iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000016127.3	ENSXETT00000035178.3	ENSXETP00000035178.3
ENSXETG00000016127.3	ENSXETT00000065178.1	ENSXETP00000060921.1
ENSXETG00000016127.3	ENSXETT00000063828.1	ENSXETP00000061204.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-07	31.8	385	424

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    ++s ++  CP Cr
   Q: 385  CKICAENDKD-VKIEPCGHLMCTSCLTSW----QESDGQ-GCPFCR 424
           99********.******************....555555.5****8 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

SSSGDLTNSG CSSDEAVTGR LPGARSANPR KARILGLFDA IQDAVGPPKQ AAADRRTVEK 60
TWKLMDKVVR LCQNPKLQLK NSPPYILDIL PDTYQHLRLI LSKYDDNQKL AQLSENEYFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTCCTCCG GTGACCTCAC CAACTCAGGC TGCAGCTCGG ATGAGGAGGG GAGCAGAGAG 60
TTTGCTGAGC CCATCAGGCG CTGAAGTGTA GGGGGGCGTC CAGGCAGCAC CCGGGTGTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001412	Ailuropoda melanoleuca	92.38	0.00e+00	980.00
IUUC-Apl-004148	Anas platyrhynchos	92.28	0.00e+00	992.00
IUUC-Aca-005204	Anolis carolinensis	94.39	0.00e+00	975.00
IUUC-Ame-011919	Astyanax mexicanus	78.68	0.00e+00	832.00
IUUC-Bta-013044	Bos taurus	92.58	0.00e+00	982.00
IUUC-Cel-018674	Caenorhabditis elegans	53.92	4.00e-134	471.00
IUUC-Cja-018813	Callithrix jacchus	71.78	0.00e+00	1104.00
IUUC-Cfa-021054	Canis familiaris	92.58	0.00e+00	983.00
IUUC-Cpo-022514	Cavia porcellus	71.30	0.00e+00	1110.00
IUUC-Csa-024110	Chlorocebus sabaeus	92.58	0.00e+00	982.00
IUUC-Cho-024886	Choloepus hoffmanni	73.92	0.00e+00	667.00
IUUC-Dre-027480	Danio rerio	82.97	0.00e+00	871.00
IUUC-Dno-028923	Dasypus novemcinctus	92.18	0.00e+00	954.00
IUUC-Dor-031040	Dipodomys ordii	83.93	0.00e+00	759.00
IUUC-Ete-032406	Echinops telfairi	66.43	0.00e+00	1002.00
IUUC-Eca-033849	Equus caballus	92.38	0.00e+00	981.00
IUUC-Fca-036224	Felis catus	92.58	0.00e+00	984.00
IUUC-Fal-036860	Ficedula albicollis	93.05	0.00e+00	979.00
IUUC-Gga-040159	Gallus gallus	93.44	0.00e+00	1004.00
IUUC-Gac-042312	Gasterosteus aculeatus	82.49	0.00e+00	857.00
IUUC-Ggo-045175	Gorilla gorilla	71.41	0.00e+00	1123.00
IUUC-Hsa-046306	Homo sapiens	92.58	0.00e+00	983.00
IUUC-Loc-052524	Lepisosteus oculatus	85.97	0.00e+00	874.00
IUUC-Laf-053635	Loxodonta africana	86.74	0.00e+00	907.00
IUUC-Mcc-055536	Macaca mulatta	92.58	0.00e+00	982.00
IUUC-Meu-056045	Macropus eugenii	77.54	0.00e+00	783.00
IUUC-Mga-060177	Meleagris gallopavo	93.08	0.00e+00	914.00
IUUC-Mmr-061088	Microcebus murinus	92.38	0.00e+00	979.00
IUUC-Mdo-062020	Monodelphis domestica	92.97	0.00e+00	988.00
IUUC-Mmu-063114	Mus musculus	92.77	0.00e+00	985.00
IUUC-Mpu-066632	Mustela putorius furo	92.58	0.00e+00	982.00
IUUC-Mlu-067145	Myotis lucifugus	92.19	0.00e+00	978.00
IUUC-Ont-072323	Oreochromis niloticus	81.58	0.00e+00	876.00
IUUC-Oan-073165	Ornithorhynchus anatinus	92.97	0.00e+00	990.00
IUUC-Ocu-074723	Oryctolagus cuniculus	92.58	0.00e+00	982.00
IUUC-Oga-088021	Otolemur garnettii	92.58	0.00e+00	979.00
IUUC-Oar-089809	Ovis aries	92.58	0.00e+00	981.00
IUUC-Ptr-090834	Pan troglodytes	92.58	0.00e+00	983.00
IUUC-Pan-092225	Papio anubis	92.77	0.00e+00	985.00
IUUC-Psi-093317	Pelodiscus sinensis	69.86	0.00e+00	1142.00
IUUC-Pma-094249	Petromyzon marinus	74.74	7.00e-127	446.00
IUUC-Pab-097595	Pongo abelii	92.58	0.00e+00	983.00
IUUC-Pca-100844	Procavia capensis	78.32	0.00e+00	778.00
IUUC-Pva-103216	Pteropus vampyrus	93.14	0.00e+00	983.00
IUUC-Rno-105381	Rattus norvegicus	92.77	0.00e+00	985.00
IUUC-Sha-107574	Sarcophilus harrisii	92.97	0.00e+00	989.00
IUUC-Sar-113500	Sorex araneus	81.55	0.00e+00	783.00
IUUC-Ssc-115856	Sus scrofa	91.04	0.00e+00	763.00
IUUC-Tgu-116866	Taeniopygia guttata	93.05	0.00e+00	976.00
IUUC-Tru-118579	Takifugu rubripes	85.12	0.00e+00	870.00
IUUC-Tsy-119167	Tarsius syrichta	79.30	0.00e+00	810.00
IUUC-Tni-120788	Tetraodon nigroviridis	83.95	0.00e+00	874.00
IUUC-Tbe-127830	Tupaia belangeri	86.91	0.00e+00	903.00
IUUC-Ttr-128631	Tursiops truncatus	92.58	0.00e+00	983.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence