iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Itr-049085

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01058627

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000004036.2	ENSSTOT00000004031.2	ENSSTOP00000003615.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.00e-33	111.1	153	186
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	6.80e-15	54.7	358	405
UBD/Beta-Prp	3.00e-80	269.6	127	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 216  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqlepamddSDVHMSSLRSVCF 303
           ********************.********************************************99999988888667888888888* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ +       +  +n ++  f+p++  +++g+ Dg +++W
   Q: 304  SPEGLYLATVADDRLLRIWALELK--APVAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 362
           *********************888..57789999*************************** PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MLSPATEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC IVKLIPWPLE 60
EQFIPKGFEA KSRSSKNDTK GRGSPKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTTTTGA AGCATGCTGT CTCCTGCCAC AGAGGAACCG CTGCTGCTGG CAGAACTCAA 60
GCCCGGGCGC CCCCACCAAT TTGATTGGAA GTCGAGCTGT GAAACCTGGA GTGTCGCCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR023294--Tachylectin2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	97.78	0.00e+00	820.00
IUUC-Apl-004107	Anas platyrhynchos	69.03	9.00e-132	462.00
IUUC-Aca-004354	Anolis carolinensis	73.63	3.00e-169	587.00
IUUC-Bta-012627	Bos taurus	97.78	0.00e+00	776.00
IUUC-Cja-018897	Callithrix jacchus	96.40	0.00e+00	778.00
IUUC-Cfa-020122	Canis familiaris	98.03	0.00e+00	820.00
IUUC-Cpo-022540	Cavia porcellus	97.78	0.00e+00	795.00
IUUC-Csa-023719	Chlorocebus sabaeus	97.68	0.00e+00	790.00
IUUC-Cho-024367	Choloepus hoffmanni	96.31	3.00e-171	593.00
IUUC-Dno-029021	Dasypus novemcinctus	97.54	0.00e+00	793.00
IUUC-Dor-030321	Dipodomys ordii	98.20	0.00e+00	790.00
IUUC-Ete-032955	Echinops telfairi	97.74	0.00e+00	782.00
IUUC-Eca-033485	Equus caballus	97.95	0.00e+00	766.00
IUUC-Fca-035389	Felis catus	98.20	0.00e+00	791.00
IUUC-Fal-037184	Ficedula albicollis	84.81	2.00e-143	501.00
IUUC-Gga-041014	Gallus gallus	77.26	5.00e-178	616.00
IUUC-Ggo-045585	Gorilla gorilla	97.95	0.00e+00	797.00
IUUC-Hsa-046344	Homo sapiens	97.78	0.00e+00	798.00
IUUC-Lch-050131	Latimeria chalumnae	70.00	4.00e-169	587.00
IUUC-Loc-052807	Lepisosteus oculatus	54.57	7.00e-117	413.00
IUUC-Laf-053528	Loxodonta africana	98.03	0.00e+00	776.00
IUUC-Mcc-055665	Macaca mulatta	97.78	0.00e+00	798.00
IUUC-Meu-056054	Macropus eugenii	88.38	0.00e+00	700.00
IUUC-Mga-059326	Meleagris gallopavo	77.75	0.00e+00	634.00
IUUC-Mmr-060815	Microcebus murinus	95.81	0.00e+00	781.00
IUUC-Mdo-062000	Monodelphis domestica	91.07	0.00e+00	749.00
IUUC-Mmu-063927	Mus musculus	97.69	0.00e+00	789.00
IUUC-Mpu-065726	Mustela putorius furo	96.92	0.00e+00	778.00
IUUC-Mlu-067527	Myotis lucifugus	98.10	3.00e-120	423.00
IUUC-Nle-069680	Nomascus leucogenys	97.95	0.00e+00	791.00
IUUC-Opr-070356	Ochotona princeps	97.74	0.00e+00	803.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.58	2.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.54	0.00e+00	790.00
IUUC-Oga-088797	Otolemur garnettii	97.30	0.00e+00	788.00
IUUC-Oar-089187	Ovis aries	97.95	0.00e+00	774.00
IUUC-Ptr-091317	Pan troglodytes	97.95	0.00e+00	797.00
IUUC-Pan-092694	Papio anubis	89.87	0.00e+00	679.00
IUUC-Psi-093392	Pelodiscus sinensis	80.15	0.00e+00	644.00
IUUC-Pab-098145	Pongo abelii	97.68	0.00e+00	789.00
IUUC-Pca-100454	Procavia capensis	88.72	0.00e+00	719.00
IUUC-Pva-102986	Pteropus vampyrus	89.97	0.00e+00	728.00
IUUC-Rno-104931	Rattus norvegicus	96.39	0.00e+00	776.00
IUUC-Sha-106476	Sarcophilus harrisii	92.27	0.00e+00	748.00
IUUC-Ssc-115643	Sus scrofa	98.45	0.00e+00	791.00
IUUC-Tgu-117522	Taeniopygia guttata	64.37	1.00e-137	482.00
IUUC-Tsy-119301	Tarsius syrichta	97.99	0.00e+00	811.00
IUUC-Ttr-128683	Tursiops truncatus	98.45	0.00e+00	791.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence