iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042441

UUCD1 version

UUC-GaA-01265

Ensembl Protein ID

ENSGACP00000013232.1

UniProt Accession

G3P6K9; G3P6K9_GASAC

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000010015.1	ENSGACT00000013257.1	ENSGACP00000013232.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-54	186.4	336	866
UBD/Alpha-Helix/UBA	2.80e-18	65.8	733	768

Active Site

Position(s)	Description	Evidence
345	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
829	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG kNlgN+CY+  v+Q+L++ip++++++   + +++ + +p +p+++++++++kl + l                       k+++k 
   Q: 336  TGVKNLGNSCYLGTVIQVLFSIPDFQRMYVG-NLQRIFDYSPLDPSQDFATQMAKLGHGLlsglyskppmkselieqvmkegHKHQQKG 423
           79*****************************.7777778889******************9999999999999998876654499999* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           vspr+l++ +++ ++efs+++qqDa+Efl+++++ +e++                               +++  sd+F++ ++++++c
   Q: 424  VSPRMLKALVSRGHPEFSSNRQQDAHEFLQHMVNLVERNS-----------------------------AGSENPSDVFRFLVEERVQC 483
           *************************************999.............................678899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  ++   + ++lp p +  t+ e                            ++ cL++ft++e++ +   ++++  ++k+  +
   Q: 484  CQTRRVRYTQRVDYCIQLPAPIEAATNREelvayetkrreaeenmqappdpvtariPFTACLQAFTEPENVPD---FWSSALQAKSAGV 569
           9999998777766666666666665555567****************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ +++++Pe+L+l++k+f+f  + ++++k++  +++p+ Ldls+  ++                                        
   Q: 570  KTSRFSSFPEYLVLQIKKFTFGVD-WVPKKLDLAIDVPDFLDLSRLRATglqtseeelpdllppivlpedtrgteqgtllvapeideaa 657
           *********************776.*******************988887888888888888888888888888777777777777777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 658  vmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpsealmdpgpstsespmggtppgnsppeesisiltsmgfpr 746
           77777777777777777777777777777777777777777777777777777777777666666666666666666666666666666 PP
   S: 268  ........................peekqke....................................kkkYeLiavvvHsG.slssGHY 295
                                   p     e                                    + +YeL+a ++H+G s+ sGHY
   Q: 747  ahsiqalkatnnnleraldwifihP-----EqqeeesdalsdeadtqpndnafsndrgasgprvkdgPGRYELFAFISHMGaSTMSGHY 830
           6666666655555555555555551.....0555556777888888888888999999999999999********************** PP
   S: 296  vayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           v+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 831  VCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYHR 866
           ******.9***********988..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLl 39
           e+ +  l++MGF+r + +qaL a+nnnle+A+++++
   Q: 733  EESISILTSMGFPRAHSIQALKATNNNLERALDWIF 768
           88999*****************************98 PP

Organism

Gasterosteus aculeatus

Protein Sequence
(Fasta)

PRCRAAPRHC GARSRNAKMA ADLGELLVPY MPTIRVPRTG DRVYKSECVF SFDSPESEGG 60
LYVCMNTFLG FGREHVERHY RKTGQSVYMH LKRHVKEKAT GAAAGAVPRR RNGKVFLDLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGCTGCC GCGCGGCTCC GCGGCACTGT GGCGCGAGGA GCAGGAATGC AAAGATGGCT 60
GCGGACCTCG GCGAGCTGCT GGTCCCGTAC ATGCCCACCA TCCGAGTGCC CAGGACGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	72.18	0.00e+00	1226.00
IUUC-Apl-003712	Anas platyrhynchos	72.83	0.00e+00	1208.00
IUUC-Aca-004634	Anolis carolinensis	72.20	0.00e+00	1239.00
IUUC-Ame-011470	Astyanax mexicanus	80.65	0.00e+00	1412.00
IUUC-Bta-013349	Bos taurus	72.47	0.00e+00	1235.00
IUUC-Cja-019021	Callithrix jacchus	72.37	0.00e+00	1221.00
IUUC-Cfa-020614	Canis familiaris	72.42	0.00e+00	1224.00
IUUC-Cpo-022484	Cavia porcellus	71.17	0.00e+00	1157.00
IUUC-Csa-024078	Chlorocebus sabaeus	72.48	0.00e+00	1228.00
IUUC-Cho-024522	Choloepus hoffmanni	59.95	0.00e+00	909.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.15	5.00e-55	209.00
IUUC-Dre-027651	Danio rerio	80.79	0.00e+00	1476.00
IUUC-Dno-028975	Dasypus novemcinctus	72.20	0.00e+00	1219.00
IUUC-Dor-030130	Dipodomys ordii	52.98	0.00e+00	794.00
IUUC-Ete-032251	Echinops telfairi	60.57	0.00e+00	949.00
IUUC-Eca-033568	Equus caballus	71.87	0.00e+00	1158.00
IUUC-Fca-036280	Felis catus	72.04	0.00e+00	1160.00
IUUC-Fal-036610	Ficedula albicollis	73.11	0.00e+00	1191.00
IUUC-Gmo-038906	Gadus morhua	84.62	0.00e+00	1511.00
IUUC-Gga-041215	Gallus gallus	72.70	0.00e+00	1261.00
IUUC-Ggo-044446	Gorilla gorilla	72.37	0.00e+00	1228.00
IUUC-Hsa-046546	Homo sapiens	72.13	0.00e+00	1222.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	67.21	0.00e+00	1112.00
IUUC-Lch-050425	Latimeria chalumnae	71.94	0.00e+00	1286.00
IUUC-Loc-052072	Lepisosteus oculatus	77.35	0.00e+00	1342.00
IUUC-Laf-053909	Loxodonta africana	70.30	0.00e+00	1213.00
IUUC-Mcc-054686	Macaca mulatta	72.37	0.00e+00	1228.00
IUUC-Meu-056361	Macropus eugenii	72.51	0.00e+00	944.00
IUUC-Mga-059972	Meleagris gallopavo	70.25	0.00e+00	1151.00
IUUC-Mmr-060916	Microcebus murinus	71.43	0.00e+00	1224.00
IUUC-Mdo-062302	Monodelphis domestica	73.89	0.00e+00	1307.00
IUUC-Mmu-063639	Mus musculus	71.75	0.00e+00	1216.00
IUUC-Mpu-066533	Mustela putorius furo	72.06	0.00e+00	1225.00
IUUC-Mlu-067786	Myotis lucifugus	68.14	0.00e+00	1143.00
IUUC-Nle-069997	Nomascus leucogenys	71.71	0.00e+00	1148.00
IUUC-Ont-071859	Oreochromis niloticus	86.98	0.00e+00	1553.00
IUUC-Oan-072959	Ornithorhynchus anatinus	74.69	7.00e-107	379.00
IUUC-Ocu-074265	Oryctolagus cuniculus	70.90	0.00e+00	1218.00
IUUC-Ola-087344	Oryzias latipes	87.84	0.00e+00	1592.00
IUUC-Oga-088734	Otolemur garnettii	72.14	0.00e+00	1207.00
IUUC-Oar-089636	Ovis aries	72.48	0.00e+00	1196.00
IUUC-Ptr-090982	Pan troglodytes	72.25	0.00e+00	1226.00
IUUC-Pan-091991	Papio anubis	72.48	0.00e+00	1229.00
IUUC-Psi-093509	Pelodiscus sinensis	72.73	0.00e+00	1278.00
IUUC-Pfo-096029	Poecilia formosa	88.70	0.00e+00	1600.00
IUUC-Pab-098672	Pongo abelii	68.97	0.00e+00	1139.00
IUUC-Pca-100860	Procavia capensis	54.68	0.00e+00	768.00
IUUC-Pva-102545	Pteropus vampyrus	67.13	0.00e+00	1108.00
IUUC-Rno-105210	Rattus norvegicus	71.63	0.00e+00	1207.00
IUUC-Sar-113733	Sorex araneus	73.83	1.00e-173	603.00
IUUC-Tgu-116591	Taeniopygia guttata	73.14	0.00e+00	1276.00
IUUC-Tru-118627	Takifugu rubripes	86.64	0.00e+00	1576.00
IUUC-Tsy-119278	Tarsius syrichta	64.25	0.00e+00	1035.00
IUUC-Tni-120804	Tetraodon nigroviridis	88.52	0.00e+00	1604.00
IUUC-Tbe-127699	Tupaia belangeri	60.30	0.00e+00	659.00
IUUC-Ttr-128295	Tursiops truncatus	65.77	0.00e+00	1112.00
IUUC-Vpa-130170	Vicugna pacos	63.39	0.00e+00	987.00
IUUC-Xtr-132809	Xenopus tropicalis	69.11	0.00e+00	1211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence