iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118627

UUCD1 version

UUC-TaR-01164

Ensembl Protein ID

ENSTRUP00000045130.1

UniProt Accession

H2V7E1; H2V7E1_TAKRU

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

usp13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017606.1	ENSTRUT00000045282.1	ENSTRUP00000045130.1
ENSTRUG00000017606.1	ENSTRUT00000045283.1	ENSTRUP00000045131.1
ENSTRUG00000017606.1	ENSTRUT00000045284.1	ENSTRUP00000045132.1
ENSTRUG00000017606.1	ENSTRUT00000045285.1	ENSTRUP00000045133.1
ENSTRUG00000017606.1	ENSTRUT00000045286.1	ENSTRUP00000045134.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-54	187.2	324	876
UBD/Alpha-Helix/UBA	1.70e-14	54.6	734	771

Active Site

Position(s)	Description	Evidence
333	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
839	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgNtCY+  v+Q+L++ip++++++   + +++ + +p +p+++++++++kl + l                       ++++k 
   Q: 324  TGIKNLGNTCYLSTVMQVLFSIPDFQRMYVG-NLQRIFDYSPLDPSQDFATQMAKLGHGLlsgqyskppmkselieqvicpeIQHQQKG 411
           7******************************.7777778889******************9999999999999988876665499999* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           vspr+l++ +++ ++efs+++qqDa+Efl +l++ +e++                               +++  sd+F++ ++++++c
   Q: 412  VSPRMLKALVSRGHPEFSSNRQQDAHEFLLHLINLVERNS-----------------------------AGSENPSDVFRFLVEERVQC 471
           *************************************999.............................678899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke.............................slqdcLesftkeeelegenkyycekckkkqe 216
            + ++v   +++ +d+ +++p   e + +                              ++ cL++ft++e++ +   ++++  ++k+ 
   Q: 472  CQSRQVR--YSQRVDYCIQLPAPLEAAINreelltyeakkkeaeenmqpppepvrariPFTACLQAFTEPENVPD---FWSSALQAKSA 555
           5555555..555554444444333333333467899999999*******************************97...*********** PP
   S: 217  aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts...................................... 267
            +k+ ++ ++Pe+Lil++k+f+f  + ++++k++  +++p+ Ldl++  ++                                      
   Q: 556  GVKTSRFASFPEYLILQIKKFTFGVD-WVPKKLDLAIDVPDFLDLNRLRATglqaseeelpdlmppivlpedtrerfvlfspdehvfca 643
           ***********************776.*******************9888878888888888888888888888888888888888777 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 644  pkecrktsspeideaavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpslmdsapstsdsvmgatpldpnpp 732
           77777777777777777777777777777777777777666666666666666666666666666666666666666666666665555 PP
   S: 268  ..................peekqke................................................................ 274
                                   +                                                                
   Q: 733  peesisiltsmgfprthsI-----Nalkamnnnleraldwifthpepeesdalsdmadtepndnafsnanshsdatlspdrdttgprik 816
           5555555555555555550.....05555555555556666666666666666677777777777777888888889999999999999 PP
   S: 275  ..kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
             + +YeL+a ++H+G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 817  dgPGRYELFAFISHMGeSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYHR 876
           99****************************.9***********988..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+ +  l++MGF+r + + aL a nnnle+A+++++++
   Q: 734  EESISILTSMGFPRTHSINALKAMNNNLERALDWIFTH 771
           889999******************************98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MATDLGELLV PYMPTIRVPR TGDRVFKSEC AFSFDSPESE GGLYVCMNTF LGFGREHVER 60
HYRKTGQSVY MHLKRHVKEK ATGAAGGAIP RRRNGKVFLD LELNRDFNGD DYEYEDEAKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATGTGAAG ATGGCAACAG ACCTCGGAGA GCTGCTGGTC CCCTACATGC CCACCATCAG 60
GGTTCCCAGG ACCGGAGACC GGGTGTTCAA GAGCGAGTGC GCGTTTTCCT TCGACTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	39.69	5.00e-167	581.00
IUUC-Aml-001356	Ailuropoda melanoleuca	71.07	0.00e+00	1226.00
IUUC-Apl-003712	Anas platyrhynchos	70.73	0.00e+00	1210.00
IUUC-Aca-004634	Anolis carolinensis	71.67	0.00e+00	1248.00
IUUC-Afl-008547	Aspergillus flavus	33.87	2.00e-103	369.00
IUUC-Ani-009441	Aspergillus nidulans	31.82	2.00e-88	320.00
IUUC-Ame-011470	Astyanax mexicanus	80.57	0.00e+00	1440.00
IUUC-Bta-013349	Bos taurus	70.94	0.00e+00	1236.00
IUUC-Cja-019021	Callithrix jacchus	70.91	0.00e+00	1218.00
IUUC-Cfa-020614	Canis familiaris	71.07	0.00e+00	1224.00
IUUC-Cpo-022484	Cavia porcellus	69.92	0.00e+00	1157.00
IUUC-Csa-024078	Chlorocebus sabaeus	71.02	0.00e+00	1226.00
IUUC-Cho-024522	Choloepus hoffmanni	58.98	0.00e+00	908.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.21	1.00e-50	195.00
IUUC-Dre-027651	Danio rerio	82.86	0.00e+00	1503.00
IUUC-Dno-028975	Dasypus novemcinctus	70.52	0.00e+00	1215.00
IUUC-Dor-030130	Dipodomys ordii	59.11	0.00e+00	690.00
IUUC-Ete-032251	Echinops telfairi	59.12	0.00e+00	954.00
IUUC-Eca-033568	Equus caballus	70.87	0.00e+00	1162.00
IUUC-Fca-036280	Felis catus	70.75	0.00e+00	1161.00
IUUC-Fal-036610	Ficedula albicollis	70.98	0.00e+00	1186.00
IUUC-Gmo-038906	Gadus morhua	80.95	0.00e+00	1442.00
IUUC-Gga-041215	Gallus gallus	71.18	0.00e+00	1262.00
IUUC-Gac-042441	Gasterosteus aculeatus	86.52	0.00e+00	1554.00
IUUC-Ggo-044446	Gorilla gorilla	70.91	0.00e+00	1226.00
IUUC-Hsa-046546	Homo sapiens	70.68	0.00e+00	1220.00
IUUC-Hvu-047563	Hordeum vulgare	43.85	3.00e-158	551.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	65.79	0.00e+00	1133.00
IUUC-Lch-050425	Latimeria chalumnae	72.07	0.00e+00	1299.00
IUUC-Loc-052072	Lepisosteus oculatus	75.23	0.00e+00	1317.00
IUUC-Laf-053909	Loxodonta africana	69.89	0.00e+00	1209.00
IUUC-Mcc-054686	Macaca mulatta	70.91	0.00e+00	1225.00
IUUC-Meu-056361	Macropus eugenii	72.76	0.00e+00	950.00
IUUC-Mga-059972	Meleagris gallopavo	70.52	0.00e+00	1173.00
IUUC-Mmr-060916	Microcebus murinus	70.11	0.00e+00	1223.00
IUUC-Mdo-062302	Monodelphis domestica	72.78	0.00e+00	1310.00
IUUC-Mmu-063639	Mus musculus	70.09	0.00e+00	1224.00
IUUC-Mac-065634	Musa acuminata	37.18	6.00e-163	568.00
IUUC-Mpu-066533	Mustela putorius furo	70.96	0.00e+00	1223.00
IUUC-Mlu-067786	Myotis lucifugus	68.23	0.00e+00	1155.00
IUUC-Nle-069997	Nomascus leucogenys	70.06	0.00e+00	1141.00
IUUC-Ont-071859	Oreochromis niloticus	89.04	0.00e+00	1608.00
IUUC-Oan-072959	Ornithorhynchus anatinus	74.90	2.00e-108	385.00
IUUC-Ocu-074265	Oryctolagus cuniculus	70.45	0.00e+00	1217.00
IUUC-Ola-087344	Oryzias latipes	86.85	0.00e+00	1589.00
IUUC-Oga-088734	Otolemur garnettii	70.66	0.00e+00	1205.00
IUUC-Oar-089636	Ovis aries	70.73	0.00e+00	1199.00
IUUC-Ptr-090982	Pan troglodytes	70.80	0.00e+00	1224.00
IUUC-Pan-091991	Papio anubis	71.02	0.00e+00	1227.00
IUUC-Psi-093509	Pelodiscus sinensis	72.70	0.00e+00	1286.00
IUUC-Pfo-096029	Poecilia formosa	89.24	0.00e+00	1640.00
IUUC-Pab-098672	Pongo abelii	67.50	0.00e+00	1137.00
IUUC-Pva-102545	Pteropus vampyrus	69.75	0.00e+00	1021.00
IUUC-Rno-105210	Rattus norvegicus	69.41	0.00e+00	1205.00
IUUC-Spo-108144	Schizosaccharomyces pombe	29.67	7.00e-102	365.00
IUUC-Sar-113733	Sorex araneus	73.90	1.00e-176	613.00
IUUC-Tgu-116591	Taeniopygia guttata	70.88	0.00e+00	1272.00
IUUC-Tsy-119278	Tarsius syrichta	63.35	0.00e+00	1031.00
IUUC-Tni-120804	Tetraodon nigroviridis	93.63	0.00e+00	1707.00
IUUC-Ttr-128295	Tursiops truncatus	63.79	0.00e+00	1104.00
IUUC-Vpa-130170	Vicugna pacos	62.20	0.00e+00	984.00
IUUC-Xtr-132809	Xenopus tropicalis	66.70	0.00e+00	1193.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence