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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046463
UUCD1 version UUC-HoS-01140
Ensembl Protein ID ENSP00000360994.3
UniProt Accession Q96FJ0; B3KPA7; Q5T9N4; Q5T9N9; Q7Z420; Q9P2H4; STALP_HUMAN
Genbank Protein ID BAC77766.1; BAA92611.1; BAG51619.1; CAI13861.1; CAI13862.1; CAI13863.1; EAW50156.1; AAH10846.2
Protein Name AMSH-like protease; STAM-binding protein-like 1
Genbank Nucleotide ID AB010120; AB037794; AK056086; AL157394; AL157394; AL157394; CH471066; BC010846
Gene Name STAMBPL1; AMSHLP; KIAA1373; AMSH-LP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138134.11 ENST00000371926.7 ENSP00000360994.3
ENSG00000138134.11 ENST00000371927.7 ENSP00000360995.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/JAMM JAMM 16716190
Classification
Family E-value Score Start End
UBD/Jab_MPN 1.10e-49 169.5 268 393
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Jab_MPN
   S: 5    vvvlpkrllkkflelsdvkiavavevyGlllgelvkdkevktvvlvpkqlagvgsvqvenvedvfdlldqeGlivlGWiHthpeelkflssv 96
            vvlp+ l++kfl+l+++++ +++e++G+l+g+l ++++++t+v+vpkq+ag +++++enve++f+++dq+ l +lGWiHthp++++flssv
   Q: 268  CVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSV 359
           69****************************************************************************************** PP
   S: 97   dvathsslealkkrsvaivsspkfqelsafkltd 130
           d++th+s++ ++++ +aiv+spk +++++f+lt+
   Q: 360  DLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTN 393
           ********************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
 Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains.
Protein Sequence
(Fasta)
MDQPFTVNSL KKLAAMPDHT DVSLSPEERV RALSKLGCNI TISEDITPRR YFRSGVEMER 60
MASVYLEEGN LENAFVLYNK FITLFVEKLP NHRDYQQCAV PEKQDIMKKL KEIAFPRTDE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046463|DUB,JAMM;UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAACATCCAG GAGATATTCT AATACTTCTT ATTTTCCAAG TACACACAAA TTGGGGGTAG 60
GGGGAAGGGC TAAGATGCTT AATAGTGGGC GTAGCCAGTT GTGGATAAAT ATCAAAAAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046463|DUB,JAMM;UBD,Jab_MPN|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR000555--JAMM/MPN+_dom
IPR007330--MIT
IPR015063--USP8_dimer
Pfam

PF01398--JAB
PF08969--USP8_dimer
SMART

SM00232--JAB_MPN
Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0016579--P:protein deubiquitination
KEGG hsa:57559
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000506 Aegilops tauschii 50.57 8.00e-44 172.00
IUUC-Aml-001297 Ailuropoda melanoleuca 89.68 0.00e+00 776.00
IUUC-Apl-003560 Anas platyrhynchos 80.50 0.00e+00 700.00
IUUC-Aca-004523 Anolis carolinensis 81.92 0.00e+00 688.00
IUUC-Aly-005784 Arabidopsis lyrata 41.63 6.00e-44 172.00
IUUC-Ath-007385 Arabidopsis thaliana 41.63 6.00e-44 172.00
IUUC-Ang-009659 Aspergillus niger 44.24 1.00e-43 171.00
IUUC-Ame-011650 Astyanax mexicanus 65.53 7.00e-157 546.00
IUUC-Bgr-012260 Blumeria graminis 46.33 2.00e-41 163.00
IUUC-Bta-012468 Bos taurus 92.66 0.00e+00 847.00
IUUC-Bdi-014845 Brachypodium distachyon 50.00 1.00e-43 171.00
IUUC-Cja-019809 Callithrix jacchus 98.62 0.00e+00 863.00
IUUC-Cfa-020729 Canis familiaris 88.07 0.00e+00 767.00
IUUC-Cpo-022124 Cavia porcellus 93.35 0.00e+00 816.00
IUUC-Cre-022989 Chlamydomonas reinhardtii 47.78 1.00e-33 135.00
IUUC-Csa-023702 Chlorocebus sabaeus 94.39 0.00e+00 833.00
IUUC-Cho-024802 Choloepus hoffmanni 87.32 0.00e+00 718.00
IUUC-Dre-027852 Danio rerio 65.98 2.00e-164 572.00
IUUC-Dno-029491 Dasypus novemcinctus 95.50 0.00e+00 814.00
IUUC-Dor-030785 Dipodomys ordii 93.63 0.00e+00 765.00
IUUC-Dse-031153 Dothistroma septosporum 49.72 6.00e-40 159.00
IUUC-Dme-031787 Drosophila melanogaster 40.53 1.00e-79 290.00
IUUC-Ete-032842 Echinops telfairi 90.21 0.00e+00 795.00
IUUC-Eca-034082 Equus caballus 93.81 0.00e+00 855.00
IUUC-Eeu-034738 Erinaceus europaeus 76.74 3.00e-169 587.00
IUUC-Fca-036175 Felis catus 90.83 0.00e+00 790.00
IUUC-Fal-037252 Ficedula albicollis 81.19 0.00e+00 709.00
IUUC-Gga-041246 Gallus gallus 78.90 0.00e+00 688.00
IUUC-Ggo-044665 Gorilla gorilla 91.14 0.00e+00 771.00
IUUC-Itr-047930 Ictidomys tridecemlineatus 95.41 0.00e+00 835.00
IUUC-Kpa-049381 Komagataella pastoris 31.40 1.00e-49 190.00
IUUC-Lch-049954 Latimeria chalumnae 79.17 0.00e+00 699.00
IUUC-Loc-052178 Lepisosteus oculatus 67.66 3.00e-173 601.00
IUUC-Laf-053366 Loxodonta africana 95.18 0.00e+00 832.00
IUUC-Mcc-055560 Macaca mulatta 99.04 0.00e+00 830.00
IUUC-Mtr-057642 Medicago truncatula 48.52 1.00e-44 174.00
IUUC-Mga-059433 Meleagris gallopavo 79.13 0.00e+00 689.00
IUUC-Mmr-061327 Microcebus murinus 96.18 0.00e+00 802.00
IUUC-Mdo-062783 Monodelphis domestica 75.21 2.00e-147 514.00
IUUC-Mmu-064307 Mus musculus 91.06 0.00e+00 798.00
IUUC-Mac-065572 Musa acuminata 48.82 8.00e-44 171.00
IUUC-Mpu-066259 Mustela putorius furo 90.83 0.00e+00 792.00
IUUC-Mlu-067657 Myotis lucifugus 93.81 0.00e+00 818.00
IUUC-Nle-069180 Nomascus leucogenys 98.11 0.00e+00 832.00
IUUC-Opr-070830 Ochotona princeps 94.50 0.00e+00 788.00
IUUC-Ont-071929 Oreochromis niloticus 61.68 1.00e-147 516.00
IUUC-Oan-073314 Ornithorhynchus anatinus 80.31 2.00e-174 604.00
IUUC-Ocu-074386 Oryctolagus cuniculus 95.87 0.00e+00 837.00
IUUC-Oba-075358 Oryza barthii 50.00 1.00e-43 170.00
IUUC-Obr-076024 Oryza brachyantha 50.00 8.00e-45 174.00
IUUC-Ogl-077100 Oryza glaberrima 50.00 5.00e-43 169.00
IUUC-Ogu-078047 Oryza glumaepatula 50.00 1.00e-43 171.00
IUUC-Oin-079545 Oryza indica 50.00 1.00e-43 171.00
IUUC-Olo-080359 Oryza longistaminata 50.00 1.00e-43 171.00
IUUC-Ome-081619 Oryza meridionalis 50.00 1.00e-43 171.00
IUUC-Oni-082079 Oryza nivara 50.00 1.00e-43 171.00
IUUC-Opu-083914 Oryza punctata 50.00 6.00e-43 168.00
IUUC-Oru-085251 Oryza rufipogon 50.00 1.00e-43 171.00
IUUC-Osa-085426 Oryza sativa 50.00 1.00e-43 171.00
IUUC-Ola-087457 Oryzias latipes 71.94 2.00e-55 207.00
IUUC-Oga-088150 Otolemur garnettii 95.28 0.00e+00 805.00
IUUC-Oar-089824 Ovis aries 91.18 0.00e+00 840.00
IUUC-Ptr-090702 Pan troglodytes 99.77 0.00e+00 869.00
IUUC-Pan-091924 Papio anubis 99.31 0.00e+00 861.00
IUUC-Psi-093069 Pelodiscus sinensis 83.72 0.00e+00 698.00
IUUC-Ppa-095540 Physcomitrella patens 47.93 5.00e-44 172.00
IUUC-Pab-098080 Pongo abelii 98.85 0.00e+00 865.00
IUUC-Pca-100352 Procavia capensis 94.50 0.00e+00 793.00
IUUC-Rno-104938 Rattus norvegicus 90.83 0.00e+00 792.00
IUUC-Sha-107154 Sarcophilus harrisii 84.63 0.00e+00 774.00
IUUC-Sja-107679 Schizosaccharomyces japonicus 34.21 8.00e-53 201.00
IUUC-Sit-110118 Setaria italica 45.37 3.00e-45 176.00
IUUC-Sly-111816 Solanum lycopersicum 50.30 3.00e-44 172.00
IUUC-Stu-112240 Solanum tuberosum 50.30 3.00e-44 172.00
IUUC-Sar-112924 Sorex araneus 93.06 0.00e+00 756.00
IUUC-Sbi-114439 Sorghum bicolor 45.97 2.00e-44 173.00
IUUC-Ssc-115372 Sus scrofa 93.81 0.00e+00 822.00
IUUC-Tsy-119100 Tarsius syrichta 95.22 0.00e+00 634.00
IUUC-Tae-124826 Triticum aestivum 50.57 5.00e-44 172.00
IUUC-Tur-126001 Triticum urartu 50.57 6.00e-44 172.00
IUUC-Tme-126874 Tuber melanosporum 48.33 2.00e-45 177.00
IUUC-Tbe-127977 Tupaia belangeri 94.24 0.00e+00 650.00
IUUC-Ttr-128291 Tursiops truncatus 94.27 0.00e+00 715.00
IUUC-Vpa-130821 Vicugna pacos 95.59 0.00e+00 780.00
IUUC-Vvi-131576 Vitis vinifera 45.25 3.00e-45 176.00
IUUC-Xma-133318 Xiphophorus maculatus 60.94 3.00e-149 521.00
IUUC-Yli-134641 Yarrowia lipolytica 49.71 5.00e-47 182.00
Created Date 25-Jun-2017

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