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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106173
UUCD1 version UUC-SaC-00137
Ensembl Protein ID YER093C
UniProt Accession P40061; D3DM00; TSC11_YEAST
Genbank Protein ID AAB64648.1; AAB60298.1; DAA07754.1
Protein Name Target of rapamycin complex 2 subunit TSC11; Adheres voraciously to TOR2 protein 3; Temperature-sensitive CSG2 suppressor protein 11
Genbank Nucleotide ID U18839; U32508; BK006939
Gene Name TSC11; AVO3; YER093C
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER093C YER093C YER093C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMUniProtBioGRID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/Other 29.51 7.00e-42 171.00 IUUC-Hsa-046897
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1.
 Essential component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway. TSC11 may exert its functions through two distinct mechanisms, one mediated by AVO1 and the other mediated by AVO2 and SLM1.
Protein Sequence
(Fasta)
MSIPHSAKQS SPLSSRRRSV TNTTPLLTPR HSRDNSSTQI SSAKNITSSS PSTITNESSK 60
RNKQNLVLST SFISTKRLEN SAPSPTSPLM ARRTRSTMTK ALLNLKAEIN NQYQELARLR 120
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Protein Fasta Sequence


>IUUC-Sce-106173|E3,Cullin RING/Other|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCATAC CTCACAGTGC AAAACAGAGT AGCCCTCTCT CAAGTCGGCG CCGGTCAGTA 60
ACTAATACTA CTCCACTGTT AACCCCTAGA CATAGCCGTG ATAACTCGAG CACCCAAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106173|E3,Cullin RING/Other|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0926--Vacuole
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR028268--Pianissimo_fam
IPR028267--Pianissimo_N
IPR029453--Rictor_IV
IPR029451--RICTOR_M
IPR029452--RICTOR_V
Pfam

PF14663--RasGEF_N_2
PF14666--RICTOR_M
PF14664--RICTOR_N
PF14668--RICTOR_V
SMART

SM01307--RICTOR_M
SM01308--RICTOR_N
SM01310--RICTOR_V
Gene Ontology

GO:0005886--C:plasma membrane
GO:0031932--C:TORC2 complex
GO:0005774--C:vacuolar membrane
GO:0008047--F:enzyme activator activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0031532--P:actin cytoskeleton reorganization
GO:0030010--P:establishment of cell polarity
GO:0030950--P:establishment or maintenance of actin cytoskeleton polarity
GO:0031505--P:fungal-type cell wall organization
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0001558--P:regulation of cell growth
GO:0042325--P:regulation of phosphorylation
GO:0030148--P:sphingolipid biosynthetic process
GO:0031929--P:TOR signaling
KEGG sce:YER093C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004111 Anas platyrhynchos 24.32 3.00e-51 196.00
IUUC-Aca-004885 Anolis carolinensis 23.56 3.00e-54 206.00
IUUC-Ago-007975 Ashbya gossypii 40.23 0.00e+00 957.00
IUUC-Acl-008267 Aspergillus clavatus 42.31 7.40e-01 26.90
IUUC-Afu-008889 Aspergillus fumigatus 27.90 3.00e-116 411.00
IUUC-Ang-009838 Aspergillus niger 26.96 2.00e-109 388.00
IUUC-Ate-010586 Aspergillus terreus 25.91 1.00e-116 412.00
IUUC-Bgr-012287 Blumeria graminis 26.74 8.00e-118 416.00
IUUC-Bta-013347 Bos taurus 24.53 3.00e-60 225.00
IUUC-Bci-013718 Botrytis cinerea 29.42 9.00e-124 436.00
IUUC-Cja-019360 Callithrix jacchus 24.48 2.00e-59 223.00
IUUC-Cpo-022258 Cavia porcellus 26.46 2.00e-11 60.50
IUUC-Cho-024748 Choloepus hoffmanni 22.47 4.00e-29 122.00
IUUC-Cin-025491 Ciona intestinalis 26.09 1.00e-24 106.00
IUUC-Csv-025990 Ciona savignyi 24.81 5.00e-07 47.80
IUUC-Cgl-026666 Colletotrichum gloeosporioides 26.63 6.00e-104 370.00
IUUC-Cne-026882 Cryptococcus neoformans 30.69 1.00e-70 259.00
IUUC-Dre-027391 Danio rerio 29.22 2.00e-47 183.00
IUUC-Dno-029612 Dasypus novemcinctus 24.61 2.00e-59 223.00
IUUC-Dor-030974 Dipodomys ordii 29.04 1.00e-22 100.00
IUUC-Ete-032905 Echinops telfairi 24.54 4.00e-58 218.00
IUUC-Eca-033490 Equus caballus 29.51 1.00e-46 181.00
IUUC-Eeu-035218 Erinaceus europaeus 36.36 4.00e-18 85.90
IUUC-Fca-035568 Felis catus 29.92 5.00e-47 181.00
IUUC-Fal-037265 Ficedula albicollis 24.02 5.00e-58 218.00
IUUC-Fox-037847 Fusarium oxysporum 27.00 5.00e-104 370.00
IUUC-Fso-038392 Fusarium solani 27.58 1.00e-105 376.00
IUUC-Gmo-039569 Gadus morhua 23.93 3.00e-52 199.00
IUUC-Ggr-039786 Gaeumannomyces graminis 25.65 1.00e-112 399.00
IUUC-Gga-040814 Gallus gallus 23.75 1.00e-56 213.00
IUUC-Gac-042152 Gasterosteus aculeatus 28.66 2.00e-43 170.00
IUUC-Hsa-046897 Homo sapiens 24.71 2.00e-59 223.00
IUUC-Itr-047870 Ictidomys tridecemlineatus 25.05 2.00e-61 229.00
IUUC-Kpa-049264 Komagataella pastoris 26.22 1.00e-88 319.00
IUUC-Lch-049566 Latimeria chalumnae 28.57 1.00e-44 174.00
IUUC-Loc-052514 Lepisosteus oculatus 27.76 7.00e-41 161.00
IUUC-Lma-053045 Leptosphaeria maculans 33.09 5.00e-78 284.00
IUUC-Laf-053388 Loxodonta africana 24.84 1.00e-62 233.00
IUUC-Mcc-055195 Macaca mulatta 24.53 9.00e-57 214.00
IUUC-Meu-056687 Macropus eugenii 30.00 4.00e-10 59.30
IUUC-Mor-056999 Magnaporthe oryzae 26.05 1.00e-115 409.00
IUUC-Mpo-057301 Magnaporthe poae 25.34 4.00e-113 400.00
IUUC-Mla-058853 Melampsora laricipopulina 26.67 6.00e-77 280.00
IUUC-Mga-059725 Meleagris gallopavo 23.06 5.00e-34 138.00
IUUC-Mmr-060679 Microcebus murinus 25.03 3.00e-59 222.00
IUUC-Mmu-063859 Mus musculus 24.00 1.00e-56 214.00
IUUC-Mlu-067734 Myotis lucifugus 24.63 1.00e-60 226.00
IUUC-Nfi-068380 Neosartorya fischeri 28.11 2.00e-116 411.00
IUUC-Ncr-068779 Neurospora crassa 26.78 2.00e-117 415.00
IUUC-Opr-071025 Ochotona princeps 27.01 2.00e-40 159.00
IUUC-Ont-072104 Oreochromis niloticus 23.47 6.00e-55 208.00
IUUC-Ocu-074388 Oryctolagus cuniculus 24.40 8.00e-60 224.00
IUUC-Obr-076540 Oryza brachyantha 28.89 1.30e+00 26.20
IUUC-Ola-087503 Oryzias latipes 27.88 2.00e-44 173.00
IUUC-Oar-089642 Ovis aries 24.53 5.00e-60 224.00
IUUC-Ptr-090779 Pan troglodytes 24.71 2.00e-59 223.00
IUUC-Pan-092099 Papio anubis 24.71 2.00e-59 223.00
IUUC-Psi-093606 Pelodiscus sinensis 24.22 2.00e-56 213.00
IUUC-Pno-094990 Phaeosphaeria nodorum 27.22 2.00e-101 362.00
IUUC-Pfo-097337 Poecilia formosa 35.14 8.20e-02 30.00
IUUC-Pab-098429 Pongo abelii 24.53 9.00e-59 220.00
IUUC-Pca-101045 Procavia capensis 29.30 8.00e-47 181.00
IUUC-Pva-102675 Pteropus vampyrus 28.52 6.00e-22 98.60
IUUC-Pgr-103341 Puccinia graminis 29.96 1.00e-65 243.00
IUUC-Ptt-103999 Puccinia triticina 27.24 1.00e-53 203.00
IUUC-Rno-104957 Rattus norvegicus 24.42 2.00e-58 219.00
IUUC-Sha-107121 Sarcophilus harrisii 23.69 3.00e-57 215.00
IUUC-Sja-107806 Schizosaccharomyces japonicus 25.79 6.00e-83 300.00
IUUC-Spo-108187 Schizosaccharomyces pombe 29.17 5.00e-84 304.00
IUUC-Ssl-108665 Sclerotinia sclerotiorum 31.88 6.00e-58 217.00
IUUC-Sar-113499 Sorex araneus 29.24 4.00e-45 175.00
IUUC-Sre-114992 Sporisorium reilianum 31.23 2.00e-75 276.00
IUUC-Ssc-115246 Sus scrofa 24.61 5.00e-60 224.00
IUUC-Tgu-116455 Taeniopygia guttata 24.13 2.00e-58 220.00
IUUC-Tru-118605 Takifugu rubripes 28.04 9.00e-43 167.00
IUUC-Tsy-119061 Tarsius syrichta 23.73 4.00e-51 195.00
IUUC-Tni-119726 Tetraodon nigroviridis 27.81 3.00e-42 165.00
IUUC-Tre-121918 Trichoderma reesei 27.57 2.00e-105 375.00
IUUC-Tvi-122587 Trichoderma virens 27.44 5.00e-102 364.00
IUUC-Tur-126292 Triticum urartu 36.17 1.50e+00 29.30
IUUC-Tbe-127960 Tupaia belangeri 29.31 2.00e-44 173.00
IUUC-Ttr-128848 Tursiops truncatus 24.32 2.00e-50 192.00
IUUC-Uma-129394 Ustilago maydis 31.52 5.00e-79 288.00
IUUC-Vda-129772 Verticillium dahliae 26.56 3.00e-103 368.00
IUUC-Vpa-130325 Vicugna pacos 22.88 3.00e-40 159.00
IUUC-Xtr-132777 Xenopus tropicalis 23.77 3.00e-50 192.00
IUUC-Xma-133798 Xiphophorus maculatus 26.45 3.00e-43 169.00
IUUC-Yli-134450 Yarrowia lipolytica 31.56 9.00e-91 326.00
Created Date 25-Jun-2017

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