.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence