iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062140

UUCD1 version

UUC-MoD-01155

Ensembl Protein ID

ENSMODP00000024148.4

UniProt Accession

H9H7C2; H9H7C2_MONDO

Protein Name

Uncharacterized protein

Gene Name

USP30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000019352.4	ENSMODT00000024576.4	ENSMODP00000024148.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-54	184.3	68	500

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkekln.eenpkepkgellkslqklfeelw........kskkkavsprellkalkkea 81
           Gl NlgNtC+mNS+LQ Ls++p + + l e ++ + + +++++++ + l+ +l +l+++l         ++++++ +   ll++l+++ 
   Q: 68   GLLNLGNTCFMNSLLQGLSACPAFIRWLEE-FTAQYPaDQKETSKPQYLSLTLLRLLKALScqdvaggsEDEEEVLDAGCLLEVLRMYR 155
           9*****************************.44444404445677889999*********66666777788889999999********* PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecd 160
            ++s++e+qDa+E+++++ ++le+e    ++ ++ ++++ ++ e++ e          +   ++++++   ++ F+g+l+s+++c++c+
   Q: 156  WQISSFEEQDAHELFHVITSSLEDER--DRHPRVAHLFDMHSLEQQPEvthqqiscriRGALHPMSSTWKSQHPFHGRLTSNMVCKHCE 242
           **************************..4566666677766666666667777777779999999999********************* PP
   S: 161  nvs.sreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqe............aekklklkklPevLilhLkR 236
           ++s +r+++f +lsl++p  +   +++l++cL++f + e++++   + c++c+k +             a+  ++l+ +P +L      
   Q: 243  HQSpVRYDTFDSLSLSIPAATWGRPLTLDHCLHHFISSESVRD---VVCDNCTKVSPpppltwtvaggrAVSPISLTGCPGTLPRAPEP 328
           *****************************************97...9*****9666688888888888877777777777766544433 PP
   S: 237  f..........sfseeqksrekinkkvefpleLdlspfcts..........peekqke............................... 274
                       fs++   +  ++++ +fp+   l++  +           +                                     
   Q: 329  RsfsthptahsGFSSSYFISFLFSEHQHFPELCHLDSLKAPgaqqrpgsamS-----Pgrespaqtaeisvqpgrtkalfvngacsspa 412
           3123333333467777777777777888887777776666555555555550.....05555555556666666666666666666666 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                               + ++L+avvvH+G ++sGH+v+y ++          + +Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 413  llpspgpfslpgvpdysssVYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknpfsASSQWLWISDDTVRKASLQEVLS---SSAYLLFY 498
           66666666666666666669999***********************9888877777888*******************...******** PP
   S: 336  kr 337
           +r
   Q: 499  ER 500
           98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MFSPGTEAAG ALDRSLRRLL RAGTALRYKV MKNWGVLGGV AAALAAGIYV LWGPITERKK 60
RRKGLVPGLL NLGNTCFMNS LLQGLSACPA FIRWLEEFTA QYPADQKETS KPQYLSLTLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTCAGCC CCGGGACCGA GGCGGCGGGG GCACTGGACC GGAGCCTGCG GCGCCTCCTG 60
CGGGCTGGGA CCGCACTCAG GTTAGTGTGG CCTGTCTGGC GGTGAGGCCT GAGGAGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	24.05	2.00e-13	70.90
IUUC-Aml-001733	Ailuropoda melanoleuca	68.55	4.00e-168	584.00
IUUC-Apl-003645	Anas platyrhynchos	55.60	1.00e-66	246.00
IUUC-Aca-004583	Anolis carolinensis	67.11	2.00e-23	99.80
IUUC-Ame-010896	Astyanax mexicanus	52.72	1.00e-126	446.00
IUUC-Bta-012321	Bos taurus	69.12	5.00e-168	583.00
IUUC-Bra-016801	Brassica rapa	26.49	2.00e-18	87.00
IUUC-Cel-018308	Caenorhabditis elegans	27.00	6.00e-31	128.00
IUUC-Cja-018826	Callithrix jacchus	69.84	3.00e-177	614.00
IUUC-Cfa-021206	Canis familiaris	69.44	2.00e-169	588.00
IUUC-Cpo-021343	Cavia porcellus	69.32	2.00e-171	595.00
IUUC-Csa-023419	Chlorocebus sabaeus	69.98	3.00e-178	617.00
IUUC-Cho-024475	Choloepus hoffmanni	58.76	3.00e-73	269.00
IUUC-Cne-027061	Cryptococcus neoformans	25.10	1.00e-09	58.50
IUUC-Dre-027563	Danio rerio	54.60	3.00e-129	454.00
IUUC-Dno-029929	Dasypus novemcinctus	67.94	4.00e-170	591.00
IUUC-Dor-030166	Dipodomys ordii	59.16	7.00e-134	470.00
IUUC-Dme-031627	Drosophila melanogaster	36.57	1.00e-16	81.30
IUUC-Ete-032634	Echinops telfairi	64.68	3.00e-144	504.00
IUUC-Eca-033968	Equus caballus	70.42	1.00e-168	585.00
IUUC-Eeu-035279	Erinaceus europaeus	69.23	1.00e-51	197.00
IUUC-Fca-036525	Felis catus	69.50	9.00e-173	599.00
IUUC-Fal-036606	Ficedula albicollis	59.75	2.00e-117	415.00
IUUC-Gmo-038726	Gadus morhua	50.62	2.00e-116	412.00
IUUC-Gga-040718	Gallus gallus	61.48	5.00e-120	424.00
IUUC-Gac-042645	Gasterosteus aculeatus	52.99	2.00e-124	439.00
IUUC-Ggo-045021	Gorilla gorilla	70.18	9.00e-178	616.00
IUUC-Hsa-045832	Homo sapiens	70.18	9.00e-178	616.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	71.43	5.00e-172	597.00
IUUC-Lch-050662	Latimeria chalumnae	59.84	2.00e-136	479.00
IUUC-Lpe-051640	Leersia perrieri	26.46	6.00e-14	73.20
IUUC-Loc-052611	Lepisosteus oculatus	58.27	2.00e-143	502.00
IUUC-Laf-053752	Loxodonta africana	70.42	5.00e-168	583.00
IUUC-Mcc-054892	Macaca mulatta	70.38	5.00e-179	620.00
IUUC-Meu-056673	Macropus eugenii	65.47	9.00e-134	469.00
IUUC-Mtr-057976	Medicago truncatula	28.28	2.00e-16	80.90
IUUC-Mla-058970	Melampsora laricipopulina	22.89	8.00e-18	85.10
IUUC-Mga-059543	Meleagris gallopavo	64.45	1.00e-150	526.00
IUUC-Mmr-061534	Microcebus murinus	70.12	1.00e-172	599.00
IUUC-Mmu-063673	Mus musculus	68.92	9.00e-166	576.00
IUUC-Mpu-066328	Mustela putorius furo	68.51	8.00e-170	590.00
IUUC-Mlu-067938	Myotis lucifugus	70.06	6.00e-176	610.00
IUUC-Nle-069426	Nomascus leucogenys	68.22	1.00e-157	549.00
IUUC-Opr-070796	Ochotona princeps	55.51	1.00e-62	233.00
IUUC-Ont-072248	Oreochromis niloticus	52.52	3.00e-126	444.00
IUUC-Oan-072916	Ornithorhynchus anatinus	69.55	6.00e-172	597.00
IUUC-Ocu-074459	Oryctolagus cuniculus	63.22	3.00e-125	441.00
IUUC-Oba-075765	Oryza barthii	26.95	7.00e-13	68.90
IUUC-Obr-076005	Oryza brachyantha	28.82	1.00e-12	67.80
IUUC-Ogl-077916	Oryza glaberrima	29.20	2.00e-15	77.40
IUUC-Ogu-078263	Oryza glumaepatula	26.95	6.00e-13	68.90
IUUC-Ome-081928	Oryza meridionalis	28.40	2.00e-12	67.40
IUUC-Ola-087429	Oryzias latipes	48.63	1.00e-116	412.00
IUUC-Oga-087981	Otolemur garnettii	69.92	5.00e-173	600.00
IUUC-Oar-089927	Ovis aries	69.12	2.00e-167	582.00
IUUC-Ptr-090878	Pan troglodytes	70.18	9.00e-178	616.00
IUUC-Pan-092698	Papio anubis	70.38	5.00e-179	620.00
IUUC-Psi-093451	Pelodiscus sinensis	64.88	2.00e-164	572.00
IUUC-Pfo-096096	Poecilia formosa	53.86	1.00e-124	440.00
IUUC-Pab-098676	Pongo abelii	68.99	3.00e-173	601.00
IUUC-Pca-100418	Procavia capensis	83.46	4.00e-114	405.00
IUUC-Ppe-101898	Prunus persica	23.13	5.00e-17	82.80
IUUC-Pva-103018	Pteropus vampyrus	67.75	8.00e-170	590.00
IUUC-Pgr-103423	Puccinia graminis	40.54	6.00e-09	56.60
IUUC-Rno-105708	Rattus norvegicus	66.73	2.00e-164	572.00
IUUC-Sha-106971	Sarcophilus harrisii	76.23	0.00e+00	692.00
IUUC-Sit-110442	Setaria italica	26.69	2.00e-21	97.10
IUUC-Ssc-116397	Sus scrofa	69.52	9.00e-170	590.00
IUUC-Tgu-117446	Taeniopygia guttata	58.78	1.00e-140	493.00
IUUC-Tru-118268	Takifugu rubripes	51.71	3.00e-116	412.00
IUUC-Tsy-119484	Tarsius syrichta	76.27	2.00e-42	167.00
IUUC-Tni-119735	Tetraodon nigroviridis	49.67	2.00e-97	349.00
IUUC-Tae-125383	Triticum aestivum	25.35	6.00e-20	92.40
IUUC-Tur-126458	Triticum urartu	23.43	1.00e-16	81.30
IUUC-Tbe-127740	Tupaia belangeri	64.34	1.00e-148	519.00
IUUC-Ttr-129273	Tursiops truncatus	68.66	3.00e-167	581.00
IUUC-Xtr-132374	Xenopus tropicalis	56.37	2.00e-135	476.00
IUUC-Xma-133267	Xiphophorus maculatus	54.38	7.00e-124	437.00
IUUC-Yli-134426	Yarrowia lipolytica	24.34	5.00e-04	40.00
IUUC-Zma-135796	Zea mays	24.39	7.00e-21	95.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence